Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYCS (cytochrome c, somatic)

Identity

Alias (NCBI)CYC
HCS
THC4
HGNC (Hugo) CYCS
HGNC Alias symbHCS
CYC
LocusID (NCBI) 54205
Atlas_Id 47391
Location 7p15.3  [Link to chromosome band 7p15]
Location_base_pair Starts at 25118656 and ends at 25125260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYCS (7p15.3) / MARCH4 (2q35)CYCS (7p15.3) / RDH11 (14q24.1)TPK1 (7q35) / CYCS (7p15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  i(7)(q10)


External links

 

Nomenclature
HGNC (Hugo)CYCS   19986
LRG (Locus Reference Genomic)LRG_876
Cards
Entrez_Gene (NCBI)CYCS    cytochrome c, somatic
AliasesCYC; HCS; THC4
GeneCards (Weizmann)CYCS
Ensembl hg19 (Hinxton)ENSG00000172115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172115 [Gene_View]  ENSG00000172115 [Sequence]  chr7:25118656-25125260 [Contig_View]  CYCS [Vega]
ICGC DataPortalENSG00000172115
TCGA cBioPortalCYCS
AceView (NCBI)CYCS
Genatlas (Paris)CYCS
SOURCE (Princeton)CYCS
Genetics Home Reference (NIH)CYCS
Genomic and cartography
GoldenPath hg38 (UCSC)CYCS  -     chr7:25118656-25125260 -  7p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYCS  -     7p15.3   [Description]    (hg19-Feb_2009)
GoldenPathCYCS - 7p15.3 [CytoView hg19]  CYCS - 7p15.3 [CytoView hg38]
ImmunoBaseENSG00000172115
Genome Data Viewer NCBICYCS [Mapview hg19]  
OMIM123970   612004   
Gene and transcription
Genbank (Entrez)AI365318 AK056360 AK311836 AL713681 BC005299
RefSeq transcript (Entrez)NM_018947
Consensus coding sequences : CCDS (NCBI)CYCS
Gene ExpressionCYCS [ NCBI-GEO ]   CYCS [ EBI - ARRAY_EXPRESS ]   CYCS [ SEEK ]   CYCS [ MEM ]
Gene Expression Viewer (FireBrowse)CYCS [ Firebrowse - Broad ]
GenevisibleExpression of CYCS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54205
GTEX Portal (Tissue expression)CYCS
Human Protein AtlasENSG00000172115-CYCS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP99999   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP99999  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP99999
PhosPhoSitePlusP99999
Domaine pattern : Prosite (Expaxy)CYTC (PS51007)   
Domains : Interpro (EBI)Cyt_c-like_dom    Cyt_c-like_dom_sf    Cyt_c_1A/1B   
Domain families : Pfam (Sanger)Cytochrom_C (PF00034)   
Domain families : Pfam (NCBI)pfam00034   
Conserved Domain (NCBI)CYCS
PDB (RSDB)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
PDB Europe1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
PDB (PDBSum)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
PDB (IMB)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
Structural Biology KnowledgeBase1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
SCOP (Structural Classification of Proteins)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
CATH (Classification of proteins structures)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5O10    5TY3    6DUJ    6ECJ   
SuperfamilyP99999
AlphaFold pdb e-kbP99999   
Human Protein Atlas [tissue]ENSG00000172115-CYCS [tissue]
HPRD00479
Protein Interaction databases
DIP (DOE-UCLA)P99999
IntAct (EBI)P99999
BioGRIDCYCS
STRING (EMBL)CYCS
ZODIACCYCS
Ontologies - Pathways
QuickGOP99999
Ontology : AmiGOprotein binding  nucleus  nucleus  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial intermembrane space  mitochondrial intermembrane space  cytosol  cytosol  cytosol  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, cytochrome c to oxygen  apoptotic process  mitochondrion organization  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  electron transfer activity  heme binding  cellular response to oxidative stress  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  cellular respiration  metal ion binding  respirasome  
Ontology : EGO-EBIprotein binding  nucleus  nucleus  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial intermembrane space  mitochondrial intermembrane space  cytosol  cytosol  cytosol  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, cytochrome c to oxygen  apoptotic process  mitochondrion organization  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  electron transfer activity  heme binding  cellular response to oxidative stress  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  cellular respiration  metal ion binding  respirasome  
Pathways : KEGGSulfur metabolism    p53 signaling pathway    Apoptosis    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Legionellosis    Toxoplasmosis    Tuberculosis    Hepatitis B    Influenza A    Herpes simplex infection    Pathways in cancer    Colorectal cancer    Small cell lung cancer    Viral myocarditis   
NDEx NetworkCYCS
Atlas of Cancer Signalling NetworkCYCS
Wikipedia pathwaysCYCS
Orthology - Evolution
OrthoDB54205
GeneTree (enSembl)ENSG00000172115
Phylogenetic Trees/Animal Genes : TreeFamCYCS
Homologs : HomoloGeneCYCS
Homology/Alignments : Family Browser (UCSC)CYCS
Gene fusions - Rearrangements
Fusion : QuiverCYCS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYCS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYCS
dbVarCYCS
ClinVarCYCS
MonarchCYCS
1000_GenomesCYCS 
Exome Variant ServerCYCS
GNOMAD BrowserENSG00000172115
Varsome BrowserCYCS
ACMGCYCS variants
VarityP99999
Genomic Variants (DGV)CYCS [DGVbeta]
DECIPHERCYCS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYCS 
Mutations
ICGC Data PortalCYCS 
TCGA Data PortalCYCS 
Broad Tumor PortalCYCS
OASIS PortalCYCS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYCS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYCS
Mutations and Diseases : HGMDCYCS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCYCS
DgiDB (Drug Gene Interaction Database)CYCS
DoCM (Curated mutations)CYCS
CIViC (Clinical Interpretations of Variants in Cancer)CYCS
Cancer3DCYCS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123970    612004   
Orphanet17789   
DisGeNETCYCS
MedgenCYCS
Genetic Testing Registry CYCS
NextProtP99999 [Medical]
GENETestsCYCS
Target ValidationCYCS
Huge Navigator CYCS [HugePedia]
ClinGenCYCS
Clinical trials, drugs, therapy
MyCancerGenomeCYCS
Protein Interactions : CTDCYCS
Pharm GKB GenePA134981636
Pharm GKB PathwaysPA165292164   PA166115250   
PharosP99999
Clinical trialCYCS
Miscellaneous
canSAR (ICR)CYCS
HarmonizomeCYCS
DataMed IndexCYCS
Probes
Litterature
PubMed179 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCYCS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:05:51 CEST 2021

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