Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CUBN (cubilin)

Identity

Other aliasIFCR
MGA1
gp280
HGNC (Hugo) CUBN
LocusID (NCBI) 8029
Atlas_Id 56699
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 16823966 and ends at 17129817 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP5L (11q23.3) / CUBN (10p13)FLNA (Xq28) / CUBN (10p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CUBN   2548
LRG (Locus Reference Genomic)LRG_540
Cards
Entrez_Gene (NCBI)CUBN  8029  cubilin
AliasesIFCR; MGA1; gp280
GeneCards (Weizmann)CUBN
Ensembl hg19 (Hinxton)ENSG00000107611 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107611 [Gene_View]  ENSG00000107611 [Sequence]  chr10:16823966-17129817 [Contig_View]  CUBN [Vega]
ICGC DataPortalENSG00000107611
TCGA cBioPortalCUBN
AceView (NCBI)CUBN
Genatlas (Paris)CUBN
WikiGenes8029
SOURCE (Princeton)CUBN
Genetics Home Reference (NIH)CUBN
Genomic and cartography
GoldenPath hg38 (UCSC)CUBN  -     chr10:16823966-17129817 -  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUBN  -     10p13   [Description]    (hg19-Feb_2009)
EnsemblCUBN - 10p13 [CytoView hg19]  CUBN - 10p13 [CytoView hg38]
Mapping of homologs : NCBICUBN [Mapview hg19]  CUBN [Mapview hg38]
OMIM261100   602997   
Gene and transcription
Genbank (Entrez)AB209880 AF034611 AF086456 AK074536 AK075228
RefSeq transcript (Entrez)NM_001081
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUBN
Cluster EST : UnigeneHs.166206 [ NCBI ]
CGAP (NCI)Hs.166206
Alternative Splicing GalleryENSG00000107611
Gene ExpressionCUBN [ NCBI-GEO ]   CUBN [ EBI - ARRAY_EXPRESS ]   CUBN [ SEEK ]   CUBN [ MEM ]
Gene Expression Viewer (FireBrowse)CUBN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8029
GTEX Portal (Tissue expression)CUBN
Human Protein AtlasENSG00000107611-CUBN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60494   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60494  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60494
Splice isoforms : SwissVarO60494
PhosPhoSitePlusO60494
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CUB (PS01180)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)   
Domains : Interpro (EBI)CUB_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    EGF_dom    Growth_fac_rcpt_cys_sf    Sperma_CUB_dom_sf   
Domain families : Pfam (Sanger)CUB (PF00431)    EGF (PF00008)    EGF_3 (PF12947)    EGF_CA (PF07645)   
Domain families : Pfam (NCBI)pfam00431    pfam00008    pfam12947    pfam07645   
Domain families : Smart (EMBL)CUB (SM00042)  EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)CUBN
DMDM Disease mutations8029
Blocks (Seattle)CUBN
PDB (SRS)3KQ4   
PDB (PDBSum)3KQ4   
PDB (IMB)3KQ4   
PDB (RSDB)3KQ4   
Structural Biology KnowledgeBase3KQ4   
SCOP (Structural Classification of Proteins)3KQ4   
CATH (Classification of proteins structures)3KQ4   
SuperfamilyO60494
Human Protein Atlas [tissue]ENSG00000107611-CUBN [tissue]
Peptide AtlasO60494
IPIIPI00160130   IPI01012405   IPI00643901   IPI00641203   IPI00641832   
Protein Interaction databases
DIP (DOE-UCLA)O60494
IntAct (EBI)O60494
FunCoupENSG00000107611
BioGRIDCUBN
STRING (EMBL)CUBN
ZODIACCUBN
Ontologies - Pathways
QuickGOO60494
Ontology : AmiGOin utero embryonic development  tissue homeostasis  thigmotaxis  transporter activity  calcium ion binding  protein binding  lysosomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi-associated vesicle  cytosol  plasma membrane  clathrin-coated pit  receptor-mediated endocytosis  hyperosmotic response  response to nutrient  drug binding  drug binding  cholesterol metabolic process  ionotropic glutamate receptor complex  adult locomotory behavior  cobalamin metabolic process  response to bacterium  endosome membrane  cobalamin transport  membrane  channel regulator activity  apical plasma membrane  apical plasma membrane  apical plasma membrane  endocytic hemoglobin import  coated vesicle  endocytic vesicle  endocytic vesicle  hemoglobin binding  endocytic vesicle membrane  extrinsic component of external side of plasma membrane  cobalamin binding  brush border membrane  brush border membrane  brush border membrane  neuron projection membrane  high-density lipoprotein particle clearance  signaling receptor activity  cargo receptor activity  regulation of locomotion  vitamin D metabolic process  cobalamin catabolic process  protein homodimerization activity  protein homodimerization activity  lipoprotein transport  lysosomal lumen  lysosomal lumen  synapse  lateral inhibition  positive regulation of synaptic transmission, glutamatergic  extracellular exosome  extracellular exosome  extracellular exosome  protein homotrimerization  
Ontology : EGO-EBIin utero embryonic development  tissue homeostasis  thigmotaxis  transporter activity  calcium ion binding  protein binding  lysosomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi-associated vesicle  cytosol  plasma membrane  clathrin-coated pit  receptor-mediated endocytosis  hyperosmotic response  response to nutrient  drug binding  drug binding  cholesterol metabolic process  ionotropic glutamate receptor complex  adult locomotory behavior  cobalamin metabolic process  response to bacterium  endosome membrane  cobalamin transport  membrane  channel regulator activity  apical plasma membrane  apical plasma membrane  apical plasma membrane  endocytic hemoglobin import  coated vesicle  endocytic vesicle  endocytic vesicle  hemoglobin binding  endocytic vesicle membrane  extrinsic component of external side of plasma membrane  cobalamin binding  brush border membrane  brush border membrane  brush border membrane  neuron projection membrane  high-density lipoprotein particle clearance  signaling receptor activity  cargo receptor activity  regulation of locomotion  vitamin D metabolic process  cobalamin catabolic process  protein homodimerization activity  protein homodimerization activity  lipoprotein transport  lysosomal lumen  lysosomal lumen  synapse  lateral inhibition  positive regulation of synaptic transmission, glutamatergic  extracellular exosome  extracellular exosome  extracellular exosome  protein homotrimerization  
Pathways : KEGGVitamin digestion and absorption   
NDEx NetworkCUBN
Atlas of Cancer Signalling NetworkCUBN
Wikipedia pathwaysCUBN
Orthology - Evolution
OrthoDB8029
GeneTree (enSembl)ENSG00000107611
Phylogenetic Trees/Animal Genes : TreeFamCUBN
HOVERGENO60494
HOGENOMO60494
Homologs : HomoloGeneCUBN
Homology/Alignments : Family Browser (UCSC)CUBN
Gene fusions - Rearrangements
Fusion : QuiverCUBN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUBN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUBN
dbVarCUBN
ClinVarCUBN
1000_GenomesCUBN 
Exome Variant ServerCUBN
ExAC (Exome Aggregation Consortium)ENSG00000107611
GNOMAD BrowserENSG00000107611
Varsome BrowserCUBN
Genetic variants : HAPMAP8029
Genomic Variants (DGV)CUBN [DGVbeta]
DECIPHERCUBN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUBN 
Mutations
ICGC Data PortalCUBN 
TCGA Data PortalCUBN 
Broad Tumor PortalCUBN
OASIS PortalCUBN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUBN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUBN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUBN
DgiDB (Drug Gene Interaction Database)CUBN
DoCM (Curated mutations)CUBN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUBN (select a term)
intoGenCUBN
Cancer3DCUBN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM261100    602997   
Orphanet
DisGeNETCUBN
MedgenCUBN
Genetic Testing Registry CUBN
NextProtO60494 [Medical]
TSGene8029
GENETestsCUBN
Target ValidationCUBN
Huge Navigator CUBN [HugePedia]
snp3D : Map Gene to Disease8029
BioCentury BCIQCUBN
ClinGenCUBN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8029
Chemical/Pharm GKB GenePA27044
Clinical trialCUBN
Miscellaneous
canSAR (ICR)CUBN (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUBN
EVEXCUBN
GoPubMedCUBN
iHOPCUBN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:00:56 CET 2018

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