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CTSA (cathepsin A)

Identity

Other namesGLB2
GSL
NGBE
PPCA
PPGB
HGNC (Hugo) CTSA
LocusID (NCBI) 5476
Atlas_Id 43911
Location 20q13.12
Location_base_pair Starts at 44518783 and ends at 44527458 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CTSA (20q13.12) / ATP6V0A4 (7q34)CTSA (20q13.12) / PIGQ (16p13.3)CTSA (20q13.12) / SUZ12 (17q11.2)
FXR1 (3q26.33) / CTSA (20q13.12)GSTP1 (11q13.2) / CTSA (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTSA   9251
Cards
Entrez_Gene (NCBI)CTSA  5476  cathepsin A
GeneCards (Weizmann)CTSA
Ensembl hg19 (Hinxton)ENSG00000064601 [Gene_View]  chr20:44518783-44527458 [Contig_View]  CTSA [Vega]
Ensembl hg38 (Hinxton)ENSG00000064601 [Gene_View]  chr20:44518783-44527458 [Contig_View]  CTSA [Vega]
ICGC DataPortalENSG00000064601
TCGA cBioPortalCTSA
AceView (NCBI)CTSA
Genatlas (Paris)CTSA
WikiGenes5476
SOURCE (Princeton)CTSA
Genomic and cartography
GoldenPath hg19 (UCSC)CTSA  -     chr20:44518783-44527458 +  20q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CTSA  -     20q13.12   [Description]    (hg38-Dec_2013)
EnsemblCTSA - 20q13.12 [CytoView hg19]  CTSA - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBICTSA [Mapview hg19]  CTSA [Mapview hg38]
OMIM256540   613111   
Gene and transcription
Genbank (Entrez)AB209705 AF086236 AK055177 AK097786 AK172808
RefSeq transcript (Entrez)NM_000308 NM_001127695 NM_001167594
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_008291 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)CTSA
Cluster EST : UnigeneHs.609336 [ NCBI ]
CGAP (NCI)Hs.609336
Alternative Splicing : Fast-db (Paris)GSHG0018793
Alternative Splicing GalleryENSG00000064601
Gene ExpressionCTSA [ NCBI-GEO ]   CTSA [ EBI - ARRAY_EXPRESS ]   CTSA [ SEEK ]   CTSA [ MEM ]
Gene Expression Viewer (FireBrowse)CTSA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5476
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10619 (Uniprot)
NextProtP10619  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10619
Splice isoforms : SwissVarP10619 (Swissvar)
Catalytic activity : Enzyme3.4.16.5 [ Enzyme-Expasy ]   3.4.16.53.4.16.5 [ IntEnz-EBI ]   3.4.16.5 [ BRENDA ]   3.4.16.5 [ KEGG ]   
PhosPhoSitePlusP10619
Domaine pattern : Prosite (Expaxy)CARBOXYPEPT_SER_HIS (PS00560)    CARBOXYPEPT_SER_SER (PS00131)   
Domains : Interpro (EBI)AB_hydrolase    Peptidase_S10    Ser_caboxypep_his_AS    Ser_caboxypep_ser_AS   
Domain families : Pfam (Sanger)Peptidase_S10 (PF00450)   
Domain families : Pfam (NCBI)pfam00450   
DMDM Disease mutations5476
Blocks (Seattle)CTSA
PDB (SRS)1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
PDB (PDBSum)1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
PDB (IMB)1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
PDB (RSDB)1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
Structural Biology KnowledgeBase1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
SCOP (Structural Classification of Proteins)1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
CATH (Classification of proteins structures)1IVY    3BP4    3BP7    3BXN    4AZ0    4AZ3    4CI9    4CIA    4CIB    4MWS    4MWT   
SuperfamilyP10619
Human Protein AtlasENSG00000064601
Peptide AtlasP10619
HPRD02020
IPIIPI00021794   IPI00641157   IPI00640525   IPI00643801   
Protein Interaction databases
DIP (DOE-UCLA)P10619
IntAct (EBI)P10619
FunCoupENSG00000064601
BioGRIDCTSA
STRING (EMBL)CTSA
ZODIACCTSA
Ontologies - Pathways
QuickGOP10619
Ontology : AmiGOcarboxypeptidase activity  serine-type carboxypeptidase activity  exo-alpha-sialidase activity  nucleoplasm  lysosome  endoplasmic reticulum  proteolysis  glycosphingolipid metabolic process  intracellular protein transport  enzyme activator activity  membrane  regulation of protein stability  positive regulation of catalytic activity  lysosomal lumen  intracellular membrane-bounded organelle  proteolysis involved in cellular protein catabolic process  chaperone-mediated autophagy  extracellular exosome  lumenal side of lysosomal membrane  regulation of chaperone-mediated autophagy  
Ontology : EGO-EBIcarboxypeptidase activity  serine-type carboxypeptidase activity  exo-alpha-sialidase activity  nucleoplasm  lysosome  endoplasmic reticulum  proteolysis  glycosphingolipid metabolic process  intracellular protein transport  enzyme activator activity  membrane  regulation of protein stability  positive regulation of catalytic activity  lysosomal lumen  intracellular membrane-bounded organelle  proteolysis involved in cellular protein catabolic process  chaperone-mediated autophagy  extracellular exosome  lumenal side of lysosomal membrane  regulation of chaperone-mediated autophagy  
Pathways : KEGGLysosome    Renin-angiotensin system   
NDEx Network
Atlas of Cancer Signalling NetworkCTSA
Wikipedia pathwaysCTSA
Orthology - Evolution
OrthoDB5476
GeneTree (enSembl)ENSG00000064601
Phylogenetic Trees/Animal Genes : TreeFamCTSA
Homologs : HomoloGeneCTSA
Homology/Alignments : Family Browser (UCSC)CTSA
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCTSA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTSA
dbVarCTSA
ClinVarCTSA
1000_GenomesCTSA 
Exome Variant ServerCTSA
ExAC (Exome Aggregation Consortium)CTSA (select the gene name)
SNP (GeneSNP Utah)CTSA
SNP : HGBaseCTSA
Genetic variants : HAPMAPCTSA
Genomic Variants (DGV)CTSA [DGVbeta]
Mutations
ICGC Data PortalCTSA 
TCGA Data PortalCTSA 
Broad Tumor PortalCTSA
OASIS PortalCTSA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTSA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTSA
DgiDB (Drug Gene Interaction Database)CTSA
DoCM (Curated mutations)CTSA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTSA (select a term)
intoGenCTSA
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:44518783-44527458
CONAN: Copy Number AnalysisCTSA 
Mutations and Diseases : HGMDCTSA
OMIM256540    613111   
MedgenCTSA
Genetic Testing Registry CTSA
NextProtP10619 [Medical]
TSGene5476
GENETestsCTSA
Huge Navigator CTSA [HugePedia]  CTSA [HugeCancerGEM]
snp3D : Map Gene to Disease5476
BioCentury BCIQCTSA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5476
Chemical/Pharm GKB GenePA33572
Clinical trialCTSA
Miscellaneous
canSAR (ICR)CTSA (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTSA
GoPubMedCTSA
iHOPCTSA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:41:35 CEST 2016

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