Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCL6 (C-X-C motif chemokine ligand 6)

Identity

Alias_namesSCYB6
small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2)
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chemokine (C-X-C motif) ligand 6
Alias_symbol (synonym)GCP-2
CKA-3
Other aliasGCP2
HGNC (Hugo) CXCL6
LocusID (NCBI) 6372
Atlas_Id 46373
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 74702273 and ends at 74704477 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXCL6   10643
Cards
Entrez_Gene (NCBI)CXCL6  6372  C-X-C motif chemokine ligand 6
AliasesCKA-3; GCP-2; GCP2; SCYB6
GeneCards (Weizmann)CXCL6
Ensembl hg19 (Hinxton)ENSG00000124875 [Gene_View]  chr4:74702273-74704477 [Contig_View]  CXCL6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000124875 [Gene_View]  chr4:74702273-74704477 [Contig_View]  CXCL6 [Vega]
ICGC DataPortalENSG00000124875
TCGA cBioPortalCXCL6
AceView (NCBI)CXCL6
Genatlas (Paris)CXCL6
WikiGenes6372
SOURCE (Princeton)CXCL6
Genetics Home Reference (NIH)CXCL6
Genomic and cartography
GoldenPath hg19 (UCSC)CXCL6  -     chr4:74702273-74704477 +  4q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CXCL6  -     4q13.3   [Description]    (hg38-Dec_2013)
EnsemblCXCL6 - 4q13.3 [CytoView hg19]  CXCL6 - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBICXCL6 [Mapview hg19]  CXCL6 [Mapview hg38]
OMIM138965   
Gene and transcription
Genbank (Entrez)AK311981 BC013744 BP204144 DQ891500 DQ894692
RefSeq transcript (Entrez)NM_002993
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)CXCL6
Cluster EST : UnigeneHs.164021 [ NCBI ]
CGAP (NCI)Hs.164021
Alternative Splicing GalleryENSG00000124875
Gene ExpressionCXCL6 [ NCBI-GEO ]   CXCL6 [ EBI - ARRAY_EXPRESS ]   CXCL6 [ SEEK ]   CXCL6 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6372
GTEX Portal (Tissue expression)CXCL6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80162   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80162  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80162
Splice isoforms : SwissVarP80162
PhosPhoSitePlusP80162
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CXCL6
DMDM Disease mutations6372
Blocks (Seattle)CXCL6
SuperfamilyP80162
Human Protein AtlasENSG00000124875
Peptide AtlasP80162
HPRD00735
IPIIPI00008079   IPI00177494   IPI00964487   
Protein Interaction databases
DIP (DOE-UCLA)P80162
IntAct (EBI)P80162
FunCoupENSG00000124875
BioGRIDCXCL6
STRING (EMBL)CXCL6
ZODIACCXCL6
Ontologies - Pathways
QuickGOP80162
Ontology : AmiGOneutrophil mediated immunity  positive regulation of leukocyte chemotaxis  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  heparin binding  response to lipopolysaccharide  regulation of cell proliferation  defense response to bacterium  CXCR chemokine receptor binding  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  
Ontology : EGO-EBIneutrophil mediated immunity  positive regulation of leukocyte chemotaxis  extracellular region  extracellular space  chemotaxis  inflammatory response  immune response  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  heparin binding  response to lipopolysaccharide  regulation of cell proliferation  defense response to bacterium  CXCR chemokine receptor binding  cell chemotaxis  cell chemotaxis  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Pertussis    Rheumatoid arthritis   
NDEx NetworkCXCL6
Atlas of Cancer Signalling NetworkCXCL6
Wikipedia pathwaysCXCL6
Orthology - Evolution
OrthoDB6372
GeneTree (enSembl)ENSG00000124875
Phylogenetic Trees/Animal Genes : TreeFamCXCL6
HOVERGENP80162
HOGENOMP80162
Homologs : HomoloGeneCXCL6
Homology/Alignments : Family Browser (UCSC)CXCL6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCL6
dbVarCXCL6
ClinVarCXCL6
1000_GenomesCXCL6 
Exome Variant ServerCXCL6
ExAC (Exome Aggregation Consortium)CXCL6 (select the gene name)
Genetic variants : HAPMAP6372
Genomic Variants (DGV)CXCL6 [DGVbeta]
DECIPHER (Syndromes)4:74702273-74704477  ENSG00000124875
CONAN: Copy Number AnalysisCXCL6 
Mutations
ICGC Data PortalCXCL6 
TCGA Data PortalCXCL6 
Broad Tumor PortalCXCL6
OASIS PortalCXCL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCL6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCXCL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCL6
DgiDB (Drug Gene Interaction Database)CXCL6
DoCM (Curated mutations)CXCL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCL6 (select a term)
intoGenCXCL6
Cancer3DCXCL6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138965   
Orphanet
MedgenCXCL6
Genetic Testing Registry CXCL6
NextProtP80162 [Medical]
TSGene6372
GENETestsCXCL6
Huge Navigator CXCL6 [HugePedia]
snp3D : Map Gene to Disease6372
BioCentury BCIQCXCL6
ClinGenCXCL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6372
Chemical/Pharm GKB GenePA35574
Clinical trialCXCL6
Miscellaneous
canSAR (ICR)CXCL6 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXCL6
EVEXCXCL6
GoPubMedCXCL6
iHOPCXCL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:02:20 CET 2017

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