Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYC1 (cytochrome c1)

Identity

Alias (NCBI)MC3DN6
UQCR4
HGNC (Hugo) CYC1
HGNC Alias symbUQCR4
LocusID (NCBI) 1537
Atlas_Id 43222
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144095076 and ends at 144097525 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYC1 (8q24.3) / C1QB (1p36.12)CYC1 (8q24.3) / TRBV20-1 ()MIS18A (21q22.11) / CYC1 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CYC1   2579
Cards
Entrez_Gene (NCBI)CYC1    cytochrome c1
AliasesMC3DN6; UQCR4
GeneCards (Weizmann)CYC1
Ensembl hg19 (Hinxton)ENSG00000179091 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179091 [Gene_View]  ENSG00000179091 [Sequence]  chr8:144095076-144097525 [Contig_View]  CYC1 [Vega]
ICGC DataPortalENSG00000179091
TCGA cBioPortalCYC1
AceView (NCBI)CYC1
Genatlas (Paris)CYC1
SOURCE (Princeton)CYC1
Genetics Home Reference (NIH)CYC1
Genomic and cartography
GoldenPath hg38 (UCSC)CYC1  -     chr8:144095076-144097525 +  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYC1  -     8q24.3   [Description]    (hg19-Feb_2009)
GoldenPathCYC1 - 8q24.3 [CytoView hg19]  CYC1 - 8q24.3 [CytoView hg38]
ImmunoBaseENSG00000179091
Genome Data Viewer NCBICYC1 [Mapview hg19]  
OMIM123980   615453   
Gene and transcription
Genbank (Entrez)AK026633 AK225796 BC001006 BC015616 BC020566
RefSeq transcript (Entrez)NM_001916
Consensus coding sequences : CCDS (NCBI)CYC1
Gene ExpressionCYC1 [ NCBI-GEO ]   CYC1 [ EBI - ARRAY_EXPRESS ]   CYC1 [ SEEK ]   CYC1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYC1 [ Firebrowse - Broad ]
GenevisibleExpression of CYC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1537
GTEX Portal (Tissue expression)CYC1
Human Protein AtlasENSG00000179091-CYC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08574   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08574  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08574
Catalytic activity : Enzyme7.1.1.8 [ Enzyme-Expasy ]   7.1.1.87.1.1.8 [ IntEnz-EBI ]   7.1.1.8 [ BRENDA ]   7.1.1.8 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP08574
Domains : Interpro (EBI)Cyt_c-like_dom_sf    Cyt_c1    Cyt_c1_TM_anchor_C   
Domain families : Pfam (Sanger)Cytochrom_C1 (PF02167)   
Domain families : Pfam (NCBI)pfam02167   
Conserved Domain (NCBI)CYC1
PDB (RSDB)5XTE    5XTH    5XTI   
PDB Europe5XTE    5XTH    5XTI   
PDB (PDBSum)5XTE    5XTH    5XTI   
PDB (IMB)5XTE    5XTH    5XTI   
Structural Biology KnowledgeBase5XTE    5XTH    5XTI   
SCOP (Structural Classification of Proteins)5XTE    5XTH    5XTI   
CATH (Classification of proteins structures)5XTE    5XTH    5XTI   
SuperfamilyP08574
AlphaFold pdb e-kbP08574   
Human Protein Atlas [tissue]ENSG00000179091-CYC1 [tissue]
HPRD00480
Protein Interaction databases
DIP (DOE-UCLA)P08574
IntAct (EBI)P08574
BioGRIDCYC1
STRING (EMBL)CYC1
ZODIACCYC1
Ontologies - Pathways
QuickGOP08574
Ontology : AmiGOprotein binding  nucleus  mitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex III  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, ubiquinol to cytochrome c  ubiquinol-cytochrome-c reductase activity  membrane  integral component of membrane  heme binding  response to glucagon  metal ion binding  
Ontology : EGO-EBIprotein binding  nucleus  mitochondrion  mitochondrial inner membrane  mitochondrial respiratory chain complex III  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, ubiquinol to cytochrome c  ubiquinol-cytochrome-c reductase activity  membrane  integral component of membrane  heme binding  response to glucagon  metal ion binding  
Pathways : KEGGOxidative phosphorylation    Cardiac muscle contraction    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkCYC1
Atlas of Cancer Signalling NetworkCYC1
Wikipedia pathwaysCYC1
Orthology - Evolution
OrthoDB1537
GeneTree (enSembl)ENSG00000179091
Phylogenetic Trees/Animal Genes : TreeFamCYC1
Homologs : HomoloGeneCYC1
Homology/Alignments : Family Browser (UCSC)CYC1
Gene fusions - Rearrangements
Fusion : QuiverCYC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYC1
dbVarCYC1
ClinVarCYC1
MonarchCYC1
1000_GenomesCYC1 
Exome Variant ServerCYC1
GNOMAD BrowserENSG00000179091
Varsome BrowserCYC1
ACMGCYC1 variants
VarityP08574
Genomic Variants (DGV)CYC1 [DGVbeta]
DECIPHERCYC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYC1 
Mutations
ICGC Data PortalCYC1 
TCGA Data PortalCYC1 
Broad Tumor PortalCYC1
OASIS PortalCYC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYC1
Mutations and Diseases : HGMDCYC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCYC1
DgiDB (Drug Gene Interaction Database)CYC1
DoCM (Curated mutations)CYC1
CIViC (Clinical Interpretations of Variants in Cancer)CYC1
Cancer3DCYC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123980    615453   
Orphanet3378   
DisGeNETCYC1
MedgenCYC1
Genetic Testing Registry CYC1
NextProtP08574 [Medical]
GENETestsCYC1
Target ValidationCYC1
Huge Navigator CYC1 [HugePedia]
ClinGenCYC1
Clinical trials, drugs, therapy
MyCancerGenomeCYC1
Protein Interactions : CTDCYC1
Pharm GKB GenePA27077
PharosP08574
Clinical trialCYC1
Miscellaneous
canSAR (ICR)CYC1
HarmonizomeCYC1
DataMed IndexCYC1
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCYC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:05:51 CEST 2021

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