Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CXCR2 (chemokine (C-X-C motif) receptor 2)

Identity

Other namesCD182
CDw128b
CMKAR2
IL8R2
IL8RA
IL8RB
HGNC (Hugo) CXCR2
LocusID (NCBI) 3579
Location 2q35
Location_base_pair Starts at 218990013 and ends at 219001976 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)CXCR2   6027
Entrez_Gene (NCBI)CXCR2  3579  chemokine (C-X-C motif) receptor 2
Cards
GeneCards (Weizmann)CXCR2
Ensembl (Hinxton)ENSG00000180871 [Gene_View]  chr2:218990013-219001976 [Contig_View]  CXCR2 [Vega]
AceView (NCBI)CXCR2
Genatlas (Paris)CXCR2
SOURCE (Stanford)NM_001168298 NM_001557
Genomic and cartography
GoldenPath (UCSC)CXCR2  -  2q35   chr2:218990013-219001976 +  2q35   [Description]    (hg19-Feb_2009)
EnsemblCXCR2 - 2q35 [CytoView]
Mapping of homologs : NCBICXCR2 [Mapview]
OMIM146928   
Gene and transcription
Genbank (Entrez)AJ710879 AK290906 AK312664 BC037961 DA670033
RefSeq transcript (SRS)NM_001168298 NM_001557
RefSeq transcript (Entrez)NM_001168298 NM_001557
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838865 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_005403 NW_001838865 NW_004078008
Consensus coding sequences : CCDS (NCBI)CXCR2
Cluster EST : UnigeneHs.846 [ SRS ] Hs.846 [ NCBI ]
CGAP (NCI)Hs.846
Alternative Splicing : Fast-db (Paris)GSHG0017185
Alternative Splicing GalleryENSG00000180871
Gene ExpressionCXCR2 [ NCBI-GEO ]   CXCR2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25025 (SRS) P25025 (Uniprot)
NextProtP25025
With graphics : InterProP25025
Splice isoforms : SwissVarP25025(Swissvar)
Domaine pattern : Prosite (SRS)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (SRS)7TM_GPCR_Rhodpsn    Chemokine_CXC/IL8_rcpt    Chemokine_CXCR2/IL8RB    GPCR_Rhodpsn_supfam   
Domains : Interpro (EBI)7TM_GPCR_Rhodpsn    Chemokine_CXC/IL8_rcpt    Chemokine_CXCR2/IL8RB    GPCR_Rhodpsn_supfam   
Related proteins : CluSTrP25025
Domain families : Pfam (SRS)7tm_1 (PF00001)   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
DMDM3579
Blocks (Seattle)P25025
Human Protein AtlasENSG00000180871
HPRD00907
IPIIPI00012320   IPI00926680   IPI00927014   IPI00927219   IPI00927459   IPI00927903   
Protein Interaction databases
DIP (DOE-UCLA)P25025
IntAct (EBI)P25025
FunCoupENSG00000180871
REACTOMECXCR2
Protein Interaction Database3579
BioGRIDCXCR2
InParanoidP25025
Interologous Interaction database P25025
IntegromeDBCXCR2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CXCR2
SNP (GeneSNP Utah)CXCR2
SNP : HGBaseCXCR2
Genetic variants : HAPMAPCXCR2
Somatic Mutations in Cancer : COSMICCXCR2 
CONAN: Copy Number AnalysisCXCR2 
Mutations and Diseases : HGMDCXCR2
OMIM146928   
GENETests146928   
Disease Genetic AssociationCXCR2
Huge Navigator CXCR2 [HugePedia]  CXCR2 [HugeCancerGEM]
Genomic VariantsCXCR2  CXCR2 [DGVbeta]
snp3D : Map Gene to Disease3579
General knowledge
Homologs : HomoloGeneCXCR2
Homology/Alignments : Family Browser (UCSC)CXCR2
Phylogenetic Trees/Animal Genes : TreeFamCXCR2
Chemical/Protein Interactions : CTD3579
Chemical/Pharm GKB GenePA29843
Clinical trialCXCR2
Cancer Resource (Charite)ENSG00000180871
Ontology : AmiGOdendritic cell chemotaxis  signal transducer activity  interleukin-8 receptor activity  intracellular  plasma membrane  integral to plasma membrane  apoptotic process  chemotaxis  inflammatory response  cellular defense response  signal transduction  cell surface receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  cell surface  membrane  C-X-C chemokine receptor activity  interleukin-8 binding  neutrophil chemotaxis  receptor internalization  interleukin-8-mediated signaling pathway  neutrophil activation  mast cell granule  
Ontology : EGO-EBIdendritic cell chemotaxis  signal transducer activity  interleukin-8 receptor activity  intracellular  plasma membrane  integral to plasma membrane  apoptotic process  chemotaxis  inflammatory response  cellular defense response  signal transduction  cell surface receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  cell surface  membrane  C-X-C chemokine receptor activity  interleukin-8 binding  neutrophil chemotaxis  receptor internalization  interleukin-8-mediated signaling pathway  neutrophil activation  mast cell granule  
Pathways : KEGGEpithelial cell signaling in Helicobacter pylori infectionCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
PubGeneCXCR2
iHOPCXCR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:11 CEST 2013
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