CTSS (cathepsin S)

2009-08-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1520
MIM: 116845
HGNC: 2545
Ensembl: ENSG00000163131

Variants:

dbSNP: 1520
ClinVar: 1520
TCGA: ENSG00000163131
COSMIC: CTSS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163131ENST00000368985P25774
ENSG00000163131ENST00000448301P25774
ENSG00000163131ENST00000472977U3KPS4
ENSG00000163131ENST00000483930U3KQE7

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Antigen processing and presentationKEGGko04612
ApoptosisKEGGhsa04210
Antigen processing and presentationKEGGhsa04612
LysosomeKEGGko04142
LysosomeKEGGhsa04142
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Endosomal/Vacuolar pathwayREACTOMER-HSA-1236977
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250867472014Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
245230672014Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma.58
275953252016Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.51
219671082011Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.45
251182822014Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.45
248755362014Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathways.38
161403062006Increased serum cathepsin S in patients with atherosclerosis and diabetes.34
168253212006Cathepsin s promotes human preadipocyte differentiation: possible involvement of fibronectin degradation.33
201806362010Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis.33

Citation

Dessen P

CTSS (cathepsin S)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51039/ctss