Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXADR (coxsackie virus and adenovirus receptor)

Identity

Alias_symbol (synonym)CAR
Other aliasCAR4/6
HCAR
HGNC (Hugo) CXADR
LocusID (NCBI) 1525
Atlas_Id 45974
Location 21q21.1  [Link to chromosome band 21q21]
Location_base_pair Starts at 18885224 and ends at 18942429 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CXADR (21q21.1) / CMC4 (Xq28)CXADR (21q21.1) / CXADR (21q21.1)TTLL5 (14q24.3) / CXADR (21q21.1)
CXADR 21q21.1 MTCP1NB

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXADR   2559
Cards
Entrez_Gene (NCBI)CXADR  1525  coxsackie virus and adenovirus receptor
AliasesCAR; CAR4/6; HCAR
GeneCards (Weizmann)CXADR
Ensembl hg19 (Hinxton)ENSG00000154639 [Gene_View]  chr21:18885224-18942429 [Contig_View]  CXADR [Vega]
Ensembl hg38 (Hinxton)ENSG00000154639 [Gene_View]  chr21:18885224-18942429 [Contig_View]  CXADR [Vega]
ICGC DataPortalENSG00000154639
TCGA cBioPortalCXADR
AceView (NCBI)CXADR
Genatlas (Paris)CXADR
WikiGenes1525
SOURCE (Princeton)CXADR
Genetics Home Reference (NIH)CXADR
Genomic and cartography
GoldenPath hg19 (UCSC)CXADR  -     chr21:18885224-18942429 +  21q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CXADR  -     21q21.1   [Description]    (hg38-Dec_2013)
EnsemblCXADR - 21q21.1 [CytoView hg19]  CXADR - 21q21.1 [CytoView hg38]
Mapping of homologs : NCBICXADR [Mapview hg19]  CXADR [Mapview hg38]
OMIM602621   
Gene and transcription
Genbank (Entrez)AF124598 AI498294 AK313526 AY072910 AY072911
RefSeq transcript (Entrez)NM_001207063 NM_001207064 NM_001207065 NM_001207066 NM_001338
RefSeq genomic (Entrez)NC_000021 NC_018932 NG_029458 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)CXADR
Cluster EST : UnigeneHs.627078 [ NCBI ]
CGAP (NCI)Hs.627078
Alternative Splicing GalleryENSG00000154639
Gene ExpressionCXADR [ NCBI-GEO ]   CXADR [ EBI - ARRAY_EXPRESS ]   CXADR [ SEEK ]   CXADR [ MEM ]
Gene Expression Viewer (FireBrowse)CXADR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1525
GTEX Portal (Tissue expression)CXADR
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78310   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78310  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78310
Splice isoforms : SwissVarP78310
PhosPhoSitePlusP78310
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2    Ig_V-set    Immunoglobulin   
Domain families : Pfam (Sanger)ig (PF00047)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam00047    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)CXADR
DMDM Disease mutations1525
Blocks (Seattle)CXADR
PDB (SRS)1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
PDB (PDBSum)1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
PDB (IMB)1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
PDB (RSDB)1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
Structural Biology KnowledgeBase1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
SCOP (Structural Classification of Proteins)1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
CATH (Classification of proteins structures)1EAJ    1F5W    1JEW    1KAC    1P69    1P6A    1RSF    2J12    2J1K    2NPL    2W9L    2WBW    3J6L    3J6M    3J6N    3J6O   
SuperfamilyP78310
Human Protein AtlasENSG00000154639
Peptide AtlasP78310
HPRD11804
IPIIPI00019146   IPI00383114   IPI00103423   IPI00103422   IPI00956707   IPI00607658   
Protein Interaction databases
DIP (DOE-UCLA)P78310
IntAct (EBI)P78310
FunCoupENSG00000154639
BioGRIDCXADR
STRING (EMBL)CXADR
ZODIACCXADR
Ontologies - Pathways
QuickGOP78310
Ontology : AmiGOvirus receptor activity  acrosomal vesicle  receptor binding  integrin binding  protein binding  extracellular region  extracellular space  nucleoplasm  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  bicellular tight junction  mitochondrion organization  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  heart development  beta-catenin binding  germ cell migration  cell surface  epithelial structure maintenance  intercalated disc  basolateral plasma membrane  apicolateral plasma membrane  cell junction  PDZ domain binding  filopodium  growth cone  neutrophil chemotaxis  actin cytoskeleton reorganization  neuromuscular junction  homotypic cell-cell adhesion  identical protein binding  neuron projection  protein complex  cell body  membrane raft  cell-cell junction organization  gamma-delta T cell activation  viral entry into host cell  cardiac muscle fiber development  regulation of immune response  cell adhesion molecule binding  leukocyte migration  defense response to virus  transepithelial transport  connexin binding  AV node cell to bundle of His cell communication  
Ontology : EGO-EBIvirus receptor activity  acrosomal vesicle  receptor binding  integrin binding  protein binding  extracellular region  extracellular space  nucleoplasm  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cell-cell junction  adherens junction  bicellular tight junction  mitochondrion organization  heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  heart development  beta-catenin binding  germ cell migration  cell surface  epithelial structure maintenance  intercalated disc  basolateral plasma membrane  apicolateral plasma membrane  cell junction  PDZ domain binding  filopodium  growth cone  neutrophil chemotaxis  actin cytoskeleton reorganization  neuromuscular junction  homotypic cell-cell adhesion  identical protein binding  neuron projection  protein complex  cell body  membrane raft  cell-cell junction organization  gamma-delta T cell activation  viral entry into host cell  cardiac muscle fiber development  regulation of immune response  cell adhesion molecule binding  leukocyte migration  defense response to virus  transepithelial transport  connexin binding  AV node cell to bundle of His cell communication  
Pathways : KEGGViral myocarditis   
NDEx NetworkCXADR
Atlas of Cancer Signalling NetworkCXADR
Wikipedia pathwaysCXADR
Orthology - Evolution
OrthoDB1525
GeneTree (enSembl)ENSG00000154639
Phylogenetic Trees/Animal Genes : TreeFamCXADR
HOVERGENP78310
HOGENOMP78310
Homologs : HomoloGeneCXADR
Homology/Alignments : Family Browser (UCSC)CXADR
Gene fusions - Rearrangements
Fusion : MitelmanCXADR/CMC4 [21q21.1/Xq28]  
Fusion: TCGACXADR 21q21.1 MTCP1NB KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXADR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXADR
dbVarCXADR
ClinVarCXADR
1000_GenomesCXADR 
Exome Variant ServerCXADR
ExAC (Exome Aggregation Consortium)CXADR (select the gene name)
Genetic variants : HAPMAP1525
Genomic Variants (DGV)CXADR [DGVbeta]
DECIPHER (Syndromes)21:18885224-18942429  ENSG00000154639
CONAN: Copy Number AnalysisCXADR 
Mutations
ICGC Data PortalCXADR 
TCGA Data PortalCXADR 
Broad Tumor PortalCXADR
OASIS PortalCXADR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXADR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCXADR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXADR
DgiDB (Drug Gene Interaction Database)CXADR
DoCM (Curated mutations)CXADR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXADR (select a term)
intoGenCXADR
Cancer3DCXADR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602621   
Orphanet
MedgenCXADR
Genetic Testing Registry CXADR
NextProtP78310 [Medical]
TSGene1525
GENETestsCXADR
Huge Navigator CXADR [HugePedia]
snp3D : Map Gene to Disease1525
BioCentury BCIQCXADR
ClinGenCXADR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1525
Chemical/Pharm GKB GenePA27055
Clinical trialCXADR
Miscellaneous
canSAR (ICR)CXADR (select the gene name)
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXADR
EVEXCXADR
GoPubMedCXADR
iHOPCXADR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:58:05 CEST 2017

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