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CUL5 (cullin 5)

Identity

Other namesVACM-1
VACM1
HGNC (Hugo) CUL5
LocusID (NCBI) 8065
Atlas_Id 40216
Location 11q22.3
Location_base_pair Starts at 107879408 and ends at 107978488 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DDX10 (11q22.3) / CUL5 (11q22.3)MTDH (8q22.1) / CUL5 (11q22.3)YAP1 (11q22.1) / CUL5 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CUL5   2556
Cards
Entrez_Gene (NCBI)CUL5  8065  cullin 5
GeneCards (Weizmann)CUL5
Ensembl hg19 (Hinxton)ENSG00000166266 [Gene_View]  chr11:107879408-107978488 [Contig_View]  CUL5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166266 [Gene_View]  chr11:107879408-107978488 [Contig_View]  CUL5 [Vega]
ICGC DataPortalENSG00000166266
TCGA cBioPortalCUL5
AceView (NCBI)CUL5
Genatlas (Paris)CUL5
WikiGenes8065
SOURCE (Princeton)CUL5
Genomic and cartography
GoldenPath hg19 (UCSC)CUL5  -     chr11:107879408-107978488 +  11q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CUL5  -     11q22.3   [Description]    (hg38-Dec_2013)
EnsemblCUL5 - 11q22.3 [CytoView hg19]  CUL5 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICUL5 [Mapview hg19]  CUL5 [Mapview hg38]
OMIM601741   
Gene and transcription
Genbank (Entrez)AA099369 AA403092 AA471067 AF017061 AF327710
RefSeq transcript (Entrez)NM_003478
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)CUL5
Cluster EST : UnigeneHs.440320 [ NCBI ]
CGAP (NCI)Hs.440320
Alternative Splicing GalleryENSG00000166266
Gene ExpressionCUL5 [ NCBI-GEO ]   CUL5 [ EBI - ARRAY_EXPRESS ]   CUL5 [ SEEK ]   CUL5 [ MEM ]
Gene Expression Viewer (FireBrowse)CUL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8065
GTEX Portal (Tissue expression)CUL5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93034 (Uniprot)
NextProtQ93034  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93034
Splice isoforms : SwissVarQ93034 (Swissvar)
PhosPhoSitePlusQ93034
Domaine pattern : Prosite (Expaxy)CULLIN_1 (PS01256)    CULLIN_2 (PS50069)   
Domains : Interpro (EBI)Cullin_CS    Cullin_homology    Cullin_N    Cullin_neddylation_domain    Cullin_repeat-like_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)Cullin (PF00888)    Cullin_Nedd8 (PF10557)   
Domain families : Pfam (NCBI)pfam00888    pfam10557   
Domain families : Smart (EMBL)CULLIN (SM00182)  Cullin_Nedd8 (SM00884)  
DMDM Disease mutations8065
Blocks (Seattle)CUL5
PDB (SRS)3DPL    3DQV    4JGH    4N9F   
PDB (PDBSum)3DPL    3DQV    4JGH    4N9F   
PDB (IMB)3DPL    3DQV    4JGH    4N9F   
PDB (RSDB)3DPL    3DQV    4JGH    4N9F   
Structural Biology KnowledgeBase3DPL    3DQV    4JGH    4N9F   
SCOP (Structural Classification of Proteins)3DPL    3DQV    4JGH    4N9F   
CATH (Classification of proteins structures)3DPL    3DQV    4JGH    4N9F   
SuperfamilyQ93034
Human Protein AtlasENSG00000166266
Peptide AtlasQ93034
HPRD03444
IPIIPI00216003   IPI00978224   IPI00979455   
Protein Interaction databases
DIP (DOE-UCLA)Q93034
IntAct (EBI)Q93034
FunCoupENSG00000166266
BioGRIDCUL5
STRING (EMBL)CUL5
ZODIACCUL5
Ontologies - Pathways
QuickGOQ93034
Ontology : AmiGOG1/S transition of mitotic cell cycle  ubiquitin-protein transferase activity  receptor activity  calcium channel activity  protein binding  cytosol  cell cycle arrest  cell proliferation  negative regulation of cell proliferation  viral process  Cul5-RING ubiquitin ligase complex  ubiquitin protein ligase binding  ERBB2 signaling pathway  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  ubiquitin protein ligase activity  calcium ion transmembrane transport  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  ubiquitin-protein transferase activity  receptor activity  calcium channel activity  protein binding  cytosol  cell cycle arrest  cell proliferation  negative regulation of cell proliferation  viral process  Cul5-RING ubiquitin ligase complex  ubiquitin protein ligase binding  ERBB2 signaling pathway  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  ubiquitin protein ligase activity  calcium ion transmembrane transport  intrinsic apoptotic signaling pathway  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx Network
Atlas of Cancer Signalling NetworkCUL5
Wikipedia pathwaysCUL5
Orthology - Evolution
OrthoDB8065
GeneTree (enSembl)ENSG00000166266
Phylogenetic Trees/Animal Genes : TreeFamCUL5
Homologs : HomoloGeneCUL5
Homology/Alignments : Family Browser (UCSC)CUL5
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCUL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUL5
dbVarCUL5
ClinVarCUL5
1000_GenomesCUL5 
Exome Variant ServerCUL5
ExAC (Exome Aggregation Consortium)CUL5 (select the gene name)
Genetic variants : HAPMAP8065
Genomic Variants (DGV)CUL5 [DGVbeta]
Mutations
ICGC Data PortalCUL5 
TCGA Data PortalCUL5 
Broad Tumor PortalCUL5
OASIS PortalCUL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUL5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUL5
DgiDB (Drug Gene Interaction Database)CUL5
DoCM (Curated mutations)CUL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUL5 (select a term)
intoGenCUL5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:107879408-107978488  ENSG00000166266
CONAN: Copy Number AnalysisCUL5 
Mutations and Diseases : HGMDCUL5
OMIM601741   
MedgenCUL5
Genetic Testing Registry CUL5
NextProtQ93034 [Medical]
TSGene8065
GENETestsCUL5
Huge Navigator CUL5 [HugePedia]
snp3D : Map Gene to Disease8065
BioCentury BCIQCUL5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8065
Chemical/Pharm GKB GenePA27052
Clinical trialCUL5
Miscellaneous
canSAR (ICR)CUL5 (select the gene name)
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUL5
EVEXCUL5
GoPubMedCUL5
iHOPCUL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 8 18:42:57 CEST 2016

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