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CTSC (cathepsin C)

Identity

Alias_namesPLS
PALS
Alias_symbol (synonym)DPP1
Other aliasCPPI
DPP-I
DPPI
HMS
JP
JPD
PDON1
HGNC (Hugo) CTSC
LocusID (NCBI) 1075
Atlas_Id 54242
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 88320811 and ends at 88337787 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTSC (11q14.2) / GRM5 (11q14.2)CTSC (11q14.2) / RAB38 (11q14.2)CTSC (11q14.2) / SMCHD1 (18p11.32)
CTSC (11q14.2) / WWC3 (Xp22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTSC   2528
LRG (Locus Reference Genomic)LRG_50
Cards
Entrez_Gene (NCBI)CTSC  1075  cathepsin C
AliasesCPPI; DPP-I; DPP1; DPPI; 
HMS; JP; JPD; PALS; PDON1; PLS
GeneCards (Weizmann)CTSC
Ensembl hg19 (Hinxton)ENSG00000109861 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109861 [Gene_View]  chr11:88320811-88337787 [Contig_View]  CTSC [Vega]
ICGC DataPortalENSG00000109861
TCGA cBioPortalCTSC
AceView (NCBI)CTSC
Genatlas (Paris)CTSC
WikiGenes1075
SOURCE (Princeton)CTSC
Genetics Home Reference (NIH)CTSC
Genomic and cartography
GoldenPath hg38 (UCSC)CTSC  -     chr11:88320811-88337787 -  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTSC  -     11q14.2   [Description]    (hg19-Feb_2009)
EnsemblCTSC - 11q14.2 [CytoView hg19]  CTSC - 11q14.2 [CytoView hg38]
Mapping of homologs : NCBICTSC [Mapview hg19]  CTSC [Mapview hg38]
OMIM170650   245000   245010   602365   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001114173 NM_001814 NM_148170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTSC
Cluster EST : UnigeneHs.128065 [ NCBI ]
CGAP (NCI)Hs.128065
Alternative Splicing GalleryENSG00000109861
Gene ExpressionCTSC [ NCBI-GEO ]   CTSC [ EBI - ARRAY_EXPRESS ]   CTSC [ SEEK ]   CTSC [ MEM ]
Gene Expression Viewer (FireBrowse)CTSC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1075
GTEX Portal (Tissue expression)CTSC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53634   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53634  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53634
Splice isoforms : SwissVarP53634
Catalytic activity : Enzyme3.4.14.1 [ Enzyme-Expasy ]   3.4.14.13.4.14.1 [ IntEnz-EBI ]   3.4.14.1 [ BRENDA ]   3.4.14.1 [ KEGG ]   
PhosPhoSitePlusP53634
Domaine pattern : Prosite (Expaxy)THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (EBI)CathepsinC_exc    DPP_I    Pept_asp_AS    Pept_cys_AS    Pept_his_AS    Peptidase_C1A    Peptidase_C1A_C   
Domain families : Pfam (Sanger)CathepsinC_exc (PF08773)    Peptidase_C1 (PF00112)   
Domain families : Pfam (NCBI)pfam08773    pfam00112   
Domain families : Smart (EMBL)Pept_C1 (SM00645)  
Conserved Domain (NCBI)CTSC
DMDM Disease mutations1075
Blocks (Seattle)CTSC
PDB (SRS)1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
PDB (PDBSum)1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
PDB (IMB)1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
PDB (RSDB)1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
Structural Biology KnowledgeBase1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
SCOP (Structural Classification of Proteins)1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
CATH (Classification of proteins structures)1K3B    2DJF    2DJG    3PDF    4CDC    4CDD    4CDE    4CDF    4OEL    4OEM   
SuperfamilyP53634
Human Protein AtlasENSG00000109861
Peptide AtlasP53634
HPRD03841
IPIIPI00022810   IPI00171323   IPI01013193   IPI00978325   IPI00978933   IPI00872258   
Protein Interaction databases
DIP (DOE-UCLA)P53634
IntAct (EBI)P53634
FunCoupENSG00000109861
BioGRIDCTSC
STRING (EMBL)CTSC
ZODIACCTSC
Ontologies - Pathways
QuickGOP53634
Ontology : AmiGOGolgi membrane  T cell mediated cytotoxicity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  nucleoplasm  lysosome  lysosome  endoplasmic reticulum lumen  centrosome  proteolysis  ER to Golgi vesicle-mediated transport  apoptotic process  immune response  aging  cysteine-type peptidase activity  response to organic substance  membrane  peptidase activator activity involved in apoptotic process  phosphatase binding  ER to Golgi transport vesicle  chloride ion binding  endoplasmic reticulum-Golgi intermediate compartment membrane  azurophil granule lumen  identical protein binding  intracellular membrane-bounded organelle  neutrophil degranulation  protein self-association  COPII vesicle coating  chaperone binding  proteolysis involved in cellular protein catabolic process  extracellular exosome  positive regulation of proteolysis involved in cellular protein catabolic process  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIGolgi membrane  T cell mediated cytotoxicity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  nucleoplasm  lysosome  lysosome  endoplasmic reticulum lumen  centrosome  proteolysis  ER to Golgi vesicle-mediated transport  apoptotic process  immune response  aging  cysteine-type peptidase activity  response to organic substance  membrane  peptidase activator activity involved in apoptotic process  phosphatase binding  ER to Golgi transport vesicle  chloride ion binding  endoplasmic reticulum-Golgi intermediate compartment membrane  azurophil granule lumen  identical protein binding  intracellular membrane-bounded organelle  neutrophil degranulation  protein self-association  COPII vesicle coating  chaperone binding  proteolysis involved in cellular protein catabolic process  extracellular exosome  positive regulation of proteolysis involved in cellular protein catabolic process  positive regulation of apoptotic signaling pathway  
Pathways : KEGGLysosome   
NDEx NetworkCTSC
Atlas of Cancer Signalling NetworkCTSC
Wikipedia pathwaysCTSC
Orthology - Evolution
OrthoDB1075
GeneTree (enSembl)ENSG00000109861
Phylogenetic Trees/Animal Genes : TreeFamCTSC
HOVERGENP53634
HOGENOMP53634
Homologs : HomoloGeneCTSC
Homology/Alignments : Family Browser (UCSC)CTSC
Gene fusions - Rearrangements
Fusion : MitelmanCTSC/RAB38 [11q14.2/11q14.2]  
Fusion Cancer (Beijing)CTSC [11q14.2]  -  SMCHD1 [18p11.32]  [FUSC002488]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTSC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTSC
dbVarCTSC
ClinVarCTSC
1000_GenomesCTSC 
Exome Variant ServerCTSC
ExAC (Exome Aggregation Consortium)CTSC (select the gene name)
Genetic variants : HAPMAP1075
Genomic Variants (DGV)CTSC [DGVbeta]
DECIPHERCTSC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTSC 
Mutations
ICGC Data PortalCTSC 
TCGA Data PortalCTSC 
Broad Tumor PortalCTSC
OASIS PortalCTSC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTSC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTSC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CTSC
DgiDB (Drug Gene Interaction Database)CTSC
DoCM (Curated mutations)CTSC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTSC (select a term)
intoGenCTSC
Cancer3DCTSC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170650    245000    245010    602365   
Orphanet2194    2551   
MedgenCTSC
Genetic Testing Registry CTSC
NextProtP53634 [Medical]
TSGene1075
GENETestsCTSC
Target ValidationCTSC
Huge Navigator CTSC [HugePedia]
snp3D : Map Gene to Disease1075
BioCentury BCIQCTSC
ClinGenCTSC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1075
Chemical/Pharm GKB GenePA27028
Clinical trialCTSC
Miscellaneous
canSAR (ICR)CTSC (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTSC
EVEXCTSC
GoPubMedCTSC
iHOPCTSC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:04:16 CEST 2017

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