Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CTTN (cortactin)

Identity

Alias_namesEMS1
ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)
Other alias
HGNC (Hugo) CTTN
LocusID (NCBI) 2017
Atlas_Id 369
Location 11q13.3  [Link to chromosome band 11q13]
Location_base_pair Starts at 70398506 and ends at 70436584 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C7orf50 (7p22.3) / CTTN (11q13.3)CTTN (11q13.3) / ANO1 (11q13.3)CTTN (11q13.3) / CBS (21q22.3)
CTTN (11q13.3) / CSF2RB (22q12.3)CTTN (11q13.3) / CTTN (11q13.3)CTTN (11q13.3) / DDX27 (20q13.13)
CTTN (11q13.3) / DSG1 (18q12.1)CTTN (11q13.3) / FAM153A (5q35.3)CTTN (11q13.3) / FOLR1 (11q13.4)
CTTN (11q13.3) / GTF3C6 (6q21)CTTN (11q13.3) / KLRG2 (7q34)CTTN (11q13.3) / LASP1 (17q12)
CTTN (11q13.3) / MYC (8q24.21)CTTN (11q13.3) / MYO5A (15q21.2)CTTN (11q13.3) / PLEKHA5 (12p12.3)
CTTN (11q13.3) / PSME2 (14q12)FBXL4 (6q16.1) / CTTN (11q13.3)LOC286442 () / CTTN (11q13.3)
SAT1 (Xp22.11) / CTTN (11q13.3)STAT6 (12q13.3) / CTTN (11q13.3)CTTN 11q13.3 / ANO1 11q13.3
CTTN 11q13.3 / CBS 21q22.3CTTN 11q13.3 / DDX27 20q13.13CTTN 11q13.3 / DSG1 18q12.1
CTTN 11q13.3 / FOLR1 11q13.4CTTN 11q13.3 / PLEKHA5 12p12.3CTTN 11q13.3 / PSME2 14q12
SAT1 Xp22.11 / CTTN 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Bladder: Urothelial carcinomas
Head and Neck: Epidermoid carcinoma
Head and Neck: Laryngeal squamous cell carcinoma
Squamous cell cancer


External links

Nomenclature
HGNC (Hugo)CTTN   3338
Cards
Entrez_Gene (NCBI)CTTN  2017  cortactin
AliasesEMS1
GeneCards (Weizmann)CTTN
Ensembl hg19 (Hinxton)ENSG00000085733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085733 [Gene_View]  chr11:70398506-70436584 [Contig_View]  CTTN [Vega]
ICGC DataPortalENSG00000085733
TCGA cBioPortalCTTN
AceView (NCBI)CTTN
Genatlas (Paris)CTTN
WikiGenes2017
SOURCE (Princeton)CTTN
Genetics Home Reference (NIH)CTTN
Genomic and cartography
GoldenPath hg38 (UCSC)CTTN  -     chr11:70398506-70436584 +  11q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CTTN  -     11q13.3   [Description]    (hg19-Feb_2009)
EnsemblCTTN - 11q13.3 [CytoView hg19]  CTTN - 11q13.3 [CytoView hg38]
Mapping of homologs : NCBICTTN [Mapview hg19]  CTTN [Mapview hg38]
OMIM164765   
Gene and transcription
Genbank (Entrez)AA325227 AK023333 AK091778 AK222613 AK291097
RefSeq transcript (Entrez)NM_001184740 NM_005231 NM_138565
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CTTN
Cluster EST : UnigeneHs.596164 [ NCBI ]
CGAP (NCI)Hs.596164
Alternative Splicing GalleryENSG00000085733
Gene ExpressionCTTN [ NCBI-GEO ]   CTTN [ EBI - ARRAY_EXPRESS ]   CTTN [ SEEK ]   CTTN [ MEM ]
Gene Expression Viewer (FireBrowse)CTTN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2017
GTEX Portal (Tissue expression)CTTN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14247   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14247  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14247
Splice isoforms : SwissVarQ14247
PhosPhoSitePlusQ14247
Domaine pattern : Prosite (Expaxy)CORTACTIN (PS51090)    SH3 (PS50002)   
Domains : Interpro (EBI)Cortactin    Hs1_Cortactin    SH3_domain   
Domain families : Pfam (Sanger)HS1_rep (PF02218)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam02218    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  
Conserved Domain (NCBI)CTTN
DMDM Disease mutations2017
Blocks (Seattle)CTTN
PDB (SRS)1X69    2D1X   
PDB (PDBSum)1X69    2D1X   
PDB (IMB)1X69    2D1X   
PDB (RSDB)1X69    2D1X   
Structural Biology KnowledgeBase1X69    2D1X   
SCOP (Structural Classification of Proteins)1X69    2D1X   
CATH (Classification of proteins structures)1X69    2D1X   
SuperfamilyQ14247
Human Protein AtlasENSG00000085733
Peptide AtlasQ14247
HPRD01268
IPIIPI00029601   IPI00746806   IPI00062884   IPI00791680   IPI01013939   IPI00981988   IPI00974229   IPI00977878   IPI00983145   
Protein Interaction databases
DIP (DOE-UCLA)Q14247
IntAct (EBI)Q14247
FunCoupENSG00000085733
BioGRIDCTTN
STRING (EMBL)CTTN
ZODIACCTTN
Ontologies - Pathways
QuickGOQ14247
Ontology : AmiGOruffle  podosome  protein binding  profilin binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  cytoskeleton  actin filament  plasma membrane  clathrin-coated pit  focal adhesion  cell cortex  cell cortex  intracellular protein transport  receptor-mediated endocytosis  substrate-dependent cell migration, cell extension  voltage-gated potassium channel complex  lamellipodium  lamellipodium  actin filament polymerization  growth cone  regulation of axon extension  positive regulation of actin filament polymerization  positive regulation of actin filament polymerization  cortical cytoskeleton  actin cytoskeleton reorganization  dendritic spine  intracellular membrane-bounded organelle  cadherin binding  positive regulation of smooth muscle contraction  focal adhesion assembly  neuron projection morphogenesis  cell motility  membrane organization  extracellular exosome  dendritic spine maintenance  lamellipodium organization  regulation of mitophagy  mitotic spindle midzone  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIruffle  podosome  protein binding  profilin binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  cytoskeleton  actin filament  plasma membrane  clathrin-coated pit  focal adhesion  cell cortex  cell cortex  intracellular protein transport  receptor-mediated endocytosis  substrate-dependent cell migration, cell extension  voltage-gated potassium channel complex  lamellipodium  lamellipodium  actin filament polymerization  growth cone  regulation of axon extension  positive regulation of actin filament polymerization  positive regulation of actin filament polymerization  cortical cytoskeleton  actin cytoskeleton reorganization  dendritic spine  intracellular membrane-bounded organelle  cadherin binding  positive regulation of smooth muscle contraction  focal adhesion assembly  neuron projection morphogenesis  cell motility  membrane organization  extracellular exosome  dendritic spine maintenance  lamellipodium organization  regulation of mitophagy  mitotic spindle midzone  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGTight junction    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Proteoglycans in cancer   
NDEx NetworkCTTN
Atlas of Cancer Signalling NetworkCTTN
Wikipedia pathwaysCTTN
Orthology - Evolution
OrthoDB2017
GeneTree (enSembl)ENSG00000085733
Phylogenetic Trees/Animal Genes : TreeFamCTTN
HOVERGENQ14247
HOGENOMQ14247
Homologs : HomoloGeneCTTN
Homology/Alignments : Family Browser (UCSC)CTTN
Gene fusions - Rearrangements
Fusion : MitelmanCTTN/ANO1 [11q13.3/11q13.3]  
Fusion : MitelmanCTTN/CBS [11q13.3/21q22.3]  [t(11;21)(q13;q22)]  
Fusion : MitelmanCTTN/DDX27 [11q13.3/20q13.13]  [t(11;20)(q13;q13)]  
Fusion : MitelmanCTTN/DSG1 [11q13.3/18q12.1]  [t(11;18)(q13;q12)]  
Fusion : MitelmanCTTN/FOLR1 [11q13.3/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanCTTN/PLEKHA5 [11q13.3/12p12.3]  [t(11;12)(q13;p12)]  
Fusion : MitelmanCTTN/PSME2 [11q13.3/14q12]  [t(11;14)(q13;q12)]  
Fusion : MitelmanSAT1/CTTN [Xp22.11/11q13.3]  [t(X;11)(p22;q13)]  
Fusion: TCGACTTN 11q13.3 ANO1 11q13.3 BRCA
Fusion: TCGACTTN 11q13.3 CBS 21q22.3 HNSC
Fusion: TCGACTTN 11q13.3 DDX27 20q13.13 BLCA
Fusion: TCGACTTN 11q13.3 DSG1 18q12.1 LUSC
Fusion: TCGACTTN 11q13.3 FOLR1 11q13.4 BRCA LGG
Fusion: TCGACTTN 11q13.3 PLEKHA5 12p12.3 BRCA
Fusion: TCGACTTN 11q13.3 PSME2 14q12 BRCA
Fusion: TCGASAT1 Xp22.11 CTTN 11q13.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCTTN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CTTN
dbVarCTTN
ClinVarCTTN
1000_GenomesCTTN 
Exome Variant ServerCTTN
ExAC (Exome Aggregation Consortium)CTTN (select the gene name)
Genetic variants : HAPMAP2017
Genomic Variants (DGV)CTTN [DGVbeta]
DECIPHERCTTN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCTTN 
Mutations
ICGC Data PortalCTTN 
TCGA Data PortalCTTN 
Broad Tumor PortalCTTN
OASIS PortalCTTN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCTTN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCTTN
intOGen PortalCTTN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CTTN
DgiDB (Drug Gene Interaction Database)CTTN
DoCM (Curated mutations)CTTN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CTTN (select a term)
intoGenCTTN
Cancer3DCTTN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164765   
Orphanet
MedgenCTTN
Genetic Testing Registry CTTN
NextProtQ14247 [Medical]
TSGene2017
GENETestsCTTN
Target ValidationCTTN
Huge Navigator CTTN [HugePedia]
snp3D : Map Gene to Disease2017
BioCentury BCIQCTTN
ClinGenCTTN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2017
Chemical/Pharm GKB GenePA27775
Clinical trialCTTN
Miscellaneous
canSAR (ICR)CTTN (select the gene name)
Probes
Litterature
PubMed251 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCTTN
EVEXCTTN
GoPubMedCTTN
iHOPCTTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:30:06 CEST 2017

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