Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYBA (cytochrome b-245 alpha chain)

Identity

Alias_namescytochrome b-245
Alias_symbol (synonym)p22-PHOX
HGNC (Hugo) CYBA
LocusID (NCBI) 1535
Atlas_Id 43882
Location 16q24.3  [Link to chromosome band 16q24]
Location_base_pair Starts at 88709697 and ends at 88717492 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CYBA (16q24.3) / CYBA (16q24.3)CYBA (16q24.3) / ELOVL5 (6p12.1)CYBA (16q24.3) / ST3GAL2 (16q22.1)
TLDC1 (16q24.1) / CYBA (16q24.3)KIAA1609 CYBA 16q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYBA   2577
LRG (Locus Reference Genomic)LRG_52
Cards
Entrez_Gene (NCBI)CYBA  1535  cytochrome b-245 alpha chain
Aliasesp22-PHOX
GeneCards (Weizmann)CYBA
Ensembl hg19 (Hinxton)ENSG00000051523 [Gene_View]  chr16:88709697-88717492 [Contig_View]  CYBA [Vega]
Ensembl hg38 (Hinxton)ENSG00000051523 [Gene_View]  chr16:88709697-88717492 [Contig_View]  CYBA [Vega]
ICGC DataPortalENSG00000051523
TCGA cBioPortalCYBA
AceView (NCBI)CYBA
Genatlas (Paris)CYBA
WikiGenes1535
SOURCE (Princeton)CYBA
Genetics Home Reference (NIH)CYBA
Genomic and cartography
GoldenPath hg19 (UCSC)CYBA  -     chr16:88709697-88717492 -  16q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYBA  -     16q24.3   [Description]    (hg38-Dec_2013)
EnsemblCYBA - 16q24.3 [CytoView hg19]  CYBA - 16q24.3 [CytoView hg38]
Mapping of homologs : NCBICYBA [Mapview hg19]  CYBA [Mapview hg38]
OMIM233690   608508   
Gene and transcription
Genbank (Entrez)AK097127 AK125578 AK300049 AK309030 BC006465
RefSeq transcript (Entrez)NM_000101
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_007291 NT_010498 NW_004929403
Consensus coding sequences : CCDS (NCBI)CYBA
Cluster EST : UnigeneHs.513803 [ NCBI ]
CGAP (NCI)Hs.513803
Alternative Splicing GalleryENSG00000051523
Gene ExpressionCYBA [ NCBI-GEO ]   CYBA [ EBI - ARRAY_EXPRESS ]   CYBA [ SEEK ]   CYBA [ MEM ]
Gene Expression Viewer (FireBrowse)CYBA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1535
GTEX Portal (Tissue expression)CYBA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13498   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13498  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13498
Splice isoforms : SwissVarP13498
PhosPhoSitePlusP13498
Domains : Interpro (EBI)Cyt_b558_asu   
Domain families : Pfam (Sanger)Cytochrom_B558a (PF05038)   
Domain families : Pfam (NCBI)pfam05038   
Conserved Domain (NCBI)CYBA
DMDM Disease mutations1535
Blocks (Seattle)CYBA
PDB (SRS)1WLP   
PDB (PDBSum)1WLP   
PDB (IMB)1WLP   
PDB (RSDB)1WLP   
Structural Biology KnowledgeBase1WLP   
SCOP (Structural Classification of Proteins)1WLP   
CATH (Classification of proteins structures)1WLP   
SuperfamilyP13498
Human Protein AtlasENSG00000051523
Peptide AtlasP13498
HPRD01989
IPIIPI00218433   
Protein Interaction databases
DIP (DOE-UCLA)P13498
IntAct (EBI)P13498
FunCoupENSG00000051523
BioGRIDCYBA
STRING (EMBL)CYBA
ZODIACCYBA
Ontologies - Pathways
QuickGOP13498
Ontology : AmiGOresponse to reactive oxygen species  positive regulation of endothelial cell proliferation  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  negative regulation of glomerular filtration by angiotensin  protein binding  mitochondrion  endosome  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  superoxide metabolic process  inflammatory response  electron carrier activity  electron carrier activity  smooth muscle hypertrophy  membrane  superoxide-generating NADPH oxidase activity  superoxide-generating NADPH oxidase activity  apical plasma membrane  cytochrome complex assembly  SH3 domain binding  heme binding  secretory granule  positive regulation of cell growth  dendrite  phagocytic vesicle membrane  response to nutrient levels  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of superoxide anion generation  positive regulation of toll-like receptor 2 signaling pathway  response to drug  superoxide anion generation  NADPH oxidase complex  NADPH oxidase complex  NADPH oxidase complex  neuronal cell body  innate immune response  cell redox homeostasis  respiratory burst  metal ion binding  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of smooth muscle cell proliferation  hydrogen peroxide biosynthetic process  positive regulation of phagocytosis  regulation of release of sequestered calcium ion into cytosol  oxidation-reduction process  positive regulation of mucus secretion  response to interleukin-1  cellular response to amino acid stimulus  cellular response to mechanical stimulus  cellular response to glucose stimulus  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  cellular response to gamma radiation  perinuclear endoplasmic reticulum  positive regulation of defense response to bacterium  positive regulation of reactive oxygen species biosynthetic process  
Ontology : EGO-EBIresponse to reactive oxygen species  positive regulation of endothelial cell proliferation  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  negative regulation of glomerular filtration by angiotensin  protein binding  mitochondrion  endosome  endoplasmic reticulum membrane  Golgi apparatus  plasma membrane  superoxide metabolic process  inflammatory response  electron carrier activity  electron carrier activity  smooth muscle hypertrophy  membrane  superoxide-generating NADPH oxidase activity  superoxide-generating NADPH oxidase activity  apical plasma membrane  cytochrome complex assembly  SH3 domain binding  heme binding  secretory granule  positive regulation of cell growth  dendrite  phagocytic vesicle membrane  response to nutrient levels  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of superoxide anion generation  positive regulation of toll-like receptor 2 signaling pathway  response to drug  superoxide anion generation  NADPH oxidase complex  NADPH oxidase complex  NADPH oxidase complex  neuronal cell body  innate immune response  cell redox homeostasis  respiratory burst  metal ion binding  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of smooth muscle cell proliferation  hydrogen peroxide biosynthetic process  positive regulation of phagocytosis  regulation of release of sequestered calcium ion into cytosol  oxidation-reduction process  positive regulation of mucus secretion  response to interleukin-1  cellular response to amino acid stimulus  cellular response to mechanical stimulus  cellular response to glucose stimulus  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  cellular response to gamma radiation  perinuclear endoplasmic reticulum  positive regulation of defense response to bacterium  positive regulation of reactive oxygen species biosynthetic process  
Pathways : KEGGPhagosome    Osteoclast differentiation    Leukocyte transendothelial migration    Leishmaniasis   
NDEx NetworkCYBA
Atlas of Cancer Signalling NetworkCYBA
Wikipedia pathwaysCYBA
Orthology - Evolution
OrthoDB1535
GeneTree (enSembl)ENSG00000051523
Phylogenetic Trees/Animal Genes : TreeFamCYBA
HOVERGENP13498
HOGENOMP13498
Homologs : HomoloGeneCYBA
Homology/Alignments : Family Browser (UCSC)CYBA
Gene fusions - Rearrangements
Fusion : MitelmanTLDC1/CYBA [16q24.1/16q24.3]  [t(16;16)(q24;q24)]  
Fusion: TCGAKIAA1609 CYBA 16q24.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYBA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYBA
dbVarCYBA
ClinVarCYBA
1000_GenomesCYBA 
Exome Variant ServerCYBA
ExAC (Exome Aggregation Consortium)CYBA (select the gene name)
Genetic variants : HAPMAP1535
Genomic Variants (DGV)CYBA [DGVbeta]
DECIPHER (Syndromes)16:88709697-88717492  ENSG00000051523
CONAN: Copy Number AnalysisCYBA 
Mutations
ICGC Data PortalCYBA 
TCGA Data PortalCYBA 
Broad Tumor PortalCYBA
OASIS PortalCYBA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYBA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYBA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CYBA
DgiDB (Drug Gene Interaction Database)CYBA
DoCM (Curated mutations)CYBA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYBA (select a term)
intoGenCYBA
Cancer3DCYBA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM233690    608508   
Orphanet176   
MedgenCYBA
Genetic Testing Registry CYBA
NextProtP13498 [Medical]
TSGene1535
GENETestsCYBA
Huge Navigator CYBA [HugePedia]
snp3D : Map Gene to Disease1535
BioCentury BCIQCYBA
ClinGenCYBA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1535
Chemical/Pharm GKB GenePA27075
Clinical trialCYBA
Miscellaneous
canSAR (ICR)CYBA (select the gene name)
Probes
Litterature
PubMed279 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYBA
EVEXCYBA
GoPubMedCYBA
iHOPCYBA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:35:10 CET 2016

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