CX3CR1 (C-X3-C motif chemokine receptor 1)

2007-02-01  

Identity

HGNC
LOCATION
3p22.2
LOCUSID
ALIAS
CCRL1,CMKBRL1,CMKDR1,GPR13,GPRV28,V28

Other Information

Locus ID:

NCBI: 1524
MIM: 601470
HGNC: 2558
Ensembl: ENSG00000168329

Variants:

dbSNP: 1524
ClinVar: 1524
TCGA: ENSG00000168329
COSMIC: CX3CR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168329ENST00000358309P49238
ENSG00000168329ENST00000399220P49238
ENSG00000168329ENST00000412814C9JLM2
ENSG00000168329ENST00000435290C9JN40
ENSG00000168329ENST00000541347P49238
ENSG00000168329ENST00000542107P49238

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203056482010Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.208
250241362014CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.128
174763382007Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo.109
217717912011CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.99
152082702004The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.95
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
243527392013Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage.83
210384152010The fractalkine receptor CX₃CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes.82
241774282013CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.82
112641532001Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease.77

Citation

Dessen P

CX3CR1 (C-X3-C motif chemokine receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46228/cx3cr1