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CUL3 (cullin 3)

Identity

Alias (NCBI)CUL-3
NEDAUS
PHA2E
HGNC (Hugo) CUL3
LocusID (NCBI) 8452
Atlas_Id 40213
Location 2q36.2  [Link to chromosome band 2q36]
Location_base_pair Starts at 224470150 and ends at 224585363 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CUL3 (2q36.2)::CUL3 (2q36.2)CUL3 (2q36.2)::IRS1 (2q36.3)CUL3 (2q36.2)::PRRC1 (5q23.2)
JUP (17q21.2)::CUL3 (2q36.2)SCMH1 (1p34.2)::CUL3 (2q36.2)CUL3 2q36.2::IRS1 2q36.3
SCMH1 1p34.2::CUL3 2q36.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CUL3   2553
Cards
Entrez_Gene (NCBI)CUL3    cullin 3
AliasesCUL-3; NEDAUS; PHA2E
GeneCards (Weizmann)CUL3
Ensembl hg19 (Hinxton)ENSG00000036257 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000036257 [Gene_View]  ENSG00000036257 [Sequence]  chr2:224470150-224585363 [Contig_View]  CUL3 [Vega]
ICGC DataPortalENSG00000036257
TCGA cBioPortalCUL3
AceView (NCBI)CUL3
Genatlas (Paris)CUL3
SOURCE (Princeton)CUL3
Genetics Home Reference (NIH)CUL3
Genomic and cartography
GoldenPath hg38 (UCSC)CUL3  -     chr2:224470150-224585363 -  2q36.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL3  -     2q36.2   [Description]    (hg19-Feb_2009)
GoldenPathCUL3 - 2q36.2 [CytoView hg19]  CUL3 - 2q36.2 [CytoView hg38]
ImmunoBaseENSG00000036257
Genome Data Viewer NCBICUL3 [Mapview hg19]  
OMIM603136   614496   619239   
Gene and transcription
Genbank (Entrez)AB014517 AF052147 AF062537 AF064087 AK098531
RefSeq transcript (Entrez)NM_001257197 NM_001257198 NM_003590
Consensus coding sequences : CCDS (NCBI)CUL3
Gene ExpressionCUL3 [ NCBI-GEO ]   CUL3 [ EBI - ARRAY_EXPRESS ]   CUL3 [ SEEK ]   CUL3 [ MEM ]
Gene Expression Viewer (FireBrowse)CUL3 [ Firebrowse - Broad ]
GenevisibleExpression of CUL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8452
GTEX Portal (Tissue expression)CUL3
Human Protein AtlasENSG00000036257-CUL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13618   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13618  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13618
PhosPhoSitePlusQ13618
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_homology_sf    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom_sf    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL3
PDB (RSDB)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
PDB Europe2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
PDB (PDBSum)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
PDB (IMB)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
Structural Biology KnowledgeBase2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
SCOP (Structural Classification of Proteins)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
CATH (Classification of proteins structures)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI    5NLB    6I2M   
SuperfamilyQ13618
AlphaFold pdb e-kbQ13618   
Human Protein Atlas [tissue]ENSG00000036257-CUL3 [tissue]
HPRD09123
Protein Interaction databases
DIP (DOE-UCLA)Q13618
IntAct (EBI)Q13618
BioGRIDCUL3
STRING (EMBL)CUL3
ZODIACCUL3
Ontologies - Pathways
QuickGOQ13618
Ontology : AmiGOG1/S transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  protein polyubiquitination  spindle pole  trophectodermal cellular morphogenesis  ubiquitin-protein transferase activity  Notch binding  protein binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  centrosome  polar microtubule  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  endoplasmic reticulum to Golgi vesicle-mediated transport  mitotic metaphase plate congression  integrin-mediated signaling pathway  gastrulation  positive regulation of cell population proliferation  membrane  Wnt signaling pathway  cell migration  protein ubiquitination  protein ubiquitination  stem cell division  cell projection organization  cyclin binding  anaphase-promoting complex-dependent catabolic process  POZ domain binding  positive regulation of protein ubiquitination  cullin-RING ubiquitin ligase complex  Cul3-RING ubiquitin ligase complex  Cul3-RING ubiquitin ligase complex  ubiquitin protein ligase binding  ubiquitin protein ligase binding  protein destabilization  positive regulation of cytokinesis  negative regulation of Rho protein signal transduction  sperm flagellum  embryonic cleavage  identical protein binding  stress fiber assembly  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  fibroblast apoptotic process  positive regulation of mitotic metaphase/anaphase transition  COPII vesicle coating  protein autoubiquitination  ubiquitin protein ligase activity  extracellular exosome  protein K48-linked ubiquitination  nuclear protein quality control by the ubiquitin-proteasome system  liver morphogenesis  mitotic spindle  intrinsic apoptotic signaling pathway  positive regulation of mitotic cell cycle phase transition  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  protein polyubiquitination  spindle pole  trophectodermal cellular morphogenesis  ubiquitin-protein transferase activity  Notch binding  protein binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  centrosome  polar microtubule  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein monoubiquitination  endoplasmic reticulum to Golgi vesicle-mediated transport  mitotic metaphase plate congression  integrin-mediated signaling pathway  gastrulation  positive regulation of cell population proliferation  membrane  Wnt signaling pathway  cell migration  protein ubiquitination  protein ubiquitination  stem cell division  cell projection organization  cyclin binding  anaphase-promoting complex-dependent catabolic process  POZ domain binding  positive regulation of protein ubiquitination  cullin-RING ubiquitin ligase complex  Cul3-RING ubiquitin ligase complex  Cul3-RING ubiquitin ligase complex  ubiquitin protein ligase binding  ubiquitin protein ligase binding  protein destabilization  positive regulation of cytokinesis  negative regulation of Rho protein signal transduction  sperm flagellum  embryonic cleavage  identical protein binding  stress fiber assembly  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  fibroblast apoptotic process  positive regulation of mitotic metaphase/anaphase transition  COPII vesicle coating  protein autoubiquitination  ubiquitin protein ligase activity  extracellular exosome  protein K48-linked ubiquitination  nuclear protein quality control by the ubiquitin-proteasome system  liver morphogenesis  mitotic spindle  intrinsic apoptotic signaling pathway  positive regulation of mitotic cell cycle phase transition  
Pathways : KEGGKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS   
NDEx NetworkCUL3
Atlas of Cancer Signalling NetworkCUL3
Wikipedia pathwaysCUL3
Orthology - Evolution
OrthoDB8452
GeneTree (enSembl)ENSG00000036257
Phylogenetic Trees/Animal Genes : TreeFamCUL3
Homologs : HomoloGeneCUL3
Homology/Alignments : Family Browser (UCSC)CUL3
Gene fusions - Rearrangements
Fusion : MitelmanCUL3::IRS1 [2q36.2/2q36.3]  
Fusion : MitelmanSCMH1::CUL3 [1p34.2/2q36.2]  
Fusion : QuiverCUL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL3
dbVarCUL3
ClinVarCUL3
MonarchCUL3
1000_GenomesCUL3 
Exome Variant ServerCUL3
GNOMAD BrowserENSG00000036257
Varsome BrowserCUL3
ACMGCUL3 variants
VarityQ13618
Genomic Variants (DGV)CUL3 [DGVbeta]
DECIPHERCUL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL3 
Mutations
ICGC Data PortalCUL3 
TCGA Data PortalCUL3 
Broad Tumor PortalCUL3
OASIS PortalCUL3 [ Somatic mutations - Copy number]
Cancer Gene: CensusCUL3 
Somatic Mutations in Cancer : COSMICCUL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCUL3
Mutations and Diseases : HGMDCUL3
intOGen PortalCUL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCUL3
DgiDB (Drug Gene Interaction Database)CUL3
DoCM (Curated mutations)CUL3
CIViC (Clinical Interpretations of Variants in Cancer)CUL3
Cancer3DCUL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603136    614496    619239   
Orphanet21126   
DisGeNETCUL3
MedgenCUL3
Genetic Testing Registry CUL3
NextProtQ13618 [Medical]
GENETestsCUL3
Target ValidationCUL3
Huge Navigator CUL3 [HugePedia]
ClinGenCUL3
Clinical trials, drugs, therapy
MyCancerGenomeCUL3
Protein Interactions : CTDCUL3
Pharm GKB GenePA27049
PharosQ13618
Clinical trialCUL3
Miscellaneous
canSAR (ICR)CUL3
HarmonizomeCUL3
ARCHS4CUL3
DataMed IndexCUL3
Probes
Litterature
PubMed363 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCUL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:29:31 CET 2022

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