Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CUL1 (cullin 1)

Identity

Other alias-
HGNC (Hugo) CUL1
LocusID (NCBI) 8454
Atlas_Id 40211
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 148698841 and ends at 148801110 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP85L (6q22.31) / CUL1 (7q36.1)CUL1 (7q36.1) / BRAF (7q34)CUL1 (7q36.1) / CUL1 (7q36.1)
CUL1 (7q36.1) / DPP6 (7q36.2)CUL1 (7q36.1) / GIMAP5 (7q36.1)CUL1 (7q36.1) / LYZ (12q15)
CUL1 (7q36.1) / MUT (6p12.3)TMEM57 (1p36.11) / CUL1 (7q36.1)ZNF282 (7q36.1) / CUL1 (7q36.1)
CUL1 7q36.1 / GIMAP5 7q36.1CUL1 7q36.1 / MUT 6p12.3ZNF282 7q36.1 / CUL1 7q36.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;7)(q36;q36) CUL1/DPP6

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(6;7)(p12;q36) CUL1/MUT
t(7;7)(q36;q36) CUL1/GIMAP5
t(7;7)(q36;q36) ZNF282/CUL1

External links

Nomenclature
HGNC (Hugo)CUL1   2551
Cards
Entrez_Gene (NCBI)CUL1  8454  cullin 1
Aliases
GeneCards (Weizmann)CUL1
Ensembl hg19 (Hinxton)ENSG00000055130 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000055130 [Gene_View]  chr7:148698841-148801110 [Contig_View]  CUL1 [Vega]
ICGC DataPortalENSG00000055130
TCGA cBioPortalCUL1
AceView (NCBI)CUL1
Genatlas (Paris)CUL1
WikiGenes8454
SOURCE (Princeton)CUL1
Genetics Home Reference (NIH)CUL1
Genomic and cartography
GoldenPath hg38 (UCSC)CUL1  -     chr7:148698841-148801110 +  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL1  -     7q36.1   [Description]    (hg19-Feb_2009)
EnsemblCUL1 - 7q36.1 [CytoView hg19]  CUL1 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBICUL1 [Mapview hg19]  CUL1 [Mapview hg38]
OMIM603134   
Gene and transcription
Genbank (Entrez)AF062536 AK096163 AK096505 AK296909 AK315023
RefSeq transcript (Entrez)NM_003592
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUL1
Cluster EST : UnigeneHs.146806 [ NCBI ]
CGAP (NCI)Hs.146806
Alternative Splicing GalleryENSG00000055130
Gene ExpressionCUL1 [ NCBI-GEO ]   CUL1 [ EBI - ARRAY_EXPRESS ]   CUL1 [ SEEK ]   CUL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CUL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8454
GTEX Portal (Tissue expression)CUL1
Human Protein AtlasENSG00000055130-CUL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13616
Splice isoforms : SwissVarQ13616
PhosPhoSitePlusQ13616
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL1
DMDM Disease mutations8454
Blocks (Seattle)CUL1
PDB (SRS)1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
PDB (PDBSum)1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
PDB (IMB)1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
PDB (RSDB)1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
Structural Biology KnowledgeBase1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
SCOP (Structural Classification of Proteins)1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
CATH (Classification of proteins structures)1LDJ    1LDK    1U6G    3RTR    3TDU    3TDZ    4F52    4P5O   
SuperfamilyQ13616
Human Protein Atlas [tissue]ENSG00000055130-CUL1 [tissue]
Peptide AtlasQ13616
HPRD04389
IPIIPI00014310   IPI01010643   IPI00917192   
Protein Interaction databases
DIP (DOE-UCLA)Q13616
IntAct (EBI)Q13616
FunCoupENSG00000055130
BioGRIDCUL1
STRING (EMBL)CUL1
ZODIACCUL1
Ontologies - Pathways
QuickGOQ13616
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleoplasm  cytosol  protein monoubiquitination  cellular iron ion homeostasis  cell cycle arrest  cell proliferation  negative regulation of cell proliferation  animal organ morphogenesis  SCF complex assembly  negative regulation of G2/M transition of mitotic cell cycle  viral process  Wnt signaling pathway  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cullin-RING ubiquitin ligase complex  ubiquitin protein ligase binding  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  T cell receptor signaling pathway  stress-activated MAPK cascade  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  ubiquitin protein ligase activity  interleukin-1-mediated signaling pathway  intrinsic apoptotic signaling pathway  Parkin-FBXW7-Cul1 ubiquitin ligase complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleoplasm  cytosol  protein monoubiquitination  cellular iron ion homeostasis  cell cycle arrest  cell proliferation  negative regulation of cell proliferation  animal organ morphogenesis  SCF complex assembly  negative regulation of G2/M transition of mitotic cell cycle  viral process  Wnt signaling pathway  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cullin-RING ubiquitin ligase complex  ubiquitin protein ligase binding  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  T cell receptor signaling pathway  stress-activated MAPK cascade  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  ubiquitin protein ligase activity  interleukin-1-mediated signaling pathway  intrinsic apoptotic signaling pathway  Parkin-FBXW7-Cul1 ubiquitin ligase complex  
Pathways : BIOCARTAE2F1 Destruction Pathway [Genes]    Cyclin E Destruction Pathway [Genes]    ER¿associated degradation (ERAD) Pathway [Genes]    Regulation of p27 Phosphorylation during Cell Cycle Progression [Genes]   
Pathways : KEGGTGF-beta signaling pathway    Ubiquitin mediated proteolysis    Cell cycle    Wnt signaling pathway   
NDEx NetworkCUL1
Atlas of Cancer Signalling NetworkCUL1
Wikipedia pathwaysCUL1
Orthology - Evolution
OrthoDB8454
GeneTree (enSembl)ENSG00000055130
Phylogenetic Trees/Animal Genes : TreeFamCUL1
HOVERGENQ13616
HOGENOMQ13616
Homologs : HomoloGeneCUL1
Homology/Alignments : Family Browser (UCSC)CUL1
Gene fusions - Rearrangements
Fusion : MitelmanCUL1/DPP6 [7q36.1/7q36.2]  
Fusion : MitelmanCUL1/GIMAP5 [7q36.1/7q36.1]  [t(7;7)(q36;q36)]  
Fusion : MitelmanCUL1/MUT [7q36.1/6p12.3]  [t(6;7)(p12;q36)]  
Fusion : MitelmanZNF282/CUL1 [7q36.1/7q36.1]  [t(7;7)(q36;q36)]  
Fusion: TCGA_MDACCCUL1 7q36.1 GIMAP5 7q36.1 BRCA
Fusion: TCGA_MDACCCUL1 7q36.1 MUT 6p12.3 OV
Fusion: TCGA_MDACCZNF282 7q36.1 CUL1 7q36.1 BRCA
Fusion PortalCUL1 7q36.1 GIMAP5 7q36.1 BRCA
Fusion PortalCUL1 7q36.1 MUT 6p12.3 OV
Fusion PortalZNF282 7q36.1 CUL1 7q36.1 BRCA
Fusion : QuiverCUL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL1
dbVarCUL1
ClinVarCUL1
1000_GenomesCUL1 
Exome Variant ServerCUL1
ExAC (Exome Aggregation Consortium)ENSG00000055130
GNOMAD BrowserENSG00000055130
Genetic variants : HAPMAP8454
Genomic Variants (DGV)CUL1 [DGVbeta]
DECIPHERCUL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL1 
Mutations
ICGC Data PortalCUL1 
TCGA Data PortalCUL1 
Broad Tumor PortalCUL1
OASIS PortalCUL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUL1
intOGen PortalCUL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL1
DgiDB (Drug Gene Interaction Database)CUL1
DoCM (Curated mutations)CUL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL1 (select a term)
intoGenCUL1
Cancer3DCUL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603134   
Orphanet
DisGeNETCUL1
MedgenCUL1
Genetic Testing Registry CUL1
NextProtQ13616 [Medical]
TSGene8454
GENETestsCUL1
Target ValidationCUL1
Huge Navigator CUL1 [HugePedia]
snp3D : Map Gene to Disease8454
BioCentury BCIQCUL1
ClinGenCUL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8454
Chemical/Pharm GKB GenePA27047
Clinical trialCUL1
Miscellaneous
canSAR (ICR)CUL1 (select the gene name)
Probes
Litterature
PubMed397 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL1
EVEXCUL1
GoPubMedCUL1
iHOPCUL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:08:25 CET 2018
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