Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCL2 (C-X-C motif chemokine ligand 2)

Identity

Alias_namesGRO2
GRO2 oncogene
chemokine (C-X-C motif) ligand 2
Alias_symbol (synonym)SCYB2
GROb
MIP-2a
MGSA-b
CINC-2a
Other aliasMIP2
MIP2A
HGNC (Hugo) CXCL2
LocusID (NCBI) 2920
Atlas_Id 40221
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 74962754 and ends at 74964997 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXCL2   4603
Cards
Entrez_Gene (NCBI)CXCL2  2920  C-X-C motif chemokine ligand 2
AliasesCINC-2a; GRO2; GROb; MGSA-b; 
MIP-2a; MIP2; MIP2A; SCYB2
GeneCards (Weizmann)CXCL2
Ensembl hg19 (Hinxton)ENSG00000081041 [Gene_View]  chr4:74962754-74964997 [Contig_View]  CXCL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000081041 [Gene_View]  chr4:74962754-74964997 [Contig_View]  CXCL2 [Vega]
ICGC DataPortalENSG00000081041
TCGA cBioPortalCXCL2
AceView (NCBI)CXCL2
Genatlas (Paris)CXCL2
WikiGenes2920
SOURCE (Princeton)CXCL2
Genetics Home Reference (NIH)CXCL2
Genomic and cartography
GoldenPath hg19 (UCSC)CXCL2  -     chr4:74962754-74964997 -  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CXCL2  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblCXCL2 - 4q13.3 [CytoView hg19]  CXCL2 - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBICXCL2 [Mapview hg19]  CXCL2 [Mapview hg38]
OMIM139110   
Gene and transcription
Genbank (Entrez)AF043340 AK308504 BC015753 BC053653 BX334969
RefSeq transcript (Entrez)NM_002089
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)CXCL2
Cluster EST : UnigeneHs.75765 [ NCBI ]
CGAP (NCI)Hs.75765
Alternative Splicing GalleryENSG00000081041
Gene ExpressionCXCL2 [ NCBI-GEO ]   CXCL2 [ EBI - ARRAY_EXPRESS ]   CXCL2 [ SEEK ]   CXCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2920
GTEX Portal (Tissue expression)CXCL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19875   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19875  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19875
Splice isoforms : SwissVarP19875
PhosPhoSitePlusP19875
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CXCL2
DMDM Disease mutations2920
Blocks (Seattle)CXCL2
PDB (SRS)1QNK   
PDB (PDBSum)1QNK   
PDB (IMB)1QNK   
PDB (RSDB)1QNK   
Structural Biology KnowledgeBase1QNK   
SCOP (Structural Classification of Proteins)1QNK   
CATH (Classification of proteins structures)1QNK   
SuperfamilyP19875
Human Protein AtlasENSG00000081041
Peptide AtlasP19875
HPRD00741
IPIIPI00021067   
Protein Interaction databases
DIP (DOE-UCLA)P19875
IntAct (EBI)P19875
FunCoupENSG00000081041
BioGRIDCXCL2
STRING (EMBL)CXCL2
ZODIACCXCL2
Ontologies - Pathways
QuickGOP19875
Ontology : AmiGOresponse to molecule of bacterial origin  protein binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  G-protein coupled receptor signaling pathway  chemokine activity  response to lipopolysaccharide  regulation of cell proliferation  CXCR chemokine receptor binding  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  positive regulation of neutrophil chemotaxis  
Ontology : EGO-EBIresponse to molecule of bacterial origin  protein binding  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  G-protein coupled receptor signaling pathway  chemokine activity  response to lipopolysaccharide  regulation of cell proliferation  CXCR chemokine receptor binding  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  positive regulation of neutrophil chemotaxis  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NF-kappa B signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Salmonella infection    Legionellosis   
NDEx NetworkCXCL2
Atlas of Cancer Signalling NetworkCXCL2
Wikipedia pathwaysCXCL2
Orthology - Evolution
OrthoDB2920
GeneTree (enSembl)ENSG00000081041
Phylogenetic Trees/Animal Genes : TreeFamCXCL2
HOVERGENP19875
HOGENOMP19875
Homologs : HomoloGeneCXCL2
Homology/Alignments : Family Browser (UCSC)CXCL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCL2
dbVarCXCL2
ClinVarCXCL2
1000_GenomesCXCL2 
Exome Variant ServerCXCL2
ExAC (Exome Aggregation Consortium)CXCL2 (select the gene name)
Genetic variants : HAPMAP2920
Genomic Variants (DGV)CXCL2 [DGVbeta]
DECIPHER (Syndromes)4:74962754-74964997  ENSG00000081041
CONAN: Copy Number AnalysisCXCL2 
Mutations
ICGC Data PortalCXCL2 
TCGA Data PortalCXCL2 
Broad Tumor PortalCXCL2
OASIS PortalCXCL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCXCL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCL2
DgiDB (Drug Gene Interaction Database)CXCL2
DoCM (Curated mutations)CXCL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCL2 (select a term)
intoGenCXCL2
Cancer3DCXCL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139110   
Orphanet
MedgenCXCL2
Genetic Testing Registry CXCL2
NextProtP19875 [Medical]
TSGene2920
GENETestsCXCL2
Huge Navigator CXCL2 [HugePedia]
snp3D : Map Gene to Disease2920
BioCentury BCIQCXCL2
ClinGenCXCL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2920
Chemical/Pharm GKB GenePA35051
Clinical trialCXCL2
Miscellaneous
canSAR (ICR)CXCL2 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXCL2
EVEXCXCL2
GoPubMedCXCL2
iHOPCXCL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:58:06 CEST 2017

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