Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYFIP1 (cytoplasmic FMR1 interacting protein 1)

Identity

Alias_symbol (synonym)KIAA0068
P140SRA-1
SHYC
Other aliasSRA-1
SRA1
HGNC (Hugo) CYFIP1
LocusID (NCBI) 23191
Atlas_Id 51038
Location 15q11.2  [Link to chromosome band 15q11]
Location_base_pair Starts at 22955755 and ends at 23003603 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACSF2 (17q21.33) / CYFIP1 (15q11.2)CYFIP1 (15q11.2) / TUBGCP5 (15q11.2)CYFIP1 (15q11.2) / UBR4 (1p36.13)
CYP19A1 (15q21.2) / CYFIP1 (15q11.2)TEX9 (15q21.3) / CYFIP1 (15q11.2)CYFIP1 15q11.2 / TUBGCP5 15q11.2
TEX9 15q21.3 / CYFIP1 15q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYFIP1   13759
Cards
Entrez_Gene (NCBI)CYFIP1  23191  cytoplasmic FMR1 interacting protein 1
AliasesP140SRA-1; SHYC; SRA-1; SRA1
GeneCards (Weizmann)CYFIP1
Ensembl hg19 (Hinxton)ENSG00000273749 [Gene_View]  chr15:22955755-23003603 [Contig_View]  CYFIP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000273749 [Gene_View]  chr15:22955755-23003603 [Contig_View]  CYFIP1 [Vega]
ICGC DataPortalENSG00000273749
TCGA cBioPortalCYFIP1
AceView (NCBI)CYFIP1
Genatlas (Paris)CYFIP1
WikiGenes23191
SOURCE (Princeton)CYFIP1
Genetics Home Reference (NIH)CYFIP1
Genomic and cartography
GoldenPath hg19 (UCSC)CYFIP1  -     chr15:22955755-23003603 +  15q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYFIP1  -     15q11.2   [Description]    (hg38-Dec_2013)
EnsemblCYFIP1 - 15q11.2 [CytoView hg19]  CYFIP1 - 15q11.2 [CytoView hg38]
Mapping of homologs : NCBICYFIP1 [Mapview hg19]  CYFIP1 [Mapview hg38]
OMIM606322   
Gene and transcription
Genbank (Entrez)AK024816 AK125784 AK125936 AK127094 AK291604
RefSeq transcript (Entrez)NM_001033028 NM_001287810 NM_014608
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_078094 NT_187603 NW_004929396
Consensus coding sequences : CCDS (NCBI)CYFIP1
Cluster EST : UnigeneHs.26704 [ NCBI ]
CGAP (NCI)Hs.26704
Alternative Splicing GalleryENSG00000273749
Gene ExpressionCYFIP1 [ NCBI-GEO ]   CYFIP1 [ EBI - ARRAY_EXPRESS ]   CYFIP1 [ SEEK ]   CYFIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYFIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23191
GTEX Portal (Tissue expression)CYFIP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L576   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L576  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L576
Splice isoforms : SwissVarQ7L576
PhosPhoSitePlusQ7L576
Domains : Interpro (EBI)Cytoplasmic_FMR1-int    DUF1394   
Domain families : Pfam (Sanger)DUF1394 (PF07159)    FragX_IP (PF05994)   
Domain families : Pfam (NCBI)pfam07159    pfam05994   
Conserved Domain (NCBI)CYFIP1
DMDM Disease mutations23191
Blocks (Seattle)CYFIP1
PDB (SRS)3P8C    4N78   
PDB (PDBSum)3P8C    4N78   
PDB (IMB)3P8C    4N78   
PDB (RSDB)3P8C    4N78   
Structural Biology KnowledgeBase3P8C    4N78   
SCOP (Structural Classification of Proteins)3P8C    4N78   
CATH (Classification of proteins structures)3P8C    4N78   
SuperfamilyQ7L576
Human Protein AtlasENSG00000273749
Peptide AtlasQ7L576
HPRD05890
IPIIPI00644231   IPI00550212   IPI00790673   IPI00903062   
Protein Interaction databases
DIP (DOE-UCLA)Q7L576
IntAct (EBI)Q7L576
FunCoupENSG00000273749
BioGRIDCYFIP1
STRING (EMBL)CYFIP1
ZODIACCYFIP1
Ontologies - Pathways
QuickGOQ7L576
Ontology : AmiGOruffle  protein binding  cytosol  mRNA cap binding complex  focal adhesion  regulation of cell shape  Rac protein signal transduction  lamellipodium  lamellipodium assembly  SCAR complex  ruffle organization  protein complex binding  protein complex binding  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  synapse  vascular endothelial growth factor receptor signaling pathway  Rac GTPase binding  Rac GTPase binding  perinuclear region of cytoplasm  axon extension  cognition  actin filament binding  extracellular exosome  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIruffle  protein binding  cytosol  mRNA cap binding complex  focal adhesion  regulation of cell shape  Rac protein signal transduction  lamellipodium  lamellipodium assembly  SCAR complex  ruffle organization  protein complex binding  protein complex binding  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  synapse  vascular endothelial growth factor receptor signaling pathway  Rac GTPase binding  Rac GTPase binding  perinuclear region of cytoplasm  axon extension  cognition  actin filament binding  extracellular exosome  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : KEGGRNA transport    Regulation of actin cytoskeleton   
NDEx NetworkCYFIP1
Atlas of Cancer Signalling NetworkCYFIP1
Wikipedia pathwaysCYFIP1
Orthology - Evolution
OrthoDB23191
GeneTree (enSembl)ENSG00000273749
Phylogenetic Trees/Animal Genes : TreeFamCYFIP1
HOVERGENQ7L576
HOGENOMQ7L576
Homologs : HomoloGeneCYFIP1
Homology/Alignments : Family Browser (UCSC)CYFIP1
Gene fusions - Rearrangements
Fusion : MitelmanCYFIP1/TUBGCP5 [15q11.2/15q11.2]  
Fusion : MitelmanTEX9/CYFIP1 [15q21.3/15q11.2]  [t(15;15)(q11;q21)]  
Fusion: TCGACYFIP1 15q11.2 TUBGCP5 15q11.2 BLCA BRCA
Fusion: TCGATEX9 15q21.3 CYFIP1 15q11.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYFIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYFIP1
dbVarCYFIP1
ClinVarCYFIP1
1000_GenomesCYFIP1 
Exome Variant ServerCYFIP1
ExAC (Exome Aggregation Consortium)CYFIP1 (select the gene name)
Genetic variants : HAPMAP23191
Genomic Variants (DGV)CYFIP1 [DGVbeta]
DECIPHER (Syndromes)15:22955755-23003603  ENSG00000273749
CONAN: Copy Number AnalysisCYFIP1 
Mutations
ICGC Data PortalCYFIP1 
TCGA Data PortalCYFIP1 
Broad Tumor PortalCYFIP1
OASIS PortalCYFIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYFIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYFIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYFIP1
DgiDB (Drug Gene Interaction Database)CYFIP1
DoCM (Curated mutations)CYFIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYFIP1 (select a term)
intoGenCYFIP1
Cancer3DCYFIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606322   
Orphanet
MedgenCYFIP1
Genetic Testing Registry CYFIP1
NextProtQ7L576 [Medical]
TSGene23191
GENETestsCYFIP1
Huge Navigator CYFIP1 [HugePedia]
snp3D : Map Gene to Disease23191
BioCentury BCIQCYFIP1
ClinGenCYFIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23191
Chemical/Pharm GKB GenePA38367
Clinical trialCYFIP1
Miscellaneous
canSAR (ICR)CYFIP1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYFIP1
EVEXCYFIP1
GoPubMedCYFIP1
iHOPCYFIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:58:11 CEST 2017

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