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CTDSP2 (CTD small phosphatase 2)

Identity

Alias (NCBI)OS4
PSR2
SCP2
HGNC (Hugo) CTDSP2
HGNC Alias symbOS4
SCP2
PSR2
HGNC Alias nameconserved gene amplified in osteosarcoma
 nuclear LIM interactor-interacting factor 2
 NLI-interacting factor 2
 small CTD phosphatase 2
HGNC Previous nameCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
LocusID (NCBI) 10106
Atlas_Id 40188
Location 12q14.1  [Link to chromosome band 12q14]
Location_base_pair Starts at 57819927 and ends at 57846729 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTDSP2 (12q14.1) / C12orf10 (12q13.13)CTDSP2 (12q14.1) / COL15A1 (9q22.33)CTDSP2 (12q14.1) / DCUN1D4 (4q12)
CTDSP2 (12q14.1) / EPSTI1 (13q14.11)CTDSP2 (12q14.1) / FAM19A2 (12q14.1)CTDSP2 (12q14.1) / MDM2 (12q15)
CTDSP2 (12q14.1) / RTN4IP1 (6q21)CTDSP2 (12q14.1) / TSPAN31 (12q14.1)KIF5A (12q13.3) / CTDSP2 (12q14.1)
PDAP1 (7q22.1) / CTDSP2 (12q14.1)RAP1B (12q15) / CTDSP2 (12q14.1)CTDSP2 12q14.1 / C12orf10 12q13.13
CTDSP2 12q14.1 / COL15A1 9q22.33CTDSP2 12q14.1 / DCUN1D4 4q12CTDSP2 12q14.1 / MDM2 12q15
CTDSP2 12q14.1 / RTN4IP1 6q21CTDSP2 12q14.1 / TSPAN31 12q14.1RAP1B 12q15 / CTDSP2 12q14.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)CTDSP2   17077
Cards
Entrez_Gene (NCBI)CTDSP2    CTD small phosphatase 2
AliasesOS4; PSR2; SCP2
GeneCards (Weizmann)CTDSP2
Ensembl hg19 (Hinxton)ENSG00000175215 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175215 [Gene_View]  ENSG00000175215 [Sequence]  chr12:57819927-57846729 [Contig_View]  CTDSP2 [Vega]
ICGC DataPortalENSG00000175215
TCGA cBioPortalCTDSP2
AceView (NCBI)CTDSP2
Genatlas (Paris)CTDSP2
SOURCE (Princeton)CTDSP2
Genetics Home Reference (NIH)CTDSP2
Genomic and cartography
GoldenPath hg38 (UCSC)CTDSP2  -     chr12:57819927-57846729 -  12q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTDSP2  -     12q14.1   [Description]    (hg19-Feb_2009)
GoldenPathCTDSP2 - 12q14.1 [CytoView hg19]  CTDSP2 - 12q14.1 [CytoView hg38]
ImmunoBaseENSG00000175215
genome Data Viewer NCBICTDSP2 [Mapview hg19]  
OMIM608711   
Gene and transcription
Genbank (Entrez)AF000152 AF022231 AK226076 AK291289 AK294930
RefSeq transcript (Entrez)NM_005730
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTDSP2
Alternative Splicing GalleryENSG00000175215
Gene ExpressionCTDSP2 [ NCBI-GEO ]   CTDSP2 [ EBI - ARRAY_EXPRESS ]   CTDSP2 [ SEEK ]   CTDSP2 [ MEM ]
Gene Expression Viewer (FireBrowse)CTDSP2 [ Firebrowse - Broad ]
GenevisibleExpression of CTDSP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10106
GTEX Portal (Tissue expression)CTDSP2
Human Protein AtlasENSG00000175215-CTDSP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14595   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14595  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14595
Splice isoforms : SwissVarO14595
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO14595
Domaine pattern : Prosite (Expaxy)FCP1 (PS50969)   
Domains : Interpro (EBI)Dullard_phosphatase    FCP1_dom    HAD-like_sf    HAD_sf    RNA_Pol_CTD_Phosphatase   
Domain families : Pfam (Sanger)NIF (PF03031)   
Domain families : Pfam (NCBI)pfam03031   
Domain families : Smart (EMBL)CPDc (SM00577)  
Conserved Domain (NCBI)CTDSP2
Blocks (Seattle)CTDSP2
PDB (RSDB)2Q5E   
PDB Europe2Q5E   
PDB (PDBSum)2Q5E   
PDB (IMB)2Q5E   
Structural Biology KnowledgeBase2Q5E   
SCOP (Structural Classification of Proteins)2Q5E   
CATH (Classification of proteins structures)2Q5E   
SuperfamilyO14595
Human Protein Atlas [tissue]ENSG00000175215-CTDSP2 [tissue]
Peptide AtlasO14595
HPRD12281
IPIIPI00873134   IPI00796721   IPI00383634   IPI01022227   IPI01022423   IPI01022576   IPI01022757   
Protein Interaction databases
DIP (DOE-UCLA)O14595
IntAct (EBI)O14595
BioGRIDCTDSP2
STRING (EMBL)CTDSP2
ZODIACCTDSP2
Ontologies - Pathways
QuickGOO14595
Ontology : AmiGOnegative regulation of protein phosphorylation  phosphoprotein phosphatase activity  protein binding  nucleoplasm  protein dephosphorylation  RNA polymerase II CTD heptapeptide repeat phosphatase activity  RNA polymerase II CTD heptapeptide repeat phosphatase activity  IRE1-mediated unfolded protein response  metal ion binding  protein serine phosphatase activity  protein threonine phosphatase activity  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBInegative regulation of protein phosphorylation  phosphoprotein phosphatase activity  protein binding  nucleoplasm  protein dephosphorylation  RNA polymerase II CTD heptapeptide repeat phosphatase activity  RNA polymerase II CTD heptapeptide repeat phosphatase activity  IRE1-mediated unfolded protein response  metal ion binding  protein serine phosphatase activity  protein threonine phosphatase activity  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkCTDSP2
Atlas of Cancer Signalling NetworkCTDSP2
Wikipedia pathwaysCTDSP2
Orthology - Evolution
OrthoDB10106
GeneTree (enSembl)ENSG00000175215
Phylogenetic Trees/Animal Genes : TreeFamCTDSP2
HOGENOMO14595
Homologs : HomoloGeneCTDSP2
Homology/Alignments : Family Browser (UCSC)CTDSP2
Gene fusions - Rearrangements
Fusion : MitelmanCTDSP2/C12orf10 [12q14.1/12q13.13]  
Fusion : MitelmanCTDSP2/COL15A1 [12q14.1/9q22.33]  
Fusion : MitelmanCTDSP2/DCUN1D4 [12q14.1/4q12]  
Fusion : MitelmanCTDSP2/FAM19A2 [12q14.1/12q14.1]  
Fusion : MitelmanCTDSP2/MDM2 [12q14.1/12q15]  
Fusion : MitelmanCTDSP2/RTN4IP1 [12q14.1/6q21]  
Fusion : MitelmanCTDSP2/TSPAN31 [12q14.1/12q14.1]  
Fusion : MitelmanRAP1B/CTDSP2 [12q15/12q14.1]  
Fusion PortalCTDSP2 12q14.1 C12orf10 12q13.13 GBM
Fusion PortalCTDSP2 12q14.1 COL15A1 9q22.33 LGG
Fusion PortalCTDSP2 12q14.1 DCUN1D4 4q12 GBM
Fusion PortalCTDSP2 12q14.1 MDM2 12q15 GBM
Fusion PortalCTDSP2 12q14.1 RTN4IP1 6q21 LUAD
Fusion PortalCTDSP2 12q14.1 TSPAN31 12q14.1 GBM
Fusion PortalRAP1B 12q15 CTDSP2 12q14.1 GBM
Fusion : QuiverCTDSP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTDSP2 [hg38]
dbVarCTDSP2
ClinVarCTDSP2
MonarchCTDSP2
1000_GenomesCTDSP2 
Exome Variant ServerCTDSP2
GNOMAD BrowserENSG00000175215
Varsome BrowserCTDSP2
Genomic Variants (DGV)CTDSP2 [DGVbeta]
DECIPHERCTDSP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTDSP2 
Mutations
ICGC Data PortalCTDSP2 
TCGA Data PortalCTDSP2 
Broad Tumor PortalCTDSP2
OASIS PortalCTDSP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTDSP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCTDSP2
Mutations and Diseases : HGMDCTDSP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTDSP2
DgiDB (Drug Gene Interaction Database)CTDSP2
DoCM (Curated mutations)CTDSP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTDSP2 (select a term)
intoGenCTDSP2
Cancer3DCTDSP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608711   
Orphanet
DisGeNETCTDSP2
MedgenCTDSP2
Genetic Testing Registry CTDSP2
NextProtO14595 [Medical]
GENETestsCTDSP2
Target ValidationCTDSP2
Huge Navigator CTDSP2 [HugePedia]
ClinGenCTDSP2
Clinical trials, drugs, therapy
MyCancerGenomeCTDSP2
Protein Interactions : CTD
Pharm GKB GenePA128394568
PharosO14595
Clinical trialCTDSP2
Miscellaneous
canSAR (ICR)CTDSP2 (select the gene name)
HarmonizomeCTDSP2
DataMed IndexCTDSP2
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCTDSP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:17:20 CET 2021

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