Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCL8 (C-X-C motif chemokine ligand 8)

Identity

Alias_namesIL8
interleukin 8
chemokine (C-X-C motif) ligand 8
Alias_symbol (synonym)SCYB8
LUCT
LECT
MDNCF
TSG-1
IL-8
NAP-1
3-10C
MONAP
AMCF-I
LYNAP
NAF
b-ENAP
GCP-1
K60
GCP1
NAP1
Other alias
HGNC (Hugo) CXCL8
LocusID (NCBI) 3576
Atlas_Id 53870
Location 4q13.3  [Link to chromosome band 4q13]
Location_base_pair Starts at 73740506 and ends at 73743716 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CXCL8 (4q13.3) / ARNT2 (15q25.1)CXCL8 (4q13.3) / NDC1 (1p32.3)NKIRAS1 (3p24.2) / CXCL8 (4q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXCL8   6025
Cards
Entrez_Gene (NCBI)CXCL8  3576  C-X-C motif chemokine ligand 8
AliasesGCP-1; GCP1; IL8; LECT; 
LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1
GeneCards (Weizmann)CXCL8
Ensembl hg19 (Hinxton)ENSG00000169429 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169429 [Gene_View]  chr4:73740506-73743716 [Contig_View]  CXCL8 [Vega]
ICGC DataPortalENSG00000169429
TCGA cBioPortalCXCL8
AceView (NCBI)CXCL8
Genatlas (Paris)CXCL8
WikiGenes3576
SOURCE (Princeton)CXCL8
Genetics Home Reference (NIH)CXCL8
Genomic and cartography
GoldenPath hg38 (UCSC)CXCL8  -     chr4:73740506-73743716 +  4q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CXCL8  -     4q13.3   [Description]    (hg19-Feb_2009)
EnsemblCXCL8 - 4q13.3 [CytoView hg19]  CXCL8 - 4q13.3 [CytoView hg38]
Mapping of homologs : NCBICXCL8 [Mapview hg19]  CXCL8 [Mapview hg38]
OMIM146930   
Gene and transcription
Genbank (Entrez)AJ227913 AK131067 AK311874 BC013615 BG497712
RefSeq transcript (Entrez)NM_000584
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CXCL8
Cluster EST : UnigeneHs.624 [ NCBI ]
CGAP (NCI)Hs.624
Alternative Splicing GalleryENSG00000169429
Gene ExpressionCXCL8 [ NCBI-GEO ]   CXCL8 [ EBI - ARRAY_EXPRESS ]   CXCL8 [ SEEK ]   CXCL8 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCL8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3576
GTEX Portal (Tissue expression)CXCL8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10145   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10145  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10145
Splice isoforms : SwissVarP10145
PhosPhoSitePlusP10145
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CXC (PS00471)   
Domains : Interpro (EBI)Chemokine_CXC    Chemokine_CXC_CS    Chemokine_IL8-like_dom    CXC_Chemokine_domain    Interleukin-8   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CXCL8
DMDM Disease mutations3576
Blocks (Seattle)CXCL8
PDB (SRS)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
PDB (PDBSum)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
PDB (IMB)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
PDB (RSDB)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
Structural Biology KnowledgeBase1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
SCOP (Structural Classification of Proteins)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
CATH (Classification of proteins structures)1ICW    1IKL    1IKM    1IL8    1ILP    1ILQ    1QE6    1ROD    2IL8    3IL8    4XDX    5D14   
SuperfamilyP10145
Human Protein AtlasENSG00000169429
Peptide AtlasP10145
HPRD00909
IPIIPI00288914   IPI00215621   IPI00894389   
Protein Interaction databases
DIP (DOE-UCLA)P10145
IntAct (EBI)P10145
FunCoupENSG00000169429
BioGRIDCXCL8
STRING (EMBL)CXCL8
ZODIACCXCL8
Ontologies - Pathways
QuickGOP10145
Ontology : AmiGOangiogenesis  response to molecule of bacterial origin  interleukin-8 receptor binding  protein binding  extracellular region  extracellular space  intracellular  movement of cell or subcellular component  chemotaxis  inflammatory response  immune response  cell cycle arrest  signal transduction  G-protein coupled receptor signaling pathway  chemokine activity  chemokine activity  negative regulation of cell proliferation  calcium-mediated signaling  regulation of cell adhesion  neutrophil chemotaxis  neutrophil chemotaxis  receptor internalization  response to endoplasmic reticulum stress  intracellular signal transduction  PERK-mediated unfolded protein response  neutrophil activation  neutrophil activation  cellular response to fibroblast growth factor stimulus  regulation of single stranded viral RNA replication via double stranded DNA intermediate  negative regulation of G-protein coupled receptor protein signaling pathway  positive regulation of angiogenesis  embryonic digestive tract development  induction of positive chemotaxis  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of neutrophil chemotaxis  regulation of entry of bacterium into host cell  
Ontology : EGO-EBIangiogenesis  response to molecule of bacterial origin  interleukin-8 receptor binding  protein binding  extracellular region  extracellular space  intracellular  movement of cell or subcellular component  chemotaxis  inflammatory response  immune response  cell cycle arrest  signal transduction  G-protein coupled receptor signaling pathway  chemokine activity  chemokine activity  negative regulation of cell proliferation  calcium-mediated signaling  regulation of cell adhesion  neutrophil chemotaxis  neutrophil chemotaxis  receptor internalization  response to endoplasmic reticulum stress  intracellular signal transduction  PERK-mediated unfolded protein response  neutrophil activation  neutrophil activation  cellular response to fibroblast growth factor stimulus  regulation of single stranded viral RNA replication via double stranded DNA intermediate  negative regulation of G-protein coupled receptor protein signaling pathway  positive regulation of angiogenesis  embryonic digestive tract development  induction of positive chemotaxis  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of neutrophil chemotaxis  regulation of entry of bacterium into host cell  
Pathways : BIOCARTA [Genes]   
NDEx NetworkCXCL8
Atlas of Cancer Signalling NetworkCXCL8
Wikipedia pathwaysCXCL8
Orthology - Evolution
OrthoDB3576
GeneTree (enSembl)ENSG00000169429
Phylogenetic Trees/Animal Genes : TreeFamCXCL8
HOVERGENP10145
HOGENOMP10145
Homologs : HomoloGeneCXCL8
Homology/Alignments : Family Browser (UCSC)CXCL8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCL8
dbVarCXCL8
ClinVarCXCL8
1000_GenomesCXCL8 
Exome Variant ServerCXCL8
ExAC (Exome Aggregation Consortium)CXCL8 (select the gene name)
Genetic variants : HAPMAP3576
Genomic Variants (DGV)CXCL8 [DGVbeta]
DECIPHERCXCL8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCXCL8 
Mutations
ICGC Data PortalCXCL8 
TCGA Data PortalCXCL8 
Broad Tumor PortalCXCL8
OASIS PortalCXCL8 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCXCL8
BioMutasearch CXCL8
DgiDB (Drug Gene Interaction Database)CXCL8
DoCM (Curated mutations)CXCL8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCL8 (select a term)
intoGenCXCL8
Cancer3DCXCL8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146930   
Orphanet
MedgenCXCL8
Genetic Testing Registry CXCL8
NextProtP10145 [Medical]
TSGene3576
GENETestsCXCL8
Target ValidationCXCL8
Huge Navigator CXCL8 [HugePedia]
snp3D : Map Gene to Disease3576
BioCentury BCIQCXCL8
ClinGenCXCL8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3576
Chemical/Pharm GKB GenePA29841
Clinical trialCXCL8
Miscellaneous
canSAR (ICR)CXCL8 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXCL8
EVEXCXCL8
GoPubMedCXCL8
iHOPCXCL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 16:58:59 CEST 2017

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