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CXCR5 (C-X-C motif chemokine receptor 5)

Identity

Alias (NCBI)BLR1
CD185
MDR15
HGNC (Hugo) CXCR5
HGNC Alias symbMDR15
CD185
HGNC Previous nameBLR1
HGNC Previous nameBurkitt lymphoma receptor 1, GTP-binding protein
 Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
 chemokine (C-X-C motif) receptor 5
LocusID (NCBI) 643
Atlas_Id 805
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118893392 and ends at 118896271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADH7 (4q23) / CXCR5 (11q23.3)CBL (11q23.3) / CXCR5 (11q23.3)CCT2 (12q15) / CXCR5 (11q23.3)
CNPY3 (6p21.1) / CXCR5 (11q23.3)CXCR5 (11q23.3) / CXorf36 (Xp11.3)IGFBP5 (2q35) / CXCR5 (11q23.3)
P4HB (17q25.3) / CXCR5 (11q23.3)ADH7 4q23 / CXCR5 11q23.3CBL 11q23.3 / CXCR5 11q23.3
CCT2 12q15 / CXCR5 11q23.3CNPY3 6p21.1 / CXCR5 11q23.3IGFBP5 2q35 / CXCR5 11q23.3
P4HB 17q25.3 / CXCR5 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CXCR5   1060
Cards
Entrez_Gene (NCBI)CXCR5    C-X-C motif chemokine receptor 5
AliasesBLR1; CD185; MDR15
GeneCards (Weizmann)CXCR5
Ensembl hg19 (Hinxton)ENSG00000160683 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160683 [Gene_View]  ENSG00000160683 [Sequence]  chr11:118893392-118896271 [Contig_View]  CXCR5 [Vega]
ICGC DataPortalENSG00000160683
TCGA cBioPortalCXCR5
AceView (NCBI)CXCR5
Genatlas (Paris)CXCR5
SOURCE (Princeton)CXCR5
Genetics Home Reference (NIH)CXCR5
Genomic and cartography
GoldenPath hg38 (UCSC)CXCR5  -     chr11:118893392-118896271 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CXCR5  -     11q23.3   [Description]    (hg19-Feb_2009)
GoldenPathCXCR5 - 11q23.3 [CytoView hg19]  CXCR5 - 11q23.3 [CytoView hg38]
ImmunoBaseENSG00000160683
Genome Data Viewer NCBICXCR5 [Mapview hg19]  
OMIM601613   
Gene and transcription
Genbank (Entrez)AK291512 AW575330 BC110352 CO958128 DA815880
RefSeq transcript (Entrez)NM_001716 NM_032966
Consensus coding sequences : CCDS (NCBI)CXCR5
Gene ExpressionCXCR5 [ NCBI-GEO ]   CXCR5 [ EBI - ARRAY_EXPRESS ]   CXCR5 [ SEEK ]   CXCR5 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCR5 [ Firebrowse - Broad ]
GenevisibleExpression of CXCR5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)643
GTEX Portal (Tissue expression)CXCR5
Human Protein AtlasENSG00000160683-CXCR5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32302   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32302  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32302
PhosPhoSitePlusP32302
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CXCR5    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CXCR5
SuperfamilyP32302
AlphaFold pdb e-kbP32302   
Human Protein Atlas [tissue]ENSG00000160683-CXCR5 [tissue]
HPRD03367
Protein Interaction databases
DIP (DOE-UCLA)P32302
IntAct (EBI)P32302
BioGRIDCXCR5
STRING (EMBL)CXCR5
ZODIACCXCR5
Ontologies - Pathways
QuickGOP32302
Ontology : AmiGOG protein-coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  immune response  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  C-C chemokine receptor activity  C-X-C chemokine receptor activity  calcium-mediated signaling  C-C chemokine binding  leukocyte chemotaxis  positive regulation of cytokinesis  B cell activation  lymph node development  cell chemotaxis  chemokine-mediated signaling pathway  
Ontology : EGO-EBIG protein-coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  immune response  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  C-C chemokine receptor activity  C-X-C chemokine receptor activity  calcium-mediated signaling  C-C chemokine binding  leukocyte chemotaxis  positive regulation of cytokinesis  B cell activation  lymph node development  cell chemotaxis  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCXCR5
Atlas of Cancer Signalling NetworkCXCR5
Wikipedia pathwaysCXCR5
Orthology - Evolution
OrthoDB643
GeneTree (enSembl)ENSG00000160683
Phylogenetic Trees/Animal Genes : TreeFamCXCR5
Homologs : HomoloGeneCXCR5
Homology/Alignments : Family Browser (UCSC)CXCR5
Gene fusions - Rearrangements
Fusion : MitelmanADH7/CXCR5 [4q23/11q23.3]  
Fusion : MitelmanCBL/CXCR5 [11q23.3/11q23.3]  
Fusion : MitelmanCCT2/CXCR5 [12q15/11q23.3]  
Fusion : MitelmanCNPY3/CXCR5 [6p21.1/11q23.3]  
Fusion : MitelmanIGFBP5/CXCR5 [2q35/11q23.3]  
Fusion : MitelmanP4HB/CXCR5 [17q25.3/11q23.3]  
Fusion : QuiverCXCR5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCR5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCR5
dbVarCXCR5
ClinVarCXCR5
MonarchCXCR5
1000_GenomesCXCR5 
Exome Variant ServerCXCR5
GNOMAD BrowserENSG00000160683
Varsome BrowserCXCR5
ACMGCXCR5 variants
VarityP32302
Genomic Variants (DGV)CXCR5 [DGVbeta]
DECIPHERCXCR5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCXCR5 
Mutations
ICGC Data PortalCXCR5 
TCGA Data PortalCXCR5 
Broad Tumor PortalCXCR5
OASIS PortalCXCR5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCR5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCXCR5
Mutations and Diseases : HGMDCXCR5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCXCR5
DgiDB (Drug Gene Interaction Database)CXCR5
DoCM (Curated mutations)CXCR5
CIViC (Clinical Interpretations of Variants in Cancer)CXCR5
Cancer3DCXCR5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601613   
Orphanet
DisGeNETCXCR5
MedgenCXCR5
Genetic Testing Registry CXCR5
NextProtP32302 [Medical]
GENETestsCXCR5
Target ValidationCXCR5
Huge Navigator CXCR5 [HugePedia]
ClinGenCXCR5
Clinical trials, drugs, therapy
MyCancerGenomeCXCR5
Protein Interactions : CTDCXCR5
Pharm GKB GenePA162383046
PharosP32302
Clinical trialCXCR5
Miscellaneous
canSAR (ICR)CXCR5
HarmonizomeCXCR5
DataMed IndexCXCR5
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCXCR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:47 CEST 2021

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