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CTNNA2 (catenin alpha 2)

Identity

Alias_namescatenin (cadherin-associated protein)
Alias_symbol (synonym)CAP-R
CT114
Other aliasCAPR
CTNR
HGNC (Hugo) CTNNA2
LocusID (NCBI) 1496
Atlas_Id 53898
Location 2p12  [Link to chromosome band 2p12]
Location_base_pair Starts at 79740060 and ends at 80875988 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AIG1 (6q24.2) / CTNNA2 (2p12)CTNNA2 (2p12) / AC084193.1 ()CTNNA2 (2p12) / CTNNA2 (2p12)
CTNNA2 (2p12) / RNU5F-1 (1q41)CTNNA2 (2p12) / UBXN4 (2q21.3)GLIS3 (9p24.2) / CTNNA2 (2p12)
HIBCH (2q32.2) / CTNNA2 (2p12)MAGI2 (7q21.11) / CTNNA2 (2p12)MRPL35 (2p11.2) / CTNNA2 (2p12)
PIGN (18q21.33) / CTNNA2 (2p12)PIGT (20q13.12) / CTNNA2 (2p12)GLIS3 9p24.2 / CTNNA2 2p12
HIBCH 2q32.2 / CTNNA2 2p12MRPL35 2p11.2 / CTNNA2 2p12PIGN 18q21.33 / CTNNA2 2p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTNNA2   2510
Cards
Entrez_Gene (NCBI)CTNNA2  1496  catenin alpha 2
AliasesCAP-R; CAPR; CT114; CTNR
GeneCards (Weizmann)CTNNA2
Ensembl hg19 (Hinxton)ENSG00000066032 [Gene_View]  chr2:79740060-80875988 [Contig_View]  CTNNA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000066032 [Gene_View]  chr2:79740060-80875988 [Contig_View]  CTNNA2 [Vega]
ICGC DataPortalENSG00000066032
TCGA cBioPortalCTNNA2
AceView (NCBI)CTNNA2
Genatlas (Paris)CTNNA2
WikiGenes1496
SOURCE (Princeton)CTNNA2
Genetics Home Reference (NIH)CTNNA2
Genomic and cartography
GoldenPath hg19 (UCSC)CTNNA2  -     chr2:79740060-80875988 +  2p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CTNNA2  -     2p12   [Description]    (hg38-Dec_2013)
EnsemblCTNNA2 - 2p12 [CytoView hg19]  CTNNA2 - 2p12 [CytoView hg38]
Mapping of homologs : NCBICTNNA2 [Mapview hg19]  CTNNA2 [Mapview hg38]
OMIM114025   
Gene and transcription
Genbank (Entrez)AK127226 AK294362 AK295181 AK295493 AK303035
RefSeq transcript (Entrez)NM_001164883 NM_001282597 NM_001282598 NM_001282599 NM_001282600 NM_001320810 NM_004389
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)CTNNA2
Cluster EST : UnigeneHs.167368 [ NCBI ]
CGAP (NCI)Hs.167368
Alternative Splicing GalleryENSG00000066032
Gene ExpressionCTNNA2 [ NCBI-GEO ]   CTNNA2 [ EBI - ARRAY_EXPRESS ]   CTNNA2 [ SEEK ]   CTNNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CTNNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1496
GTEX Portal (Tissue expression)CTNNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26232   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26232  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26232
Splice isoforms : SwissVarP26232
PhosPhoSitePlusP26232
Domaine pattern : Prosite (Expaxy)VINCULIN_1 (PS00663)   
Domains : Interpro (EBI)Alpha_catenin    CTNNA2    Vinculin/catenin    Vinculin_CS   
Domain families : Pfam (Sanger)Vinculin (PF01044)   
Domain families : Pfam (NCBI)pfam01044   
Conserved Domain (NCBI)CTNNA2
DMDM Disease mutations1496
Blocks (Seattle)CTNNA2
SuperfamilyP26232
Human Protein AtlasENSG00000066032
Peptide AtlasP26232
HPRD00228
IPIIPI00385055   IPI00743859   IPI00916487   IPI00944563   IPI00944536   IPI00514038   IPI00917211   IPI00917375   IPI01013932   
Protein Interaction databases
DIP (DOE-UCLA)P26232
IntAct (EBI)P26232
FunCoupENSG00000066032
BioGRIDCTNNA2
STRING (EMBL)CTNNA2
ZODIACCTNNA2
Ontologies - Pathways
QuickGOP26232
Ontology : AmiGOstructural constituent of cytoskeleton  protein binding  nucleus  cytoplasm  cytosol  adherens junction  cell-cell adherens junction  axonogenesis  actin cytoskeleton  basolateral plasma membrane  single organismal cell-cell adhesion  radial glia guided migration of Purkinje cell  lamellipodium  axon  cadherin binding  dendrite morphogenesis  brain morphogenesis  actin filament binding  positive regulation of muscle cell differentiation  regulation of synapse structural plasticity  prepulse inhibition  neuronal postsynaptic density  
Ontology : EGO-EBIstructural constituent of cytoskeleton  protein binding  nucleus  cytoplasm  cytosol  adherens junction  cell-cell adherens junction  axonogenesis  actin cytoskeleton  basolateral plasma membrane  single organismal cell-cell adhesion  radial glia guided migration of Purkinje cell  lamellipodium  axon  cadherin binding  dendrite morphogenesis  brain morphogenesis  actin filament binding  positive regulation of muscle cell differentiation  regulation of synapse structural plasticity  prepulse inhibition  neuronal postsynaptic density  
Pathways : BIOCARTACell to Cell Adhesion Signaling [Genes]   
Pathways : KEGGHippo signaling pathway    Adherens junction    Tight junction    Leukocyte transendothelial migration    Bacterial invasion of epithelial cells    Pathways in cancer    Endometrial cancer    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkCTNNA2
Atlas of Cancer Signalling NetworkCTNNA2
Wikipedia pathwaysCTNNA2
Orthology - Evolution
OrthoDB1496
GeneTree (enSembl)ENSG00000066032
Phylogenetic Trees/Animal Genes : TreeFamCTNNA2
HOVERGENP26232
HOGENOMP26232
Homologs : HomoloGeneCTNNA2
Homology/Alignments : Family Browser (UCSC)CTNNA2
Gene fusions - Rearrangements
Fusion : MitelmanGLIS3/CTNNA2 [9p24.2/2p12]  [t(2;9)(p12;p24)]  
Fusion : MitelmanHIBCH/CTNNA2 [2q32.2/2p12]  [t(2;2)(p12;q32)]  
Fusion : MitelmanMRPL35/CTNNA2 [2p11.2/2p12]  [t(2;2)(p11;p12)]  
Fusion : MitelmanPIGN/CTNNA2 [18q21.33/2p12]  [t(2;18)(p12;q21)]  
Fusion: TCGAGLIS3 9p24.2 CTNNA2 2p12 HNSC
Fusion: TCGAHIBCH 2q32.2 CTNNA2 2p12 BRCA
Fusion: TCGAMRPL35 2p11.2 CTNNA2 2p12 LUSC
Fusion: TCGAPIGN 18q21.33 CTNNA2 2p12 BRCA
Fusion Cancer (Beijing)CTNNA2 [2p12]  -  AC084193.1 [FUSC000305]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTNNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTNNA2
dbVarCTNNA2
ClinVarCTNNA2
1000_GenomesCTNNA2 
Exome Variant ServerCTNNA2
ExAC (Exome Aggregation Consortium)CTNNA2 (select the gene name)
Genetic variants : HAPMAP1496
Genomic Variants (DGV)CTNNA2 [DGVbeta]
DECIPHER (Syndromes)2:79740060-80875988  ENSG00000066032
CONAN: Copy Number AnalysisCTNNA2 
Mutations
ICGC Data PortalCTNNA2 
TCGA Data PortalCTNNA2 
Broad Tumor PortalCTNNA2
OASIS PortalCTNNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTNNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTNNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTNNA2
DgiDB (Drug Gene Interaction Database)CTNNA2
DoCM (Curated mutations)CTNNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTNNA2 (select a term)
intoGenCTNNA2
Cancer3DCTNNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114025   
Orphanet
MedgenCTNNA2
Genetic Testing Registry CTNNA2
NextProtP26232 [Medical]
TSGene1496
GENETestsCTNNA2
Huge Navigator CTNNA2 [HugePedia]
snp3D : Map Gene to Disease1496
BioCentury BCIQCTNNA2
ClinGenCTNNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1496
Chemical/Pharm GKB GenePA27009
Clinical trialCTNNA2
Miscellaneous
canSAR (ICR)CTNNA2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTNNA2
EVEXCTNNA2
GoPubMedCTNNA2
iHOPCTNNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:57:57 CEST 2017

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