Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 80319
MIM: 611645
HGNC: 24593
Ensembl: ENSG00000168772
Variants:
dbSNP: 80319
ClinVar: 80319
TCGA: ENSG00000168772
COSMIC: CXXC4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000168772 | ENST00000394767 | J9JIF5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713176 | Platinum compounds | Chemical | ClinicalAnnotation | associated | PD | 24980784 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 24980784 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34076982 | 2021 | SPZ1 promotes glioma aggravation via targeting CXXC4. | 2 |
| 34076982 | 2021 | SPZ1 promotes glioma aggravation via targeting CXXC4. | 2 |
| 32715641 | 2020 | CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway. | 18 |
| 33107235 | 2020 | LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer. | 5 |
| 33205068 | 2020 | Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia. | 10 |
| 32715641 | 2020 | CXXC finger protein 4 inhibits the CDK18-ERK1/2 axis to suppress the immune escape of gastric cancer cells with involvement of ELK1/MIR100HG pathway. | 18 |
| 33107235 | 2020 | LUCAT1 Epigenetically Downregulates the Tumor Suppressor Genes CXXC4 and SFRP2 in Gastric Cancer. | 5 |
| 33205068 | 2020 | Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia. | 10 |
| 29337063 | 2018 | BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX. | 14 |
| 30042169 | 2018 | MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4. | 10 |
| 29337063 | 2018 | BMI1 activates WNT signaling in colon cancer by negatively regulating the WNT antagonist IDAX. | 14 |
| 30042169 | 2018 | MiR-629-5p promotes colorectal cancer progression through targetting CXXC finger protein 4. | 10 |
| 25064842 | 2014 | New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling. | 10 |
| 25085016 | 2014 | CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients. | 3 |
| 25064842 | 2014 | New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling. | 10 |
Citation
Dessen P
CXXC4 (CXXC finger protein 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40226/cxxc4
