Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCL1 (chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha))

Identity

Other namesFSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
HGNC (Hugo) CXCL1
LocusID (NCBI) 2919
Atlas_Id 40217
Location 4q13.3
Location_base_pair Starts at 74735109 and ends at 74737019 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CXCL1   4602
Cards
Entrez_Gene (NCBI)CXCL1  2919  chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
GeneCards (Weizmann)CXCL1
Ensembl hg19 (Hinxton)ENSG00000163739 [Gene_View]  chr4:74735109-74737019 [Contig_View]  CXCL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163739 [Gene_View]  chr4:74735109-74737019 [Contig_View]  CXCL1 [Vega]
ICGC DataPortalENSG00000163739
TCGA cBioPortalCXCL1
AceView (NCBI)CXCL1
Genatlas (Paris)CXCL1
WikiGenes2919
SOURCE (Princeton)CXCL1
Genomic and cartography
GoldenPath hg19 (UCSC)CXCL1  -     chr4:74735109-74737019 +  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CXCL1  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblCXCL1 - 4q13.3 [CytoView hg19]  CXCL1 - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBICXCL1 [Mapview hg19]  CXCL1 [Mapview hg38]
OMIM155730   
Gene and transcription
Genbank (Entrez)BC011976 BG121608 BM554448 BM996663 BQ000742
RefSeq transcript (Entrez)NM_001511
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)CXCL1
Cluster EST : UnigeneHs.708652 [ NCBI ]
CGAP (NCI)Hs.708652
Alternative Splicing : Fast-db (Paris)GSHG0022658
Alternative Splicing GalleryENSG00000163739
Gene ExpressionCXCL1 [ NCBI-GEO ]     CXCL1 [ SEEK ]   CXCL1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09341 (Uniprot)
NextProtP09341  [Medical]
With graphics : InterProP09341
Splice isoforms : SwissVarP09341 (Swissvar)
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom   
Related proteins : CluSTrP09341
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM Disease mutations2919
Blocks (Seattle)P09341
PDB (SRS)1MGS    1MSG    1MSH    1ROD   
PDB (PDBSum)1MGS    1MSG    1MSH    1ROD   
PDB (IMB)1MGS    1MSG    1MSH    1ROD   
PDB (RSDB)1MGS    1MSG    1MSH    1ROD   
Human Protein AtlasENSG00000163739
Peptide AtlasP09341
HPRD01119
IPIIPI00013874   
Protein Interaction databases
DIP (DOE-UCLA)P09341
IntAct (EBI)P09341
FunCoupENSG00000163739
BioGRIDCXCL1
IntegromeDBCXCL1
STRING (EMBL)CXCL1
Ontologies - Pathways
QuickGOP09341
Ontology : AmiGOpositive regulation of leukocyte chemotaxis  receptor binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  nervous system development  chemokine activity  enzyme activator activity  growth factor activity  cell proliferation  negative regulation of cell proliferation  actin cytoskeleton organization  response to lipopolysaccharide  intracellular signal transduction  positive regulation of catalytic activity  CXCR chemokine receptor binding  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of leukocyte chemotaxis  receptor binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  nervous system development  chemokine activity  enzyme activator activity  growth factor activity  cell proliferation  negative regulation of cell proliferation  actin cytoskeleton organization  response to lipopolysaccharide  intracellular signal transduction  positive regulation of catalytic activity  CXCR chemokine receptor binding  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection    Legionellosis    Amoebiasis    Rheumatoid arthritis   
Protein Interaction DatabaseCXCL1
DoCM (Curated mutations)CXCL1
Wikipedia pathwaysCXCL1
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerCXCL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCL1
dbVarCXCL1
ClinVarCXCL1
1000_GenomesCXCL1 
Exome Variant ServerCXCL1
SNP (GeneSNP Utah)CXCL1
SNP : HGBaseCXCL1
Genetic variants : HAPMAPCXCL1
Genomic Variants (DGV)CXCL1 [DGVbeta]
Mutations
ICGC Data PortalCXCL1 
TCGA Data PortalCXCL1 
Tumor PortalCXCL1
Somatic Mutations in Cancer : COSMICCXCL1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:74735109-74737019
CONAN: Copy Number AnalysisCXCL1 
Mutations and Diseases : HGMDCXCL1
OMIM155730   
MedgenCXCL1
NextProtP09341 [Medical]
GENETestsCXCL1
Disease Genetic AssociationCXCL1
Huge Navigator CXCL1 [HugePedia]  CXCL1 [HugeCancerGEM]
snp3D : Map Gene to Disease2919
DGIdb (Drug Gene Interaction db)CXCL1
General knowledge
Homologs : HomoloGeneCXCL1
Homology/Alignments : Family Browser (UCSC)CXCL1
Phylogenetic Trees/Animal Genes : TreeFamCXCL1
Chemical/Protein Interactions : CTD2919
Chemical/Pharm GKB GenePA35050
Clinical trialCXCL1
Cancer Resource (Charite)ENSG00000163739
Other databases
Probes
Litterature
PubMed159 Pubmed reference(s) in Entrez
CoreMineCXCL1
GoPubMedCXCL1
iHOPCXCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:16:52 CEST 2015

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