Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CXCL1 (chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha))

Identity

Other namesFSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
HGNC (Hugo) CXCL1
LocusID (NCBI) 2919
Location 4q13.3
Location_base_pair Starts at 74735109 and ends at 74737019 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CXCL1   4602
Cards
Entrez_Gene (NCBI)CXCL1  2919  chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
GeneCards (Weizmann)CXCL1
Ensembl (Hinxton)ENSG00000163739 [Gene_View]  chr4:74735109-74737019 [Contig_View]  CXCL1 [Vega]
ICGC DataPortalENSG00000163739
cBioPortalCXCL1
AceView (NCBI)CXCL1
Genatlas (Paris)CXCL1
WikiGenes2919
SOURCE (Princeton)NM_001511
Genomic and cartography
GoldenPath (UCSC)CXCL1  -  4q13.3   chr4:74735109-74737019 +  4q13.3   [Description]    (hg19-Feb_2009)
EnsemblCXCL1 - 4q13.3 [CytoView]
Mapping of homologs : NCBICXCL1 [Mapview]
OMIM155730   
Gene and transcription
Genbank (Entrez)BC011976 BG121608 BM554448 BM996663 BQ000742
RefSeq transcript (Entrez)NM_001511
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838914 NW_004929320
Consensus coding sequences : CCDS (NCBI)CXCL1
Cluster EST : UnigeneHs.708652 [ NCBI ]
CGAP (NCI)Hs.708652
Alternative Splicing : Fast-db (Paris)GSHG0022658
Alternative Splicing GalleryENSG00000163739
Gene ExpressionCXCL1 [ NCBI-GEO ]     CXCL1 [ SEEK ]   CXCL1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09341 (Uniprot)
NextProtP09341  [Medical]
With graphics : InterProP09341
Splice isoforms : SwissVarP09341 (Swissvar)
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC [organisation]   Chemokine_CXC_CS [organisation]   Chemokine_IL8-like_dom [organisation]  
Related proteins : CluSTrP09341
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM Disease mutations2919
Blocks (Seattle)P09341
PDB (SRS)1MGS    1MSG    1MSH    1ROD   
PDB (PDBSum)1MGS    1MSG    1MSH    1ROD   
PDB (IMB)1MGS    1MSG    1MSH    1ROD   
PDB (RSDB)1MGS    1MSG    1MSH    1ROD   
Human Protein AtlasENSG00000163739 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP09341
HPRD01119
IPIIPI00013874   
Protein Interaction databases
DIP (DOE-UCLA)P09341
IntAct (EBI)P09341
FunCoupENSG00000163739
BioGRIDCXCL1
InParanoidP09341
Interologous Interaction database P09341
IntegromeDBCXCL1
STRING (EMBL)CXCL1
Ontologies - Pathways
Ontology : AmiGOreceptor binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  nervous system development  chemokine activity  enzyme activator activity  growth factor activity  cell proliferation  negative regulation of cell proliferation  actin cytoskeleton organization  intracellular signal transduction  positive regulation of catalytic activity  cell chemotaxis  cell chemotaxis  
Ontology : EGO-EBIreceptor binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  nervous system development  chemokine activity  enzyme activator activity  growth factor activity  cell proliferation  negative regulation of cell proliferation  actin cytoskeleton organization  intracellular signal transduction  positive regulation of catalytic activity  cell chemotaxis  cell chemotaxis  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection    Legionellosis    Amoebiasis    Rheumatoid arthritis   
Protein Interaction DatabaseCXCL1
Wikipedia pathwaysCXCL1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CXCL1
snp3D : Map Gene to Disease2919
SNP (GeneSNP Utah)CXCL1
SNP : HGBaseCXCL1
Genetic variants : HAPMAPCXCL1
Exome VariantCXCL1
1000_GenomesCXCL1 
ICGC programENSG00000163739 
Somatic Mutations in Cancer : COSMICCXCL1 
CONAN: Copy Number AnalysisCXCL1 
Mutations and Diseases : HGMDCXCL1
Genomic VariantsCXCL1  CXCL1 [DGVbeta]
dbVarCXCL1
ClinVarCXCL1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM155730   
MedgenCXCL1
GENETestsCXCL1
Disease Genetic AssociationCXCL1
Huge Navigator CXCL1 [HugePedia]  CXCL1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCXCL1
Homology/Alignments : Family Browser (UCSC)CXCL1
Phylogenetic Trees/Animal Genes : TreeFamCXCL1
Chemical/Protein Interactions : CTD2919
Chemical/Pharm GKB GenePA35050
Clinical trialCXCL1
Cancer Resource (Charite)ENSG00000163739
Other databases
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
CoreMineCXCL1
iHOPCXCL1
OncoSearchCXCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:50:25 CEST 2014
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