Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCL11 (C-X-C motif chemokine ligand 11)

Identity

Alias_namesSCYB9B
SCYB11
small inducible cytokine subfamily B (Cys-X-Cys), member 11
chemokine (C-X-C motif) ligand 11
Alias_symbol (synonym)H174
b-R1
I-TAC
IP-9
Other aliasIP9
HGNC (Hugo) CXCL11
LocusID (NCBI) 6373
Atlas_Id 50256
Location 4q21.1  [Link to chromosome band 4q21]
Location_base_pair Starts at 76033687 and ends at 76036197 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKL2 (4q21.1) / CXCL11 (4q21.1)ZZZ3 (1p31.1) / CXCL11 (4q21.1)CDKL2 4q21.1 / CXCL11 4q21.1
ZZZ3 1p31.1 / CXCL11 4q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXCL11   10638
Cards
Entrez_Gene (NCBI)CXCL11  6373  C-X-C motif chemokine ligand 11
AliasesH174; I-TAC; IP-9; IP9; 
SCYB11; SCYB9B; b-R1
GeneCards (Weizmann)CXCL11
Ensembl hg19 (Hinxton)ENSG00000169248 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169248 [Gene_View]  chr4:76033687-76036197 [Contig_View]  CXCL11 [Vega]
ICGC DataPortalENSG00000169248
TCGA cBioPortalCXCL11
AceView (NCBI)CXCL11
Genatlas (Paris)CXCL11
WikiGenes6373
SOURCE (Princeton)CXCL11
Genetics Home Reference (NIH)CXCL11
Genomic and cartography
GoldenPath hg38 (UCSC)CXCL11  -     chr4:76033687-76036197 -  4q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CXCL11  -     4q21.1   [Description]    (hg19-Feb_2009)
EnsemblCXCL11 - 4q21.1 [CytoView hg19]  CXCL11 - 4q21.1 [CytoView hg38]
Mapping of homologs : NCBICXCL11 [Mapview hg19]  CXCL11 [Mapview hg38]
OMIM604852   
Gene and transcription
Genbank (Entrez)AF002985 AF030514 AF352781 AL703031 BC005292
RefSeq transcript (Entrez)NM_001302123 NM_005409
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CXCL11
Cluster EST : UnigeneHs.632592 [ NCBI ]
CGAP (NCI)Hs.632592
Alternative Splicing GalleryENSG00000169248
Gene ExpressionCXCL11 [ NCBI-GEO ]   CXCL11 [ EBI - ARRAY_EXPRESS ]   CXCL11 [ SEEK ]   CXCL11 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCL11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6373
GTEX Portal (Tissue expression)CXCL11
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14625   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14625  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14625
Splice isoforms : SwissVarO14625
PhosPhoSitePlusO14625
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom    CXC_Chemokine_domain    CXCL11   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CXCL11
DMDM Disease mutations6373
Blocks (Seattle)CXCL11
PDB (SRS)1RJT   
PDB (PDBSum)1RJT   
PDB (IMB)1RJT   
PDB (RSDB)1RJT   
Structural Biology KnowledgeBase1RJT   
SCOP (Structural Classification of Proteins)1RJT   
CATH (Classification of proteins structures)1RJT   
SuperfamilyO14625
Human Protein AtlasENSG00000169248
Peptide AtlasO14625
HPRD05329
IPIIPI00023056   
Protein Interaction databases
DIP (DOE-UCLA)O14625
IntAct (EBI)O14625
FunCoupENSG00000169248
BioGRIDCXCL11
STRING (EMBL)CXCL11
ZODIACCXCL11
Ontologies - Pathways
QuickGOO14625
Ontology : AmiGOpositive regulation of leukocyte chemotaxis  protein binding  extracellular region  extracellular space  cell  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  heparin binding  T cell chemotaxis  positive regulation of cAMP metabolic process  response to lipopolysaccharide  regulation of cell proliferation  positive regulation of cAMP-mediated signaling  CXCR3 chemokine receptor binding  positive regulation of release of sequestered calcium ion into cytosol  chemokine-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of leukocyte chemotaxis  protein binding  extracellular region  extracellular space  cell  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  heparin binding  T cell chemotaxis  positive regulation of cAMP metabolic process  response to lipopolysaccharide  regulation of cell proliferation  positive regulation of cAMP-mediated signaling  CXCR3 chemokine receptor binding  positive regulation of release of sequestered calcium ion into cytosol  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Toll-like receptor signaling pathway   
NDEx NetworkCXCL11
Atlas of Cancer Signalling NetworkCXCL11
Wikipedia pathwaysCXCL11
Orthology - Evolution
OrthoDB6373
GeneTree (enSembl)ENSG00000169248
Phylogenetic Trees/Animal Genes : TreeFamCXCL11
HOVERGENO14625
HOGENOMO14625
Homologs : HomoloGeneCXCL11
Homology/Alignments : Family Browser (UCSC)CXCL11
Gene fusions - Rearrangements
Fusion : MitelmanCDKL2/CXCL11 [4q21.1/4q21.1]  [t(4;4)(q21;q21)]  
Fusion : MitelmanZZZ3/CXCL11 [1p31.1/4q21.1]  [t(1;4)(p31;q21)]  
Fusion: TCGACDKL2 4q21.1 CXCL11 4q21.1 LUAD
Fusion: TCGAZZZ3 1p31.1 CXCL11 4q21.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCL11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCL11
dbVarCXCL11
ClinVarCXCL11
1000_GenomesCXCL11 
Exome Variant ServerCXCL11
ExAC (Exome Aggregation Consortium)CXCL11 (select the gene name)
Genetic variants : HAPMAP6373
Genomic Variants (DGV)CXCL11 [DGVbeta]
DECIPHERCXCL11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCXCL11 
Mutations
ICGC Data PortalCXCL11 
TCGA Data PortalCXCL11 
Broad Tumor PortalCXCL11
OASIS PortalCXCL11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCL11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCXCL11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCL11
DgiDB (Drug Gene Interaction Database)CXCL11
DoCM (Curated mutations)CXCL11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCL11 (select a term)
intoGenCXCL11
Cancer3DCXCL11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604852   
Orphanet
MedgenCXCL11
Genetic Testing Registry CXCL11
NextProtO14625 [Medical]
TSGene6373
GENETestsCXCL11
Huge Navigator CXCL11 [HugePedia]
snp3D : Map Gene to Disease6373
BioCentury BCIQCXCL11
ClinGenCXCL11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6373
Chemical/Pharm GKB GenePA35569
Clinical trialCXCL11
Miscellaneous
canSAR (ICR)CXCL11 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXCL11
EVEXCXCL11
GoPubMedCXCL11
iHOPCXCL11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:12:21 CEST 2017

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