CYC1 (cytochrome c1)

2006-10-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
MC3DN6,UQCR4
FUSION GENES

Other Information

Locus ID:

NCBI: 1537
MIM: 123980
HGNC: 2579
Ensembl: ENSG00000179091

Variants:

dbSNP: 1537
ClinVar: 1537
TCGA: ENSG00000179091
COSMIC: CYC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179091ENST00000318911P08574

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Metabolic pathwaysKEGGhsa01100
Cytochrome bc1 complex respiratory unitKEGGhsa_M00151
Cytochrome bc1 complexKEGGhsa_M00152
Cytochrome bc1 complex respiratory unitKEGGM00151
Cytochrome bc1 complexKEGGM00152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
127882272003Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts.22
149661232004Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor.22
204405432010Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis.18
215772352012Caspase cleavage of cytochrome c1 disrupts mitochondrial function and enhances cytochrome c release.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
166999482006Serum leucine-rich alpha-2-glycoprotein-1 binds cytochrome c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay.11
255621552014CYC1 silencing sensitizes osteosarcoma cells to TRAIL-induced apoptosis.7
271176632016Apoptosis Markers in Breast Cancer Therapy.7
272390882016CYC1 Predicts Poor Prognosis in Patients with Breast Cancer.5

Citation

Dessen P

CYC1 (cytochrome c1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43222/cyc1