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CTNNB1 (Catenin, beta-1)

Written2002-03Brigitte Debuire, Antoinette Lemoine, Raphael Saffroy
Service de Biochimie et Biologie moléculaire, Hôpital Universitaire Paul Brousse, UPRES 1596-Faculté de Médecine Paris-Sud, 14 avenue Paul Vaillant Couturier, 94804 Villejuif Cedex, France

(Note : for Links provided by Atlas : click)

Identity

Other namesCadherin-associated protein, beta
HGNC (Hugo) CTNNB1
LocusID (NCBI) 1499
Atlas_Id 71
Location 3p22.1  [Link to chromosome band 3p22]
Location_base_pair Starts at 41240942 and ends at 41281939 bp from pter ( according to hg19-Feb_2009)  [Mapping CTNNB1.png]
 
  CTNNB1 (3p22) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2016)
CTNNB1 (3p22.1) / AKAP11 (13q14.11)CTNNB1 (3p22.1) / BOLA2 (16p11.2)CTNNB1 (3p22.1) / FAR1 (11p15.2)
CTNNB1 (3p22.1) / MRPS33 (7q34)CTNNB1 (3p22.1) / OLFML2B (1q23.3)CTNNB1 (3p22.1) / PLAG1 (8q12.1)
CTNNB1 (3p22.1) / SLC38A5 (Xp11.23)CTNNB1 (3p22.1) / SREK1 (5q12.3)CTNNB1 (3p22.1) / THRB (3p24.2)
GSN (9q33.2) / CTNNB1 (3p22.1)PLAG1 (8q12.1) / CTNNB1 (3p22.1)RACK1 (5q35.3) / CTNNB1 (3p22.1)
RHOA (3p21.31) / CTNNB1 (3p22.1)SCAF11 (12q12) / CTNNB1 (3p22.1)TG (8q24.22) / CTNNB1 (3p22.1)
TTLL9 (20q11.21) / CTNNB1 (3p22.1)

DNA/RNA

 
Description The gene encompasses 23.2kb of DNA ; 16 exons (the first is non-coding).
Transcription 3362 nucleotides mRNA ; 2343 bp open reading frame. Alternative splicing within exon 16 produces a splice variant that is 159 bp shorter in the 3' untranslated region.

Protein

 
Description 781 amino acids ; 92 kDa protein. Can be phosphorylated ; contains from N-term to C-term, a phosphorylation site by the serine-threonine glycogen synthase kinase -3b(GSK-3b), an a-catenin binding site, 13 armadillo repeats and a transactivating domain.
Expression Widely expressed.
Localisation Cytoplasm and nucleus
Function Important functions in the E-cadherin-mediated cell-cell adhesion system and also as a dowstream signaling molecule in the Wnt pathway. Cytoplasmic accumulation of b catenin allows it to translocate to the nucleus to form complexes with transcription factors of the T cell factor-lymphoid enhancer factor (Tcf-Lef) family. b-catenin is assumed to transactivate mostly unknown target genes, which may stimulate cell proliferation (acts as an oncogene) or inhibit apoptosis. The b-catenin level in the cell is regulated by its association with the adenomatous polyposis coli ( APC) tumor suppressor protein, axin and GSK-3b. Phosphorylation of b-catenin by the APC-axin-GSK-3b complex leads to its degradation by the ubiquitin-proteasome system.
Homology The b-catenin protein shares 70 % amino acid identity with both plakoglobin (intracellular junction in desmosomes) and the product of the Drosphila segment polarity gene "armadillo".

Mutations

Somatic Two mechanisms underlying the increase in b-catenin levels by stabilizing b-catenin are known. One is inactivating mutation in the APC gene, the other is activating mutation at the GSK-3b phosphorylation sites within exon 3 of the b-catenin gene.
b-catenin plays a key role in the development of colorectal cancer and has been found mutated in colorectal cancer cell lines. b-catenin aberration is a frequent event in the development of hepatocellular carcinoma and may facilitate its development in the course of chronic hepatitis. b-catenin has also been found mutated in hepatoblastoma, ovarian carcinoma, medulloblastoma, pilomatricoma as well as in melanoma cell lines.

Bibliography

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Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.
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The gene for the APC-binding protein beta-catenin (CTNNB1) maps to chromosome 3p22, a region frequently altered in human malignancies.
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Citation

This paper should be referenced as such :
Debuire, B ; Lemoine, A ; Saffroy, R
CTNNB1 (catenin, beta-1)
Atlas Genet Cytogenet Oncol Haematol. 2002;6(3):180-183.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CTNNB1ID71.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Chronic myelogenous leukaemia (CML)
t(1;14)(q21;q32);t(1;22)(q21;q11)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 16 ]
  Head and Neck: Odontogenic tumor: Ameloblastoma
Thyroid: Anaplastic (undifferentiated) carcinoma
Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma
Neuro-Endocrine/Endocrine System: Carcinoid tumors
Colon: Colorectal adenocarcinoma
Soft Tissues: Desmoid-type fibromatosis
Gastric Tumors: an overview
Head and Neck: Epidermoid carcinoma
Liver: Hepatoblastoma
Liver: Hepatocellular carcinoma
Liver: Adenoma
Liver tumors: an overview
Skin: Pilomatricoma
Head and Neck: Salivary gland tumors: an overview
Skin: Melanoma
Soft tissue tumors: an overview
Kidney: Nephroblastoma (Wilms tumor)

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hereditary desmoid disease.

External links

Nomenclature
HGNC (Hugo)CTNNB1   2514
Cards
AtlasCTNNB1ID71
Entrez_Gene (NCBI)CTNNB1  1499  catenin beta 1
AliasesCTNNB; MRD19; armadillo
GeneCards (Weizmann)CTNNB1
Ensembl hg19 (Hinxton)ENSG00000168036 [Gene_View]  chr3:41240942-41281939 [Contig_View]  CTNNB1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168036 [Gene_View]  chr3:41240942-41281939 [Contig_View]  CTNNB1 [Vega]
ICGC DataPortalENSG00000168036
TCGA cBioPortalCTNNB1
AceView (NCBI)CTNNB1
Genatlas (Paris)CTNNB1
WikiGenes1499
SOURCE (Princeton)CTNNB1
Genomic and cartography
GoldenPath hg19 (UCSC)CTNNB1  -     chr3:41240942-41281939 +  3p21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CTNNB1  -     3p21   [Description]    (hg38-Dec_2013)
EnsemblCTNNB1 - 3p21 [CytoView hg19]  CTNNB1 - 3p21 [CytoView hg38]
Mapping of homologs : NCBICTNNB1 [Mapview hg19]  CTNNB1 [Mapview hg38]
OMIM114500   114550   116806   132600   167000   615075   
Gene and transcription
Genbank (Entrez)AB062292 AB451264 AB451392 AK095242 AK289932
RefSeq transcript (Entrez)NM_001098209 NM_001098210 NM_001904
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_013302 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)CTNNB1
Cluster EST : UnigeneHs.712929 [ NCBI ]
CGAP (NCI)Hs.712929
Alternative Splicing GalleryENSG00000168036
Gene ExpressionCTNNB1 [ NCBI-GEO ]   CTNNB1 [ EBI - ARRAY_EXPRESS ]   CTNNB1 [ SEEK ]   CTNNB1 [ MEM ]
Gene Expression Viewer (FireBrowse)CTNNB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1499
GTEX Portal (Tissue expression)CTNNB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35222 (Uniprot)
NextProtP35222  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35222
Splice isoforms : SwissVarP35222 (Swissvar)
PhosPhoSitePlusP35222
Domaine pattern : Prosite (Expaxy)ARM_REPEAT (PS50176)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Armadillo    Beta-catenin   
Domain families : Pfam (Sanger)Arm (PF00514)   
Domain families : Pfam (NCBI)pfam00514   
Domain families : Smart (EMBL)ARM (SM00185)  
DMDM Disease mutations1499
Blocks (Seattle)CTNNB1
PDB (SRS)1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
PDB (PDBSum)1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
PDB (IMB)1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
PDB (RSDB)1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
Structural Biology KnowledgeBase1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
SCOP (Structural Classification of Proteins)1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
CATH (Classification of proteins structures)1G3J    1JDH    1JPW    1LUJ    1P22    1QZ7    1T08    1TH1    2G57    2GL7    2Z6H    3DIW    3FQN    3FQR    3SL9    3SLA    3TX7    4DJS   
SuperfamilyP35222
Human Protein AtlasENSG00000168036
Peptide AtlasP35222
HPRD00286
IPIIPI00017292   IPI00978637   IPI00927799   IPI00925425   IPI00924834   IPI00925083   IPI00926114   IPI00924607   
Protein Interaction databases
DIP (DOE-UCLA)P35222
IntAct (EBI)P35222
FunCoupENSG00000168036
BioGRIDCTNNB1
STRING (EMBL)CTNNB1
ZODIACCTNNB1
Ontologies - Pathways
QuickGOP35222
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  embryonic axis specification  spindle pole  RNA polymerase II transcription factor binding  RNA polymerase II activating transcription factor binding  patterning of blood vessels  branching involved in ureteric bud morphogenesis  in utero embryonic development  gastrulation with mouth forming second  cell fate specification  endodermal cell fate commitment  neuron migration  epithelial to mesenchymal transition  neural plate development  liver development  positive regulation of neuroblast proliferation  positive regulation of mesenchymal cell proliferation  lens morphogenesis in camera-type eye  regulation of secondary heart field cardioblast proliferation  metanephros morphogenesis  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  double-stranded DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  transcription coactivator activity  signal transducer activity  protein binding  nucleus  nucleoplasm  transcription factor complex  nuclear euchromatin  cytoplasm  centrosome  cytosol  cytosol  plasma membrane  cell-cell junction  adherens junction  cell-cell adherens junction  fascia adherens  bicellular tight junction  focal adhesion  cell cortex  transcription, DNA-templated  cell adhesion  cell-matrix adhesion  Wnt signaling pathway, calcium modulating pathway  synaptic transmission  ectoderm development  glial cell fate determination  midgut development  protein C-terminus binding  transcription factor binding  transcription factor binding  negative regulation of cell proliferation  anterior/posterior axis specification  dorsal/ventral axis specification  proximal/distal pattern formation  positive regulation of epithelial to mesenchymal transition  positive regulation of heparan sulfate proteoglycan biosynthetic process  Schwann cell proliferation  response to activity  membrane  Wnt signaling pathway  Wnt signaling pathway  basolateral plasma membrane  lateral plasma membrane  single organismal cell-cell adhesion  catenin complex  flotillin complex  stem cell population maintenance  enzyme binding  kinase binding  protein kinase binding  protein phosphatase binding  layer formation in cerebral cortex  central nervous system vasculogenesis  Z disc  lamellipodium  cell junction  cell junction  osteoclast differentiation  estrogen receptor binding  androgen receptor signaling pathway  male genitalia development  beta-catenin destruction complex  midbrain development  hindbrain development  regulation of centriole-centriole cohesion  pancreas development  hair follicle morphogenesis  microvillus membrane  regulation of myelination  positive regulation of telomere maintenance via telomerase  negative regulation of chondrocyte differentiation  response to estradiol  protein complex binding  positive regulation of type I interferon production  protein-DNA complex  T cell differentiation in thymus  negative regulation of protein sumoylation  response to cytokine  adherens junction assembly  protein localization to cell surface  Scrib-APC-beta-catenin complex  embryonic heart tube development  genitalia morphogenesis  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  ionotropic glutamate receptor binding  nuclear hormone receptor binding  nuclear hormone receptor binding  hair cell differentiation  catenin import into nucleus  embryonic skeletal limb joint morphogenesis  regulation of T cell proliferation  odontogenesis of dentin-containing tooth  response to drug  embryonic digit morphogenesis  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  dendritic shaft  protein complex  positive regulation of MAPK cascade  positive regulation of neuron apoptotic process  transcription regulatory region DNA binding  transcription regulatory region DNA binding  ion channel binding  canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  canonical Wnt signaling pathway involved in negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  apical part of cell  synapse  alpha-catenin binding  cadherin binding  myoblast differentiation  bone resorption  positive regulation of endothelial cell differentiation  positive regulation of osteoblast differentiation  negative regulation of osteoclast differentiation  positive regulation of fibroblast growth factor receptor signaling pathway  regulation of angiogenesis  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  negative regulation of mitotic cell cycle, embryonic  SMAD binding  response to cadmium ion  chromatin-mediated maintenance of transcription  regulation of fibroblast proliferation  cell maturation  perinuclear region of cytoplasm  synaptic vesicle transport  thymus development  oocyte development  embryonic foregut morphogenesis  positive regulation of skeletal muscle tissue development  regulation of smooth muscle cell proliferation  embryonic cranial skeleton morphogenesis  negative regulation of oligodendrocyte differentiation  androgen receptor binding  regulation of neurogenesis  synapse organization  nitric-oxide synthase binding  positive regulation of sequence-specific DNA binding transcription factor activity  smooth muscle cell differentiation  positive regulation of muscle cell differentiation  protein heterooligomerization  positive regulation of histone H3-K4 methylation  positive regulation of telomerase activity  oviduct development  canonical Wnt signaling pathway  trachea formation  epithelial tube branching involved in lung morphogenesis  lung cell differentiation  lung-associated mesenchyme development  lung induction  epithelial cell differentiation involved in prostate gland development  positive regulation of epithelial cell proliferation involved in prostate gland development  hair follicle placode formation  mesenchymal cell proliferation involved in lung development  endothelial tube morphogenesis  fungiform papilla formation  canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation  sympathetic ganglion development  cranial ganglion development  extracellular exosome  beta-catenin-TCF7L2 complex  I-SMAD binding  R-SMAD binding  repressing transcription factor binding  regulation of centromeric sister chromatid cohesion  cellular response to mechanical stimulus  cellular response to lithium ion  cellular response to growth factor stimulus  dopaminergic neuron differentiation  cellular response to indole-3-methanol  cell periphery  renal vesicle formation  renal inner medulla development  renal outer medulla development  nephron tubule formation  regulation of nephron tubule epithelial cell differentiation  regulation of calcium ion import  negative regulation of neuron death  positive regulation of chromatin-mediated maintenance of transcription  regulation of euchromatin binding  regulation of core promoter binding  beta-catenin-TCF complex assembly  beta-catenin destruction complex disassembly  euchromatin binding  cellular response to insulin-like growth factor stimulus  embryonic brain development  dorsal root ganglion development  beta-catenin-TCF complex  Wnt signalosome  regulation of protein localization to cell surface  positive regulation of determination of dorsal identity  positive regulation of DNA-templated transcription, initiation  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  embryonic axis specification  spindle pole  RNA polymerase II transcription factor binding  RNA polymerase II activating transcription factor binding  patterning of blood vessels  branching involved in ureteric bud morphogenesis  in utero embryonic development  gastrulation with mouth forming second  cell fate specification  endodermal cell fate commitment  neuron migration  epithelial to mesenchymal transition  neural plate development  liver development  positive regulation of neuroblast proliferation  positive regulation of mesenchymal cell proliferation  lens morphogenesis in camera-type eye  regulation of secondary heart field cardioblast proliferation  metanephros morphogenesis  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  double-stranded DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  transcription coactivator activity  signal transducer activity  protein binding  nucleus  nucleoplasm  transcription factor complex  nuclear euchromatin  cytoplasm  centrosome  cytosol  cytosol  plasma membrane  cell-cell junction  adherens junction  cell-cell adherens junction  fascia adherens  bicellular tight junction  focal adhesion  cell cortex  transcription, DNA-templated  cell adhesion  cell-matrix adhesion  Wnt signaling pathway, calcium modulating pathway  synaptic transmission  ectoderm development  glial cell fate determination  midgut development  protein C-terminus binding  transcription factor binding  transcription factor binding  negative regulation of cell proliferation  anterior/posterior axis specification  dorsal/ventral axis specification  proximal/distal pattern formation  positive regulation of epithelial to mesenchymal transition  positive regulation of heparan sulfate proteoglycan biosynthetic process  Schwann cell proliferation  response to activity  membrane  Wnt signaling pathway  Wnt signaling pathway  basolateral plasma membrane  lateral plasma membrane  single organismal cell-cell adhesion  catenin complex  flotillin complex  stem cell population maintenance  enzyme binding  kinase binding  protein kinase binding  protein phosphatase binding  layer formation in cerebral cortex  central nervous system vasculogenesis  Z disc  lamellipodium  cell junction  cell junction  osteoclast differentiation  estrogen receptor binding  androgen receptor signaling pathway  male genitalia development  beta-catenin destruction complex  midbrain development  hindbrain development  regulation of centriole-centriole cohesion  pancreas development  hair follicle morphogenesis  microvillus membrane  regulation of myelination  positive regulation of telomere maintenance via telomerase  negative regulation of chondrocyte differentiation  response to estradiol  protein complex binding  positive regulation of type I interferon production  protein-DNA complex  T cell differentiation in thymus  negative regulation of protein sumoylation  response to cytokine  adherens junction assembly  protein localization to cell surface  Scrib-APC-beta-catenin complex  embryonic heart tube development  genitalia morphogenesis  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  ionotropic glutamate receptor binding  nuclear hormone receptor binding  nuclear hormone receptor binding  hair cell differentiation  catenin import into nucleus  embryonic skeletal limb joint morphogenesis  regulation of T cell proliferation  odontogenesis of dentin-containing tooth  response to drug  embryonic digit morphogenesis  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  dendritic shaft  protein complex  positive regulation of MAPK cascade  positive regulation of neuron apoptotic process  transcription regulatory region DNA binding  transcription regulatory region DNA binding  ion channel binding  canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition  canonical Wnt signaling pathway involved in negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  apical part of cell  synapse  alpha-catenin binding  cadherin binding  myoblast differentiation  bone resorption  positive regulation of endothelial cell differentiation  positive regulation of osteoblast differentiation  negative regulation of osteoclast differentiation  positive regulation of fibroblast growth factor receptor signaling pathway  regulation of angiogenesis  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  negative regulation of mitotic cell cycle, embryonic  SMAD binding  response to cadmium ion  chromatin-mediated maintenance of transcription  regulation of fibroblast proliferation  cell maturation  perinuclear region of cytoplasm  synaptic vesicle transport  thymus development  oocyte development  embryonic foregut morphogenesis  positive regulation of skeletal muscle tissue development  regulation of smooth muscle cell proliferation  embryonic cranial skeleton morphogenesis  negative regulation of oligodendrocyte differentiation  androgen receptor binding  regulation of neurogenesis  synapse organization  nitric-oxide synthase binding  positive regulation of sequence-specific DNA binding transcription factor activity  smooth muscle cell differentiation  positive regulation of muscle cell differentiation  protein heterooligomerization  positive regulation of histone H3-K4 methylation  positive regulation of telomerase activity  oviduct development  canonical Wnt signaling pathway  trachea formation  epithelial tube branching involved in lung morphogenesis  lung cell differentiation  lung-associated mesenchyme development  lung induction  epithelial cell differentiation involved in prostate gland development  positive regulation of epithelial cell proliferation involved in prostate gland development  hair follicle placode formation  mesenchymal cell proliferation involved in lung development  endothelial tube morphogenesis  fungiform papilla formation  canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation  sympathetic ganglion development  cranial ganglion development  extracellular exosome  beta-catenin-TCF7L2 complex  I-SMAD binding  R-SMAD binding  repressing transcription factor binding  regulation of centromeric sister chromatid cohesion  cellular response to mechanical stimulus  cellular response to lithium ion  cellular response to growth factor stimulus  dopaminergic neuron differentiation  cellular response to indole-3-methanol  cell periphery  renal vesicle formation  renal inner medulla development  renal outer medulla development  nephron tubule formation  regulation of nephron tubule epithelial cell differentiation  regulation of calcium ion import  negative regulation of neuron death  positive regulation of chromatin-mediated maintenance of transcription  regulation of euchromatin binding  regulation of core promoter binding  beta-catenin-TCF complex assembly  beta-catenin destruction complex disassembly  euchromatin binding  cellular response to insulin-like growth factor stimulus  embryonic brain development  dorsal root ganglion development  beta-catenin-TCF complex  Wnt signalosome  regulation of protein localization to cell surface  positive regulation of determination of dorsal identity  positive regulation of DNA-templated transcription, initiation  negative regulation of apoptotic signaling pathway  
Pathways : BIOCARTACell to Cell Adhesion Signaling [Genes]    Multi-step Regulation of Transcription by Pitx2 [Genes]    ALK in cardiac myocytes [Genes]    Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages [Genes]    Presenilin action in Notch and Wnt signaling [Genes]    WNT Signaling Pathway [Genes]    Trefoil Factors Initiate Mucosal Healing [Genes]   
Pathways : KEGGRap1 signaling pathway    Wnt signaling pathway    Hippo signaling pathway    Focal adhesion    Adherens junction    Tight junction    Leukocyte transendothelial migration    Melanogenesis    Thyroid hormone signaling pathway    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Colorectal cancer    Endometrial cancer    Prostate cancer    Thyroid cancer    Basal cell carcinoma    Arrhythmogenic right ventricular cardiomyopathy (ARVC)   
REACTOMEP35222 [protein]
REACTOME PathwaysR-HSA-4641262 disassembly of the destruction complex and recruitment of AXIN to the membrane [pathway]
REACTOME PathwaysR-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-375170 CDO in myogenesis [pathway]
REACTOME PathwaysR-HSA-4086398 Ca2+ pathway [pathway]
REACTOME PathwaysR-HSA-201681 TCF dependent signaling in response to WNT [pathway]
REACTOME PathwaysR-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production [pathway]
REACTOME PathwaysR-HSA-201722 formation of the beta-catenin:TCF transactivating complex [pathway]
REACTOME PathwaysR-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated [pathway]
REACTOME PathwaysR-HSA-4411364 binding of TCF/LEF:CTNNB1 to target gene promoters [pathway]
REACTOME PathwaysR-HSA-5626467 RHO GTPases activate IQGAPs [pathway]
REACTOME PathwaysR-HSA-3769402 deactivation of the beta-catenin transactivating complex [pathway]
REACTOME PathwaysR-HSA-4641265 repression of WNT target genes [pathway]
NDEx NetworkCTNNB1
Atlas of Cancer Signalling NetworkCTNNB1
Wikipedia pathwaysCTNNB1
Orthology - Evolution
OrthoDB1499
GeneTree (enSembl)ENSG00000168036
Phylogenetic Trees/Animal Genes : TreeFamCTNNB1
Homologs : HomoloGeneCTNNB1
Homology/Alignments : Family Browser (UCSC)CTNNB1
Gene fusions - Rearrangements
Fusion : MitelmanCTNNB1/PLAG1 [3p22.1/8q12.1]  
Fusion : MitelmanCTNNB1/SLC38A5 [3p22.1/Xp11.23]  [t(X;3)(p11;p22)]  
Fusion : MitelmanCTNNB1/THRB [3p22.1/3p24.2]  [t(3;3)(p22;p24)]  
Fusion : MitelmanGSN/CTNNB1 [9q33.2/3p22.1]  [t(3;9)(p22;q33)]  
Fusion : COSMICPLAG1 [8q12.1]  -  CTNNB1 [3p22.1]  [fusion_1081]  [fusion_1082]  [fusion_1083]  [fusion_1084]  
Fusion: TCGACTNNB1 3p22.1 SLC38A5 Xp11.23 BRCA
Fusion: TCGACTNNB1 3p22.1 THRB 3p24.2 BRCA
Fusion: TCGAGSN 9q33.2 CTNNB1 3p22.1 THCA
Polymorphisms : SNP, variants
NCBI Variation ViewerCTNNB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTNNB1
dbVarCTNNB1
ClinVarCTNNB1
1000_GenomesCTNNB1 
Exome Variant ServerCTNNB1
ExAC (Exome Aggregation Consortium)CTNNB1 (select the gene name)
Genetic variants : HAPMAP1499
Genomic Variants (DGV)CTNNB1 [DGVbeta]
Mutations
ICGC Data PortalCTNNB1 
TCGA Data PortalCTNNB1 
Broad Tumor PortalCTNNB1
OASIS PortalCTNNB1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCTNNB1 
Somatic Mutations in Cancer : COSMICCTNNB1 
intOGen PortalCTNNB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTNNB1
DgiDB (Drug Gene Interaction Database)CTNNB1
DoCM (Curated mutations)CTNNB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTNNB1 (select a term)
intoGenCTNNB1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:41240942-41281939  ENSG00000168036
CONAN: Copy Number AnalysisCTNNB1 
Mutations and Diseases : HGMDCTNNB1
OMIM114500    114550    116806    132600    167000    615075   
MedgenCTNNB1
Genetic Testing Registry CTNNB1
NextProtP35222 [Medical]
TSGene1499
GENETestsCTNNB1
Huge Navigator CTNNB1 [HugePedia]
snp3D : Map Gene to Disease1499
BioCentury BCIQCTNNB1
ClinGenCTNNB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1499
Chemical/Pharm GKB GenePA27013
Drug Sensitivity CTNNB1
Clinical trialCTNNB1
Miscellaneous
canSAR (ICR)CTNNB1 (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=CTNNB1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTNNB1
EVEXCTNNB1
GoPubMedCTNNB1
iHOPCTNNB1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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