Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CUL5 (cullin 5)

Identity

Alias (NCBI)CUL-5
VACM-1
VACM1
HGNC (Hugo) CUL5
HGNC Alias symbVACM-1
LocusID (NCBI) 8065
Atlas_Id 40216
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 108008898 and ends at 108107759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX10 (11q22.3) / CUL5 (11q22.3)MTDH (8q22.1) / CUL5 (11q22.3)YAP1 (11q22.1) / CUL5 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;11)(q13;q22) POC5/CUL5

External links

Nomenclature
HGNC (Hugo)CUL5   2556
Cards
Entrez_Gene (NCBI)CUL5  8065  cullin 5
AliasesCUL-5; VACM-1; VACM1
GeneCards (Weizmann)CUL5
Ensembl hg19 (Hinxton)ENSG00000166266 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166266 [Gene_View]  ENSG00000166266 [Sequence]  chr11:108008898-108107759 [Contig_View]  CUL5 [Vega]
ICGC DataPortalENSG00000166266
TCGA cBioPortalCUL5
AceView (NCBI)CUL5
Genatlas (Paris)CUL5
WikiGenes8065
SOURCE (Princeton)CUL5
Genetics Home Reference (NIH)CUL5
Genomic and cartography
GoldenPath hg38 (UCSC)CUL5  -     chr11:108008898-108107759 +  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUL5  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathCUL5 - 11q22.3 [CytoView hg19]  CUL5 - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000166266
genome Data Viewer NCBICUL5 [Mapview hg19]  
OMIM601741   
Gene and transcription
Genbank (Entrez)AA099369 AA403092 AA471067 AF017061 AF327710
RefSeq transcript (Entrez)NM_003478
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUL5
Alternative Splicing GalleryENSG00000166266
Gene ExpressionCUL5 [ NCBI-GEO ]   CUL5 [ EBI - ARRAY_EXPRESS ]   CUL5 [ SEEK ]   CUL5 [ MEM ]
Gene Expression Viewer (FireBrowse)CUL5 [ Firebrowse - Broad ]
GenevisibleExpression of CUL5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8065
GTEX Portal (Tissue expression)CUL5
Human Protein AtlasENSG00000166266-CUL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93034   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93034  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93034
Splice isoforms : SwissVarQ93034
PhosPhoSitePlusQ93034
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_homology_sf    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom_sf    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
Conserved Domain (NCBI)CUL5
DMDM Disease mutations8065
Blocks (Seattle)CUL5
PDB (RSDB)3DPL    3DQV    4JGH    4N9F   
PDB Europe3DPL    3DQV    4JGH    4N9F   
PDB (PDBSum)3DPL    3DQV    4JGH    4N9F   
PDB (IMB)3DPL    3DQV    4JGH    4N9F   
Structural Biology KnowledgeBase3DPL    3DQV    4JGH    4N9F   
SCOP (Structural Classification of Proteins)3DPL    3DQV    4JGH    4N9F   
CATH (Classification of proteins structures)3DPL    3DQV    4JGH    4N9F   
SuperfamilyQ93034
Human Protein Atlas [tissue]ENSG00000166266-CUL5 [tissue]
Peptide AtlasQ93034
HPRD03444
IPIIPI00216003   IPI00978224   IPI00979455   
Protein Interaction databases
DIP (DOE-UCLA)Q93034
IntAct (EBI)Q93034
FunCoupENSG00000166266
BioGRIDCUL5
STRING (EMBL)CUL5
ZODIACCUL5
Ontologies - Pathways
QuickGOQ93034
Ontology : AmiGOG1/S transition of mitotic cell cycle  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  calcium channel activity  protein binding  cytosol  ubiquitin-dependent protein catabolic process  viral process  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cullin-RING ubiquitin ligase complex  Cul5-RING ubiquitin ligase complex  Cul5-RING ubiquitin ligase complex  ubiquitin protein ligase binding  ubiquitin protein ligase binding  signaling receptor activity  ERBB2 signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  calcium ion transmembrane transport  site of DNA damage  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  calcium channel activity  protein binding  cytosol  ubiquitin-dependent protein catabolic process  viral process  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cullin-RING ubiquitin ligase complex  Cul5-RING ubiquitin ligase complex  Cul5-RING ubiquitin ligase complex  ubiquitin protein ligase binding  ubiquitin protein ligase binding  signaling receptor activity  ERBB2 signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  post-translational protein modification  calcium ion transmembrane transport  site of DNA damage  intrinsic apoptotic signaling pathway  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkCUL5
Atlas of Cancer Signalling NetworkCUL5
Wikipedia pathwaysCUL5
Orthology - Evolution
OrthoDB8065
GeneTree (enSembl)ENSG00000166266
Phylogenetic Trees/Animal Genes : TreeFamCUL5
HOGENOMQ93034
Homologs : HomoloGeneCUL5
Homology/Alignments : Family Browser (UCSC)CUL5
Gene fusions - Rearrangements
Fusion : QuiverCUL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL5
dbVarCUL5
ClinVarCUL5
MonarchCUL5
1000_GenomesCUL5 
Exome Variant ServerCUL5
GNOMAD BrowserENSG00000166266
Varsome BrowserCUL5
Genetic variants : HAPMAP8065
Genomic Variants (DGV)CUL5 [DGVbeta]
DECIPHERCUL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUL5 
Mutations
ICGC Data PortalCUL5 
TCGA Data PortalCUL5 
Broad Tumor PortalCUL5
OASIS PortalCUL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCUL5
Mutations and Diseases : HGMDCUL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL5
DgiDB (Drug Gene Interaction Database)CUL5
DoCM (Curated mutations)CUL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL5 (select a term)
intoGenCUL5
Cancer3DCUL5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601741   
Orphanet
DisGeNETCUL5
MedgenCUL5
Genetic Testing Registry CUL5
NextProtQ93034 [Medical]
TSGene8065
GENETestsCUL5
Target ValidationCUL5
Huge Navigator CUL5 [HugePedia]
snp3D : Map Gene to Disease8065
BioCentury BCIQCUL5
ClinGenCUL5
Clinical trials, drugs, therapy
Protein Interactions : CTD8065
Pharm GKB GenePA27052
Clinical trialCUL5
Miscellaneous
canSAR (ICR)CUL5 (select the gene name)
HarmonizomeCUL5
DataMed IndexCUL5
Probes
Litterature
PubMed203 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL5
EVEXCUL5
GoPubMedCUL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:07:48 CEST 2020
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