Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYFIP2 (cytoplasmic FMR1 interacting protein 2)

Identity

Alias_symbol (synonym)PIR121
Other aliasEIEE65
HGNC (Hugo) CYFIP2
LocusID (NCBI) 26999
Atlas_Id 52345
Location 5q33.3  [Link to chromosome band 5q33]
Location_base_pair Starts at 157269342 and ends at 157395598 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C1S (12p13.31) / CYFIP2 (5q33.3)CYFIP2 (5q33.3) / CYFIP2 (5q33.3)CYFIP2 (5q33.3) / MGST2 (4q31.1)
CYFIP2 (5q33.3) / PLCG2 (16q23.3)SYP (Xp11.23) / CYFIP2 (5q33.3)TAF7 (5q31.3) / CYFIP2 (5q33.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYFIP2   13760
Cards
Entrez_Gene (NCBI)CYFIP2  26999  cytoplasmic FMR1 interacting protein 2
AliasesEIEE65; PIR121
GeneCards (Weizmann)CYFIP2
Ensembl hg19 (Hinxton)ENSG00000055163 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000055163 [Gene_View]  ENSG00000055163 [Sequence]  chr5:157269342-157395598 [Contig_View]  CYFIP2 [Vega]
ICGC DataPortalENSG00000055163
TCGA cBioPortalCYFIP2
AceView (NCBI)CYFIP2
Genatlas (Paris)CYFIP2
WikiGenes26999
SOURCE (Princeton)CYFIP2
Genetics Home Reference (NIH)CYFIP2
Genomic and cartography
GoldenPath hg38 (UCSC)CYFIP2  -     chr5:157269342-157395598 +  5q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYFIP2  -     5q33.3   [Description]    (hg19-Feb_2009)
GoldenPathCYFIP2 - 5q33.3 [CytoView hg19]  CYFIP2 - 5q33.3 [CytoView hg38]
ImmunoBaseENSG00000055163
Mapping of homologs : NCBICYFIP2 [Mapview hg19]  CYFIP2 [Mapview hg38]
OMIM606323   618008   
Gene and transcription
Genbank (Entrez)AB032994 AF132197 AF160973 AK172724 AK223604
RefSeq transcript (Entrez)NM_001037332 NM_001037333 NM_001291721 NM_001291722 NM_014376
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYFIP2
Cluster EST : UnigeneHs.519702 [ NCBI ]
CGAP (NCI)Hs.519702
Alternative Splicing GalleryENSG00000055163
Gene ExpressionCYFIP2 [ NCBI-GEO ]   CYFIP2 [ EBI - ARRAY_EXPRESS ]   CYFIP2 [ SEEK ]   CYFIP2 [ MEM ]
Gene Expression Viewer (FireBrowse)CYFIP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26999
GTEX Portal (Tissue expression)CYFIP2
Human Protein AtlasENSG00000055163-CYFIP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96F07   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96F07  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96F07
Splice isoforms : SwissVarQ96F07
PhosPhoSitePlusQ96F07
Domains : Interpro (EBI)Cytoplasmic_FMR1-int    DUF1394   
Domain families : Pfam (Sanger)DUF1394 (PF07159)    FragX_IP (PF05994)   
Domain families : Pfam (NCBI)pfam07159    pfam05994   
Conserved Domain (NCBI)CYFIP2
DMDM Disease mutations26999
Blocks (Seattle)CYFIP2
SuperfamilyQ96F07
Human Protein Atlas [tissue]ENSG00000055163-CYFIP2 [tissue]
Peptide AtlasQ96F07
HPRD07556
IPIIPI00789699   IPI00719600   IPI01018740   IPI01010578   IPI00383109   IPI00006514   IPI01019048   IPI00984777   IPI00975903   IPI00973795   
Protein Interaction databases
DIP (DOE-UCLA)Q96F07
IntAct (EBI)Q96F07
FunCoupENSG00000055163
BioGRIDCYFIP2
STRING (EMBL)CYFIP2
ZODIACCYFIP2
Ontologies - Pathways
QuickGOQ96F07
Ontology : AmiGORNA 7-methylguanosine cap binding  cell morphogenesis  protein binding  nucleus  cytoplasm  cytosol  apoptotic process  apoptotic process  axon guidance  membrane  cell projection assembly  cell junction  SCAR complex  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  synapse  synapse  positive regulation of proteolysis  vascular endothelial growth factor receptor signaling pathway  perinuclear region of cytoplasm  positive regulation of neurotrophin TRK receptor signaling pathway  extracellular exosome  activation of cysteine-type endopeptidase activity  activation of cysteine-type endopeptidase activity  dendrite extension  cell-cell adhesion  
Ontology : EGO-EBIRNA 7-methylguanosine cap binding  cell morphogenesis  protein binding  nucleus  cytoplasm  cytosol  apoptotic process  apoptotic process  axon guidance  membrane  cell projection assembly  cell junction  SCAR complex  Fc-gamma receptor signaling pathway involved in phagocytosis  neuron projection  synapse  synapse  positive regulation of proteolysis  vascular endothelial growth factor receptor signaling pathway  perinuclear region of cytoplasm  positive regulation of neurotrophin TRK receptor signaling pathway  extracellular exosome  activation of cysteine-type endopeptidase activity  activation of cysteine-type endopeptidase activity  dendrite extension  cell-cell adhesion  
Pathways : KEGGRNA transport    Regulation of actin cytoskeleton   
NDEx NetworkCYFIP2
Atlas of Cancer Signalling NetworkCYFIP2
Wikipedia pathwaysCYFIP2
Orthology - Evolution
OrthoDB26999
GeneTree (enSembl)ENSG00000055163
Phylogenetic Trees/Animal Genes : TreeFamCYFIP2
HOGENOMQ96F07
Homologs : HomoloGeneCYFIP2
Homology/Alignments : Family Browser (UCSC)CYFIP2
Gene fusions - Rearrangements
Fusion : QuiverCYFIP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYFIP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYFIP2
dbVarCYFIP2
ClinVarCYFIP2
1000_GenomesCYFIP2 
Exome Variant ServerCYFIP2
ExAC (Exome Aggregation Consortium)ENSG00000055163
GNOMAD BrowserENSG00000055163
Varsome BrowserCYFIP2
Genetic variants : HAPMAP26999
Genomic Variants (DGV)CYFIP2 [DGVbeta]
DECIPHERCYFIP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYFIP2 
Mutations
ICGC Data PortalCYFIP2 
TCGA Data PortalCYFIP2 
Broad Tumor PortalCYFIP2
OASIS PortalCYFIP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYFIP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCYFIP2
Mutations and Diseases : HGMDCYFIP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYFIP2
DgiDB (Drug Gene Interaction Database)CYFIP2
DoCM (Curated mutations)CYFIP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYFIP2 (select a term)
intoGenCYFIP2
Cancer3DCYFIP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606323    618008   
Orphanet
DisGeNETCYFIP2
MedgenCYFIP2
Genetic Testing Registry CYFIP2
NextProtQ96F07 [Medical]
TSGene26999
GENETestsCYFIP2
Target ValidationCYFIP2
Huge Navigator CYFIP2 [HugePedia]
snp3D : Map Gene to Disease26999
BioCentury BCIQCYFIP2
ClinGenCYFIP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26999
Chemical/Pharm GKB GenePA38368
Clinical trialCYFIP2
Miscellaneous
canSAR (ICR)CYFIP2 (select the gene name)
DataMed IndexCYFIP2
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYFIP2
EVEXCYFIP2
GoPubMedCYFIP2
iHOPCYFIP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Nov 13 17:39:28 CET 2019
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