CXADR (CXADR Ig-like cell adhesion molecule)

2007-02-01  

Identity

HGNC
LOCATION
21q21.1
LOCUSID
ALIAS
CAR,CAR4/6,HCAR
FUSION GENES

Other Information

Locus ID:

NCBI: 1525
MIM: 602621
HGNC: 2559
Ensembl: ENSG00000154639

Variants:

dbSNP: 1525
ClinVar: 1525
TCGA: ENSG00000154639
COSMIC: CXADR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154639ENST00000284878P78310
ENSG00000154639ENST00000356275P78310
ENSG00000154639ENST00000400165P78310
ENSG00000154639ENST00000400166P78310
ENSG00000154639ENST00000400169P78310

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Viral myocarditisKEGGhsa05416
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218438682011Drifting motions of the adenovirus receptor CAR and immobile integrins initiate virus uncoating and membrane lytic protein exposure.71
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191315512009Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1.60
206228802010Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction.53
191194242009The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution.47
153649092004The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.46
169238082006Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor.46
153045262004A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth.38
155968632005Interaction with coxsackievirus and adenovirus receptor, but not with decay-accelerating factor (DAF), induces A-particle formation in a DAF-binding coxsackievirus B3 isolate.33
209490782010Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X.33

Citation

Dessen P

CXADR (CXADR Ig-like cell adhesion molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45974/cxadr