Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CUL3 (cullin 3)

Identity

Other aliasCUL-3
PHA2E
HGNC (Hugo) CUL3
LocusID (NCBI) 8452
Atlas_Id 40213
Location 2q36.2  [Link to chromosome band 2q36]
Location_base_pair Starts at 224470150 and ends at 224585397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CUL3 (2q36.2) / CUL3 (2q36.2)CUL3 (2q36.2) / IRS1 (2q36.3)CUL3 (2q36.2) / PRRC1 (5q23.2)
JUP (17q21.2) / CUL3 (2q36.2)SCMH1 (1p34.2) / CUL3 (2q36.2)CUL3 2q36.2 / IRS1 2q36.3
SCMH1 1p34.2 / CUL3 2q36.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Nervous system: Astrocytoma with t(1;17)(p36;q21) SPOP/PRDM16


External links

Nomenclature
HGNC (Hugo)CUL3   2553
Cards
Entrez_Gene (NCBI)CUL3  8452  cullin 3
AliasesCUL-3; PHA2E
GeneCards (Weizmann)CUL3
Ensembl hg19 (Hinxton)ENSG00000036257 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000036257 [Gene_View]  chr2:224470150-224585397 [Contig_View]  CUL3 [Vega]
ICGC DataPortalENSG00000036257
TCGA cBioPortalCUL3
AceView (NCBI)CUL3
Genatlas (Paris)CUL3
WikiGenes8452
SOURCE (Princeton)CUL3
Genetics Home Reference (NIH)CUL3
Genomic and cartography
GoldenPath hg38 (UCSC)CUL3  -     chr2:224470150-224585397 -  2q36.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL3  -     2q36.2   [Description]    (hg19-Feb_2009)
EnsemblCUL3 - 2q36.2 [CytoView hg19]  CUL3 - 2q36.2 [CytoView hg38]
Mapping of homologs : NCBICUL3 [Mapview hg19]  CUL3 [Mapview hg38]
OMIM603136   614496   
Gene and transcription
Genbank (Entrez)AB014517 AF052147 AF062537 AF064087 AK098531
RefSeq transcript (Entrez)NM_001257197 NM_001257198 NM_003590
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUL3
Cluster EST : UnigeneHs.372286 [ NCBI ]
CGAP (NCI)Hs.372286
Alternative Splicing GalleryENSG00000036257
Gene ExpressionCUL3 [ NCBI-GEO ]   CUL3 [ EBI - ARRAY_EXPRESS ]   CUL3 [ SEEK ]   CUL3 [ MEM ]
Gene Expression Viewer (FireBrowse)CUL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8452
GTEX Portal (Tissue expression)CUL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13618   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13618  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13618
Splice isoforms : SwissVarQ13618
PhosPhoSitePlusQ13618
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL3
DMDM Disease mutations8452
Blocks (Seattle)CUL3
PDB (SRS)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
PDB (PDBSum)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
PDB (IMB)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
PDB (RSDB)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
Structural Biology KnowledgeBase2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
SCOP (Structural Classification of Proteins)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
CATH (Classification of proteins structures)2MYL    2MYM    4AP2    4APF    4EOZ    4HXI   
SuperfamilyQ13618
Human Protein AtlasENSG00000036257
Peptide AtlasQ13618
HPRD09123
IPIIPI00014312   IPI00382458   IPI00382459   IPI00917651   IPI00917370   IPI00916926   
Protein Interaction databases
DIP (DOE-UCLA)Q13618
IntAct (EBI)Q13618
FunCoupENSG00000036257
BioGRIDCUL3
STRING (EMBL)CUL3
ZODIACCUL3
Ontologies - Pathways
QuickGOQ13618
Ontology : AmiGOG1/S transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  Golgi membrane  MAPK cascade  protein polyubiquitination  trophectodermal cellular morphogenesis  ubiquitin-protein transferase activity  Notch binding  protein binding  nucleoplasm  polar microtubule  cytosol  ubiquitin-dependent protein catabolic process  protein monoubiquitination  ER to Golgi vesicle-mediated transport  cell cycle arrest  mitotic metaphase plate congression  integrin-mediated signaling pathway  gastrulation  positive regulation of cell proliferation  membrane  Wnt signaling pathway  cell migration  protein ubiquitination  stem cell division  cell projection organization  cyclin binding  anaphase-promoting complex-dependent catabolic process  POZ domain binding  Cul3-RING ubiquitin ligase complex  ubiquitin protein ligase binding  positive regulation of cytokinesis  negative regulation of Rho protein signal transduction  embryonic cleavage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein homodimerization activity  stress fiber assembly  proteasome-mediated ubiquitin-dependent protein catabolic process  fibroblast apoptotic process  positive regulation of mitotic metaphase/anaphase transition  protein heterodimerization activity  COPII vesicle coating  ubiquitin protein ligase activity  extracellular exosome  ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome  liver morphogenesis  negative regulation of canonical Wnt signaling pathway  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  Golgi membrane  MAPK cascade  protein polyubiquitination  trophectodermal cellular morphogenesis  ubiquitin-protein transferase activity  Notch binding  protein binding  nucleoplasm  polar microtubule  cytosol  ubiquitin-dependent protein catabolic process  protein monoubiquitination  ER to Golgi vesicle-mediated transport  cell cycle arrest  mitotic metaphase plate congression  integrin-mediated signaling pathway  gastrulation  positive regulation of cell proliferation  membrane  Wnt signaling pathway  cell migration  protein ubiquitination  stem cell division  cell projection organization  cyclin binding  anaphase-promoting complex-dependent catabolic process  POZ domain binding  Cul3-RING ubiquitin ligase complex  ubiquitin protein ligase binding  positive regulation of cytokinesis  negative regulation of Rho protein signal transduction  embryonic cleavage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein homodimerization activity  stress fiber assembly  proteasome-mediated ubiquitin-dependent protein catabolic process  fibroblast apoptotic process  positive regulation of mitotic metaphase/anaphase transition  protein heterodimerization activity  COPII vesicle coating  ubiquitin protein ligase activity  extracellular exosome  ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome  liver morphogenesis  negative regulation of canonical Wnt signaling pathway  intrinsic apoptotic signaling pathway  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkCUL3
Atlas of Cancer Signalling NetworkCUL3
Wikipedia pathwaysCUL3
Orthology - Evolution
OrthoDB8452
GeneTree (enSembl)ENSG00000036257
Phylogenetic Trees/Animal Genes : TreeFamCUL3
HOVERGENQ13618
HOGENOMQ13618
Homologs : HomoloGeneCUL3
Homology/Alignments : Family Browser (UCSC)CUL3
Gene fusions - Rearrangements
Fusion : MitelmanCUL3/IRS1 [2q36.2/2q36.3]  
Fusion : MitelmanSCMH1/CUL3 [1p34.2/2q36.2]  [t(1;2)(p34;q36)]  
Fusion: TCGACUL3 2q36.2 IRS1 2q36.3 BRCA
Fusion: TCGASCMH1 1p34.2 CUL3 2q36.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL3
dbVarCUL3
ClinVarCUL3
1000_GenomesCUL3 
Exome Variant ServerCUL3
ExAC (Exome Aggregation Consortium)CUL3 (select the gene name)
Genetic variants : HAPMAP8452
Genomic Variants (DGV)CUL3 [DGVbeta]
DECIPHERCUL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL3 
Mutations
ICGC Data PortalCUL3 
TCGA Data PortalCUL3 
Broad Tumor PortalCUL3
OASIS PortalCUL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUL3
intOGen PortalCUL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL3
DgiDB (Drug Gene Interaction Database)CUL3
DoCM (Curated mutations)CUL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL3 (select a term)
intoGenCUL3
Cancer3DCUL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603136    614496   
Orphanet21126   
MedgenCUL3
Genetic Testing Registry CUL3
NextProtQ13618 [Medical]
TSGene8452
GENETestsCUL3
Target ValidationCUL3
Huge Navigator CUL3 [HugePedia]
snp3D : Map Gene to Disease8452
BioCentury BCIQCUL3
ClinGenCUL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8452
Chemical/Pharm GKB GenePA27049
Clinical trialCUL3
Miscellaneous
canSAR (ICR)CUL3 (select the gene name)
Probes
Litterature
PubMed217 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL3
EVEXCUL3
GoPubMedCUL3
iHOPCUL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:07 CEST 2017

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