Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CXCR5 (C-X-C motif chemokine receptor 5)

Identity

Alias_namesBLR1
Burkitt lymphoma receptor 1, GTP-binding protein
Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
chemokine (C-X-C motif) receptor 5
Alias_symbol (synonym)MDR15
CD185
Other alias
HGNC (Hugo) CXCR5
LocusID (NCBI) 643
Atlas_Id 805
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118883766 and ends at 118896271 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADH7 (4q23) / CXCR5 (11q23.3)CBL (11q23.3) / CXCR5 (11q23.3)CCT2 (12q15) / CXCR5 (11q23.3)
CNPY3 (6p21.1) / CXCR5 (11q23.3)CXCR5 (11q23.3) / CXorf36 (Xp11.3)IGFBP5 (2q35) / CXCR5 (11q23.3)
P4HB (17q25.3) / CXCR5 (11q23.3)ADH7 4q23 / CXCR5 11q23.3CBL 11q23.3 / CXCR5 11q23.3
CCT2 12q15 / CXCR5 11q23.3CNPY3 6p21.1 / CXCR5 11q23.3IGFBP5 2q35 / CXCR5 11q23.3
P4HB 17q25.3 / CXCR5 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CXCR5   1060
Cards
Entrez_Gene (NCBI)CXCR5  643  C-X-C motif chemokine receptor 5
AliasesBLR1; CD185; MDR15
GeneCards (Weizmann)CXCR5
Ensembl hg19 (Hinxton)ENSG00000160683 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160683 [Gene_View]  chr11:118883766-118896271 [Contig_View]  CXCR5 [Vega]
ICGC DataPortalENSG00000160683
TCGA cBioPortalCXCR5
AceView (NCBI)CXCR5
Genatlas (Paris)CXCR5
WikiGenes643
SOURCE (Princeton)CXCR5
Genetics Home Reference (NIH)CXCR5
Genomic and cartography
GoldenPath hg38 (UCSC)CXCR5  -     chr11:118883766-118896271 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CXCR5  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblCXCR5 - 11q23.3 [CytoView hg19]  CXCR5 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBICXCR5 [Mapview hg19]  CXCR5 [Mapview hg38]
OMIM601613   
Gene and transcription
Genbank (Entrez)AK291512 AW575330 BC110352 CO958128 DA815880
RefSeq transcript (Entrez)NM_001716 NM_032966
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CXCR5
Cluster EST : UnigeneHs.113916 [ NCBI ]
CGAP (NCI)Hs.113916
Alternative Splicing GalleryENSG00000160683
Gene ExpressionCXCR5 [ NCBI-GEO ]   CXCR5 [ EBI - ARRAY_EXPRESS ]   CXCR5 [ SEEK ]   CXCR5 [ MEM ]
Gene Expression Viewer (FireBrowse)CXCR5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)643
GTEX Portal (Tissue expression)CXCR5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32302   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32302  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32302
Splice isoforms : SwissVarP32302
PhosPhoSitePlusP32302
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CXCR5    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CXCR5
DMDM Disease mutations643
Blocks (Seattle)CXCR5
SuperfamilyP32302
Human Protein AtlasENSG00000160683
Peptide AtlasP32302
HPRD03367
IPIIPI00027955   IPI00018295   
Protein Interaction databases
DIP (DOE-UCLA)P32302
IntAct (EBI)P32302
FunCoupENSG00000160683
BioGRIDCXCR5
STRING (EMBL)CXCR5
ZODIACCXCR5
Ontologies - Pathways
QuickGOP32302
Ontology : AmiGOG-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  movement of cell or subcellular component  chemotaxis  immune response  G-protein coupled receptor signaling pathway  C-X-C chemokine receptor activity  positive regulation of cytokinesis  B cell activation  lymph node development  chemokine-mediated signaling pathway  
Ontology : EGO-EBIG-protein coupled receptor activity  protein binding  plasma membrane  integral component of plasma membrane  movement of cell or subcellular component  chemotaxis  immune response  G-protein coupled receptor signaling pathway  C-X-C chemokine receptor activity  positive regulation of cytokinesis  B cell activation  lymph node development  chemokine-mediated signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCXCR5
Atlas of Cancer Signalling NetworkCXCR5
Wikipedia pathwaysCXCR5
Orthology - Evolution
OrthoDB643
GeneTree (enSembl)ENSG00000160683
Phylogenetic Trees/Animal Genes : TreeFamCXCR5
HOVERGENP32302
HOGENOMP32302
Homologs : HomoloGeneCXCR5
Homology/Alignments : Family Browser (UCSC)CXCR5
Gene fusions - Rearrangements
Fusion : MitelmanADH7/CXCR5 [4q23/11q23.3]  [t(4;11)(q23;q23)]  
Fusion : MitelmanCBL/CXCR5 [11q23.3/11q23.3]  [t(11;11)(q23;q23)]  
Fusion : MitelmanCCT2/CXCR5 [12q15/11q23.3]  [t(11;12)(q23;q15)]  
Fusion : MitelmanCNPY3/CXCR5 [6p21.1/11q23.3]  [t(6;11)(p21;q23)]  
Fusion : MitelmanIGFBP5/CXCR5 [2q35/11q23.3]  [t(2;11)(q35;q23)]  
Fusion : MitelmanP4HB/CXCR5 [17q25.3/11q23.3]  [t(11;17)(q23;q25)]  
Fusion: TCGAADH7 4q23 CXCR5 11q23.3 HNSC
Fusion: TCGACBL 11q23.3 CXCR5 11q23.3 PRAD
Fusion: TCGACCT2 12q15 CXCR5 11q23.3 BRCA
Fusion: TCGACNPY3 6p21.1 CXCR5 11q23.3 LUAD
Fusion: TCGAIGFBP5 2q35 CXCR5 11q23.3 BRCA
Fusion: TCGAP4HB 17q25.3 CXCR5 11q23.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCXCR5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CXCR5
dbVarCXCR5
ClinVarCXCR5
1000_GenomesCXCR5 
Exome Variant ServerCXCR5
ExAC (Exome Aggregation Consortium)CXCR5 (select the gene name)
Genetic variants : HAPMAP643
Genomic Variants (DGV)CXCR5 [DGVbeta]
DECIPHERCXCR5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCXCR5 
Mutations
ICGC Data PortalCXCR5 
TCGA Data PortalCXCR5 
Broad Tumor PortalCXCR5
OASIS PortalCXCR5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCXCR5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCXCR5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CXCR5
DgiDB (Drug Gene Interaction Database)CXCR5
DoCM (Curated mutations)CXCR5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CXCR5 (select a term)
intoGenCXCR5
Cancer3DCXCR5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601613   
Orphanet
MedgenCXCR5
Genetic Testing Registry CXCR5
NextProtP32302 [Medical]
TSGene643
GENETestsCXCR5
Target ValidationCXCR5
Huge Navigator CXCR5 [HugePedia]
snp3D : Map Gene to Disease643
BioCentury BCIQCXCR5
ClinGenCXCR5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD643
Chemical/Pharm GKB GenePA162383046
Clinical trialCXCR5
Miscellaneous
canSAR (ICR)CXCR5 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCXCR5
EVEXCXCR5
GoPubMedCXCR5
iHOPCXCR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:59:00 CEST 2017

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