Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CX3CR1 (C-X3-C motif chemokine receptor 1)

Identity

Alias_namesGPR13
CMKBRL1
chemokine (C-X3-C) receptor 1
chemokine (C-X3-C motif) receptor 1
Alias_symbol (synonym)CMKDR1
V28
CCRL1
Other aliasGPRV28
HGNC (Hugo) CX3CR1
LocusID (NCBI) 1524
Atlas_Id 46228
Location 3p22.2  [Link to chromosome band 3p22]
Location_base_pair Starts at 39263494 and ends at 39280036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CX3CR1   2558
Cards
Entrez_Gene (NCBI)CX3CR1  1524  C-X3-C motif chemokine receptor 1
AliasesCCRL1; CMKBRL1; CMKDR1; GPR13; 
GPRV28; V28
GeneCards (Weizmann)CX3CR1
Ensembl hg19 (Hinxton)ENSG00000168329 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168329 [Gene_View]  ENSG00000168329 [Sequence]  chr3:39263494-39280036 [Contig_View]  CX3CR1 [Vega]
ICGC DataPortalENSG00000168329
TCGA cBioPortalCX3CR1
AceView (NCBI)CX3CR1
Genatlas (Paris)CX3CR1
WikiGenes1524
SOURCE (Princeton)CX3CR1
Genetics Home Reference (NIH)CX3CR1
Genomic and cartography
GoldenPath hg38 (UCSC)CX3CR1  -     chr3:39263494-39280036 -  3p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CX3CR1  -     3p22.2   [Description]    (hg19-Feb_2009)
EnsemblCX3CR1 - 3p22.2 [CytoView hg19]  CX3CR1 - 3p22.2 [CytoView hg38]
Mapping of homologs : NCBICX3CR1 [Mapview hg19]  CX3CR1 [Mapview hg38]
OMIM601470   607339   609423   613784   
Gene and transcription
Genbank (Entrez)AI400350 AK225764 AK307911 AK312373 BC017855
RefSeq transcript (Entrez)NM_001171171 NM_001171172 NM_001171174 NM_001337
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CX3CR1
Cluster EST : UnigeneHs.78913 [ NCBI ]
CGAP (NCI)Hs.78913
Alternative Splicing GalleryENSG00000168329
Gene ExpressionCX3CR1 [ NCBI-GEO ]   CX3CR1 [ EBI - ARRAY_EXPRESS ]   CX3CR1 [ SEEK ]   CX3CR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CX3CR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1524
GTEX Portal (Tissue expression)CX3CR1
Human Protein AtlasENSG00000168329-CX3CR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49238   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49238
Splice isoforms : SwissVarP49238
PhosPhoSitePlusP49238
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CX3CR1    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CX3CR1
DMDM Disease mutations1524
Blocks (Seattle)CX3CR1
SuperfamilyP49238
Human Protein Atlas [tissue]ENSG00000168329-CX3CR1 [tissue]
Peptide AtlasP49238
HPRD03277
IPIIPI00026498   IPI00409704   IPI00930189   IPI01011388   IPI00924433   IPI00924696   
Protein Interaction databases
DIP (DOE-UCLA)P49238
IntAct (EBI)P49238
FunCoupENSG00000168329
BioGRIDCX3CR1
STRING (EMBL)CX3CR1
ZODIACCX3CR1
Ontologies - Pathways
QuickGOP49238
Ontology : AmiGOpositive regulation of neuroblast proliferation  response to ischemia  G protein-coupled receptor activity  chemokine receptor activity  protein binding  nucleus  nucleoplasm  plasma membrane  integral component of plasma membrane  chemotaxis  chemotaxis  immune response  cellular defense response  cell adhesion  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  memory  G protein-coupled peptide receptor activity  response to wounding  external side of plasma membrane  cell surface  cell surface  viral process  C-C chemokine receptor activity  C-X3-C chemokine receptor activity  negative regulation of angiogenesis  calcium-mediated signaling  chemokine binding  C-C chemokine binding  C-X3-C chemokine binding  C-X3-C chemokine binding  negative regulation of cell migration  negative regulation of interleukin-1 beta production  neuronal cell body membrane  autocrine signaling  regulation of tumor necrosis factor biosynthetic process  neuron projection  innate immune response  regulation of nitric oxide biosynthetic process  positive regulation of angiogenesis  regulation of synaptic plasticity  perinuclear region of cytoplasm  regulation of neurogenesis  positive regulation of neurogenesis  leukocyte tethering or rolling  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  cell chemotaxis  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to transforming growth factor beta stimulus  dendritic tree  negative regulation of hippocampal neuron apoptotic process  negative regulation of long-term synaptic potentiation  positive regulation of I-kappaB phosphorylation  regulation of microglial cell migration  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBIpositive regulation of neuroblast proliferation  response to ischemia  G protein-coupled receptor activity  chemokine receptor activity  protein binding  nucleus  nucleoplasm  plasma membrane  integral component of plasma membrane  chemotaxis  chemotaxis  immune response  cellular defense response  cell adhesion  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  memory  G protein-coupled peptide receptor activity  response to wounding  external side of plasma membrane  cell surface  cell surface  viral process  C-C chemokine receptor activity  C-X3-C chemokine receptor activity  negative regulation of angiogenesis  calcium-mediated signaling  chemokine binding  C-C chemokine binding  C-X3-C chemokine binding  C-X3-C chemokine binding  negative regulation of cell migration  negative regulation of interleukin-1 beta production  neuronal cell body membrane  autocrine signaling  regulation of tumor necrosis factor biosynthetic process  neuron projection  innate immune response  regulation of nitric oxide biosynthetic process  positive regulation of angiogenesis  regulation of synaptic plasticity  perinuclear region of cytoplasm  regulation of neurogenesis  positive regulation of neurogenesis  leukocyte tethering or rolling  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  cell chemotaxis  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to transforming growth factor beta stimulus  dendritic tree  negative regulation of hippocampal neuron apoptotic process  negative regulation of long-term synaptic potentiation  positive regulation of I-kappaB phosphorylation  regulation of microglial cell migration  negative regulation of apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCX3CR1
Atlas of Cancer Signalling NetworkCX3CR1
Wikipedia pathwaysCX3CR1
Orthology - Evolution
OrthoDB1524
GeneTree (enSembl)ENSG00000168329
Phylogenetic Trees/Animal Genes : TreeFamCX3CR1
HOVERGENP49238
HOGENOMP49238
Homologs : HomoloGeneCX3CR1
Homology/Alignments : Family Browser (UCSC)CX3CR1
Gene fusions - Rearrangements
Fusion : QuiverCX3CR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCX3CR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CX3CR1
dbVarCX3CR1
ClinVarCX3CR1
1000_GenomesCX3CR1 
Exome Variant ServerCX3CR1
ExAC (Exome Aggregation Consortium)ENSG00000168329
GNOMAD BrowserENSG00000168329
Varsome BrowserCX3CR1
Genetic variants : HAPMAP1524
Genomic Variants (DGV)CX3CR1 [DGVbeta]
DECIPHERCX3CR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCX3CR1 
Mutations
ICGC Data PortalCX3CR1 
TCGA Data PortalCX3CR1 
Broad Tumor PortalCX3CR1
OASIS PortalCX3CR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCX3CR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCX3CR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CX3CR1
DgiDB (Drug Gene Interaction Database)CX3CR1
DoCM (Curated mutations)CX3CR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CX3CR1 (select a term)
intoGenCX3CR1
Cancer3DCX3CR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601470    607339    609423    613784   
Orphanet
DisGeNETCX3CR1
MedgenCX3CR1
Genetic Testing Registry CX3CR1
NextProtP49238 [Medical]
TSGene1524
GENETestsCX3CR1
Target ValidationCX3CR1
Huge Navigator CX3CR1 [HugePedia]
snp3D : Map Gene to Disease1524
BioCentury BCIQCX3CR1
ClinGenCX3CR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1524
Chemical/Pharm GKB GenePA27054
Clinical trialCX3CR1
Miscellaneous
canSAR (ICR)CX3CR1 (select the gene name)
Probes
Litterature
PubMed286 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCX3CR1
EVEXCX3CR1
GoPubMedCX3CR1
iHOPCX3CR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:01:01 CET 2018

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