Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTH (cystathionine gamma-lyase)

Identity

Alias_namescystathionase (cystathionine gamma-lyase)
Other alias-
HGNC (Hugo) CTH
LocusID (NCBI) 1491
Atlas_Id 55338
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 70411218 and ends at 70439851 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTH (1p31.1) / CTH (1p31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTH   2501
Cards
Entrez_Gene (NCBI)CTH  1491  cystathionine gamma-lyase
Aliases
GeneCards (Weizmann)CTH
Ensembl hg19 (Hinxton)ENSG00000116761 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116761 [Gene_View]  chr1:70411218-70439851 [Contig_View]  CTH [Vega]
ICGC DataPortalENSG00000116761
TCGA cBioPortalCTH
AceView (NCBI)CTH
Genatlas (Paris)CTH
WikiGenes1491
SOURCE (Princeton)CTH
Genetics Home Reference (NIH)CTH
Genomic and cartography
GoldenPath hg38 (UCSC)CTH  -     chr1:70411218-70439851 +  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTH  -     1p31.1   [Description]    (hg19-Feb_2009)
EnsemblCTH - 1p31.1 [CytoView hg19]  CTH - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBICTH [Mapview hg19]  CTH [Mapview hg38]
OMIM219500   607657   
Gene and transcription
Genbank (Entrez)AK223376 AK303946 AK310269 BC015807 BT006882
RefSeq transcript (Entrez)NM_001190463 NM_001902 NM_153742
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTH
Cluster EST : UnigeneHs.19904 [ NCBI ]
CGAP (NCI)Hs.19904
Alternative Splicing GalleryENSG00000116761
Gene ExpressionCTH [ NCBI-GEO ]   CTH [ EBI - ARRAY_EXPRESS ]   CTH [ SEEK ]   CTH [ MEM ]
Gene Expression Viewer (FireBrowse)CTH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1491
GTEX Portal (Tissue expression)CTH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32929   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32929  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32929
Splice isoforms : SwissVarP32929
Catalytic activity : Enzyme4.4.1.1 [ Enzyme-Expasy ]   4.4.1.14.4.1.1 [ IntEnz-EBI ]   4.4.1.1 [ BRENDA ]   4.4.1.1 [ KEGG ]   
PhosPhoSitePlusP32929
Domaine pattern : Prosite (Expaxy)CYS_MET_METAB_PP (PS00868)   
Domains : Interpro (EBI)Cys/Met-Metab_PyrdxlP-dep_enz    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Cys_Met_Meta_PP (PF01053)   
Domain families : Pfam (NCBI)pfam01053   
Conserved Domain (NCBI)CTH
DMDM Disease mutations1491
Blocks (Seattle)CTH
PDB (SRS)2NMP    3COG    3ELP    5EIG   
PDB (PDBSum)2NMP    3COG    3ELP    5EIG   
PDB (IMB)2NMP    3COG    3ELP    5EIG   
PDB (RSDB)2NMP    3COG    3ELP    5EIG   
Structural Biology KnowledgeBase2NMP    3COG    3ELP    5EIG   
SCOP (Structural Classification of Proteins)2NMP    3COG    3ELP    5EIG   
CATH (Classification of proteins structures)2NMP    3COG    3ELP    5EIG   
SuperfamilyP32929
Human Protein AtlasENSG00000116761
Peptide AtlasP32929
HPRD09633
IPIIPI00031557   IPI00221301   IPI00908512   
Protein Interaction databases
DIP (DOE-UCLA)P32929
IntAct (EBI)P32929
FunCoupENSG00000116761
BioGRIDCTH
STRING (EMBL)CTH
ZODIACCTH
Ontologies - Pathways
QuickGOP32929
Ontology : AmiGOsulfur amino acid catabolic process  cystathionine gamma-synthase activity  cystathionine gamma-lyase activity  cystathionine gamma-lyase activity  protein binding  calmodulin binding  cytoplasm  cytosol  cysteine metabolic process  carbon-sulfur lyase activity  protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine  cysteine biosynthetic process via cystathionine  cysteine biosynthetic process  transsulfuration  transsulfuration  pyridoxal phosphate binding  endoplasmic reticulum unfolded protein response  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein sulfhydration  L-cystine L-cysteine-lyase (deaminating)  homocysteine desulfhydrase activity  positive regulation of NF-kappaB transcription factor activity  protein homotetramerization  extracellular exosome  hydrogen sulfide biosynthetic process  hydrogen sulfide biosynthetic process  'de novo' L-methionine biosynthetic process  L-cysteine desulfhydrase activity  positive regulation of aortic smooth muscle cell differentiation  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBIsulfur amino acid catabolic process  cystathionine gamma-synthase activity  cystathionine gamma-lyase activity  cystathionine gamma-lyase activity  protein binding  calmodulin binding  cytoplasm  cytosol  cysteine metabolic process  carbon-sulfur lyase activity  protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine  cysteine biosynthetic process via cystathionine  cysteine biosynthetic process  transsulfuration  transsulfuration  pyridoxal phosphate binding  endoplasmic reticulum unfolded protein response  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein sulfhydration  L-cystine L-cysteine-lyase (deaminating)  homocysteine desulfhydrase activity  positive regulation of NF-kappaB transcription factor activity  protein homotetramerization  extracellular exosome  hydrogen sulfide biosynthetic process  hydrogen sulfide biosynthetic process  'de novo' L-methionine biosynthetic process  L-cysteine desulfhydrase activity  positive regulation of aortic smooth muscle cell differentiation  negative regulation of apoptotic signaling pathway  
Pathways : KEGGGlycine, serine and threonine metabolism    Cysteine and methionine metabolism    Selenocompound metabolism   
NDEx NetworkCTH
Atlas of Cancer Signalling NetworkCTH
Wikipedia pathwaysCTH
Orthology - Evolution
OrthoDB1491
GeneTree (enSembl)ENSG00000116761
Phylogenetic Trees/Animal Genes : TreeFamCTH
HOVERGENP32929
HOGENOMP32929
Homologs : HomoloGeneCTH
Homology/Alignments : Family Browser (UCSC)CTH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTH
dbVarCTH
ClinVarCTH
1000_GenomesCTH 
Exome Variant ServerCTH
ExAC (Exome Aggregation Consortium)CTH (select the gene name)
Genetic variants : HAPMAP1491
Genomic Variants (DGV)CTH [DGVbeta]
DECIPHERCTH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTH 
Mutations
ICGC Data PortalCTH 
TCGA Data PortalCTH 
Broad Tumor PortalCTH
OASIS PortalCTH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTH
DgiDB (Drug Gene Interaction Database)CTH
DoCM (Curated mutations)CTH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTH (select a term)
intoGenCTH
Cancer3DCTH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM219500    607657   
Orphanet3365   
MedgenCTH
Genetic Testing Registry CTH
NextProtP32929 [Medical]
TSGene1491
GENETestsCTH
Target ValidationCTH
Huge Navigator CTH [HugePedia]
snp3D : Map Gene to Disease1491
BioCentury BCIQCTH
ClinGenCTH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1491
Chemical/Pharm GKB GenePA27004
Clinical trialCTH
Miscellaneous
canSAR (ICR)CTH (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTH
EVEXCTH
GoPubMedCTH
iHOPCTH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:50:56 CEST 2017

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