Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CTSL2 (cathepsin L2)

Identity

Other namesCATL2
CTSU
CTSV
HGNC (Hugo) CTSL2
LocusID (NCBI) 1515
Location 9q22.33
Location_base_pair Starts at 99791959 and ends at 99801925 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CTSL2   2538
Entrez_Gene (NCBI)CTSL2  1515  cathepsin L2
Cards
GeneCards (Weizmann)CTSL2
Ensembl (Hinxton) [Gene_View]  chr9:99791959-99801925 [Contig_View]  CTSL2 [Vega]
AceView (NCBI)CTSL2
Genatlas (Paris)CTSL2
SOURCE (Stanford)NM_001201575 NM_001333
Genomic and cartography
GoldenPath (UCSC)CTSL2  -  9q22.33   chr9:99791959-99801925 -  9q22.33   [Description]    (hg19-Feb_2009)
EnsemblCTSL2 - 9q22.33 [CytoView]
Mapping of homologs : NCBICTSL2 [Mapview]
OMIM603308   
Gene and transcription
Genbank (Entrez)AB001928 AF070448 AK310645 AK310740 AK312806
RefSeq transcript (SRS)NM_001201575 NM_001333
RefSeq transcript (Entrez)NM_001201575 NM_001333
RefSeq genomic (SRS)AC_000141 NC_000009 NC_018920 NT_008470 NW_001839236 NW_004078058
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NT_008470 NW_001839236 NW_004078058
Consensus coding sequences : CCDS (NCBI)CTSL2
Cluster EST : UnigeneHs.610096 [ SRS ] Hs.610096 [ NCBI ]
CGAP (NCI)Hs.610096
Alternative Splicing : Fast-db (Paris)GSHG0030998
Gene ExpressionCTSL2 [ NCBI-GEO ]   CTSL2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60911 (SRS) O60911 (Uniprot)
NextProtO60911
With graphics : InterProO60911
Splice isoforms : SwissVarO60911(Swissvar)
Domaine pattern : Prosite (SRS)THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domaine pattern : Prosite (Expaxy)THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (SRS)Pept_asp_AS    Pept_cys_AS    Pept_his_AS    Peptidase_C1A    Peptidase_C1A_C    Prot_inhib_I29   
Domains : Interpro (EBI)Pept_asp_AS    Pept_cys_AS    Pept_his_AS    Peptidase_C1A    Peptidase_C1A_C    Prot_inhib_I29   
Related proteins : CluSTrO60911
Domain families : Pfam (SRS)Inhibitor_I29 (PF08246)    Peptidase_C1 (PF00112)   
Domain families : Pfam (Sanger)Inhibitor_I29 (PF08246)    Peptidase_C1 (PF00112)   
Domain families : Pfam (NCBI)pfam08246    pfam00112   
Domain families : Smart (EMBL)Inhibitor_I29 (SM00848)  Pept_C1 (SM00645)  
DMDM1515
Blocks (Seattle)O60911
PDB (SRS)1FH0    3H6S    3KFQ   
PDB (PDBSum)1FH0    3H6S    3KFQ   
PDB (IMB)1FH0    3H6S    3KFQ   
PDB (RSDB)1FH0    3H6S    3KFQ   
HPRD04495
IPIIPI00000013   
Protein Interaction databases
DIP (DOE-UCLA)O60911
IntAct (EBI)O60911
REACTOMECTSL2
Protein Interaction Database1515
BioGRIDCTSL2
InParanoidO60911
Interologous Interaction database O60911
IntegromeDBCTSL2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CTSL2
SNP (GeneSNP Utah)CTSL2
SNP : HGBaseCTSL2
Genetic variants : HAPMAPCTSL2
Somatic Mutations in Cancer : COSMICCTSL2 
CONAN: Copy Number AnalysisCTSL2 
Mutations and Diseases : HGMDCTSL2
OMIM603308   
GENETests603308   
Disease Genetic AssociationCTSL2
Huge Navigator CTSL2 [HugePedia]  CTSL2 [HugeCancerGEM]
Genomic VariantsCTSL2  CTSL2 [DGVbeta]
ClinVarCTSL2
snp3D : Map Gene to Disease1515
General knowledge
Homologs : HomoloGeneCTSL2
Homology/Alignments : Family Browser (UCSC)CTSL2
Phylogenetic Trees/Animal Genes : TreeFamCTSL2
Catalytic activity : Enzyme3.4.22.43 [ Enzyme-Expasy ]   3.4.22.43 [ Enzyme-SRS ]   3.4.22.43 [ IntEnz-EBI ]   3.4.22.43 [ BRENDA ]   3.4.22.43 [ KEGG ]   
Chemical/Protein Interactions : CTD1515
Chemical/Pharm GKB GenePA27036
Clinical trialCTSL2
Ontology : AmiGOaminopeptidase activity  cysteine-type endopeptidase activity  extracellular region  microvillus  proteolysis  spermatogenesis  cysteine-type peptidase activity  cellular response to starvation  response to glucose stimulus  external side of plasma membrane  multicellular organismal aging  antigen processing and presentation of exogenous peptide antigen via MHC class II  nerve development  extracellular matrix disassembly  extracellular matrix organization  kininogen binding  protein complex binding  response to gonadotropin stimulus  peptide binding  neuron projection  lysosomal lumen  perikaryon  decidualization  autophagic cell death  response to glucocorticoid stimulus  Sertoli cell differentiation  
Ontology : EGO-EBIaminopeptidase activity  cysteine-type endopeptidase activity  extracellular region  microvillus  proteolysis  spermatogenesis  cysteine-type peptidase activity  cellular response to starvation  response to glucose stimulus  external side of plasma membrane  multicellular organismal aging  antigen processing and presentation of exogenous peptide antigen via MHC class II  nerve development  extracellular matrix disassembly  extracellular matrix organization  kininogen binding  protein complex binding  response to gonadotropin stimulus  peptide binding  neuron projection  lysosomal lumen  perikaryon  decidualization  autophagic cell death  response to glucocorticoid stimulus  Sertoli cell differentiation  
Other databases
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
PubGeneCTSL2
iHOPCTSL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:25:54 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.