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CUL4A (cullin 4A)

Identity

Other alias-
HGNC (Hugo) CUL4A
LocusID (NCBI) 8451
Atlas_Id 40214
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113209505 and ends at 113265078 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CUL4A (13q34) / CUL4A (13q34)PCID2 (13q34) / CUL4A (13q34)TFDP1 (13q34) / CUL4A (13q34)
TFDP1 13q34 / CUL4A 13q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CUL4A   2554
Cards
Entrez_Gene (NCBI)CUL4A  8451  cullin 4A
Aliases
GeneCards (Weizmann)CUL4A
Ensembl hg19 (Hinxton)ENSG00000139842 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139842 [Gene_View]  chr13:113209505-113265078 [Contig_View]  CUL4A [Vega]
ICGC DataPortalENSG00000139842
TCGA cBioPortalCUL4A
AceView (NCBI)CUL4A
Genatlas (Paris)CUL4A
WikiGenes8451
SOURCE (Princeton)CUL4A
Genetics Home Reference (NIH)CUL4A
Genomic and cartography
GoldenPath hg38 (UCSC)CUL4A  -     chr13:113209505-113265078 +  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL4A  -     13q34   [Description]    (hg19-Feb_2009)
EnsemblCUL4A - 13q34 [CytoView hg19]  CUL4A - 13q34 [CytoView hg38]
Mapping of homologs : NCBICUL4A [Mapview hg19]  CUL4A [Mapview hg38]
OMIM603137   
Gene and transcription
Genbank (Entrez)AB012193 AB178950 AF077188 AK126278 AK296700
RefSeq transcript (Entrez)NM_001008895 NM_001278513 NM_001278514 NM_003589
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUL4A
Cluster EST : UnigeneHs.339735 [ NCBI ]
CGAP (NCI)Hs.339735
Alternative Splicing GalleryENSG00000139842
Gene ExpressionCUL4A [ NCBI-GEO ]   CUL4A [ EBI - ARRAY_EXPRESS ]   CUL4A [ SEEK ]   CUL4A [ MEM ]
Gene Expression Viewer (FireBrowse)CUL4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8451
GTEX Portal (Tissue expression)CUL4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13619   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13619  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13619
Splice isoforms : SwissVarQ13619
PhosPhoSitePlusQ13619
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL4A
DMDM Disease mutations8451
Blocks (Seattle)CUL4A
PDB (SRS)2HYE    4A0K   
PDB (PDBSum)2HYE    4A0K   
PDB (IMB)2HYE    4A0K   
PDB (RSDB)2HYE    4A0K   
Structural Biology KnowledgeBase2HYE    4A0K   
SCOP (Structural Classification of Proteins)2HYE    4A0K   
CATH (Classification of proteins structures)2HYE    4A0K   
SuperfamilyQ13619
Human Protein AtlasENSG00000139842
Peptide AtlasQ13619
HPRD07218
IPIIPI00419273   IPI00549919   
Protein Interaction databases
DIP (DOE-UCLA)Q13619
IntAct (EBI)Q13619
FunCoupENSG00000139842
BioGRIDCUL4A
STRING (EMBL)CUL4A
ZODIACCUL4A
Ontologies - Pathways
QuickGOQ13619
Ontology : AmiGOG1/S transition of mitotic cell cycle  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  in utero embryonic development  protein binding  nucleoplasm  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  cellular response to DNA damage stimulus  cell cycle arrest  positive regulation of cell proliferation  negative regulation of cell proliferation  viral process  hemopoiesis  negative regulation of granulocyte differentiation  Cul4A-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  nucleotide-excision repair, DNA incision  somatic stem cell population maintenance  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of protein metabolic process  ubiquitin protein ligase activity  global genome nucleotide-excision repair  Cul4-RING E3 ubiquitin ligase complex  intrinsic apoptotic signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  regulation of DNA damage checkpoint  regulation of nucleotide-excision repair  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  in utero embryonic development  protein binding  nucleoplasm  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  cellular response to DNA damage stimulus  cell cycle arrest  positive regulation of cell proliferation  negative regulation of cell proliferation  viral process  hemopoiesis  negative regulation of granulocyte differentiation  Cul4A-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  nucleotide-excision repair, DNA incision  somatic stem cell population maintenance  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of protein metabolic process  ubiquitin protein ligase activity  global genome nucleotide-excision repair  Cul4-RING E3 ubiquitin ligase complex  intrinsic apoptotic signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  regulation of DNA damage checkpoint  regulation of nucleotide-excision repair  
Pathways : KEGGNucleotide excision repair    Ubiquitin mediated proteolysis   
NDEx NetworkCUL4A
Atlas of Cancer Signalling NetworkCUL4A
Wikipedia pathwaysCUL4A
Orthology - Evolution
OrthoDB8451
GeneTree (enSembl)ENSG00000139842
Phylogenetic Trees/Animal Genes : TreeFamCUL4A
HOVERGENQ13619
HOGENOMQ13619
Homologs : HomoloGeneCUL4A
Homology/Alignments : Family Browser (UCSC)CUL4A
Gene fusions - Rearrangements
Fusion: TCGATFDP1 13q34 CUL4A 13q34 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL4A
dbVarCUL4A
ClinVarCUL4A
1000_GenomesCUL4A 
Exome Variant ServerCUL4A
ExAC (Exome Aggregation Consortium)CUL4A (select the gene name)
Genetic variants : HAPMAP8451
Genomic Variants (DGV)CUL4A [DGVbeta]
DECIPHERCUL4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL4A 
Mutations
ICGC Data PortalCUL4A 
TCGA Data PortalCUL4A 
Broad Tumor PortalCUL4A
OASIS PortalCUL4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUL4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL4A
DgiDB (Drug Gene Interaction Database)CUL4A
DoCM (Curated mutations)CUL4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL4A (select a term)
intoGenCUL4A
Cancer3DCUL4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603137   
Orphanet
MedgenCUL4A
Genetic Testing Registry CUL4A
NextProtQ13619 [Medical]
TSGene8451
GENETestsCUL4A
Huge Navigator CUL4A [HugePedia]
snp3D : Map Gene to Disease8451
BioCentury BCIQCUL4A
ClinGenCUL4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8451
Chemical/Pharm GKB GenePA27050
Clinical trialCUL4A
Miscellaneous
canSAR (ICR)CUL4A (select the gene name)
Probes
Litterature
PubMed227 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL4A
EVEXCUL4A
GoPubMedCUL4A
iHOPCUL4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:12:18 CEST 2017

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