Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYBB (cytochrome b-245, beta polypeptide)

Identity

Other namesAMCBX2
CGD
GP91-1
GP91-PHOX
GP91PHOX
NOX2
p91-PHOX
HGNC (Hugo) CYBB
LocusID (NCBI) 1536
Location Xp11.4
Location_base_pair Starts at 37639270 and ends at 37672714 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYBB   2578
Cards
Entrez_Gene (NCBI)CYBB  1536  cytochrome b-245, beta polypeptide
GeneCards (Weizmann)CYBB
Ensembl (Hinxton)ENSG00000165168 [Gene_View]  chrX:37639270-37672714 [Contig_View]  CYBB [Vega]
ICGC DataPortalENSG00000165168
cBioPortalCYBB
AceView (NCBI)CYBB
Genatlas (Paris)CYBB
WikiGenes1536
SOURCE (Princeton)NM_000397
Genomic and cartography
GoldenPath (UCSC)CYBB  -  Xp11.4   chrX:37639270-37672714 +  Xp11.4   [Description]    (hg19-Feb_2009)
EnsemblCYBB - Xp11.4 [CytoView]
Mapping of homologs : NCBICYBB [Mapview]
OMIM300481   300645   306400   
Gene and transcription
Genbank (Entrez)AK289753 AK301476 AK301491 AK304033 AK312929
RefSeq transcript (Entrez)NM_000397
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_009065 NT_079573 NW_001842361 NW_004929439
Consensus coding sequences : CCDS (NCBI)CYBB
Cluster EST : UnigeneHs.292356 [ NCBI ]
CGAP (NCI)Hs.292356
Alternative Splicing : Fast-db (Paris)GSHG0031457
Alternative Splicing GalleryENSG00000165168
Gene ExpressionCYBB [ NCBI-GEO ]     CYBB [ SEEK ]   CYBB [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04839 (Uniprot)
NextProtP04839  [Medical]
With graphics : InterProP04839
Splice isoforms : SwissVarP04839 (Swissvar)
Catalytic activity : Enzyme1.-.-.- [ Enzyme-Expasy ]   1.-.-.-1.-.-.- [ IntEnz-EBI ]   1.-.-.- [ BRENDA ]   1.-.-.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)FAD_FR (PS51384)   
Domains : Interpro (EBI)Cyt_b245_heavy_chain [organisation]   FAD-bd_8 [organisation]   Fd_Rdtase_FAD-bd [organisation]   Fe3_Rdtase_TM_dom [organisation]   Fe_red_NAD-bd_6 [organisation]   Riboflavin_synthase-like_b-brl [organisation]  
Related proteins : CluSTrP04839
Domain families : Pfam (Sanger)FAD_binding_8 (PF08022)    Ferric_reduct (PF01794)    NAD_binding_6 (PF08030)   
Domain families : Pfam (NCBI)pfam08022    pfam01794    pfam08030   
DMDM Disease mutations1536
Blocks (Seattle)P04839
PDB (SRS)3A1F   
PDB (PDBSum)3A1F   
PDB (IMB)3A1F   
PDB (RSDB)3A1F   
Human Protein AtlasENSG00000165168 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP04839
HPRD02382
IPIIPI00218646   IPI01010560   IPI01015902   
Protein Interaction databases
DIP (DOE-UCLA)P04839
IntAct (EBI)P04839
FunCoupENSG00000165168
BioGRIDCYBB
InParanoidP04839
Interologous Interaction database P04839
IntegromeDBCYBB
STRING (EMBL)CYBB
Ontologies - Pathways
Ontology : AmiGOantigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  voltage-gated ion channel activity  protein binding  mitochondrion  rough endoplasmic reticulum  Golgi apparatus  integral component of plasma membrane  superoxide metabolic process  superoxide metabolic process  ion transport  inflammatory response  response to nutrient  electron carrier activity  superoxide-generating NADPH oxidase activity  superoxide-generating NADPH oxidase activity  heme binding  dendrite  phagocytic vesicle membrane  regulation of ion transmembrane transport  response to drug  superoxide anion generation  superoxide anion generation  antigen processing and presentation of exogenous peptide antigen via MHC class I  NADPH oxidase complex  NADPH oxidase complex  neuronal cell body  innate immune response  innate immune response  respiratory burst  respiratory burst  metal ion binding  protein heterodimerization activity  flavin adenine dinucleotide binding  hydrogen peroxide biosynthetic process  interaction with host  oxidation-reduction process  oxidation-reduction process  phagosome maturation  
Ontology : EGO-EBIantigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  voltage-gated ion channel activity  protein binding  mitochondrion  rough endoplasmic reticulum  Golgi apparatus  integral component of plasma membrane  superoxide metabolic process  superoxide metabolic process  ion transport  inflammatory response  response to nutrient  electron carrier activity  superoxide-generating NADPH oxidase activity  superoxide-generating NADPH oxidase activity  heme binding  dendrite  phagocytic vesicle membrane  regulation of ion transmembrane transport  response to drug  superoxide anion generation  superoxide anion generation  antigen processing and presentation of exogenous peptide antigen via MHC class I  NADPH oxidase complex  NADPH oxidase complex  neuronal cell body  innate immune response  innate immune response  respiratory burst  respiratory burst  metal ion binding  protein heterodimerization activity  flavin adenine dinucleotide binding  hydrogen peroxide biosynthetic process  interaction with host  oxidation-reduction process  oxidation-reduction process  phagosome maturation  
Pathways : KEGGHIF-1 signaling pathway    Phagosome    Osteoclast differentiation    Leukocyte transendothelial migration   
Protein Interaction DatabaseCYBB
Wikipedia pathwaysCYBB
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYBB
snp3D : Map Gene to Disease1536
SNP (GeneSNP Utah)CYBB
SNP : HGBaseCYBB
Genetic variants : HAPMAPCYBB
Exome VariantCYBB
1000_GenomesCYBB 
ICGC programENSG00000165168 
Somatic Mutations in Cancer : COSMICCYBB 
CONAN: Copy Number AnalysisCYBB 
Mutations and Diseases : HGMDCYBB
Genomic VariantsCYBB  CYBB [DGVbeta]
dbVarCYBB
ClinVarCYBB
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM300481    300645    306400   
MedgenCYBB
GENETestsCYBB
Disease Genetic AssociationCYBB
Huge Navigator CYBB [HugePedia]  CYBB [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCYBB
Homology/Alignments : Family Browser (UCSC)CYBB
Phylogenetic Trees/Animal Genes : TreeFamCYBB
Chemical/Protein Interactions : CTD1536
Chemical/Pharm GKB GenePA27076
Clinical trialCYBB
Cancer Resource (Charite)ENSG00000165168
Other databases
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
CoreMineCYBB
iHOPCYBB
OncoSearchCYBB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:29:00 CEST 2014

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