Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYCS (cytochrome c, somatic)

Identity

Alias_symbol (synonym)HCS
CYC
Other aliasTHC4
HGNC (Hugo) CYCS
LocusID (NCBI) 54205
Atlas_Id 47391
Location 7p15.3  [Link to chromosome band 7p15]
Location_base_pair Starts at 25118651 and ends at 25125361 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYCS (7p15.3) / MARCH4 (2q35)CYCS (7p15.3) / RDH11 (14q24.1)TPK1 (7q35) / CYCS (7p15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYCS   19986
LRG (Locus Reference Genomic)LRG_876
Cards
Entrez_Gene (NCBI)CYCS  54205  cytochrome c, somatic
AliasesCYC; HCS; THC4
GeneCards (Weizmann)CYCS
Ensembl hg19 (Hinxton)ENSG00000172115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172115 [Gene_View]  ENSG00000172115 [Sequence]  chr7:25118651-25125361 [Contig_View]  CYCS [Vega]
ICGC DataPortalENSG00000172115
TCGA cBioPortalCYCS
AceView (NCBI)CYCS
Genatlas (Paris)CYCS
WikiGenes54205
SOURCE (Princeton)CYCS
Genetics Home Reference (NIH)CYCS
Genomic and cartography
GoldenPath hg38 (UCSC)CYCS  -     chr7:25118651-25125361 -  7p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYCS  -     7p15.3   [Description]    (hg19-Feb_2009)
EnsemblCYCS - 7p15.3 [CytoView hg19]  CYCS - 7p15.3 [CytoView hg38]
Mapping of homologs : NCBICYCS [Mapview hg19]  CYCS [Mapview hg38]
OMIM123970   612004   
Gene and transcription
Genbank (Entrez)AI365318 AK056360 AK311836 AL713681 BC005299
RefSeq transcript (Entrez)NM_018947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYCS
Cluster EST : UnigeneHs.617193 [ NCBI ]
CGAP (NCI)Hs.617193
Alternative Splicing GalleryENSG00000172115
Gene ExpressionCYCS [ NCBI-GEO ]   CYCS [ EBI - ARRAY_EXPRESS ]   CYCS [ SEEK ]   CYCS [ MEM ]
Gene Expression Viewer (FireBrowse)CYCS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54205
GTEX Portal (Tissue expression)CYCS
Human Protein AtlasENSG00000172115-CYCS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP99999   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP99999  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP99999
Splice isoforms : SwissVarP99999
PhosPhoSitePlusP99999
Domaine pattern : Prosite (Expaxy)CYTC (PS51007)   
Domains : Interpro (EBI)Cyt_c-like_dom    Cyt_c-like_dom_sf    Cyt_c_1A/1B   
Domain families : Pfam (Sanger)Cytochrom_C (PF00034)   
Domain families : Pfam (NCBI)pfam00034   
Conserved Domain (NCBI)CYCS
DMDM Disease mutations54205
Blocks (Seattle)CYCS
PDB (SRS)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
PDB (PDBSum)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
PDB (IMB)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
PDB (RSDB)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
Structural Biology KnowledgeBase1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
SCOP (Structural Classification of Proteins)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
CATH (Classification of proteins structures)1J3S    2N3Y    2N9I    2N9J    3NWV    3ZCF    3ZOO    5EXQ    5TY3   
SuperfamilyP99999
Human Protein Atlas [tissue]ENSG00000172115-CYCS [tissue]
Peptide AtlasP99999
HPRD00479
IPIIPI00465315   IPI00917605   
Protein Interaction databases
DIP (DOE-UCLA)P99999
IntAct (EBI)P99999
FunCoupENSG00000172115
BioGRIDCYCS
STRING (EMBL)CYCS
ZODIACCYCS
Ontologies - Pathways
QuickGOP99999
Ontology : AmiGOprotein phosphatase type 2A complex  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleus  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial intermembrane space  mitochondrial intermembrane space  cytosol  cytosol  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, cytochrome c to oxygen  protein dephosphorylation  mitochondrion organization  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  heme binding  cellular response to oxidative stress  electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity  cellular respiration  metal ion binding  respiratory chain  intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleus  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial intermembrane space  mitochondrial intermembrane space  mitochondrial intermembrane space  cytosol  cytosol  mitochondrial electron transport, ubiquinol to cytochrome c  mitochondrial electron transport, cytochrome c to oxygen  protein dephosphorylation  mitochondrion organization  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  heme binding  cellular response to oxidative stress  electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity  cellular respiration  metal ion binding  respiratory chain  intrinsic apoptotic signaling pathway  
Pathways : KEGGSulfur metabolism    p53 signaling pathway    Apoptosis    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Legionellosis    Toxoplasmosis    Tuberculosis    Hepatitis B    Influenza A    Herpes simplex infection    Pathways in cancer    Colorectal cancer    Small cell lung cancer    Viral myocarditis   
NDEx NetworkCYCS
Atlas of Cancer Signalling NetworkCYCS
Wikipedia pathwaysCYCS
Orthology - Evolution
OrthoDB54205
GeneTree (enSembl)ENSG00000172115
Phylogenetic Trees/Animal Genes : TreeFamCYCS
HOVERGENP99999
HOGENOMP99999
Homologs : HomoloGeneCYCS
Homology/Alignments : Family Browser (UCSC)CYCS
Gene fusions - Rearrangements
Fusion : QuiverCYCS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYCS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYCS
dbVarCYCS
ClinVarCYCS
1000_GenomesCYCS 
Exome Variant ServerCYCS
ExAC (Exome Aggregation Consortium)ENSG00000172115
GNOMAD BrowserENSG00000172115
Varsome BrowserCYCS
Genetic variants : HAPMAP54205
Genomic Variants (DGV)CYCS [DGVbeta]
DECIPHERCYCS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYCS 
Mutations
ICGC Data PortalCYCS 
TCGA Data PortalCYCS 
Broad Tumor PortalCYCS
OASIS PortalCYCS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYCS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYCS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CYCS
DgiDB (Drug Gene Interaction Database)CYCS
DoCM (Curated mutations)CYCS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYCS (select a term)
intoGenCYCS
Cancer3DCYCS(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123970    612004   
Orphanet17789   
DisGeNETCYCS
MedgenCYCS
Genetic Testing Registry CYCS
NextProtP99999 [Medical]
TSGene54205
GENETestsCYCS
Target ValidationCYCS
Huge Navigator CYCS [HugePedia]
snp3D : Map Gene to Disease54205
BioCentury BCIQCYCS
ClinGenCYCS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54205
Chemical/Pharm GKB GenePA134981636
Clinical trialCYCS
Miscellaneous
canSAR (ICR)CYCS (select the gene name)
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYCS
EVEXCYCS
GoPubMedCYCS
iHOPCYCS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:01:11 CET 2018

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