CYGB (cytoglobin)

2007-02-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
HGB,STAP
FUSION GENES

Other Information

Locus ID:

NCBI: 114757
MIM: 608759
HGNC: 16505
Ensembl: ENSG00000161544

Variants:

dbSNP: 114757
ClinVar: 114757
TCGA: ENSG00000161544
COSMIC: CYGB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161544ENST00000293230Q8WWM9
ENSG00000161544ENST00000293230A0A1K0FUB6
ENSG00000161544ENST00000589145K7EIM9
ENSG00000161544ENST00000589342K7EMC7
ENSG00000161544ENST00000590175K7EIM9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of nitric oxideREACTOMER-HSA-202131
eNOS activation and regulationREACTOMER-HSA-203765
eNOS activationREACTOMER-HSA-203615

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119192822002Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues.115
118937552002A ubiquitously expressed human hexacoordinate hemoglobin.87
164499962006Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.66
146605702004Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia.56
145302642003The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin.55
152990062004Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance.53
228967062012Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions.43
191474912009Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation.42
211719642011Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress.41
187941322008Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.38

Citation

Dessen P

CYGB (cytoglobin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46125/cygb