CYCS (cytochrome c, somatic)

2007-04-01 Affiliation

Identity

HGNC

CYCS

LOCATION

7p15.3

LOCUSID

54205

ALIAS

CYC,HCS,THC4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54205
MIM: 123970
HGNC: 19986
Ensembl: ENSG00000172115

Variants:

dbSNP: 54205
ClinVar: 54205
TCGA: ENSG00000172115
COSMIC: CYCS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172115	ENST00000305786	P99999
ENSG00000172115	ENST00000305786	G4XXL9
ENSG00000172115	ENST00000409409	P99999
ENSG00000172115	ENST00000409409	G4XXL9
ENSG00000172115	ENST00000409764	P99999
ENSG00000172115	ENST00000409764	G4XXL9
ENSG00000172115	ENST00000413447	C9JFR7

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Sulfur metabolism	KEGG	ko00920
p53 signaling pathway	KEGG	ko04115
Apoptosis	KEGG	ko04210
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
Huntington's disease	KEGG	ko05016
Colorectal cancer	KEGG	ko05210
Small cell lung cancer	KEGG	ko05222
Sulfur metabolism	KEGG	hsa00920
p53 signaling pathway	KEGG	hsa04115
Apoptosis	KEGG	hsa04210
Alzheimer's disease	KEGG	hsa05010
Parkinson's disease	KEGG	hsa05012
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Huntington's disease	KEGG	hsa05016
Pathways in cancer	KEGG	hsa05200
Colorectal cancer	KEGG	hsa05210
Small cell lung cancer	KEGG	hsa05222
Viral myocarditis	KEGG	hsa05416
Metabolic pathways	KEGG	hsa01100
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Legionellosis	KEGG	ko05134
Legionellosis	KEGG	hsa05134
Hepatitis B	KEGG	hsa05161
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Mitochondrial biogenesis	REACTOME	R-HSA-1592230
Transcriptional activation of mitochondrial biogenesis	REACTOME	R-HSA-2151201
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	REACTOME	R-HSA-163200
Respiratory electron transport	REACTOME	R-HSA-611105
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Intrinsic Pathway for Apoptosis	REACTOME	R-HSA-109606
Release of apoptotic factors from the mitochondria	REACTOME	R-HSA-111457
Apoptotic factor-mediated response	REACTOME	R-HSA-111471
Cytochrome c-mediated apoptotic response	REACTOME	R-HSA-111461
Formation of apoptosome	REACTOME	R-HSA-111458
Activation of caspases through apoptosome-mediated cleavage	REACTOME	R-HSA-111459
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685
Apoptosis - multiple species	KEGG	ko04215
Apoptosis - multiple species	KEGG	hsa04215
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA26094	CASP9	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
19029908	2008	Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.	123
11839755	2002	Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation.	90
22184220	2012	Label-free Raman observation of cytochrome c dynamics during apoptosis.	69
25275009	2014	Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.	47
18345000	2008	A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.	43
21712378	2011	Resveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.	37
22157762	2012	Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.	37
18417609	2008	Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c.	27
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
19770576	2009	Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant Hep G2 cells through a mitochondria-dependent oxidative stress mechanism.	23

Citation

Dessen P

CYCS (cytochrome c, somatic)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47391/cycs