Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CXCL1 (C-X-C motif chemokine ligand 1)

Identity

Alias (NCBI)FSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
HGNC (Hugo) CXCL1
HGNC Alias symbSCYB1
GROa
MGSA-a
NAP-3
HGNC Alias namemelanoma growth stimulating activity, alpha
HGNC Previous nameMGSA
 GRO1
 FSP
HGNC Previous nameGRO1 oncogene (melanoma growth stimulating activity, alpha)
 fibroblast secretory protein
 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
LocusID (NCBI) 2919
Atlas_Id 40217
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 73869393 and ends at 73871308 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNALI1 (1p34.3) / CXCL1 (4q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CXCL1   4602
Cards
Entrez_Gene (NCBI)CXCL1    C-X-C motif chemokine ligand 1
AliasesFSP; GRO1; GROa; MGSA; 
MGSA-a; NAP-3; SCYB1
GeneCards (Weizmann)CXCL1
Ensembl hg19 (Hinxton)ENSG00000163739 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163739 [Gene_View]  ENSG00000163739 [Sequence]  chr4:73869393-73871308 [Contig_View]  CXCL1 [Vega]
ICGC DataPortalENSG00000163739
TCGA cBioPortalCXCL1
AceView (NCBI)CXCL1
Genatlas (Paris)CXCL1
SOURCE (Princeton)CXCL1
Genetics Home Reference (NIH)CXCL1
Genomic and cartography
GoldenPath hg38 (UCSC)CXCL1  -     chr4:73869393-73871308 +  4q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CXCL1  -     4q13.3   [Description]    (hg19-Feb_2009)
GoldenPathCXCL1 - 4q13.3 [CytoView hg19]  CXCL1 - 4q13.3 [CytoView hg38]
ImmunoBaseENSG00000163739
genome Data Viewer NCBICXCL1 [Mapview hg19]  
OMIM155730   
Gene and transcription
Genbank (Entrez)BC011976 BG121608 BM554448 BM996663 BQ000742
RefSeq transcript (Entrez)NM_001511
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CXCL1
Alternative Splicing GalleryENSG00000163739
Gene ExpressionCXCL1 [ NCBI-GEO ]   CXCL1 [ EBI - ARRAY_EXPRESS ]   CXCL1 [ SEEK ]   CXCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCL1 [ Firebrowse - Broad ]
GenevisibleExpression of CXCL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2919
GTEX Portal (Tissue expression)CXCL1
Human Protein AtlasENSG00000163739-CXCL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09341   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09341  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09341
Splice isoforms : SwissVarP09341
PhosPhoSitePlusP09341
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom    CXC_Chemokine_domain    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CXCL1
Blocks (Seattle)CXCL1
PDB (RSDB)1MGS    1MSG    1MSH    1ROD   
PDB Europe1MGS    1MSG    1MSH    1ROD   
PDB (PDBSum)1MGS    1MSG    1MSH    1ROD   
PDB (IMB)1MGS    1MSG    1MSH    1ROD   
Structural Biology KnowledgeBase1MGS    1MSG    1MSH    1ROD   
SCOP (Structural Classification of Proteins)1MGS    1MSG    1MSH    1ROD   
CATH (Classification of proteins structures)1MGS    1MSG    1MSH    1ROD   
SuperfamilyP09341
Human Protein Atlas [tissue]ENSG00000163739-CXCL1 [tissue]
Peptide AtlasP09341
HPRD01119
IPIIPI00013874   
Protein Interaction databases
DIP (DOE-UCLA)P09341
IntAct (EBI)P09341
BioGRIDCXCL1
STRING (EMBL)CXCL1
ZODIACCXCL1
Ontologies - Pathways
QuickGOP09341
Ontology : AmiGOsignaling receptor binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G protein-coupled receptor signaling pathway  nervous system development  chemokine activity  enzyme activator activity  growth factor activity  negative regulation of cell proliferation  cytokine-mediated signaling pathway  actin cytoskeleton organization  neutrophil chemotaxis  leukocyte chemotaxis  intracellular signal transduction  specific granule lumen  positive regulation of catalytic activity  neutrophil degranulation  CXCR chemokine receptor binding  antimicrobial humoral immune response mediated by antimicrobial peptide  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  tertiary granule lumen  
Ontology : EGO-EBIsignaling receptor binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G protein-coupled receptor signaling pathway  nervous system development  chemokine activity  enzyme activator activity  growth factor activity  negative regulation of cell proliferation  cytokine-mediated signaling pathway  actin cytoskeleton organization  neutrophil chemotaxis  leukocyte chemotaxis  intracellular signal transduction  specific granule lumen  positive regulation of catalytic activity  neutrophil degranulation  CXCR chemokine receptor binding  antimicrobial humoral immune response mediated by antimicrobial peptide  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  tertiary granule lumen  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection    Legionellosis    Amoebiasis    Rheumatoid arthritis   
NDEx NetworkCXCL1
Atlas of Cancer Signalling NetworkCXCL1
Wikipedia pathwaysCXCL1
Orthology - Evolution
OrthoDB2919
GeneTree (enSembl)ENSG00000163739
Phylogenetic Trees/Animal Genes : TreeFamCXCL1
HOGENOMP09341
Homologs : HomoloGeneCXCL1
Homology/Alignments : Family Browser (UCSC)CXCL1
Gene fusions - Rearrangements
Fusion : QuiverCXCL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCL1 [hg38]
dbVarCXCL1
ClinVarCXCL1
MonarchCXCL1
1000_GenomesCXCL1 
Exome Variant ServerCXCL1
GNOMAD BrowserENSG00000163739
Varsome BrowserCXCL1
Genomic Variants (DGV)CXCL1 [DGVbeta]
DECIPHERCXCL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCXCL1 
Mutations
ICGC Data PortalCXCL1 
TCGA Data PortalCXCL1 
Broad Tumor PortalCXCL1
OASIS PortalCXCL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCXCL1
Mutations and Diseases : HGMDCXCL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCL1
DgiDB (Drug Gene Interaction Database)CXCL1
DoCM (Curated mutations)CXCL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCL1 (select a term)
intoGenCXCL1
Cancer3DCXCL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM155730   
Orphanet
DisGeNETCXCL1
MedgenCXCL1
Genetic Testing Registry CXCL1
NextProtP09341 [Medical]
GENETestsCXCL1
Target ValidationCXCL1
Huge Navigator CXCL1 [HugePedia]
ClinGenCXCL1
Clinical trials, drugs, therapy
MyCancerGenomeCXCL1
Protein Interactions : CTD
Pharm GKB GenePA35050
PharosP09341
Clinical trialCXCL1
Miscellaneous
canSAR (ICR)CXCL1 (select the gene name)
HarmonizomeCXCL1
DataMed IndexCXCL1
Probes
Litterature
PubMed244 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCXCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:11:57 CET 2021
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