Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCR2 (C-X-C motif chemokine receptor 2)

Identity

Alias_namesIL8RB
interleukin 8 receptor, beta
chemokine (C-X-C motif) receptor 2
Alias_symbol (synonym)CMKAR2
CD182
Other aliasCDw128b
IL8R2
IL8RA
HGNC (Hugo) CXCR2
LocusID (NCBI) 3579
Atlas_Id 51226
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218990013 and ends at 219001976 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXCR2   6027
Cards
Entrez_Gene (NCBI)CXCR2  3579  C-X-C motif chemokine receptor 2
AliasesCD182; CDw128b; CMKAR2; IL8R2; 
IL8RA; IL8RB
GeneCards (Weizmann)CXCR2
Ensembl hg19 (Hinxton)ENSG00000180871 [Gene_View]  chr2:218990013-219001976 [Contig_View]  CXCR2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000180871 [Gene_View]  chr2:218990013-219001976 [Contig_View]  CXCR2 [Vega]
ICGC DataPortalENSG00000180871
TCGA cBioPortalCXCR2
AceView (NCBI)CXCR2
Genatlas (Paris)CXCR2
WikiGenes3579
SOURCE (Princeton)CXCR2
Genetics Home Reference (NIH)CXCR2
Genomic and cartography
GoldenPath hg19 (UCSC)CXCR2  -     chr2:218990013-219001976 +  2q35   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CXCR2  -     2q35   [Description]    (hg38-Dec_2013)
EnsemblCXCR2 - 2q35 [CytoView hg19]  CXCR2 - 2q35 [CytoView hg38]
Mapping of homologs : NCBICXCR2 [Mapview hg19]  CXCR2 [Mapview hg38]
OMIM146928   
Gene and transcription
Genbank (Entrez)AJ710879 AK290906 AK312664 BC037961 DA670033
RefSeq transcript (Entrez)NM_001168298 NM_001557
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)CXCR2
Cluster EST : UnigeneHs.846 [ NCBI ]
CGAP (NCI)Hs.846
Alternative Splicing GalleryENSG00000180871
Gene ExpressionCXCR2 [ NCBI-GEO ]   CXCR2 [ EBI - ARRAY_EXPRESS ]   CXCR2 [ SEEK ]   CXCR2 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3579
GTEX Portal (Tissue expression)CXCR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25025   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25025  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25025
Splice isoforms : SwissVarP25025
PhosPhoSitePlusP25025
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CXCR2    Chemokine_CXCR_1/2    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CXCR2
DMDM Disease mutations3579
Blocks (Seattle)CXCR2
PDB (SRS)4Q3H   
PDB (PDBSum)4Q3H   
PDB (IMB)4Q3H   
PDB (RSDB)4Q3H   
Structural Biology KnowledgeBase4Q3H   
SCOP (Structural Classification of Proteins)4Q3H   
CATH (Classification of proteins structures)4Q3H   
SuperfamilyP25025
Human Protein AtlasENSG00000180871
Peptide AtlasP25025
HPRD00907
IPIIPI00012320   IPI00926680   IPI00927014   IPI00927219   IPI00927459   IPI00927903   
Protein Interaction databases
DIP (DOE-UCLA)P25025
IntAct (EBI)P25025
FunCoupENSG00000180871
BioGRIDCXCR2
STRING (EMBL)CXCR2
ZODIACCXCR2
Ontologies - Pathways
QuickGOP25025
Ontology : AmiGOdendritic cell chemotaxis  signal transducer activity  interleukin-8 receptor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  chemotaxis  inflammatory response  cellular defense response  signal transduction  cell surface receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  cell surface  membrane  C-X-C chemokine receptor activity  interleukin-8 binding  neutrophil chemotaxis  receptor internalization  interleukin-8-mediated signaling pathway  neutrophil activation  mast cell granule  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  
Ontology : EGO-EBIdendritic cell chemotaxis  signal transducer activity  interleukin-8 receptor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  chemotaxis  inflammatory response  cellular defense response  signal transduction  cell surface receptor signaling pathway  phospholipase C-activating G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  cell surface  membrane  C-X-C chemokine receptor activity  interleukin-8 binding  neutrophil chemotaxis  receptor internalization  interleukin-8-mediated signaling pathway  neutrophil activation  mast cell granule  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Endocytosis    Epithelial cell signaling in Helicobacter pylori infection   
NDEx NetworkCXCR2
Atlas of Cancer Signalling NetworkCXCR2
Wikipedia pathwaysCXCR2
Orthology - Evolution
OrthoDB3579
GeneTree (enSembl)ENSG00000180871
Phylogenetic Trees/Animal Genes : TreeFamCXCR2
HOVERGENP25025
HOGENOMP25025
Homologs : HomoloGeneCXCR2
Homology/Alignments : Family Browser (UCSC)CXCR2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCR2
dbVarCXCR2
ClinVarCXCR2
1000_GenomesCXCR2 
Exome Variant ServerCXCR2
ExAC (Exome Aggregation Consortium)CXCR2 (select the gene name)
Genetic variants : HAPMAP3579
Genomic Variants (DGV)CXCR2 [DGVbeta]
DECIPHER (Syndromes)2:218990013-219001976  ENSG00000180871
CONAN: Copy Number AnalysisCXCR2 
Mutations
ICGC Data PortalCXCR2 
TCGA Data PortalCXCR2 
Broad Tumor PortalCXCR2
OASIS PortalCXCR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCXCR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCR2
DgiDB (Drug Gene Interaction Database)CXCR2
DoCM (Curated mutations)CXCR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCR2 (select a term)
intoGenCXCR2
Cancer3DCXCR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146928   
Orphanet23119   
MedgenCXCR2
Genetic Testing Registry CXCR2
NextProtP25025 [Medical]
TSGene3579
GENETestsCXCR2
Huge Navigator CXCR2 [HugePedia]
snp3D : Map Gene to Disease3579
BioCentury BCIQCXCR2
ClinGenCXCR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3579
Chemical/Pharm GKB GenePA29843
Clinical trialCXCR2
Miscellaneous
canSAR (ICR)CXCR2 (select the gene name)
Probes
Litterature
PubMed280 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXCR2
EVEXCXCR2
GoPubMedCXCR2
iHOPCXCR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:58:07 CEST 2017

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