Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTSS (cathepsin S)

Identity

Other alias-
HGNC (Hugo) CTSS
LocusID (NCBI) 1520
Atlas_Id 51039
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 150730196 and ends at 150765957 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTSS (1q21.3) / CTSS (1q21.3)CTSS (1q21.3) / STYX (14q22.1)CTSS (1q21.3) / TDRD10 (1q21.3)
EDEM2 (20q11.22) / CTSS (1q21.3)GOLPH3L (1q21.3) / CTSS (1q21.3)KLC4 (6p21.1) / CTSS (1q21.3)
LEPROT (1p31.3) / CTSS (1q21.3)MCL1 (1q21.3) / CTSS (1q21.3)PRPF3 (1q21.2) / CTSS (1q21.3)
ZC3HAV1 (7q34) / CTSS (1q21.3)CTSS 1q21.3 / TDRD10 1q21.3MCL1 1q21.3 / CTSS 1q21.3
PRPF3 1q21.2 / CTSS 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTSS   2545
Cards
Entrez_Gene (NCBI)CTSS  1520  cathepsin S
Aliases
GeneCards (Weizmann)CTSS
Ensembl hg19 (Hinxton)ENSG00000163131 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163131 [Gene_View]  chr1:150730196-150765957 [Contig_View]  CTSS [Vega]
ICGC DataPortalENSG00000163131
TCGA cBioPortalCTSS
AceView (NCBI)CTSS
Genatlas (Paris)CTSS
WikiGenes1520
SOURCE (Princeton)CTSS
Genetics Home Reference (NIH)CTSS
Genomic and cartography
GoldenPath hg38 (UCSC)CTSS  -     chr1:150730196-150765957 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTSS  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblCTSS - 1q21.3 [CytoView hg19]  CTSS - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBICTSS [Mapview hg19]  CTSS [Mapview hg38]
OMIM116845   
Gene and transcription
Genbank (Entrez)AK024855 AK226095 AK301472 AK314482 BC002642
RefSeq transcript (Entrez)NM_001199739 NM_004079
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTSS
Cluster EST : UnigeneHs.181301 [ NCBI ]
CGAP (NCI)Hs.181301
Alternative Splicing GalleryENSG00000163131
Gene ExpressionCTSS [ NCBI-GEO ]   CTSS [ EBI - ARRAY_EXPRESS ]   CTSS [ SEEK ]   CTSS [ MEM ]
Gene Expression Viewer (FireBrowse)CTSS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1520
GTEX Portal (Tissue expression)CTSS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25774   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25774  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25774
Splice isoforms : SwissVarP25774
Catalytic activity : Enzyme3.4.22.27 [ Enzyme-Expasy ]   3.4.22.273.4.22.27 [ IntEnz-EBI ]   3.4.22.27 [ BRENDA ]   3.4.22.27 [ KEGG ]   
PhosPhoSitePlusP25774
Domaine pattern : Prosite (Expaxy)THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (EBI)Pept_asp_AS    Pept_cys_AS    Pept_his_AS    Peptidase_C1A    Peptidase_C1A_C    Prot_inhib_I29   
Domain families : Pfam (Sanger)Inhibitor_I29 (PF08246)    Peptidase_C1 (PF00112)   
Domain families : Pfam (NCBI)pfam08246    pfam00112   
Domain families : Smart (EMBL)Inhibitor_I29 (SM00848)  Pept_C1 (SM00645)  
Conserved Domain (NCBI)CTSS
DMDM Disease mutations1520
Blocks (Seattle)CTSS
PDB (SRS)1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
PDB (PDBSum)1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
PDB (IMB)1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
PDB (RSDB)1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
Structural Biology KnowledgeBase1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
SCOP (Structural Classification of Proteins)1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
CATH (Classification of proteins structures)1BXF    1GLO    1MS6    1NPZ    1NQC    2C0Y    2F1G    2FQ9    2FRA    2FRQ    2FT2    2FUD    2FYE    2G6D    2G7Y    2H7J    2HH5    2HHN    2HXZ    2OP3    2R9M    2R9N    2R9O    3IEJ    3KWN    3MPE    3MPF    3N3G    3N4C    3OVX    4P6E    4P6G   
SuperfamilyP25774
Human Protein AtlasENSG00000163131
Peptide AtlasP25774
HPRD00292
IPIIPI00299150   IPI00910216   
Protein Interaction databases
DIP (DOE-UCLA)P25774
IntAct (EBI)P25774
FunCoupENSG00000163131
BioGRIDCTSS
STRING (EMBL)CTSS
ZODIACCTSS
Ontologies - Pathways
QuickGOP25774
Ontology : AmiGOfibronectin binding  toll-like receptor signaling pathway  adaptive immune response  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  collagen binding  extracellular region  extracellular region  extracellular space  lysosome  proteolysis  immune response  response to acidic pH  protein processing  antigen processing and presentation  antigen processing and presentation of exogenous peptide antigen via MHC class II  extracellular matrix disassembly  collagen catabolic process  basement membrane disassembly  endolysosome lumen  lysosomal lumen  intracellular membrane-bounded organelle  laminin binding  neutrophil degranulation  proteoglycan binding  antigen processing and presentation of peptide antigen  proteolysis involved in cellular protein catabolic process  cellular response to thyroid hormone stimulus  tertiary granule lumen  ficolin-1-rich granule lumen  positive regulation of cation channel activity  
Ontology : EGO-EBIfibronectin binding  toll-like receptor signaling pathway  adaptive immune response  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  collagen binding  extracellular region  extracellular region  extracellular space  lysosome  proteolysis  immune response  response to acidic pH  protein processing  antigen processing and presentation  antigen processing and presentation of exogenous peptide antigen via MHC class II  extracellular matrix disassembly  collagen catabolic process  basement membrane disassembly  endolysosome lumen  lysosomal lumen  intracellular membrane-bounded organelle  laminin binding  neutrophil degranulation  proteoglycan binding  antigen processing and presentation of peptide antigen  proteolysis involved in cellular protein catabolic process  cellular response to thyroid hormone stimulus  tertiary granule lumen  ficolin-1-rich granule lumen  positive regulation of cation channel activity  
Pathways : KEGGLysosome    Phagosome    Antigen processing and presentation    Tuberculosis   
NDEx NetworkCTSS
Atlas of Cancer Signalling NetworkCTSS
Wikipedia pathwaysCTSS
Orthology - Evolution
OrthoDB1520
GeneTree (enSembl)ENSG00000163131
Phylogenetic Trees/Animal Genes : TreeFamCTSS
HOVERGENP25774
HOGENOMP25774
Homologs : HomoloGeneCTSS
Homology/Alignments : Family Browser (UCSC)CTSS
Gene fusions - Rearrangements
Fusion : MitelmanCTSS/TDRD10 [1q21.3/1q21.3]  
Fusion : MitelmanGOLPH3L/CTSS [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanMCL1/CTSS [1q21.3/1q21.3]  [t(1;1)(q21;q21)]  
Fusion : MitelmanPRPF3/CTSS [1q21.2/1q21.3]  [t(1;1)(q21;q21)]  
Fusion: TCGACTSS 1q21.3 TDRD10 1q21.3 SKCM
Fusion: TCGAMCL1 1q21.3 CTSS 1q21.3 OV
Fusion: TCGAPRPF3 1q21.2 CTSS 1q21.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTSS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTSS
dbVarCTSS
ClinVarCTSS
1000_GenomesCTSS 
Exome Variant ServerCTSS
ExAC (Exome Aggregation Consortium)CTSS (select the gene name)
Genetic variants : HAPMAP1520
Genomic Variants (DGV)CTSS [DGVbeta]
DECIPHERCTSS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTSS 
Mutations
ICGC Data PortalCTSS 
TCGA Data PortalCTSS 
Broad Tumor PortalCTSS
OASIS PortalCTSS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTSS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTSS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTSS
DgiDB (Drug Gene Interaction Database)CTSS
DoCM (Curated mutations)CTSS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTSS (select a term)
intoGenCTSS
Cancer3DCTSS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116845   
Orphanet
MedgenCTSS
Genetic Testing Registry CTSS
NextProtP25774 [Medical]
TSGene1520
GENETestsCTSS
Target ValidationCTSS
Huge Navigator CTSS [HugePedia]
snp3D : Map Gene to Disease1520
BioCentury BCIQCTSS
ClinGenCTSS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1520
Chemical/Pharm GKB GenePA27041
Clinical trialCTSS
Miscellaneous
canSAR (ICR)CTSS (select the gene name)
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTSS
EVEXCTSS
GoPubMedCTSS
iHOPCTSS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:30:05 CEST 2017

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