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CTNNA3 (catenin alpha 3)

Identity

Alias (NCBI)ARVD13
VR22
HGNC (Hugo) CTNNA3
HGNC Alias symbVR22
MGC26194
HGNC Alias namealpha-T-catenin
HGNC Previous namecatenin (cadherin-associated protein), alpha 3
LocusID (NCBI) 29119
Atlas_Id 47565
Location 10q21.3  [Link to chromosome band 10q21]
Location_base_pair Starts at 65912523 and ends at 67696195 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKIRIN2 (6q15) / CTNNA3 (10q21.3)CCDC6 (10q21.2) / CTNNA3 (10q21.3)CTNNA3 (10q21.3) / ARHGAP21 (10p12.1)
CTNNA3 (10q21.3) / BORCS5 (12p13.2)CTNNA3 (10q21.3) / HECTD2 (10q23.32)CTNNA3 (10q21.3) / HERC4 (10q21.3)
CTNNA3 (10q21.3) / IGF2 (11p15.5)CTNNA3 (10q21.3) / LIPK (10q23.31)CTNNA3 (10q21.3) / LRRC74A (14q24.3)
CTNNA3 (10q21.3) / MGMT (10q26.3)CTNNA3 (10q21.3) / PHTF2 (7q11.23)HERC4 (10q21.3) / CTNNA3 (10q21.3)
IGF2 (11p15.5) / CTNNA3 (10q21.3)P4HA1 (10q22.1) / CTNNA3 (10q21.3)PBX1 (1q23.3) / CTNNA3 (10q21.3)
PTEN (10q23.31) / CTNNA3 (10q21.3)CTNNA3 10q21.3 C14orf166BCTNNA3 10q21.3 LOH12CR1
CTNNA3 10q21.3 / MGMT 10q26.3HERC4 10q21.3 / CTNNA3 10q21.3P4HA1 10q22.1 / CTNNA3 10q21.3
PBX1 1q23.3 / CTNNA3 10q21.3PTEN 10q23.31 / CTNNA3 10q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;11)(q27;q23) KMT2A/AFDN
t(10;10)(p12;q21) CTNNA3/ARHGAP21


External links

 

Nomenclature
HGNC (Hugo)CTNNA3   2511
Cards
Entrez_Gene (NCBI)CTNNA3    catenin alpha 3
AliasesARVD13; VR22
GeneCards (Weizmann)CTNNA3
Ensembl hg19 (Hinxton)ENSG00000183230 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183230 [Gene_View]  ENSG00000183230 [Sequence]  chr10:65912523-67696195 [Contig_View]  CTNNA3 [Vega]
ICGC DataPortalENSG00000183230
TCGA cBioPortalCTNNA3
AceView (NCBI)CTNNA3
Genatlas (Paris)CTNNA3
SOURCE (Princeton)CTNNA3
Genetics Home Reference (NIH)CTNNA3
Genomic and cartography
GoldenPath hg38 (UCSC)CTNNA3  -     chr10:65912523-67696195 -  10q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTNNA3  -     10q21.3   [Description]    (hg19-Feb_2009)
GoldenPathCTNNA3 - 10q21.3 [CytoView hg19]  CTNNA3 - 10q21.3 [CytoView hg38]
ImmunoBaseENSG00000183230
Genome Data Viewer NCBICTNNA3 [Mapview hg19]  
OMIM607667   615616   
Gene and transcription
Genbank (Entrez)AF091606 AK289756 AK308726 AK313882 AY198183
RefSeq transcript (Entrez)NM_001127384 NM_001291133 NM_013266
Consensus coding sequences : CCDS (NCBI)CTNNA3
Gene ExpressionCTNNA3 [ NCBI-GEO ]   CTNNA3 [ EBI - ARRAY_EXPRESS ]   CTNNA3 [ SEEK ]   CTNNA3 [ MEM ]
Gene Expression Viewer (FireBrowse)CTNNA3 [ Firebrowse - Broad ]
GenevisibleExpression of CTNNA3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29119
GTEX Portal (Tissue expression)CTNNA3
Human Protein AtlasENSG00000183230-CTNNA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UI47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UI47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UI47
PhosPhoSitePlusQ9UI47
Domains : Interpro (EBI)Alpha-catenin/vinculin-like_sf    Alpha_catenin    CTNNA1/CTNNA3    Vinculin/catenin   
Domain families : Pfam (Sanger)Vinculin (PF01044)   
Domain families : Pfam (NCBI)pfam01044   
Conserved Domain (NCBI)CTNNA3
SuperfamilyQ9UI47
AlphaFold pdb e-kbQ9UI47   
Human Protein Atlas [tissue]ENSG00000183230-CTNNA3 [tissue]
HPRD09639
Protein Interaction databases
DIP (DOE-UCLA)Q9UI47
IntAct (EBI)Q9UI47
BioGRIDCTNNA3
STRING (EMBL)CTNNA3
ZODIACCTNNA3
Ontologies - Pathways
QuickGOQ9UI47
Ontology : AmiGOprotein binding  cytosol  cytoskeleton  adherens junction  fascia adherens  fascia adherens  actin filament organization  beta-catenin binding  beta-catenin binding  cell migration  lamellipodium  cadherin binding  actin filament binding  bundle of His cell-Purkinje myocyte adhesion involved in cell communication  regulation of heart rate by cardiac conduction  epithelial cell-cell adhesion  cell-cell adhesion  cell-cell adhesion  regulation of ventricular cardiac muscle cell action potential  
Ontology : EGO-EBIprotein binding  cytosol  cytoskeleton  adherens junction  fascia adherens  fascia adherens  actin filament organization  beta-catenin binding  beta-catenin binding  cell migration  lamellipodium  cadherin binding  actin filament binding  bundle of His cell-Purkinje myocyte adhesion involved in cell communication  regulation of heart rate by cardiac conduction  epithelial cell-cell adhesion  cell-cell adhesion  cell-cell adhesion  regulation of ventricular cardiac muscle cell action potential  
Pathways : BIOCARTACell to Cell Adhesion Signaling [Genes]   
Pathways : KEGGHippo signaling pathway    Adherens junction    Tight junction    Leukocyte transendothelial migration    Bacterial invasion of epithelial cells    Pathways in cancer    Endometrial cancer    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
NDEx NetworkCTNNA3
Atlas of Cancer Signalling NetworkCTNNA3
Wikipedia pathwaysCTNNA3
Orthology - Evolution
OrthoDB29119
GeneTree (enSembl)ENSG00000183230
Phylogenetic Trees/Animal Genes : TreeFamCTNNA3
Homologs : HomoloGeneCTNNA3
Homology/Alignments : Family Browser (UCSC)CTNNA3
Gene fusions - Rearrangements
Fusion : MitelmanCCDC6/CTNNA3 [10q21.2/10q21.3]  
Fusion : MitelmanCTNNA3/ARHGAP21 [10q21.3/10p12.1]  
Fusion : MitelmanCTNNA3/IGF2 [10q21.3/11p15.5]  
Fusion : MitelmanCTNNA3/LOH12CR1 [10q21.3/t(10;12)(q21;p13)]  
Fusion : MitelmanCTNNA3/LRRC74A [10q21.3/14q24.3]  
Fusion : MitelmanCTNNA3/MGMT [10q21.3/10q26.3]  
Fusion : MitelmanHERC4/CTNNA3 [10q21.3/10q21.3]  
Fusion : MitelmanIGF2/CTNNA3 [11p15.5/10q21.3]  
Fusion : MitelmanP4HA1/CTNNA3 [10q22.1/10q21.3]  
Fusion : MitelmanPBX1/CTNNA3 [1q23.3/10q21.3]  
Fusion : MitelmanPTEN/CTNNA3 [10q23.31/10q21.3]  
Fusion : QuiverCTNNA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTNNA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTNNA3
dbVarCTNNA3
ClinVarCTNNA3
MonarchCTNNA3
1000_GenomesCTNNA3 
Exome Variant ServerCTNNA3
GNOMAD BrowserENSG00000183230
Varsome BrowserCTNNA3
ACMGCTNNA3 variants
VarityQ9UI47
Genomic Variants (DGV)CTNNA3 [DGVbeta]
DECIPHERCTNNA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTNNA3 
Mutations
ICGC Data PortalCTNNA3 
TCGA Data PortalCTNNA3 
Broad Tumor PortalCTNNA3
OASIS PortalCTNNA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTNNA3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCTNNA3
Mutations and Diseases : HGMDCTNNA3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCTNNA3
DgiDB (Drug Gene Interaction Database)CTNNA3
DoCM (Curated mutations)CTNNA3
CIViC (Clinical Interpretations of Variants in Cancer)CTNNA3
Cancer3DCTNNA3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607667    615616   
Orphanet20888    20887    20886   
DisGeNETCTNNA3
MedgenCTNNA3
Genetic Testing Registry CTNNA3
NextProtQ9UI47 [Medical]
GENETestsCTNNA3
Target ValidationCTNNA3
Huge Navigator CTNNA3 [HugePedia]
ClinGenCTNNA3
Clinical trials, drugs, therapy
MyCancerGenomeCTNNA3
Protein Interactions : CTDCTNNA3
Pharm GKB GenePA27010
PharosQ9UI47
Clinical trialCTNNA3
Miscellaneous
canSAR (ICR)CTNNA3
HarmonizomeCTNNA3
DataMed IndexCTNNA3
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCTNNA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:37 CEST 2021

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