Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CUL4A (cullin 4A)

Identity

Alias (NCBI)-
HGNC (Hugo) CUL4A
LocusID (NCBI) 8451
Atlas_Id 40214
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113208772 and ends at 113267108 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CUL4A (13q34)::CUL4A (13q34)PCID2 (13q34)::CUL4A (13q34)TFDP1 (13q34)::CUL4A (13q34)
TFDP1 13q34::CUL4A 13q34

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CUL4A   2554
Cards
Entrez_Gene (NCBI)CUL4A    cullin 4A
Aliases
GeneCards (Weizmann)CUL4A
Ensembl hg19 (Hinxton)ENSG00000139842 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139842 [Gene_View]  ENSG00000139842 [Sequence]  chr13:113208772-113267108 [Contig_View]  CUL4A [Vega]
ICGC DataPortalENSG00000139842
TCGA cBioPortalCUL4A
AceView (NCBI)CUL4A
Genatlas (Paris)CUL4A
SOURCE (Princeton)CUL4A
Genetics Home Reference (NIH)CUL4A
Genomic and cartography
GoldenPath hg38 (UCSC)CUL4A  -     chr13:113208772-113267108 +  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL4A  -     13q34   [Description]    (hg19-Feb_2009)
GoldenPathCUL4A - 13q34 [CytoView hg19]  CUL4A - 13q34 [CytoView hg38]
ImmunoBaseENSG00000139842
Genome Data Viewer NCBICUL4A [Mapview hg19]  
OMIM603137   
Gene and transcription
Genbank (Entrez)AB012193 AB178950 AF077188 AK126278 AK296700
RefSeq transcript (Entrez)NM_001008895 NM_001278513 NM_001278514 NM_001354938 NM_001354939 NM_001354940 NM_001354941 NM_001354942 NM_001354943 NM_001354944 NM_003589
Consensus coding sequences : CCDS (NCBI)CUL4A
Gene ExpressionCUL4A [ NCBI-GEO ]   CUL4A [ EBI - ARRAY_EXPRESS ]   CUL4A [ SEEK ]   CUL4A [ MEM ]
Gene Expression Viewer (FireBrowse)CUL4A [ Firebrowse - Broad ]
GenevisibleExpression of CUL4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8451
GTEX Portal (Tissue expression)CUL4A
Human Protein AtlasENSG00000139842-CUL4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13619   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13619  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13619
PhosPhoSitePlusQ13619
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_homology_sf    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom_sf    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL4A
PDB (RSDB)2HYE    4A0K   
PDB Europe2HYE    4A0K   
PDB (PDBSum)2HYE    4A0K   
PDB (IMB)2HYE    4A0K   
Structural Biology KnowledgeBase2HYE    4A0K   
SCOP (Structural Classification of Proteins)2HYE    4A0K   
CATH (Classification of proteins structures)2HYE    4A0K   
SuperfamilyQ13619
AlphaFold pdb e-kbQ13619   
Human Protein Atlas [tissue]ENSG00000139842-CUL4A [tissue]
HPRD07218
Protein Interaction databases
DIP (DOE-UCLA)Q13619
IntAct (EBI)Q13619
BioGRIDCUL4A
STRING (EMBL)CUL4A
ZODIACCUL4A
Ontologies - Pathways
QuickGOQ13619
Ontology : AmiGOG1/S transition of mitotic cell cycle  in utero embryonic development  protein binding  nucleoplasm  DNA repair  cellular response to DNA damage stimulus  positive regulation of cell population proliferation  protein ubiquitination  protein ubiquitination  protein ubiquitination  protein ubiquitination  hemopoiesis  protein-macromolecule adaptor activity  negative regulation of granulocyte differentiation  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cullin-RING ubiquitin ligase complex  Cul4A-RING E3 ubiquitin ligase complex  Cul4A-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  somatic stem cell population maintenance  ribosome biogenesis  proteasome-mediated ubiquitin-dependent protein catabolic process  rhythmic process  regulation of protein metabolic process  Cul4-RING E3 ubiquitin ligase complex  Cul4-RING E3 ubiquitin ligase complex  intrinsic apoptotic signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  regulation of DNA damage checkpoint  regulation of nucleotide-excision repair  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  in utero embryonic development  protein binding  nucleoplasm  DNA repair  cellular response to DNA damage stimulus  positive regulation of cell population proliferation  protein ubiquitination  protein ubiquitination  protein ubiquitination  protein ubiquitination  hemopoiesis  protein-macromolecule adaptor activity  negative regulation of granulocyte differentiation  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cullin-RING ubiquitin ligase complex  Cul4A-RING E3 ubiquitin ligase complex  Cul4A-RING E3 ubiquitin ligase complex  ubiquitin protein ligase binding  somatic stem cell population maintenance  ribosome biogenesis  proteasome-mediated ubiquitin-dependent protein catabolic process  rhythmic process  regulation of protein metabolic process  Cul4-RING E3 ubiquitin ligase complex  Cul4-RING E3 ubiquitin ligase complex  intrinsic apoptotic signaling pathway  positive regulation of G1/S transition of mitotic cell cycle  regulation of DNA damage checkpoint  regulation of nucleotide-excision repair  
Pathways : KEGGKEGG_NUCLEOTIDE_EXCISION_REPAIR    KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS   
NDEx NetworkCUL4A
Atlas of Cancer Signalling NetworkCUL4A
Wikipedia pathwaysCUL4A
Orthology - Evolution
OrthoDB8451
GeneTree (enSembl)ENSG00000139842
Phylogenetic Trees/Animal Genes : TreeFamCUL4A
Homologs : HomoloGeneCUL4A
Homology/Alignments : Family Browser (UCSC)CUL4A
Gene fusions - Rearrangements
Fusion : QuiverCUL4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL4A
dbVarCUL4A
ClinVarCUL4A
MonarchCUL4A
1000_GenomesCUL4A 
Exome Variant ServerCUL4A
GNOMAD BrowserENSG00000139842
Varsome BrowserCUL4A
ACMGCUL4A variants
VarityQ13619
Genomic Variants (DGV)CUL4A [DGVbeta]
DECIPHERCUL4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL4A 
Mutations
ICGC Data PortalCUL4A 
TCGA Data PortalCUL4A 
Broad Tumor PortalCUL4A
OASIS PortalCUL4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL4A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCUL4A
Mutations and Diseases : HGMDCUL4A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCUL4A
DgiDB (Drug Gene Interaction Database)CUL4A
DoCM (Curated mutations)CUL4A
CIViC (Clinical Interpretations of Variants in Cancer)CUL4A
Cancer3DCUL4A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603137   
Orphanet
DisGeNETCUL4A
MedgenCUL4A
Genetic Testing Registry CUL4A
NextProtQ13619 [Medical]
GENETestsCUL4A
Target ValidationCUL4A
Huge Navigator CUL4A [HugePedia]
ClinGenCUL4A
Clinical trials, drugs, therapy
MyCancerGenomeCUL4A
Protein Interactions : CTDCUL4A
Pharm GKB GenePA27050
PharosQ13619
Clinical trialCUL4A
Miscellaneous
canSAR (ICR)CUL4A
HarmonizomeCUL4A
ARCHS4CUL4A
DataMed IndexCUL4A
Probes
Litterature
PubMed370 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCUL4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:29:31 CET 2022

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