CTSV (cathepsin V)

2013-07-01  

Identity

HGNC
LOCATION
9q22.33
LOCUSID
ALIAS
CATL2,CTSL2,CTSU

Other Information

Locus ID:

NCBI: 1515
MIM: 603308
HGNC: 2538
Ensembl: ENSG00000136943

Variants:

dbSNP: 1515
ClinVar: 1515
TCGA: ENSG00000136943
COSMIC: CTSV

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136943ENST00000259470O60911
ENSG00000136943ENST00000259470A0A024R141
ENSG00000136943ENST00000538255O60911
ENSG00000136943ENST00000538255A0A024R141

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
ApoptosisKEGGhsa04210
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Endosomal/Vacuolar pathwayREACTOMER-HSA-1236977
MHC class II antigen presentationREACTOMER-HSA-2132295
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151921012004Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages.46
165650752006Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.30
129256922003Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis.26
225623032012Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.17
223930402012Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters.12
229678982012Determination of cathepsin V activity and intracellular trafficking by N-glycosylation.10
241215142013Elastin degradation by cathepsin V requires two exosites.10
156791212004The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.9
232873602013Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis.8
224523892012Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.7

Citation

Dessen P

CTSV (cathepsin V)

Atlas Genet Cytogenet Oncol Haematol. 2013-07-01

Online version: http://atlasgeneticsoncology.org/gene/53451/ctsv