Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTLA4 (cytotoxic T-lymphocyte-associated protein 4)

Identity

Other namesCD
CD152
CELIAC3
CTLA-4
GRD4
GSE
IDDM12
HGNC (Hugo) CTLA4
LocusID (NCBI) 1493
Location 2q33.2
Location_base_pair Starts at 204732511 and ends at 204738683 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CTLA4   2505
Cards
Entrez_Gene (NCBI)CTLA4  1493  cytotoxic T-lymphocyte-associated protein 4
GeneCards (Weizmann)CTLA4
Ensembl (Hinxton)ENSG00000163599 [Gene_View]  chr2:204732511-204738683 [Contig_View]  CTLA4 [Vega]
AceView (NCBI)CTLA4
Genatlas (Paris)CTLA4
WikiGenes1493
SOURCE (Princeton)NM_001037631 NM_005214
Genomic and cartography
GoldenPath (UCSC)CTLA4  -  2q33.2   chr2:204732511-204738683 +  2q33.2   [Description]    (hg19-Feb_2009)
EnsemblCTLA4 - 2q33.2 [CytoView]
Mapping of homologs : NCBICTLA4 [Mapview]
OMIM123890   140300   275000   601388   609755   
Gene and transcription
Genbank (Entrez)AF414120 AF486806 AK313732 AY209009 AY792514
RefSeq transcript (Entrez)NM_001037631 NM_005214
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_011502 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)CTLA4
Cluster EST : UnigeneHs.247824 [ NCBI ]
CGAP (NCI)Hs.247824
Alternative Splicing : Fast-db (Paris)GSHG0017127
Alternative Splicing GalleryENSG00000163599
Gene ExpressionCTLA4 [ NCBI-GEO ]     CTLA4 [ SEEK ]   CTLA4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16410 (Uniprot)
NextProtP16410  [Medical]
With graphics : InterProP16410
Splice isoforms : SwissVarP16410 (Swissvar)
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CTLA4    Ig-like_fold    Ig_V-set    Ig_V-set_subgr   
Related proteins : CluSTrP16410
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IGv (SM00406)  
DMDM Disease mutations1493
Blocks (Seattle)P16410
PDB (SRS)1AH1    1H6E    1I85    1I8L    2X44    3BX7    3OSK   
PDB (PDBSum)1AH1    1H6E    1I85    1I8L    2X44    3BX7    3OSK   
PDB (IMB)1AH1    1H6E    1I85    1I8L    2X44    3BX7    3OSK   
PDB (RSDB)1AH1    1H6E    1I85    1I8L    2X44    3BX7    3OSK   
Human Protein AtlasENSG00000163599
Peptide AtlasP16410
HPRD00474
IPIIPI00028559   IPI01018238   IPI00604432   IPI00945919   IPI01010540   IPI00027999   IPI01010222   
Protein Interaction databases
DIP (DOE-UCLA)P16410
IntAct (EBI)P16410
FunCoupENSG00000163599
BioGRIDCTLA4
InParanoidP16410
Interologous Interaction database P16410
IntegromeDBCTLA4
STRING (EMBL)CTLA4
Ontologies - Pathways
Ontology : AmiGOprotein binding  Golgi apparatus  plasma membrane  integral to plasma membrane  immune response  cellular response to DNA damage stimulus  external side of plasma membrane  negative regulation of B cell proliferation  T cell costimulation  positive regulation of apoptotic process  clathrin-coated endocytic vesicle  negative regulation of regulatory T cell differentiation  perinuclear region of cytoplasm  B cell receptor signaling pathway  
Ontology : EGO-EBIprotein binding  Golgi apparatus  plasma membrane  integral to plasma membrane  immune response  cellular response to DNA damage stimulus  external side of plasma membrane  negative regulation of B cell proliferation  T cell costimulation  positive regulation of apoptotic process  clathrin-coated endocytic vesicle  negative regulation of regulatory T cell differentiation  perinuclear region of cytoplasm  B cell receptor signaling pathway  
Pathways : BIOCARTAThe Co-Stimulatory Signal During T-cell Activation [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    T cell receptor signaling pathway    Autoimmune thyroid disease    Rheumatoid arthritis   
REACTOMECTLA4
Protein Interaction DatabaseCTLA4
Wikipedia pathwaysCTLA4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CTLA4
SNP (GeneSNP Utah)CTLA4
SNP : HGBaseCTLA4
Genetic variants : HAPMAPCTLA4
1000_GenomesCTLA4 
ICGC programENSG00000163599 
Somatic Mutations in Cancer : COSMICCTLA4 
CONAN: Copy Number AnalysisCTLA4 
Mutations and Diseases : HGMDCTLA4
OMIM123890    140300    275000    601388    609755   
GENETestsCTLA4
Disease Genetic AssociationCTLA4
Huge Navigator CTLA4 [HugePedia]  CTLA4 [HugeCancerGEM]
Genomic VariantsCTLA4  CTLA4 [DGVbeta]
Exome VariantCTLA4
dbVarCTLA4
ClinVarCTLA4
snp3D : Map Gene to Disease1493
General knowledge
Homologs : HomoloGeneCTLA4
Homology/Alignments : Family Browser (UCSC)CTLA4
Phylogenetic Trees/Animal Genes : TreeFamCTLA4
Chemical/Protein Interactions : CTD1493
Chemical/Pharm GKB GenePA27006
Clinical trialCTLA4
Cancer Resource (Charite)ENSG00000163599
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCTLA4
iHOPCTLA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:34:55 CEST 2014

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