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CTTN (cortactin)

Identity

Alias (NCBI)EMS1
HGNC (Hugo) CTTN
HGNC Previous nameEMS1
HGNC Previous nameems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
LocusID (NCBI) 2017
Atlas_Id 369
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 70398506 and ends at 70436584 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C7orf50 (7p22.3) / CTTN (11q13.3)CTTN (11q13.3) / ANO1 (11q13.3)CTTN (11q13.3) / CBS (21q22.3)
CTTN (11q13.3) / CSF2RB (22q12.3)CTTN (11q13.3) / CTTN (11q13.3)CTTN (11q13.3) / DDX27 (20q13.13)
CTTN (11q13.3) / DSG1 (18q12.1)CTTN (11q13.3) / FAM153A (5q35.3)CTTN (11q13.3) / FOLR1 (11q13.4)
CTTN (11q13.3) / GTF3C6 (6q21)CTTN (11q13.3) / KLRG2 (7q34)CTTN (11q13.3) / LASP1 (17q12)
CTTN (11q13.3) / MYC (8q24.21)CTTN (11q13.3) / MYO5A (15q21.2)CTTN (11q13.3) / PLEKHA5 (12p12.3)
CTTN (11q13.3) / PSME2 (14q12)FBXL4 (6q16.1) / CTTN (11q13.3)LOC286442 () / CTTN (11q13.3)
SAT1 (Xp22.11) / CTTN (11q13.3)STAT6 (12q13.3) / CTTN (11q13.3)CTTN 11q13.3 / ANO1 11q13.3
CTTN 11q13.3 / CBS 21q22.3CTTN 11q13.3 / DDX27 20q13.13CTTN 11q13.3 / DSG1 18q12.1
CTTN 11q13.3 / FOLR1 11q13.4CTTN 11q13.3 / PLEKHA5 12p12.3CTTN 11q13.3 / PSME2 14q12
SAT1 Xp22.11 / CTTN 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CTTN   3338
Cards
Entrez_Gene (NCBI)CTTN    cortactin
AliasesEMS1
GeneCards (Weizmann)CTTN
Ensembl hg19 (Hinxton)ENSG00000085733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085733 [Gene_View]  ENSG00000085733 [Sequence]  chr11:70398506-70436584 [Contig_View]  CTTN [Vega]
ICGC DataPortalENSG00000085733
TCGA cBioPortalCTTN
AceView (NCBI)CTTN
Genatlas (Paris)CTTN
SOURCE (Princeton)CTTN
Genetics Home Reference (NIH)CTTN
Genomic and cartography
GoldenPath hg38 (UCSC)CTTN  -     chr11:70398506-70436584 +  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTTN  -     11q13.3   [Description]    (hg19-Feb_2009)
GoldenPathCTTN - 11q13.3 [CytoView hg19]  CTTN - 11q13.3 [CytoView hg38]
ImmunoBaseENSG00000085733
Genome Data Viewer NCBICTTN [Mapview hg19]  
OMIM164765   
Gene and transcription
Genbank (Entrez)AA325227 AK023333 AK091778 AK222613 AK291097
RefSeq transcript (Entrez)NM_001184740 NM_005231 NM_138565
Consensus coding sequences : CCDS (NCBI)CTTN
Gene ExpressionCTTN [ NCBI-GEO ]   CTTN [ EBI - ARRAY_EXPRESS ]   CTTN [ SEEK ]   CTTN [ MEM ]
Gene Expression Viewer (FireBrowse)CTTN [ Firebrowse - Broad ]
GenevisibleExpression of CTTN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2017
GTEX Portal (Tissue expression)CTTN
Human Protein AtlasENSG00000085733-CTTN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14247   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14247  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14247
PhosPhoSitePlusQ14247
Domaine pattern : Prosite (Expaxy)CORTACTIN (PS51090)    SH3 (PS50002)   
Domains : Interpro (EBI)Cortactin    Cortactin_SH3    Hs1_Cortactin    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)HS1_rep (PF02218)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam02218    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)CTTN
PDB (RSDB)1X69    2D1X   
PDB Europe1X69    2D1X   
PDB (PDBSum)1X69    2D1X   
PDB (IMB)1X69    2D1X   
Structural Biology KnowledgeBase1X69    2D1X   
SCOP (Structural Classification of Proteins)1X69    2D1X   
CATH (Classification of proteins structures)1X69    2D1X   
SuperfamilyQ14247
AlphaFold pdb e-kbQ14247   
Human Protein Atlas [tissue]ENSG00000085733-CTTN [tissue]
HPRD01268
Protein Interaction databases
DIP (DOE-UCLA)Q14247
IntAct (EBI)Q14247
BioGRIDCTTN
STRING (EMBL)CTTN
ZODIACCTTN
Ontologies - Pathways
QuickGOQ14247
Ontology : AmiGOruffle  podosome  protein binding  profilin binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  cytoskeleton  actin filament  actin filament  plasma membrane  plasma membrane  clathrin-coated pit  focal adhesion  cell cortex  cell cortex  intracellular protein transport  receptor-mediated endocytosis  substrate-dependent cell migration, cell extension  lamellipodium  lamellipodium  lamellipodium  actin filament polymerization  growth cone  site of polarized growth  regulation of axon extension  regulation of actin filament polymerization  positive regulation of actin filament polymerization  positive regulation of actin filament polymerization  cortical cytoskeleton  cortical actin cytoskeleton  actin cytoskeleton reorganization  dendritic spine  intracellular membrane-bounded organelle  cadherin binding  positive regulation of smooth muscle contraction  focal adhesion assembly  neuron projection morphogenesis  cell motility  actin filament binding  membrane organization  dendritic spine maintenance  lamellipodium organization  regulation of autophagy of mitochondrion  mitotic spindle midzone  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIruffle  podosome  protein binding  profilin binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  cytoskeleton  actin filament  actin filament  plasma membrane  plasma membrane  clathrin-coated pit  focal adhesion  cell cortex  cell cortex  intracellular protein transport  receptor-mediated endocytosis  substrate-dependent cell migration, cell extension  lamellipodium  lamellipodium  lamellipodium  actin filament polymerization  growth cone  site of polarized growth  regulation of axon extension  regulation of actin filament polymerization  positive regulation of actin filament polymerization  positive regulation of actin filament polymerization  cortical cytoskeleton  cortical actin cytoskeleton  actin cytoskeleton reorganization  dendritic spine  intracellular membrane-bounded organelle  cadherin binding  positive regulation of smooth muscle contraction  focal adhesion assembly  neuron projection morphogenesis  cell motility  actin filament binding  membrane organization  dendritic spine maintenance  lamellipodium organization  regulation of autophagy of mitochondrion  mitotic spindle midzone  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGTight junction    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Proteoglycans in cancer   
NDEx NetworkCTTN
Atlas of Cancer Signalling NetworkCTTN
Wikipedia pathwaysCTTN
Orthology - Evolution
OrthoDB2017
GeneTree (enSembl)ENSG00000085733
Phylogenetic Trees/Animal Genes : TreeFamCTTN
Homologs : HomoloGeneCTTN
Homology/Alignments : Family Browser (UCSC)CTTN
Gene fusions - Rearrangements
Fusion : MitelmanCTTN/ANO1 [11q13.3/11q13.3]  
Fusion : MitelmanCTTN/CBS [11q13.3/21q22.3]  
Fusion : MitelmanCTTN/DDX27 [11q13.3/20q13.13]  
Fusion : MitelmanCTTN/DSG1 [11q13.3/18q12.1]  
Fusion : MitelmanCTTN/FOLR1 [11q13.3/11q13.4]  
Fusion : MitelmanCTTN/PLEKHA5 [11q13.3/12p12.3]  
Fusion : MitelmanCTTN/PSME2 [11q13.3/14q12]  
Fusion : MitelmanSAT1/CTTN [Xp22.11/11q13.3]  
Fusion : QuiverCTTN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTTN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTTN
dbVarCTTN
ClinVarCTTN
MonarchCTTN
1000_GenomesCTTN 
Exome Variant ServerCTTN
GNOMAD BrowserENSG00000085733
Varsome BrowserCTTN
ACMGCTTN variants
VarityQ14247
Genomic Variants (DGV)CTTN [DGVbeta]
DECIPHERCTTN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTTN 
Mutations
ICGC Data PortalCTTN 
TCGA Data PortalCTTN 
Broad Tumor PortalCTTN
OASIS PortalCTTN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTTN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCTTN
Mutations and Diseases : HGMDCTTN
intOGen PortalCTTN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCTTN
DgiDB (Drug Gene Interaction Database)CTTN
DoCM (Curated mutations)CTTN
CIViC (Clinical Interpretations of Variants in Cancer)CTTN
Cancer3DCTTN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164765   
Orphanet
DisGeNETCTTN
MedgenCTTN
Genetic Testing Registry CTTN
NextProtQ14247 [Medical]
GENETestsCTTN
Target ValidationCTTN
Huge Navigator CTTN [HugePedia]
ClinGenCTTN
Clinical trials, drugs, therapy
MyCancerGenomeCTTN
Protein Interactions : CTDCTTN
Pharm GKB GenePA27775
PharosQ14247
Clinical trialCTTN
Miscellaneous
canSAR (ICR)CTTN
HarmonizomeCTTN
DataMed IndexCTTN
Probes
Litterature
PubMed336 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCTTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:41 CEST 2021

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