CXCL14 (C-X-C motif chemokine ligand 14)

2007-02-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
BMAC,BRAK,KEC,KS1,MIP-2g,MIP2G,NJAC,SCYB14
FUSION GENES

Other Information

Locus ID:

NCBI: 9547
MIM: 604186
HGNC: 10640
Ensembl: ENSG00000145824

Variants:

dbSNP: 9547
ClinVar: 9547
TCGA: ENSG00000145824
COSMIC: CXCL14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145824ENST00000337225O95715
ENSG00000145824ENST00000512158A0A0C4DGC1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
155486932004BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells.70
192184292009CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
158435472005Loss of new chemokine CXCL14 in tumor tissue is associated with low infiltration by dendritic cells (DC), while restoration of human CXCL14 expression in tumor cells causes attraction of DC both in vitro and in vivo.61
192763622009Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism.58
205629172010Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis.43
280875992017Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer.42
187655272008Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression.34

Citation

Dessen P

CXCL14 (C-X-C motif chemokine ligand 14)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46220/cxcl14