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CTC1 (CTS telomere maintenance complex component 1)

Identity

Alias_namesC17orf68
tmp494178
chromosome 17 open reading frame 68
CST telomere maintenance complex component 1
Alias_symbol (synonym)FLJ22170
AAF132
Other aliasAAF-132
CRMCC
HGNC (Hugo) CTC1
LocusID (NCBI) 80169
Atlas_Id 56248
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8128139 and ends at 8151413 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CTC1 (17p13.1) / COL14A1 (8q24.12)CTC1 (17p13.1) / CORO6 (17q11.2)RBM10 (Xp11.23) / CTC1 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTC1   26169
Cards
Entrez_Gene (NCBI)CTC1  80169  CTS telomere maintenance complex component 1
AliasesAAF-132; AAF132; C17orf68; CRMCC; 
tmp494178
GeneCards (Weizmann)CTC1
Ensembl hg19 (Hinxton)ENSG00000178971 [Gene_View]  chr17:8128139-8151413 [Contig_View]  CTC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000178971 [Gene_View]  chr17:8128139-8151413 [Contig_View]  CTC1 [Vega]
ICGC DataPortalENSG00000178971
TCGA cBioPortalCTC1
AceView (NCBI)CTC1
Genatlas (Paris)CTC1
WikiGenes80169
SOURCE (Princeton)CTC1
Genetics Home Reference (NIH)CTC1
Genomic and cartography
GoldenPath hg19 (UCSC)CTC1  -     chr17:8128139-8151413 -  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CTC1  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblCTC1 - 17p13.1 [CytoView hg19]  CTC1 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBICTC1 [Mapview hg19]  CTC1 [Mapview hg38]
OMIM612199   613129   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_025099
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTC1
Cluster EST : UnigeneHs.156055 [ NCBI ]
CGAP (NCI)Hs.156055
Alternative Splicing GalleryENSG00000178971
Gene ExpressionCTC1 [ NCBI-GEO ]   CTC1 [ EBI - ARRAY_EXPRESS ]   CTC1 [ SEEK ]   CTC1 [ MEM ]
Gene Expression Viewer (FireBrowse)CTC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80169
GTEX Portal (Tissue expression)CTC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ2NKJ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ2NKJ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ2NKJ3
Splice isoforms : SwissVarQ2NKJ3
PhosPhoSitePlusQ2NKJ3
Domains : Interpro (EBI)CTC1   
Domain families : Pfam (Sanger)CTC1 (PF15489)   
Domain families : Pfam (NCBI)pfam15489   
Conserved Domain (NCBI)CTC1
DMDM Disease mutations80169
Blocks (Seattle)CTC1
SuperfamilyQ2NKJ3
Human Protein AtlasENSG00000178971
Peptide AtlasQ2NKJ3
HPRD07980
IPIIPI00018087   IPI00855745   
Protein Interaction databases
DIP (DOE-UCLA)Q2NKJ3
IntAct (EBI)Q2NKJ3
FunCoupENSG00000178971
BioGRIDCTC1
STRING (EMBL)CTC1
ZODIACCTC1
Ontologies - Pathways
QuickGOQ2NKJ3
Ontology : AmiGOtelomere maintenance  nuclear chromosome, telomeric region  single-stranded DNA binding  protein binding  nucleus  nucleus  cellular response to DNA damage stimulus  regulation of G2/M transition of mitotic cell cycle  telomerase inhibitor activity  telomere maintenance via telomere lengthening  multicellular organism growth  telomeric DNA binding  positive regulation of DNA replication  positive regulation of DNA replication  positive regulation of fibroblast proliferation  spleen development  thymus development  bone marrow development  negative regulation of telomerase activity  hematopoietic stem cell proliferation  replicative senescence  G-rich strand telomeric DNA binding  regulation of telomere maintenance via telomere lengthening  CST complex  CST complex  
Ontology : EGO-EBItelomere maintenance  nuclear chromosome, telomeric region  single-stranded DNA binding  protein binding  nucleus  nucleus  cellular response to DNA damage stimulus  regulation of G2/M transition of mitotic cell cycle  telomerase inhibitor activity  telomere maintenance via telomere lengthening  multicellular organism growth  telomeric DNA binding  positive regulation of DNA replication  positive regulation of DNA replication  positive regulation of fibroblast proliferation  spleen development  thymus development  bone marrow development  negative regulation of telomerase activity  hematopoietic stem cell proliferation  replicative senescence  G-rich strand telomeric DNA binding  regulation of telomere maintenance via telomere lengthening  CST complex  CST complex  
NDEx NetworkCTC1
Atlas of Cancer Signalling NetworkCTC1
Wikipedia pathwaysCTC1
Orthology - Evolution
OrthoDB80169
GeneTree (enSembl)ENSG00000178971
Phylogenetic Trees/Animal Genes : TreeFamCTC1
HOVERGENQ2NKJ3
HOGENOMQ2NKJ3
Homologs : HomoloGeneCTC1
Homology/Alignments : Family Browser (UCSC)CTC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTC1
dbVarCTC1
ClinVarCTC1
1000_GenomesCTC1 
Exome Variant ServerCTC1
ExAC (Exome Aggregation Consortium)CTC1 (select the gene name)
Genetic variants : HAPMAP80169
Genomic Variants (DGV)CTC1 [DGVbeta]
DECIPHER (Syndromes)17:8128139-8151413  ENSG00000178971
CONAN: Copy Number AnalysisCTC1 
Mutations
ICGC Data PortalCTC1 
TCGA Data PortalCTC1 
Broad Tumor PortalCTC1
OASIS PortalCTC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTC1
DgiDB (Drug Gene Interaction Database)CTC1
DoCM (Curated mutations)CTC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTC1 (select a term)
intoGenCTC1
Cancer3DCTC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612199    613129   
Orphanet477    21456   
MedgenCTC1
Genetic Testing Registry CTC1
NextProtQ2NKJ3 [Medical]
TSGene80169
GENETestsCTC1
Huge Navigator CTC1 [HugePedia]
snp3D : Map Gene to Disease80169
BioCentury BCIQCTC1
ClinGenCTC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80169
Chemical/Pharm GKB GenePA142672251
Clinical trialCTC1
Miscellaneous
canSAR (ICR)CTC1 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTC1
EVEXCTC1
GoPubMedCTC1
iHOPCTC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:08 CET 2017

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