CXCR6 (C-X-C motif chemokine receptor 6)

2007-02-01  

Identity

HGNC
CXCR6
LOCATION
3p21.31
LOCUSID
10663
ALIAS
BONZO,CD186,CDw186,STRL33,TYMSTR

Other Information

Locus ID:

NCBI: 10663
MIM: 605163
HGNC: 16647
Ensembl: ENSG00000172215

Variants:

dbSNP: 10663
ClinVar: 10663
TCGA: ENSG00000172215
COSMIC: CXCR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172215ENST00000304552O00574
ENSG00000172215ENST00000304552A0N0N3
ENSG00000172215ENST00000438735O00574
ENSG00000172215ENST00000438735A0N0N3
ENSG00000172215ENST00000457814O00574
ENSG00000172215ENST00000457814A0N0N3
ENSG00000172215ENST00000458629O00574
ENSG00000172215ENST00000458629A0N0N3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
120700012002Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.85
190749062008CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway.51
146340542004Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells.45
196906112009The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers.41
162005802005Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis.39
207044852010Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.35
207044852010Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.35
176409642007CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity.33
220790212012T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6.30
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29

Citation

Dessen P

CXCR6 (C-X-C motif chemokine receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46390/cxcr6