Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCR4 (chemokine (C-X-C motif) receptor 4)

Identity

Other namesCD184
D2S201E
FB22
HM89
HSY3RR
LAP-3
LAP3
LCR1
LESTR
NPY3R
NPYR
NPYRL
NPYY3R
WHIM
HGNC (Hugo) CXCR4
LocusID (NCBI) 7852
Location 2q22.1
Location_base_pair Starts at 136871919 and ends at 136873813 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CXCR4   2561
Cards
Entrez_Gene (NCBI)CXCR4  7852  chemokine (C-X-C motif) receptor 4
GeneCards (Weizmann)CXCR4
Ensembl hg19 (Hinxton)ENSG00000121966 [Gene_View]  chr2:136871919-136873813 [Contig_View]  CXCR4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000121966 [Gene_View]  chr2:136871919-136873813 [Contig_View]  CXCR4 [Vega]
ICGC DataPortalENSG00000121966
cBioPortalCXCR4
AceView (NCBI)CXCR4
Genatlas (Paris)CXCR4
WikiGenes7852
SOURCE (Princeton)CXCR4
Genomic and cartography
GoldenPath hg19 (UCSC)CXCR4  -     chr2:136871919-136873813 -  2q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CXCR4  -     2q22.1   [Description]    (hg38-Dec_2013)
EnsemblCXCR4 - 2q22.1 [CytoView hg19]  CXCR4 - 2q22.1 [CytoView hg38]
Mapping of homologs : NCBICXCR4 [Mapview hg19]  CXCR4 [Mapview hg38]
OMIM162643   193670   
Gene and transcription
Genbank (Entrez)AF025375 AF147204 AF348491 AK129916 AK296674
RefSeq transcript (Entrez)NM_001008540 NM_003467
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_011587 NT_005403 NW_001838859 NW_004929304
Consensus coding sequences : CCDS (NCBI)CXCR4
Cluster EST : UnigeneHs.593413 [ NCBI ]
CGAP (NCI)Hs.593413
Alternative Splicing : Fast-db (Paris)GSHG0018035
Alternative Splicing GalleryENSG00000121966
Gene ExpressionCXCR4 [ NCBI-GEO ]     CXCR4 [ SEEK ]   CXCR4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61073 (Uniprot)
NextProtP61073  [Medical]
With graphics : InterProP61073
Splice isoforms : SwissVarP61073 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CXCR4    Chemokine_CXCR4_N_dom    Chemokine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Related proteins : CluSTrP61073
Domain families : Pfam (Sanger)7tm_1 (PF00001)    CXCR4_N (PF12109)   
Domain families : Pfam (NCBI)pfam00001    pfam12109   
DMDM Disease mutations7852
Blocks (Seattle)P61073
PDB (SRS)2K03    2K04    2K05    3ODU    3OE0    3OE6    3OE8    3OE9   
PDB (PDBSum)2K03    2K04    2K05    3ODU    3OE0    3OE6    3OE8    3OE9   
PDB (IMB)2K03    2K04    2K05    3ODU    3OE0    3OE6    3OE8    3OE9   
PDB (RSDB)2K03    2K04    2K05    3ODU    3OE0    3OE6    3OE8    3OE9   
Human Protein AtlasENSG00000121966
Peptide AtlasP61073
HPRD01217
IPIIPI00028159   IPI00216445   IPI00911043   
Protein Interaction databases
DIP (DOE-UCLA)P61073
IntAct (EBI)P61073
FunCoupENSG00000121966
BioGRIDCXCR4
IntegromeDBCXCR4
STRING (EMBL)CXCR4
Ontologies - Pathways
QuickGOP61073
Ontology : AmiGOactivation of MAPK activity  patterning of blood vessels  virus receptor activity  response to hypoxia  ameboidal cell migration  neuron migration  dendritic cell chemotaxis  actin binding  G-protein coupled receptor activity  protein binding  cytoplasm  lysosome  early endosome  late endosome  plasma membrane  plasma membrane  apoptotic process  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  germ cell development  brain development  motor neuron axon guidance  germ cell migration  response to virus  external side of plasma membrane  cell surface  coreceptor activity  integral component of membrane  cytoplasmic membrane-bounded vesicle  viral process  C-X-C chemokine receptor activity  calcium-mediated signaling  cytokine binding  cell junction  entry into host cell  regulation of cell migration  growth cone  cell leading edge  cytoplasmic vesicle  ubiquitin protein ligase binding  myosin light chain binding  T cell proliferation  neutrophil activation  ubiquitin binding  myelin maintenance  positive regulation of oligodendrocyte differentiation  regulation of chemotaxis  neural precursor cell proliferation  extracellular vesicular exosome  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  cellular response to cytokine stimulus  
Ontology : EGO-EBIactivation of MAPK activity  patterning of blood vessels  virus receptor activity  response to hypoxia  ameboidal cell migration  neuron migration  dendritic cell chemotaxis  actin binding  G-protein coupled receptor activity  protein binding  cytoplasm  lysosome  early endosome  late endosome  plasma membrane  plasma membrane  apoptotic process  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  germ cell development  brain development  motor neuron axon guidance  germ cell migration  response to virus  external side of plasma membrane  cell surface  coreceptor activity  integral component of membrane  cytoplasmic membrane-bounded vesicle  viral process  C-X-C chemokine receptor activity  calcium-mediated signaling  cytokine binding  cell junction  entry into host cell  regulation of cell migration  growth cone  cell leading edge  cytoplasmic vesicle  ubiquitin protein ligase binding  myosin light chain binding  T cell proliferation  neutrophil activation  ubiquitin binding  myelin maintenance  positive regulation of oligodendrocyte differentiation  regulation of chemotaxis  neural precursor cell proliferation  extracellular vesicular exosome  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  cellular response to cytokine stimulus  
Pathways : BIOCARTAPertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    HIV-1 defeats host-mediated resistance by CEM15 [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    CXCR4 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Endocytosis    Axon guidance    Leukocyte transendothelial migration    Intestinal immune network for IgA production   
Protein Interaction DatabaseCXCR4
DoCM (Curated mutations)CXCR4
Wikipedia pathwaysCXCR4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCXCR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCR4
dbVarCXCR4
ClinVarCXCR4
1000_GenomesCXCR4 
Exome Variant ServerCXCR4
SNP (GeneSNP Utah)CXCR4
SNP : HGBaseCXCR4
Genetic variants : HAPMAPCXCR4
Genomic VariantsCXCR4  CXCR4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000121966 
Somatic Mutations in Cancer : COSMICCXCR4 
CONAN: Copy Number AnalysisCXCR4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:136871919-136873813
Mutations and Diseases : HGMDCXCR4
OMIM162643    193670   
MedgenCXCR4
NextProtP61073 [Medical]
GENETestsCXCR4
Disease Genetic AssociationCXCR4
Huge Navigator CXCR4 [HugePedia]  CXCR4 [HugeCancerGEM]
snp3D : Map Gene to Disease7852
DGIdb (Drug Gene Interaction db)CXCR4
General knowledge
Homologs : HomoloGeneCXCR4
Homology/Alignments : Family Browser (UCSC)CXCR4
Phylogenetic Trees/Animal Genes : TreeFamCXCR4
Chemical/Protein Interactions : CTD7852
Chemical/Pharm GKB GenePA27058
Clinical trialCXCR4
Cancer Resource (Charite)ENSG00000121966
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCXCR4
GoPubMedCXCR4
iHOPCXCR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:04:43 CET 2014

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