Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTSV (cathepsin V)

Identity

Alias_namesCTSL2
cathepsin L2
Alias_symbol (synonym)CTSU
Other aliasCATL2
HGNC (Hugo) CTSV
LocusID (NCBI) 1515
Atlas_Id 53451
Location 9q22.33  [Link to chromosome band 9q22]
Location_base_pair Starts at 99791959 and ends at 99801925 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTSV   2538
Cards
Entrez_Gene (NCBI)CTSV  1515  cathepsin V
AliasesCATL2; CTSL2; CTSU
GeneCards (Weizmann)CTSV
Ensembl hg19 (Hinxton)ENSG00000136943 [Gene_View]  chr9:99791959-99801925 [Contig_View]  CTSV [Vega]
Ensembl hg38 (Hinxton)ENSG00000136943 [Gene_View]  chr9:99791959-99801925 [Contig_View]  CTSV [Vega]
ICGC DataPortalENSG00000136943
TCGA cBioPortalCTSV
AceView (NCBI)CTSV
Genatlas (Paris)CTSV
WikiGenes1515
SOURCE (Princeton)CTSV
Genetics Home Reference (NIH)CTSV
Genomic and cartography
GoldenPath hg19 (UCSC)CTSV  -     chr9:99791959-99801925 -  9q22.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CTSV  -     9q22.33   [Description]    (hg38-Dec_2013)
EnsemblCTSV - 9q22.33 [CytoView hg19]  CTSV - 9q22.33 [CytoView hg38]
Mapping of homologs : NCBICTSV [Mapview hg19]  CTSV [Mapview hg38]
OMIM603308   
Gene and transcription
Genbank (Entrez)AB001928 AF070448 AK310645 AK310740 AK312806
RefSeq transcript (Entrez)NM_001201575 NM_001333
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)CTSV
Cluster EST : UnigeneHs.610096 [ NCBI ]
CGAP (NCI)Hs.610096
Alternative Splicing GalleryENSG00000136943
Gene ExpressionCTSV [ NCBI-GEO ]   CTSV [ EBI - ARRAY_EXPRESS ]   CTSV [ SEEK ]   CTSV [ MEM ]
Gene Expression Viewer (FireBrowse)CTSV [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1515
GTEX Portal (Tissue expression)CTSV
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60911   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60911  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60911
Splice isoforms : SwissVarO60911
Catalytic activity : Enzyme3.4.22.43 [ Enzyme-Expasy ]   3.4.22.433.4.22.43 [ IntEnz-EBI ]   3.4.22.43 [ BRENDA ]   3.4.22.43 [ KEGG ]   
PhosPhoSitePlusO60911
Domaine pattern : Prosite (Expaxy)THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (EBI)Pept_asp_AS    Pept_cys_AS    Pept_his_AS    Peptidase_C1A    Peptidase_C1A_C    Prot_inhib_I29   
Domain families : Pfam (Sanger)Inhibitor_I29 (PF08246)    Peptidase_C1 (PF00112)   
Domain families : Pfam (NCBI)pfam08246    pfam00112   
Domain families : Smart (EMBL)Inhibitor_I29 (SM00848)  Pept_C1 (SM00645)  
Conserved Domain (NCBI)CTSV
DMDM Disease mutations1515
Blocks (Seattle)CTSV
PDB (SRS)1FH0    3H6S    3KFQ   
PDB (PDBSum)1FH0    3H6S    3KFQ   
PDB (IMB)1FH0    3H6S    3KFQ   
PDB (RSDB)1FH0    3H6S    3KFQ   
Structural Biology KnowledgeBase1FH0    3H6S    3KFQ   
SCOP (Structural Classification of Proteins)1FH0    3H6S    3KFQ   
CATH (Classification of proteins structures)1FH0    3H6S    3KFQ   
SuperfamilyO60911
Human Protein AtlasENSG00000136943
Peptide AtlasO60911
HPRD04495
IPIIPI00000013   
Protein Interaction databases
DIP (DOE-UCLA)O60911
IntAct (EBI)O60911
FunCoupENSG00000136943
BioGRIDCTSV
STRING (EMBL)CTSV
ZODIACCTSV
Ontologies - Pathways
QuickGOO60911
Ontology : AmiGOaminopeptidase activity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  nucleolus  lysosome  microvillus  spermatogenesis  cysteine-type peptidase activity  cellular response to starvation  response to glucose  external side of plasma membrane  multicellular organism aging  negative regulation of keratinocyte proliferation  protein autoprocessing  cysteine-type carboxypeptidase activity  antigen processing and presentation of exogenous peptide antigen via MHC class II  nerve development  extracellular matrix disassembly  secretory granule  kininogen binding  hair follicle morphogenesis  protein complex binding  response to gonadotropin  peptide binding  histone binding  neuron projection  lysosomal lumen  perikaryon  apical part of cell  decidualization  autophagic cell death  response to glucocorticoid  proteolysis involved in cellular protein catabolic process  Sertoli cell differentiation  extracellular exosome  regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIaminopeptidase activity  cysteine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  nucleolus  lysosome  microvillus  spermatogenesis  cysteine-type peptidase activity  cellular response to starvation  response to glucose  external side of plasma membrane  multicellular organism aging  negative regulation of keratinocyte proliferation  protein autoprocessing  cysteine-type carboxypeptidase activity  antigen processing and presentation of exogenous peptide antigen via MHC class II  nerve development  extracellular matrix disassembly  secretory granule  kininogen binding  hair follicle morphogenesis  protein complex binding  response to gonadotropin  peptide binding  histone binding  neuron projection  lysosomal lumen  perikaryon  apical part of cell  decidualization  autophagic cell death  response to glucocorticoid  proteolysis involved in cellular protein catabolic process  Sertoli cell differentiation  extracellular exosome  regulation of actin cytoskeleton reorganization  
Pathways : KEGGLysosome   
NDEx NetworkCTSV
Atlas of Cancer Signalling NetworkCTSV
Wikipedia pathwaysCTSV
Orthology - Evolution
OrthoDB1515
GeneTree (enSembl)ENSG00000136943
Phylogenetic Trees/Animal Genes : TreeFamCTSV
HOVERGENO60911
HOGENOMO60911
Homologs : HomoloGeneCTSV
Homology/Alignments : Family Browser (UCSC)CTSV
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTSV [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTSV
dbVarCTSV
ClinVarCTSV
1000_GenomesCTSV 
Exome Variant ServerCTSV
ExAC (Exome Aggregation Consortium)CTSV (select the gene name)
Genetic variants : HAPMAP1515
Genomic Variants (DGV)CTSV [DGVbeta]
DECIPHER (Syndromes)9:99791959-99801925  ENSG00000136943
CONAN: Copy Number AnalysisCTSV 
Mutations
ICGC Data PortalCTSV 
TCGA Data PortalCTSV 
Broad Tumor PortalCTSV
OASIS PortalCTSV [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCTSV
BioMutasearch CTSV
DgiDB (Drug Gene Interaction Database)CTSV
DoCM (Curated mutations)CTSV (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTSV (select a term)
intoGenCTSV
Cancer3DCTSV(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603308   
Orphanet
MedgenCTSV
Genetic Testing Registry CTSV
NextProtO60911 [Medical]
TSGene1515
GENETestsCTSV
Huge Navigator CTSV [HugePedia]
snp3D : Map Gene to Disease1515
BioCentury BCIQCTSV
ClinGenCTSV
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1515
Chemical/Pharm GKB GenePA27036
Clinical trialCTSV
Miscellaneous
canSAR (ICR)CTSV (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTSV
EVEXCTSV
GoPubMedCTSV
iHOPCTSV
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:14 CET 2017

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