Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CUL2 (cullin 2)

Identity

Other alias-
HGNC (Hugo) CUL2
LocusID (NCBI) 8453
Atlas_Id 40212
Location 10p11.21  [Link to chromosome band 10p11]
Location_base_pair Starts at 35008551 and ends at 35090642 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCNY (10p11.21) / CUL2 (10p11.21)NRP1 (10p11.22) / CUL2 (10p11.21)PARD3 (10p11.22) / CUL2 (10p11.21)
SNHG3 (1p35.3) / CUL2 (10p11.21)NRP1 10p11.22 / CUL2 10p11.21PARD3 10p11.22 / CUL2 10p11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Ear: Endolymphatic Sac Tumor (ELST)


External links

Nomenclature
HGNC (Hugo)CUL2   2552
Cards
Entrez_Gene (NCBI)CUL2  8453  cullin 2
Aliases
GeneCards (Weizmann)CUL2
Ensembl hg19 (Hinxton)ENSG00000108094 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108094 [Gene_View]  chr10:35008551-35090642 [Contig_View]  CUL2 [Vega]
ICGC DataPortalENSG00000108094
TCGA cBioPortalCUL2
AceView (NCBI)CUL2
Genatlas (Paris)CUL2
WikiGenes8453
SOURCE (Princeton)CUL2
Genetics Home Reference (NIH)CUL2
Genomic and cartography
GoldenPath hg38 (UCSC)CUL2  -     chr10:35008551-35090642 -  10p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL2  -     10p11.21   [Description]    (hg19-Feb_2009)
EnsemblCUL2 - 10p11.21 [CytoView hg19]  CUL2 - 10p11.21 [CytoView hg38]
Mapping of homologs : NCBICUL2 [Mapview hg19]  CUL2 [Mapview hg38]
OMIM603135   
Gene and transcription
Genbank (Entrez)AF126404 AI089201 AK095217 AK294080 AK300491
RefSeq transcript (Entrez)NM_001198777 NM_001198778 NM_001198779 NM_001324375 NM_001324376 NM_003591
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUL2
Cluster EST : UnigeneHs.82919 [ NCBI ]
CGAP (NCI)Hs.82919
Alternative Splicing GalleryENSG00000108094
Gene ExpressionCUL2 [ NCBI-GEO ]   CUL2 [ EBI - ARRAY_EXPRESS ]   CUL2 [ SEEK ]   CUL2 [ MEM ]
Gene Expression Viewer (FireBrowse)CUL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8453
GTEX Portal (Tissue expression)CUL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13617   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13617  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13617
Splice isoforms : SwissVarQ13617
PhosPhoSitePlusQ13617
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL2
DMDM Disease mutations8453
Blocks (Seattle)CUL2
PDB (SRS)4WQO   
PDB (PDBSum)4WQO   
PDB (IMB)4WQO   
PDB (RSDB)4WQO   
Structural Biology KnowledgeBase4WQO   
SCOP (Structural Classification of Proteins)4WQO   
CATH (Classification of proteins structures)4WQO   
SuperfamilyQ13617
Human Protein AtlasENSG00000108094
Peptide AtlasQ13617
HPRD06786
IPIIPI00014311   IPI00985090   IPI00982109   IPI00643617   IPI00642151   IPI00647073   
Protein Interaction databases
DIP (DOE-UCLA)Q13617
IntAct (EBI)Q13617
FunCoupENSG00000108094
BioGRIDCUL2
STRING (EMBL)CUL2
ZODIACCUL2
Ontologies - Pathways
QuickGOQ13617
Ontology : AmiGOG1/S transition of mitotic cell cycle  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytosol  cell cycle arrest  negative regulation of cell proliferation  viral process  VCB complex  Cul2-RING ubiquitin ligase complex  ubiquitin protein ligase binding  protein complex binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  ubiquitin protein ligase activity  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  protein binding  nucleoplasm  nucleoplasm  nucleolus  cytosol  cell cycle arrest  negative regulation of cell proliferation  viral process  VCB complex  Cul2-RING ubiquitin ligase complex  ubiquitin protein ligase binding  protein complex binding  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  ubiquitin protein ligase activity  intrinsic apoptotic signaling pathway  
Pathways : KEGGHIF-1 signaling pathway    Ubiquitin mediated proteolysis    Pathways in cancer    Renal cell carcinoma   
NDEx NetworkCUL2
Atlas of Cancer Signalling NetworkCUL2
Wikipedia pathwaysCUL2
Orthology - Evolution
OrthoDB8453
GeneTree (enSembl)ENSG00000108094
Phylogenetic Trees/Animal Genes : TreeFamCUL2
HOVERGENQ13617
HOGENOMQ13617
Homologs : HomoloGeneCUL2
Homology/Alignments : Family Browser (UCSC)CUL2
Gene fusions - Rearrangements
Fusion : MitelmanNRP1/CUL2 [10p11.22/10p11.21]  [t(10;10)(p11;p11)]  
Fusion : MitelmanPARD3/CUL2 [10p11.22/10p11.21]  [t(10;10)(p11;p11)]  
Fusion: TCGANRP1 10p11.22 CUL2 10p11.21 LGG
Fusion: TCGAPARD3 10p11.22 CUL2 10p11.21 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL2
dbVarCUL2
ClinVarCUL2
1000_GenomesCUL2 
Exome Variant ServerCUL2
ExAC (Exome Aggregation Consortium)CUL2 (select the gene name)
Genetic variants : HAPMAP8453
Genomic Variants (DGV)CUL2 [DGVbeta]
DECIPHERCUL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL2 
Mutations
ICGC Data PortalCUL2 
TCGA Data PortalCUL2 
Broad Tumor PortalCUL2
OASIS PortalCUL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUL2
intOGen PortalCUL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL2
DgiDB (Drug Gene Interaction Database)CUL2
DoCM (Curated mutations)CUL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL2 (select a term)
intoGenCUL2
Cancer3DCUL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603135   
Orphanet
MedgenCUL2
Genetic Testing Registry CUL2
NextProtQ13617 [Medical]
TSGene8453
GENETestsCUL2
Target ValidationCUL2
Huge Navigator CUL2 [HugePedia]
snp3D : Map Gene to Disease8453
BioCentury BCIQCUL2
ClinGenCUL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8453
Chemical/Pharm GKB GenePA27048
Clinical trialCUL2
Miscellaneous
canSAR (ICR)CUL2 (select the gene name)
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL2
EVEXCUL2
GoPubMedCUL2
iHOPCUL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:07 CEST 2017

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