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CTNNA3 (catenin alpha 3)

Identity

Alias_namescatenin (cadherin-associated protein)
Alias_symbol (synonym)VR22
MGC26194
Other aliasARVD13
HGNC (Hugo) CTNNA3
LocusID (NCBI) 29119
Atlas_Id 47565
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 65912518 and ends at 67696191 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKIRIN2 (6q15) / CTNNA3 (10q21.3)CCDC6 (10q21.2) / CTNNA3 (10q21.3)CTNNA3 (10q21.3) / ARHGAP21 (10p12.1)
CTNNA3 (10q21.3) / BORCS5 (12p13.2)CTNNA3 (10q21.3) / HECTD2 (10q23.32)CTNNA3 (10q21.3) / HERC4 (10q21.3)
CTNNA3 (10q21.3) / IGF2 (11p15.5)CTNNA3 (10q21.3) / LIPK (10q23.31)CTNNA3 (10q21.3) / LRRC74A (14q24.3)
CTNNA3 (10q21.3) / MGMT (10q26.3)CTNNA3 (10q21.3) / PHTF2 (7q11.23)HERC4 (10q21.3) / CTNNA3 (10q21.3)
IGF2 (11p15.5) / CTNNA3 (10q21.3)P4HA1 (10q22.1) / CTNNA3 (10q21.3)PBX1 (1q23.3) / CTNNA3 (10q21.3)
PTEN (10q23.31) / CTNNA3 (10q21.3)CTNNA3 10q21.3 C14orf166BCTNNA3 10q21.3 LOH12CR1
CTNNA3 10q21.3 / MGMT 10q26.3HERC4 10q21.3 / CTNNA3 10q21.3P4HA1 10q22.1 / CTNNA3 10q21.3
PBX1 1q23.3 / CTNNA3 10q21.3PTEN 10q23.31 / CTNNA3 10q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;10)(p12;q21) CTNNA3/ARHGAP21
t(10;10)(p12;q21) CTNNA3/ARHGAP21

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 12 ]
  Lung: Translocations in Small Cell Carcinoma
Lung: Translocations in Squamous Cell Carcinoma
t(1;10)(q23;q21) PBX1/CTNNA3
HERC4/CTNNA3 (10q21)
CCDC6/CTNNA3 (10q21)
t(10;10)(q21;q22) P4HA1/CTNNA3
t(10;10)(q21;q23) PTEN/CTNNA3
t(10;10)(q21;q26) CTNNA3/MGMT
t(10;11)(q21;p15) IGF2/CTNNA3
t(10;11)(q21;p15) CTNNA3/IGF2
t(10;11)(q21;q14) CTNNA3/RSF1
t(10;14)(q21;q24) CTNNA3/LRRC74A

External links

Nomenclature
HGNC (Hugo)CTNNA3   2511
Cards
Entrez_Gene (NCBI)CTNNA3  29119  catenin alpha 3
AliasesARVD13; VR22
GeneCards (Weizmann)CTNNA3
Ensembl hg19 (Hinxton)ENSG00000183230 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183230 [Gene_View]  ENSG00000183230 [Sequence]  chr10:65912518-67696191 [Contig_View]  CTNNA3 [Vega]
ICGC DataPortalENSG00000183230
TCGA cBioPortalCTNNA3
AceView (NCBI)CTNNA3
Genatlas (Paris)CTNNA3
WikiGenes29119
SOURCE (Princeton)CTNNA3
Genetics Home Reference (NIH)CTNNA3
Genomic and cartography
GoldenPath hg38 (UCSC)CTNNA3  -     chr10:65912518-67696191 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTNNA3  -     10q21.3   [Description]    (hg19-Feb_2009)
EnsemblCTNNA3 - 10q21.3 [CytoView hg19]  CTNNA3 - 10q21.3 [CytoView hg38]
Mapping of homologs : NCBICTNNA3 [Mapview hg19]  CTNNA3 [Mapview hg38]
OMIM607667   615616   
Gene and transcription
Genbank (Entrez)AF091606 AK289756 AK308726 AK313882 AY198183
RefSeq transcript (Entrez)NM_001127384 NM_001291133 NM_013266
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTNNA3
Cluster EST : UnigeneHs.660362 [ NCBI ]
CGAP (NCI)Hs.660362
Alternative Splicing GalleryENSG00000183230
Gene ExpressionCTNNA3 [ NCBI-GEO ]   CTNNA3 [ EBI - ARRAY_EXPRESS ]   CTNNA3 [ SEEK ]   CTNNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)CTNNA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29119
GTEX Portal (Tissue expression)CTNNA3
Human Protein AtlasENSG00000183230-CTNNA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UI47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI47
Splice isoforms : SwissVarQ9UI47
PhosPhoSitePlusQ9UI47
Domains : Interpro (EBI)Alpha-catenin/vinculin-like_sf    Alpha_catenin    CTNNA3    Vinculin/catenin   
Domain families : Pfam (Sanger)Vinculin (PF01044)   
Domain families : Pfam (NCBI)pfam01044   
Conserved Domain (NCBI)CTNNA3
DMDM Disease mutations29119
Blocks (Seattle)CTNNA3
SuperfamilyQ9UI47
Human Protein Atlas [tissue]ENSG00000183230-CTNNA3 [tissue]
Peptide AtlasQ9UI47
HPRD09639
IPIIPI00001712   IPI00654616   IPI00747120   IPI00937961   IPI00645669   
Protein Interaction databases
DIP (DOE-UCLA)Q9UI47
IntAct (EBI)Q9UI47
FunCoupENSG00000183230
BioGRIDCTNNA3
STRING (EMBL)CTNNA3
ZODIACCTNNA3
Ontologies - Pathways
QuickGOQ9UI47
Ontology : AmiGOprotein binding  cytoplasm  cytoskeleton  fascia adherens  beta-catenin binding  lamellipodium  cadherin binding  actin filament binding  bundle of His cell-Purkinje myocyte adhesion involved in cell communication  regulation of heart rate by cardiac conduction  cell-cell adhesion  regulation of ventricular cardiac muscle cell action potential  
Ontology : EGO-EBIprotein binding  cytoplasm  cytoskeleton  fascia adherens  beta-catenin binding  lamellipodium  cadherin binding  actin filament binding  bundle of His cell-Purkinje myocyte adhesion involved in cell communication  regulation of heart rate by cardiac conduction  cell-cell adhesion  regulation of ventricular cardiac muscle cell action potential  
Pathways : KEGGHippo signaling pathway    Adherens junction    Tight junction    Leukocyte transendothelial migration    Bacterial invasion of epithelial cells    Pathways in cancer    Endometrial cancer    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkCTNNA3
Atlas of Cancer Signalling NetworkCTNNA3
Wikipedia pathwaysCTNNA3
Orthology - Evolution
OrthoDB29119
GeneTree (enSembl)ENSG00000183230
Phylogenetic Trees/Animal Genes : TreeFamCTNNA3
HOVERGENQ9UI47
HOGENOMQ9UI47
Homologs : HomoloGeneCTNNA3
Homology/Alignments : Family Browser (UCSC)CTNNA3
Gene fusions - Rearrangements
Fusion : MitelmanCCDC6/CTNNA3 [10q21.2/10q21.3]  [t(10;10)(q21;q21)]  
Fusion : MitelmanCTNNA3/ARHGAP21 [10q21.3/10p12.1]  [t(10;10)(p12;q21)]  
Fusion : MitelmanCTNNA3/IGF2 [10q21.3/11p15.5]  [t(10;11)(q21;p15)]  
Fusion : MitelmanCTNNA3/LOH12CR1 [10q21.3/t(10;12)(q21;p13)]  
Fusion : MitelmanCTNNA3/LRRC74A [10q21.3/14q24.3]  [t(10;14)(q21;q24)]  
Fusion : MitelmanCTNNA3/MGMT [10q21.3/10q26.3]  [t(10;10)(q21;q26)]  
Fusion : MitelmanHERC4/CTNNA3 [10q21.3/10q21.3]  [t(10;10)(q21;q21)]  
Fusion : MitelmanIGF2/CTNNA3 [11p15.5/10q21.3]  [t(10;11)(q21;p15)]  
Fusion : MitelmanP4HA1/CTNNA3 [10q22.1/10q21.3]  [t(10;10)(q21;q22)]  
Fusion : MitelmanPBX1/CTNNA3 [1q23.3/10q21.3]  [t(1;10)(q23;q21)]  
Fusion : MitelmanPTEN/CTNNA3 [10q23.31/10q21.3]  [t(10;10)(q21;q23)]  
Fusion PortalCTNNA3 10q21.3 C14orf166B BRCA
Fusion PortalCTNNA3 10q21.3 LOH12CR1 BRCA
Fusion PortalCTNNA3 10q21.3 MGMT 10q26.3 BRCA
Fusion PortalHERC4 10q21.3 CTNNA3 10q21.3 HNSC
Fusion PortalP4HA1 10q22.1 CTNNA3 10q21.3 PRAD
Fusion PortalPBX1 1q23.3 CTNNA3 10q21.3 BRCA
Fusion PortalPTEN 10q23.31 CTNNA3 10q21.3 PRAD
Fusion : QuiverCTNNA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTNNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTNNA3
dbVarCTNNA3
ClinVarCTNNA3
1000_GenomesCTNNA3 
Exome Variant ServerCTNNA3
ExAC (Exome Aggregation Consortium)ENSG00000183230
GNOMAD BrowserENSG00000183230
Varsome BrowserCTNNA3
Genetic variants : HAPMAP29119
Genomic Variants (DGV)CTNNA3 [DGVbeta]
DECIPHERCTNNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTNNA3 
Mutations
ICGC Data PortalCTNNA3 
TCGA Data PortalCTNNA3 
Broad Tumor PortalCTNNA3
OASIS PortalCTNNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTNNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTNNA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTNNA3
DgiDB (Drug Gene Interaction Database)CTNNA3
DoCM (Curated mutations)CTNNA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTNNA3 (select a term)
intoGenCTNNA3
Cancer3DCTNNA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607667    615616   
Orphanet20888    20887    20886   
DisGeNETCTNNA3
MedgenCTNNA3
Genetic Testing Registry CTNNA3
NextProtQ9UI47 [Medical]
TSGene29119
GENETestsCTNNA3
Target ValidationCTNNA3
Huge Navigator CTNNA3 [HugePedia]
snp3D : Map Gene to Disease29119
BioCentury BCIQCTNNA3
ClinGenCTNNA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29119
Chemical/Pharm GKB GenePA27010
Clinical trialCTNNA3
Miscellaneous
canSAR (ICR)CTNNA3 (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTNNA3
EVEXCTNNA3
GoPubMedCTNNA3
iHOPCTNNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:00:49 CET 2018
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