CXCL6 (C-X-C motif chemokine ligand 6)

2007-02-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
CKA-3,GCP-2,GCP2,SCYB6

Other Information

Locus ID:

NCBI: 6372
MIM: 138965
HGNC: 10643
Ensembl: ENSG00000124875

Variants:

dbSNP: 6372
ClinVar: 6372
TCGA: ENSG00000124875
COSMIC: CXCL6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124875ENST00000226317P80162
ENSG00000124875ENST00000515050D6RF92

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
PertussisKEGGko05133
PertussisKEGGhsa05133
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

References

Pubmed IDYearTitleCitations
368920252023circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6.0
376124292023CXCL6: A potential therapeutic target for inflammation and cancer.2
368920252023circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6.0
376124292023CXCL6: A potential therapeutic target for inflammation and cancer.2
328681342021Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6.7
331676882021Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia.3
332419542021CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.16
333682922021CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.13
328681342021Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6.7
331676882021Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia.3
332419542021CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.16
333682922021CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.13
321857592020Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis.4
321857592020Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis.4
306053522019Wound exudate CXCL6: a potential biomarker for wound healing of diabetic foot ulcers.9

Citation

Dessen P

CXCL6 (C-X-C motif chemokine ligand 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46373/cxcl6