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CTNNBIP1 (catenin beta interacting protein 1)

Identity

Alias_namescatenin, beta-interacting protein 1
catenin, beta interacting protein 1
Alias_symbol (synonym)ICAT
MGC15093
Other alias
HGNC (Hugo) CTNNBIP1
LocusID (NCBI) 56998
Atlas_Id 40195
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 9848276 and ends at 9910258 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLSTN1 (1p36.22) / CTNNBIP1 (1p36.22)CTNNBIP1 (1p36.22) / CLSTN1 (1p36.22)CTNNBIP1 (1p36.22) / H19 (11p15.5)
CLSTN1 1p36.22 / CTNNBIP1 1p36.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Skin: Melanoma


External links

Nomenclature
HGNC (Hugo)CTNNBIP1   16913
Cards
Entrez_Gene (NCBI)CTNNBIP1  56998  catenin beta interacting protein 1
AliasesICAT
GeneCards (Weizmann)CTNNBIP1
Ensembl hg19 (Hinxton)ENSG00000178585 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178585 [Gene_View]  chr1:9848276-9910258 [Contig_View]  CTNNBIP1 [Vega]
ICGC DataPortalENSG00000178585
TCGA cBioPortalCTNNBIP1
AceView (NCBI)CTNNBIP1
Genatlas (Paris)CTNNBIP1
WikiGenes56998
SOURCE (Princeton)CTNNBIP1
Genetics Home Reference (NIH)CTNNBIP1
Genomic and cartography
GoldenPath hg38 (UCSC)CTNNBIP1  -     chr1:9848276-9910258 -  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTNNBIP1  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblCTNNBIP1 - 1p36.22 [CytoView hg19]  CTNNBIP1 - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBICTNNBIP1 [Mapview hg19]  CTNNBIP1 [Mapview hg38]
OMIM607758   
Gene and transcription
Genbank (Entrez)AB021262 BC014300 BC035794 BC146892 BC146896
RefSeq transcript (Entrez)NM_001012329 NM_020248
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTNNBIP1
Cluster EST : UnigeneHs.685322 [ NCBI ]
CGAP (NCI)Hs.685322
Alternative Splicing GalleryENSG00000178585
Gene ExpressionCTNNBIP1 [ NCBI-GEO ]   CTNNBIP1 [ EBI - ARRAY_EXPRESS ]   CTNNBIP1 [ SEEK ]   CTNNBIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CTNNBIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56998
GTEX Portal (Tissue expression)CTNNBIP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSA3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NSA3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSA3
Splice isoforms : SwissVarQ9NSA3
PhosPhoSitePlusQ9NSA3
Domains : Interpro (EBI)ICAT   
Domain families : Pfam (Sanger)ICAT (PF06384)   
Domain families : Pfam (NCBI)pfam06384   
Conserved Domain (NCBI)CTNNBIP1
DMDM Disease mutations56998
Blocks (Seattle)CTNNBIP1
PDB (SRS)1LUJ    1M1E    1T08   
PDB (PDBSum)1LUJ    1M1E    1T08   
PDB (IMB)1LUJ    1M1E    1T08   
PDB (RSDB)1LUJ    1M1E    1T08   
Structural Biology KnowledgeBase1LUJ    1M1E    1T08   
SCOP (Structural Classification of Proteins)1LUJ    1M1E    1T08   
CATH (Classification of proteins structures)1LUJ    1M1E    1T08   
SuperfamilyQ9NSA3
Human Protein AtlasENSG00000178585
Peptide AtlasQ9NSA3
HPRD09677
IPIIPI00025001   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSA3
IntAct (EBI)Q9NSA3
FunCoupENSG00000178585
BioGRIDCTNNBIP1
STRING (EMBL)CTNNBIP1
ZODIACCTNNBIP1
Ontologies - Pathways
QuickGOQ9NSA3
Ontology : AmiGObranching involved in ureteric bud morphogenesis  regulation of vascular permeability involved in acute inflammatory response  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  beta-catenin binding  anterior/posterior pattern specification  Wnt signaling pathway  negative regulation of Wnt signaling pathway  beta-catenin destruction complex  negative regulation of protein binding  negative regulation of DNA binding  negative regulation of sequence-specific DNA binding transcription factor activity  positive regulation of monocyte differentiation  positive regulation of osteoblast differentiation  negative regulation of smooth muscle cell proliferation  negative regulation of transcription initiation from RNA polymerase II promoter  armadillo repeat domain binding  negative regulation of mesenchymal cell proliferation  
Ontology : EGO-EBIbranching involved in ureteric bud morphogenesis  regulation of vascular permeability involved in acute inflammatory response  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  beta-catenin binding  anterior/posterior pattern specification  Wnt signaling pathway  negative regulation of Wnt signaling pathway  beta-catenin destruction complex  negative regulation of protein binding  negative regulation of DNA binding  negative regulation of sequence-specific DNA binding transcription factor activity  positive regulation of monocyte differentiation  positive regulation of osteoblast differentiation  negative regulation of smooth muscle cell proliferation  negative regulation of transcription initiation from RNA polymerase II promoter  armadillo repeat domain binding  negative regulation of mesenchymal cell proliferation  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkCTNNBIP1
Atlas of Cancer Signalling NetworkCTNNBIP1
Wikipedia pathwaysCTNNBIP1
Orthology - Evolution
OrthoDB56998
GeneTree (enSembl)ENSG00000178585
Phylogenetic Trees/Animal Genes : TreeFamCTNNBIP1
HOVERGENQ9NSA3
HOGENOMQ9NSA3
Homologs : HomoloGeneCTNNBIP1
Homology/Alignments : Family Browser (UCSC)CTNNBIP1
Gene fusions - Rearrangements
Fusion : MitelmanCLSTN1/CTNNBIP1 [1p36.22/1p36.22]  [t(1;1)(p36;p36)]  
Fusion: TCGACLSTN1 1p36.22 CTNNBIP1 1p36.22 LUAD
Fusion Cancer (Beijing)CTNNBIP1 [1p36.22]  -  H19 [11p15.5]  [FUSC002936]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTNNBIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTNNBIP1
dbVarCTNNBIP1
ClinVarCTNNBIP1
1000_GenomesCTNNBIP1 
Exome Variant ServerCTNNBIP1
ExAC (Exome Aggregation Consortium)CTNNBIP1 (select the gene name)
Genetic variants : HAPMAP56998
Genomic Variants (DGV)CTNNBIP1 [DGVbeta]
DECIPHERCTNNBIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTNNBIP1 
Mutations
ICGC Data PortalCTNNBIP1 
TCGA Data PortalCTNNBIP1 
Broad Tumor PortalCTNNBIP1
OASIS PortalCTNNBIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTNNBIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTNNBIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTNNBIP1
DgiDB (Drug Gene Interaction Database)CTNNBIP1
DoCM (Curated mutations)CTNNBIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTNNBIP1 (select a term)
intoGenCTNNBIP1
Cancer3DCTNNBIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607758   
Orphanet
MedgenCTNNBIP1
Genetic Testing Registry CTNNBIP1
NextProtQ9NSA3 [Medical]
TSGene56998
GENETestsCTNNBIP1
Target ValidationCTNNBIP1
Huge Navigator CTNNBIP1 [HugePedia]
snp3D : Map Gene to Disease56998
BioCentury BCIQCTNNBIP1
ClinGenCTNNBIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56998
Chemical/Pharm GKB GenePA27014
Clinical trialCTNNBIP1
Miscellaneous
canSAR (ICR)CTNNBIP1 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTNNBIP1
EVEXCTNNBIP1
GoPubMedCTNNBIP1
iHOPCTNNBIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:04:14 CEST 2017

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