Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CUX2 (cut like homeobox 2)

Identity

Alias_namesCUTL2
cut-like 2 (Drosophila)
cut-like homeobox 2
Alias_symbol (synonym)KIAA0293
CDP2
Other alias
HGNC (Hugo) CUX2
LocusID (NCBI) 23316
Atlas_Id 55545
Location 12q24.11  [Link to chromosome band 12q24]
Location_base_pair Starts at 111034024 and ends at 111350556 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CUX2 (12q24.11) / CABP1 (12q24.31)CUX2 (12q24.11) / CUX2 (12q24.11)CUX2 (12q24.11) / GRN (17q21.31)
PIGT (20q13.12) / CUX2 (12q24.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CUX2   19347
Cards
Entrez_Gene (NCBI)CUX2  23316  cut like homeobox 2
AliasesCDP2; CUTL2
GeneCards (Weizmann)CUX2
Ensembl hg19 (Hinxton)ENSG00000111249 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111249 [Gene_View]  chr12:111034024-111350556 [Contig_View]  CUX2 [Vega]
ICGC DataPortalENSG00000111249
TCGA cBioPortalCUX2
AceView (NCBI)CUX2
Genatlas (Paris)CUX2
WikiGenes23316
SOURCE (Princeton)CUX2
Genetics Home Reference (NIH)CUX2
Genomic and cartography
GoldenPath hg38 (UCSC)CUX2  -     chr12:111034024-111350556 +  12q24.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUX2  -     12q24.11   [Description]    (hg19-Feb_2009)
EnsemblCUX2 - 12q24.11 [CytoView hg19]  CUX2 - 12q24.11 [CytoView hg38]
Mapping of homologs : NCBICUX2 [Mapview hg19]  CUX2 [Mapview hg38]
OMIM610648   
Gene and transcription
Genbank (Entrez)AB006631 AF234996 AF271236 BC140440 BC151245
RefSeq transcript (Entrez)NM_015267
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUX2
Cluster EST : UnigeneHs.124953 [ NCBI ]
CGAP (NCI)Hs.124953
Alternative Splicing GalleryENSG00000111249
Gene ExpressionCUX2 [ NCBI-GEO ]   CUX2 [ EBI - ARRAY_EXPRESS ]   CUX2 [ SEEK ]   CUX2 [ MEM ]
Gene Expression Viewer (FireBrowse)CUX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23316
GTEX Portal (Tissue expression)CUX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14529   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14529  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14529
Splice isoforms : SwissVarO14529
PhosPhoSitePlusO14529
Domaine pattern : Prosite (Expaxy)CUT (PS51042)    HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)CUT_dom    Homeobox-like    Homeobox_CS    Homeobox_dom    Lambda_DNA-bd_dom   
Domain families : Pfam (Sanger)CUT (PF02376)    Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam02376    pfam00046   
Domain families : Smart (EMBL)CUT (SM01109)  HOX (SM00389)  
Conserved Domain (NCBI)CUX2
DMDM Disease mutations23316
Blocks (Seattle)CUX2
PDB (SRS)1WH6    1WH8    1X2L   
PDB (PDBSum)1WH6    1WH8    1X2L   
PDB (IMB)1WH6    1WH8    1X2L   
PDB (RSDB)1WH6    1WH8    1X2L   
Structural Biology KnowledgeBase1WH6    1WH8    1X2L   
SCOP (Structural Classification of Proteins)1WH6    1WH8    1X2L   
CATH (Classification of proteins structures)1WH6    1WH8    1X2L   
SuperfamilyO14529
Human Protein AtlasENSG00000111249
Peptide AtlasO14529
HPRD10851
IPIIPI00022370   IPI00793382   IPI01022889   
Protein Interaction databases
DIP (DOE-UCLA)O14529
IntAct (EBI)O14529
FunCoupENSG00000111249
BioGRIDCUX2
STRING (EMBL)CUX2
ZODIACCUX2
Ontologies - Pathways
QuickGOO14529
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  Golgi membrane  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  transcription, DNA-templated  multicellular organism development  short-term memory  positive regulation of gene expression  sequence-specific DNA binding  Golgi vesicle transport  positive regulation of dendrite morphogenesis  cognition  positive regulation of synapse assembly  positive regulation of dendritic spine morphogenesis  extracellular exosome  cellular response to organic substance  positive regulation of excitatory postsynaptic potential  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  Golgi membrane  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleus  transcription, DNA-templated  multicellular organism development  short-term memory  positive regulation of gene expression  sequence-specific DNA binding  Golgi vesicle transport  positive regulation of dendrite morphogenesis  cognition  positive regulation of synapse assembly  positive regulation of dendritic spine morphogenesis  extracellular exosome  cellular response to organic substance  positive regulation of excitatory postsynaptic potential  
NDEx NetworkCUX2
Atlas of Cancer Signalling NetworkCUX2
Wikipedia pathwaysCUX2
Orthology - Evolution
OrthoDB23316
GeneTree (enSembl)ENSG00000111249
Phylogenetic Trees/Animal Genes : TreeFamCUX2
HOVERGENO14529
HOGENOMO14529
Homologs : HomoloGeneCUX2
Homology/Alignments : Family Browser (UCSC)CUX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUX2
dbVarCUX2
ClinVarCUX2
1000_GenomesCUX2 
Exome Variant ServerCUX2
ExAC (Exome Aggregation Consortium)CUX2 (select the gene name)
Genetic variants : HAPMAP23316
Genomic Variants (DGV)CUX2 [DGVbeta]
DECIPHERCUX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUX2 
Mutations
ICGC Data PortalCUX2 
TCGA Data PortalCUX2 
Broad Tumor PortalCUX2
OASIS PortalCUX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUX2
DgiDB (Drug Gene Interaction Database)CUX2
DoCM (Curated mutations)CUX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUX2 (select a term)
intoGenCUX2
Cancer3DCUX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610648   
Orphanet
MedgenCUX2
Genetic Testing Registry CUX2
NextProtO14529 [Medical]
TSGene23316
GENETestsCUX2
Target ValidationCUX2
Huge Navigator CUX2 [HugePedia]
snp3D : Map Gene to Disease23316
BioCentury BCIQCUX2
ClinGenCUX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23316
Chemical/Pharm GKB GenePA162382977
Clinical trialCUX2
Miscellaneous
canSAR (ICR)CUX2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUX2
EVEXCUX2
GoPubMedCUX2
iHOPCUX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:30:09 CEST 2017

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