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CTSZ (cathepsin Z)

Identity

Alias_symbol (synonym)CTSX
Other alias
HGNC (Hugo) CTSZ
LocusID (NCBI) 1522
Atlas_Id 40210
Location 20q13.32  [Link to chromosome band 20q13]
Location_base_pair Starts at 58995187 and ends at 59007254 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCNI (4q21.1) / CTSZ (20q13.32)CTSZ (20q13.32) / AOAH (7p14.2)CTSZ (20q13.32) / CLIC1 (6p21.33)
CTSZ (20q13.32) / COL1A1 (17q21.33)CTSZ (20q13.32) / CTSZ (20q13.32)CTSZ (20q13.32) / ISCU (12q23.3)
CTSZ (20q13.32) / TNS2 (12q13.13)MALAT1 (11q13.1) / CTSZ (20q13.32)RNF220 (1p34.1) / CTSZ (20q13.32)
S100A10 (1q21.3) / CTSZ (20q13.32)TMEM74 (8q23.1) / CTSZ (20q13.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CTSZ   2547
Cards
Entrez_Gene (NCBI)CTSZ  1522  cathepsin Z
AliasesCTSX
GeneCards (Weizmann)CTSZ
Ensembl hg19 (Hinxton)ENSG00000101160 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101160 [Gene_View]  chr20:58995187-59007254 [Contig_View]  CTSZ [Vega]
ICGC DataPortalENSG00000101160
TCGA cBioPortalCTSZ
AceView (NCBI)CTSZ
Genatlas (Paris)CTSZ
WikiGenes1522
SOURCE (Princeton)CTSZ
Genetics Home Reference (NIH)CTSZ
Genomic and cartography
GoldenPath hg38 (UCSC)CTSZ  -     chr20:58995187-59007254 -  20q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTSZ  -     20q13.32   [Description]    (hg19-Feb_2009)
EnsemblCTSZ - 20q13.32 [CytoView hg19]  CTSZ - 20q13.32 [CytoView hg38]
Mapping of homologs : NCBICTSZ [Mapview hg19]  CTSZ [Mapview hg38]
OMIM603169   
Gene and transcription
Genbank (Entrez)AF009923 AF073890 AF136273 AK310046 AK314931
RefSeq transcript (Entrez)NM_001336
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTSZ
Cluster EST : UnigeneHs.252549 [ NCBI ]
CGAP (NCI)Hs.252549
Alternative Splicing GalleryENSG00000101160
Gene ExpressionCTSZ [ NCBI-GEO ]   CTSZ [ EBI - ARRAY_EXPRESS ]   CTSZ [ SEEK ]   CTSZ [ MEM ]
Gene Expression Viewer (FireBrowse)CTSZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1522
GTEX Portal (Tissue expression)CTSZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBR2
Splice isoforms : SwissVarQ9UBR2
Catalytic activity : Enzyme3.4.18.1 [ Enzyme-Expasy ]   3.4.18.13.4.18.1 [ IntEnz-EBI ]   3.4.18.1 [ BRENDA ]   3.4.18.1 [ KEGG ]   
PhosPhoSitePlusQ9UBR2
Domaine pattern : Prosite (Expaxy)THIOL_PROTEASE_ASN (PS00640)   
Domains : Interpro (EBI)Cathepsin_X    Pept_asp_AS    Peptidase_C1A    Peptidase_C1A_C   
Domain families : Pfam (Sanger)Peptidase_C1 (PF00112)   
Domain families : Pfam (NCBI)pfam00112   
Domain families : Smart (EMBL)Pept_C1 (SM00645)  
Conserved Domain (NCBI)CTSZ
DMDM Disease mutations1522
Blocks (Seattle)CTSZ
PDB (SRS)1DEU    1EF7   
PDB (PDBSum)1DEU    1EF7   
PDB (IMB)1DEU    1EF7   
PDB (RSDB)1DEU    1EF7   
Structural Biology KnowledgeBase1DEU    1EF7   
SCOP (Structural Classification of Proteins)1DEU    1EF7   
CATH (Classification of proteins structures)1DEU    1EF7   
SuperfamilyQ9UBR2
Human Protein AtlasENSG00000101160
Peptide AtlasQ9UBR2
HPRD04410
IPIIPI00002745   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBR2
IntAct (EBI)Q9UBR2
FunCoupENSG00000101160
BioGRIDCTSZ
STRING (EMBL)CTSZ
ZODIACCTSZ
Ontologies - Pathways
QuickGOQ9UBR2
Ontology : AmiGOGolgi membrane  angiotensin maturation  carboxypeptidase activity  cysteine-type endopeptidase activity  protein binding  extracellular region  extracellular space  lysosome  lysosome  endoplasmic reticulum  endoplasmic reticulum lumen  plasma membrane  proteolysis  ER to Golgi vesicle-mediated transport  cysteine-type peptidase activity  cell surface  negative regulation of plasminogen activation  negative regulation of neuron projection development  ER to Golgi transport vesicle  growth cone  cytoplasmic vesicle  negative regulation of protein binding  endoplasmic reticulum-Golgi intermediate compartment membrane  specific granule lumen  intracellular membrane-bounded organelle  neutrophil degranulation  positive regulation of neuron apoptotic process  COPII vesicle coating  proteolysis involved in cellular protein catabolic process  epithelial tube branching involved in lung morphogenesis  extracellular exosome  cell cortex region  regulation of neuron death  ficolin-1-rich granule lumen  positive regulation of neural precursor cell proliferation  
Ontology : EGO-EBIGolgi membrane  angiotensin maturation  carboxypeptidase activity  cysteine-type endopeptidase activity  protein binding  extracellular region  extracellular space  lysosome  lysosome  endoplasmic reticulum  endoplasmic reticulum lumen  plasma membrane  proteolysis  ER to Golgi vesicle-mediated transport  cysteine-type peptidase activity  cell surface  negative regulation of plasminogen activation  negative regulation of neuron projection development  ER to Golgi transport vesicle  growth cone  cytoplasmic vesicle  negative regulation of protein binding  endoplasmic reticulum-Golgi intermediate compartment membrane  specific granule lumen  intracellular membrane-bounded organelle  neutrophil degranulation  positive regulation of neuron apoptotic process  COPII vesicle coating  proteolysis involved in cellular protein catabolic process  epithelial tube branching involved in lung morphogenesis  extracellular exosome  cell cortex region  regulation of neuron death  ficolin-1-rich granule lumen  positive regulation of neural precursor cell proliferation  
Pathways : KEGGLysosome   
NDEx NetworkCTSZ
Atlas of Cancer Signalling NetworkCTSZ
Wikipedia pathwaysCTSZ
Orthology - Evolution
OrthoDB1522
GeneTree (enSembl)ENSG00000101160
Phylogenetic Trees/Animal Genes : TreeFamCTSZ
HOVERGENQ9UBR2
HOGENOMQ9UBR2
Homologs : HomoloGeneCTSZ
Homology/Alignments : Family Browser (UCSC)CTSZ
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTSZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTSZ
dbVarCTSZ
ClinVarCTSZ
1000_GenomesCTSZ 
Exome Variant ServerCTSZ
ExAC (Exome Aggregation Consortium)CTSZ (select the gene name)
Genetic variants : HAPMAP1522
Genomic Variants (DGV)CTSZ [DGVbeta]
DECIPHERCTSZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTSZ 
Mutations
ICGC Data PortalCTSZ 
TCGA Data PortalCTSZ 
Broad Tumor PortalCTSZ
OASIS PortalCTSZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTSZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTSZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch CTSZ
DgiDB (Drug Gene Interaction Database)CTSZ
DoCM (Curated mutations)CTSZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTSZ (select a term)
intoGenCTSZ
Cancer3DCTSZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603169   
Orphanet
MedgenCTSZ
Genetic Testing Registry CTSZ
NextProtQ9UBR2 [Medical]
TSGene1522
GENETestsCTSZ
Target ValidationCTSZ
Huge Navigator CTSZ [HugePedia]
snp3D : Map Gene to Disease1522
BioCentury BCIQCTSZ
ClinGenCTSZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1522
Chemical/Pharm GKB GenePA27043
Clinical trialCTSZ
Miscellaneous
canSAR (ICR)CTSZ (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTSZ
EVEXCTSZ
GoPubMedCTSZ
iHOPCTSZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:05 CEST 2017

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