Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CUZD1 (CUB and zona pellucida like domains 1)

Identity

Alias_namesCUB and zona pellucida-like domains 1
Alias_symbol (synonym)ERG-1
UO-44
Other aliasERG1
ITMAP1
HGNC (Hugo) CUZD1
LocusID (NCBI) 50624
Atlas_Id 46600
Location 10q26.13  [Link to chromosome band 10q26]
Location_base_pair Starts at 122832155 and ends at 122846175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CUZD1 (10q26.13) / PACS1 (11q13.1)TIAL1 (10q26.11) / CUZD1 (10q26.13)TIAL1 10q26.11 / CUZD1 10q26.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q26;q26) TIAL1/CUZD1

External links

Nomenclature
HGNC (Hugo)CUZD1   17937
Cards
Entrez_Gene (NCBI)CUZD1  50624  CUB and zona pellucida like domains 1
AliasesERG-1; ERG1; ITMAP1; UO-44
GeneCards (Weizmann)CUZD1
Ensembl hg19 (Hinxton)ENSG00000138161 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138161 [Gene_View]  ENSG00000138161 [Sequence]  chr10:122832155-122846175 [Contig_View]  CUZD1 [Vega]
ICGC DataPortalENSG00000138161
TCGA cBioPortalCUZD1
AceView (NCBI)CUZD1
Genatlas (Paris)CUZD1
WikiGenes50624
SOURCE (Princeton)CUZD1
Genetics Home Reference (NIH)CUZD1
Genomic and cartography
GoldenPath hg38 (UCSC)CUZD1  -     chr10:122832155-122846175 -  10q26.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CUZD1  -     10q26.13   [Description]    (hg19-Feb_2009)
EnsemblCUZD1 - 10q26.13 [CytoView hg19]  CUZD1 - 10q26.13 [CytoView hg38]
Mapping of homologs : NCBICUZD1 [Mapview hg19]  CUZD1 [Mapview hg38]
OMIM616644   
Gene and transcription
Genbank (Entrez)AF305835 AK289445 AY260047 AY260048 AY260049
RefSeq transcript (Entrez)NM_022034
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CUZD1
Cluster EST : UnigeneHs.647182 [ NCBI ]
CGAP (NCI)Hs.647182
Alternative Splicing GalleryENSG00000138161
Gene ExpressionCUZD1 [ NCBI-GEO ]   CUZD1 [ EBI - ARRAY_EXPRESS ]   CUZD1 [ SEEK ]   CUZD1 [ MEM ]
Gene Expression Viewer (FireBrowse)CUZD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50624
GTEX Portal (Tissue expression)CUZD1
Human Protein AtlasENSG00000138161-CUZD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UP6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UP6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UP6
Splice isoforms : SwissVarQ86UP6
PhosPhoSitePlusQ86UP6
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    ZP_2 (PS51034)   
Domains : Interpro (EBI)CUB_dom    ZP_dom   
Domain families : Pfam (Sanger)CUB (PF00431)    Zona_pellucida (PF00100)   
Domain families : Pfam (NCBI)pfam00431    pfam00100   
Domain families : Smart (EMBL)CUB (SM00042)  ZP (SM00241)  
Conserved Domain (NCBI)CUZD1
DMDM Disease mutations50624
Blocks (Seattle)CUZD1
SuperfamilyQ86UP6
Human Protein Atlas [tissue]ENSG00000138161-CUZD1 [tissue]
Peptide AtlasQ86UP6
HPRD06476
IPIIPI00249672   IPI00719783   IPI00642709   
Protein Interaction databases
DIP (DOE-UCLA)Q86UP6
IntAct (EBI)Q86UP6
FunCoupENSG00000138161
BioGRIDCUZD1
STRING (EMBL)CUZD1
ZODIACCUZD1
Ontologies - Pathways
QuickGOQ86UP6
Ontology : AmiGOsubstrate-dependent cell migration, cell attachment to substrate  cell cycle  cell proliferation  integral component of membrane  transport vesicle membrane  trypsinogen activation  zymogen granule membrane  cell division  
Ontology : EGO-EBIsubstrate-dependent cell migration, cell attachment to substrate  cell cycle  cell proliferation  integral component of membrane  transport vesicle membrane  trypsinogen activation  zymogen granule membrane  cell division  
Pathways : BIOCARTACadmium induces DNA synthesis and proliferation in macrophages [Genes]   
NDEx NetworkCUZD1
Atlas of Cancer Signalling NetworkCUZD1
Wikipedia pathwaysCUZD1
Orthology - Evolution
OrthoDB50624
GeneTree (enSembl)ENSG00000138161
Phylogenetic Trees/Animal Genes : TreeFamCUZD1
HOVERGENQ86UP6
HOGENOMQ86UP6
Homologs : HomoloGeneCUZD1
Homology/Alignments : Family Browser (UCSC)CUZD1
Gene fusions - Rearrangements
Fusion : MitelmanTIAL1/CUZD1 [10q26.11/10q26.13]  [t(10;10)(q26;q26)]  
Fusion PortalTIAL1 10q26.11 CUZD1 10q26.13 BRCA
Fusion : QuiverCUZD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCUZD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CUZD1
dbVarCUZD1
ClinVarCUZD1
1000_GenomesCUZD1 
Exome Variant ServerCUZD1
ExAC (Exome Aggregation Consortium)ENSG00000138161
GNOMAD BrowserENSG00000138161
Genetic variants : HAPMAP50624
Genomic Variants (DGV)CUZD1 [DGVbeta]
DECIPHERCUZD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCUZD1 
Mutations
ICGC Data PortalCUZD1 
TCGA Data PortalCUZD1 
Broad Tumor PortalCUZD1
OASIS PortalCUZD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCUZD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCUZD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CUZD1
DgiDB (Drug Gene Interaction Database)CUZD1
DoCM (Curated mutations)CUZD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CUZD1 (select a term)
intoGenCUZD1
Cancer3DCUZD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616644   
Orphanet
DisGeNETCUZD1
MedgenCUZD1
Genetic Testing Registry CUZD1
NextProtQ86UP6 [Medical]
TSGene50624
GENETestsCUZD1
Target ValidationCUZD1
Huge Navigator CUZD1 [HugePedia]
snp3D : Map Gene to Disease50624
BioCentury BCIQCUZD1
ClinGenCUZD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50624
Chemical/Pharm GKB GenePA134903546
Clinical trialCUZD1
Miscellaneous
canSAR (ICR)CUZD1 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCUZD1
EVEXCUZD1
GoPubMedCUZD1
iHOPCUZD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:21:30 CEST 2018
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