Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTBP2 (C-terminal binding protein 2)

Identity

Alias_symbol (synonym)ribeye
Other alias-
HGNC (Hugo) CTBP2
LocusID (NCBI) 1488
Atlas_Id 40186
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 124987849 and ends at 125161061 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTBP2 (10q26.13) / ADAM12 (10q26.2)CTBP2 (10q26.13) / CTBP2 (10q26.13)MIR5095 (1p32.3) / CTBP2 (10q26.13)
CTBP2 10q26.13 / ADAM12 10q26.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)CTBP2   2495
Cards
Entrez_Gene (NCBI)CTBP2  1488  C-terminal binding protein 2
Aliases
GeneCards (Weizmann)CTBP2
Ensembl hg19 (Hinxton)ENSG00000175029 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175029 [Gene_View]  chr10:124987849-125161061 [Contig_View]  CTBP2 [Vega]
ICGC DataPortalENSG00000175029
TCGA cBioPortalCTBP2
AceView (NCBI)CTBP2
Genatlas (Paris)CTBP2
WikiGenes1488
SOURCE (Princeton)CTBP2
Genetics Home Reference (NIH)CTBP2
Genomic and cartography
GoldenPath hg38 (UCSC)CTBP2  -     chr10:124987849-125161061 -  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTBP2  -     10q26.13   [Description]    (hg19-Feb_2009)
EnsemblCTBP2 - 10q26.13 [CytoView hg19]  CTBP2 - 10q26.13 [CytoView hg38]
Mapping of homologs : NCBICTBP2 [Mapview hg19]  CTBP2 [Mapview hg38]
OMIM602619   
Gene and transcription
Genbank (Entrez)AF016507 AF222711 AK290390 AL833398 BC002486
RefSeq transcript (Entrez)NM_001083914 NM_001290214 NM_001290215 NM_001321012 NM_001321013 NM_001321014 NM_001329 NM_022802
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTBP2
Cluster EST : UnigeneHs.501345 [ NCBI ]
CGAP (NCI)Hs.501345
Alternative Splicing GalleryENSG00000175029
Gene ExpressionCTBP2 [ NCBI-GEO ]   CTBP2 [ EBI - ARRAY_EXPRESS ]   CTBP2 [ SEEK ]   CTBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)CTBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1488
GTEX Portal (Tissue expression)CTBP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56545   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56545  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56545
Splice isoforms : SwissVarP56545
PhosPhoSitePlusP56545
Domaine pattern : Prosite (Expaxy)D_2_HYDROXYACID_DH_3 (PS00671)   
Domains : Interpro (EBI)D-isomer_2_OHA_DH_cat_dom    D-isomer_DH_CS    D-isomer_DH_NAD-bd    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)2-Hacid_dh (PF00389)    2-Hacid_dh_C (PF02826)   
Domain families : Pfam (NCBI)pfam00389    pfam02826   
Conserved Domain (NCBI)CTBP2
DMDM Disease mutations1488
Blocks (Seattle)CTBP2
PDB (SRS)2OME    4LCJ   
PDB (PDBSum)2OME    4LCJ   
PDB (IMB)2OME    4LCJ   
PDB (RSDB)2OME    4LCJ   
Structural Biology KnowledgeBase2OME    4LCJ   
SCOP (Structural Classification of Proteins)2OME    4LCJ   
CATH (Classification of proteins structures)2OME    4LCJ   
SuperfamilyP56545
Human Protein AtlasENSG00000175029
Peptide AtlasP56545
HPRD04016
IPIIPI00010120   IPI00010136   IPI00647506   IPI00983748   
Protein Interaction databases
DIP (DOE-UCLA)P56545
IntAct (EBI)P56545
FunCoupENSG00000175029
BioGRIDCTBP2
STRING (EMBL)CTBP2
ZODIACCTBP2
Ontologies - Pathways
QuickGOP56545
Ontology : AmiGOchromatin binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  nucleus  transcription, DNA-templated  negative regulation of cell proliferation  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  transcriptional repressor complex  viral genome replication  protein kinase binding  cell junction  protein complex binding  positive regulation of chromatin binding  retinoic acid receptor binding  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of retinoic acid receptor signaling pathway  white fat cell differentiation  NAD binding  oxidation-reduction process  ribbon synapse  
Ontology : EGO-EBIchromatin binding  transcription coactivator activity  transcription corepressor activity  protein binding  nucleus  nucleus  transcription, DNA-templated  negative regulation of cell proliferation  oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  transcriptional repressor complex  viral genome replication  protein kinase binding  cell junction  protein complex binding  positive regulation of chromatin binding  retinoic acid receptor binding  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of retinoic acid receptor signaling pathway  white fat cell differentiation  NAD binding  oxidation-reduction process  ribbon synapse  
Pathways : KEGGWnt signaling pathway    Notch signaling pathway    Pathways in cancer    Chronic myeloid leukemia   
NDEx NetworkCTBP2
Atlas of Cancer Signalling NetworkCTBP2
Wikipedia pathwaysCTBP2
Orthology - Evolution
OrthoDB1488
GeneTree (enSembl)ENSG00000175029
Phylogenetic Trees/Animal Genes : TreeFamCTBP2
HOVERGENP56545
HOGENOMP56545
Homologs : HomoloGeneCTBP2
Homology/Alignments : Family Browser (UCSC)CTBP2
Gene fusions - Rearrangements
Fusion : MitelmanCTBP2/ADAM12 [10q26.13/10q26.2]  
Fusion: TCGACTBP2 10q26.13 ADAM12 10q26.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTBP2
dbVarCTBP2
ClinVarCTBP2
1000_GenomesCTBP2 
Exome Variant ServerCTBP2
ExAC (Exome Aggregation Consortium)CTBP2 (select the gene name)
Genetic variants : HAPMAP1488
Genomic Variants (DGV)CTBP2 [DGVbeta]
DECIPHERCTBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTBP2 
Mutations
ICGC Data PortalCTBP2 
TCGA Data PortalCTBP2 
Broad Tumor PortalCTBP2
OASIS PortalCTBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTBP2
DgiDB (Drug Gene Interaction Database)CTBP2
DoCM (Curated mutations)CTBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTBP2 (select a term)
intoGenCTBP2
Cancer3DCTBP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602619   
Orphanet
MedgenCTBP2
Genetic Testing Registry CTBP2
NextProtP56545 [Medical]
TSGene1488
GENETestsCTBP2
Target ValidationCTBP2
Huge Navigator CTBP2 [HugePedia]
snp3D : Map Gene to Disease1488
BioCentury BCIQCTBP2
ClinGenCTBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1488
Chemical/Pharm GKB GenePA26996
Clinical trialCTBP2
Miscellaneous
canSAR (ICR)CTBP2 (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTBP2
EVEXCTBP2
GoPubMedCTBP2
iHOPCTBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:58:51 CEST 2017

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