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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

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CUL5 (cullin 5)

Identity

Other namesVACM-1
VACM1
HGNC (Hugo) CUL5
LocusID (NCBI) 8065
Location 11q22.3
Location_base_pair Starts at 107879408 and ends at 107978488 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CUL5   2556
Cards
Entrez_Gene (NCBI)CUL5  8065  cullin 5
GeneCards (Weizmann)CUL5
Ensembl hg19 (Hinxton)ENSG00000166266 [Gene_View]  chr11:107879408-107978488 [Contig_View]  CUL5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166266 [Gene_View]  chr11:107879408-107978488 [Contig_View]  CUL5 [Vega]
ICGC DataPortalENSG00000166266
cBioPortalCUL5
AceView (NCBI)CUL5
Genatlas (Paris)CUL5
WikiGenes8065
SOURCE (Princeton)CUL5
Genomic and cartography
GoldenPath hg19 (UCSC)CUL5  -     chr11:107879408-107978488 +  11q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CUL5  -     11q22.3   [Description]    (hg38-Dec_2013)
EnsemblCUL5 - 11q22.3 [CytoView hg19]  CUL5 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICUL5 [Mapview hg19]  CUL5 [Mapview hg38]
OMIM601741   
Gene and transcription
Genbank (Entrez)AA099369 AA403092 AA471067 AF017061 AF327710
RefSeq transcript (Entrez)NM_003478
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)CUL5
Cluster EST : UnigeneHs.440320 [ NCBI ]
CGAP (NCI)Hs.440320
Alternative Splicing : Fast-db (Paris)GSHG0005220
Alternative Splicing GalleryENSG00000166266
Gene ExpressionCUL5 [ NCBI-GEO ]     CUL5 [ SEEK ]   CUL5 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93034 (Uniprot)
NextProtQ93034  [Medical]
With graphics : InterProQ93034
Splice isoforms : SwissVarQ93034 (Swissvar)
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Related proteins : CluSTrQ93034
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
DMDM Disease mutations8065
Blocks (Seattle)Q93034
PDB (SRS)3DPL    3DQV    4JGH    4N9F   
PDB (PDBSum)3DPL    3DQV    4JGH    4N9F   
PDB (IMB)3DPL    3DQV    4JGH    4N9F   
PDB (RSDB)3DPL    3DQV    4JGH    4N9F   
Human Protein AtlasENSG00000166266
Peptide AtlasQ93034
HPRD03444
IPIIPI00216003   IPI00978224   IPI00979455   
Protein Interaction databases
DIP (DOE-UCLA)Q93034
IntAct (EBI)Q93034
FunCoupENSG00000166266
BioGRIDCUL5
IntegromeDBCUL5
STRING (EMBL)CUL5
Ontologies - Pathways
QuickGOQ93034
Ontology : AmiGOG1/S transition of mitotic cell cycle  receptor activity  calcium channel activity  protein binding  nucleus  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  response to osmotic stress  cell cycle arrest  cell proliferation  negative regulation of cell proliferation  viral process  protein ubiquitination  Cul5-RING ubiquitin ligase complex  ubiquitin protein ligase binding  cytosolic calcium ion homeostasis  calcium ion transmembrane transport  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  receptor activity  calcium channel activity  protein binding  nucleus  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  response to osmotic stress  cell cycle arrest  cell proliferation  negative regulation of cell proliferation  viral process  protein ubiquitination  Cul5-RING ubiquitin ligase complex  ubiquitin protein ligase binding  cytosolic calcium ion homeostasis  calcium ion transmembrane transport  intrinsic apoptotic signaling pathway  
Pathways : KEGGUbiquitin mediated proteolysis   
Protein Interaction DatabaseCUL5
DoCM (Curated mutations)CUL5
Wikipedia pathwaysCUL5
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCUL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL5
dbVarCUL5
ClinVarCUL5
1000_GenomesCUL5 
Exome Variant ServerCUL5
SNP (GeneSNP Utah)CUL5
SNP : HGBaseCUL5
Genetic variants : HAPMAPCUL5
Genomic Variants (DGV)CUL5 [DGVbeta]
Mutations
ICGC Data PortalENSG00000166266 
Somatic Mutations in Cancer : COSMICCUL5 
CONAN: Copy Number AnalysisCUL5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:107879408-107978488
Mutations and Diseases : HGMDCUL5
OMIM601741   
MedgenCUL5
NextProtQ93034 [Medical]
GENETestsCUL5
Disease Genetic AssociationCUL5
Huge Navigator CUL5 [HugePedia]  CUL5 [HugeCancerGEM]
snp3D : Map Gene to Disease8065
DGIdb (Drug Gene Interaction db)CUL5
General knowledge
Homologs : HomoloGeneCUL5
Homology/Alignments : Family Browser (UCSC)CUL5
Phylogenetic Trees/Animal Genes : TreeFamCUL5
Chemical/Protein Interactions : CTD8065
Chemical/Pharm GKB GenePA27052
Clinical trialCUL5
Cancer Resource (Charite)ENSG00000166266
Other databases
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
CoreMineCUL5
GoPubMedCUL5
iHOPCUL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 15:21:24 CET 2015
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