Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CX3CR1 (C-X3-C motif chemokine receptor 1)

Identity

Alias_namesGPR13
CMKBRL1
chemokine (C-X3-C) receptor 1
chemokine (C-X3-C motif) receptor 1
Alias_symbol (synonym)CMKDR1
V28
CCRL1
Other aliasGPRV28
HGNC (Hugo) CX3CR1
LocusID (NCBI) 1524
Atlas_Id 46228
Location 3p22.2  [Link to chromosome band 3p22]
Location_base_pair Starts at 39304985 and ends at 39322764 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CX3CR1   2558
Cards
Entrez_Gene (NCBI)CX3CR1  1524  C-X3-C motif chemokine receptor 1
AliasesCCRL1; CMKBRL1; CMKDR1; GPR13; 
GPRV28; V28
GeneCards (Weizmann)CX3CR1
Ensembl hg19 (Hinxton)ENSG00000168329 [Gene_View]  chr3:39304985-39322764 [Contig_View]  CX3CR1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168329 [Gene_View]  chr3:39304985-39322764 [Contig_View]  CX3CR1 [Vega]
ICGC DataPortalENSG00000168329
TCGA cBioPortalCX3CR1
AceView (NCBI)CX3CR1
Genatlas (Paris)CX3CR1
WikiGenes1524
SOURCE (Princeton)CX3CR1
Genetics Home Reference (NIH)CX3CR1
Genomic and cartography
GoldenPath hg19 (UCSC)CX3CR1  -     chr3:39304985-39322764 -  3p22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CX3CR1  -     3p22.2   [Description]    (hg38-Dec_2013)
EnsemblCX3CR1 - 3p22.2 [CytoView hg19]  CX3CR1 - 3p22.2 [CytoView hg38]
Mapping of homologs : NCBICX3CR1 [Mapview hg19]  CX3CR1 [Mapview hg38]
OMIM601470   607339   609423   613784   
Gene and transcription
Genbank (Entrez)AI400350 AK225764 AK307911 AK312373 BC017855
RefSeq transcript (Entrez)NM_001171171 NM_001171172 NM_001171174 NM_001337
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_016362 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)CX3CR1
Cluster EST : UnigeneHs.78913 [ NCBI ]
CGAP (NCI)Hs.78913
Alternative Splicing GalleryENSG00000168329
Gene ExpressionCX3CR1 [ NCBI-GEO ]   CX3CR1 [ EBI - ARRAY_EXPRESS ]   CX3CR1 [ SEEK ]   CX3CR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CX3CR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1524
GTEX Portal (Tissue expression)CX3CR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49238   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49238
Splice isoforms : SwissVarP49238
PhosPhoSitePlusP49238
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CX3CR1    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CX3CR1
DMDM Disease mutations1524
Blocks (Seattle)CX3CR1
SuperfamilyP49238
Human Protein AtlasENSG00000168329
Peptide AtlasP49238
HPRD03277
IPIIPI00026498   IPI00409704   IPI00930189   IPI01011388   IPI00924433   IPI00924696   
Protein Interaction databases
DIP (DOE-UCLA)P49238
IntAct (EBI)P49238
FunCoupENSG00000168329
BioGRIDCX3CR1
STRING (EMBL)CX3CR1
ZODIACCX3CR1
Ontologies - Pathways
QuickGOP49238
Ontology : AmiGOpositive regulation of neuroblast proliferation  microglial cell activation involved in immune response  negative regulation of chronic inflammatory response to non-antigenic stimulus  chemokine receptor activity  protein binding  plasma membrane  integral component of plasma membrane  chemotaxis  cellular defense response  cell adhesion  G-protein coupled receptor signaling pathway  memory  response to wounding  viral process  C-X3-C chemokine receptor activity  negative regulation of angiogenesis  C-X3-C chemokine binding  cerebral cortex cell migration  negative regulation of cell migration  neuronal cell body membrane  neuron projection  positive regulation of angiogenesis  macrophage chemotaxis  perinuclear region of cytoplasm  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to transforming growth factor beta stimulus  negative regulation of long-term synaptic potentiation  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIpositive regulation of neuroblast proliferation  microglial cell activation involved in immune response  negative regulation of chronic inflammatory response to non-antigenic stimulus  chemokine receptor activity  protein binding  plasma membrane  integral component of plasma membrane  chemotaxis  cellular defense response  cell adhesion  G-protein coupled receptor signaling pathway  memory  response to wounding  viral process  C-X3-C chemokine receptor activity  negative regulation of angiogenesis  C-X3-C chemokine binding  cerebral cortex cell migration  negative regulation of cell migration  neuronal cell body membrane  neuron projection  positive regulation of angiogenesis  macrophage chemotaxis  perinuclear region of cytoplasm  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to transforming growth factor beta stimulus  negative regulation of long-term synaptic potentiation  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCX3CR1
Atlas of Cancer Signalling NetworkCX3CR1
Wikipedia pathwaysCX3CR1
Orthology - Evolution
OrthoDB1524
GeneTree (enSembl)ENSG00000168329
Phylogenetic Trees/Animal Genes : TreeFamCX3CR1
HOVERGENP49238
HOGENOMP49238
Homologs : HomoloGeneCX3CR1
Homology/Alignments : Family Browser (UCSC)CX3CR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCX3CR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CX3CR1
dbVarCX3CR1
ClinVarCX3CR1
1000_GenomesCX3CR1 
Exome Variant ServerCX3CR1
ExAC (Exome Aggregation Consortium)CX3CR1 (select the gene name)
Genetic variants : HAPMAP1524
Genomic Variants (DGV)CX3CR1 [DGVbeta]
DECIPHER (Syndromes)3:39304985-39322764  ENSG00000168329
CONAN: Copy Number AnalysisCX3CR1 
Mutations
ICGC Data PortalCX3CR1 
TCGA Data PortalCX3CR1 
Broad Tumor PortalCX3CR1
OASIS PortalCX3CR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCX3CR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCX3CR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CX3CR1
DgiDB (Drug Gene Interaction Database)CX3CR1
DoCM (Curated mutations)CX3CR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CX3CR1 (select a term)
intoGenCX3CR1
Cancer3DCX3CR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601470    607339    609423    613784   
Orphanet
MedgenCX3CR1
Genetic Testing Registry CX3CR1
NextProtP49238 [Medical]
TSGene1524
GENETestsCX3CR1
Huge Navigator CX3CR1 [HugePedia]
snp3D : Map Gene to Disease1524
BioCentury BCIQCX3CR1
ClinGenCX3CR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1524
Chemical/Pharm GKB GenePA27054
Clinical trialCX3CR1
Miscellaneous
canSAR (ICR)CX3CR1 (select the gene name)
Probes
Litterature
PubMed253 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCX3CR1
EVEXCX3CR1
GoPubMedCX3CR1
iHOPCX3CR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:18 CET 2017

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