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CYP11A1 (cytochrome P450 family 11 subfamily A member 1)

Identity

Alias_namesCYP11A
cytochrome P450, subfamily XIA (cholesterol side chain cleavage)
cytochrome P450, family 11, subfamily A, polypeptide 1
Alias_symbol (synonym)P450SCC
Other aliasCYPXIA1
HGNC (Hugo) CYP11A1
LocusID (NCBI) 1583
Atlas_Id 45822
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74337762 and ends at 74367740 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYP11A1 (15q24.1) / CYP11A1 (15q24.1)SFSWAP (12q24.33) / CYP11A1 (15q24.1)TFE3 (Xp11.23) / CYP11A1 (15q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP11A1   2590
Cards
Entrez_Gene (NCBI)CYP11A1  1583  cytochrome P450 family 11 subfamily A member 1
AliasesCYP11A; CYPXIA1; P450SCC
GeneCards (Weizmann)CYP11A1
Ensembl hg19 (Hinxton)ENSG00000140459 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140459 [Gene_View]  chr15:74337762-74367740 [Contig_View]  CYP11A1 [Vega]
ICGC DataPortalENSG00000140459
TCGA cBioPortalCYP11A1
AceView (NCBI)CYP11A1
Genatlas (Paris)CYP11A1
WikiGenes1583
SOURCE (Princeton)CYP11A1
Genetics Home Reference (NIH)CYP11A1
Genomic and cartography
GoldenPath hg38 (UCSC)CYP11A1  -     chr15:74337762-74367740 -  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP11A1  -     15q24.1   [Description]    (hg19-Feb_2009)
EnsemblCYP11A1 - 15q24.1 [CytoView hg19]  CYP11A1 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBICYP11A1 [Mapview hg19]  CYP11A1 [Mapview hg38]
OMIM118485   613743   
Gene and transcription
Genbank (Entrez)AI149078 AK056794 AK225715 AK292300 AK292301
RefSeq transcript (Entrez)NM_000781 NM_001099773
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP11A1
Cluster EST : UnigeneHs.303980 [ NCBI ]
CGAP (NCI)Hs.303980
Alternative Splicing GalleryENSG00000140459
Gene ExpressionCYP11A1 [ NCBI-GEO ]   CYP11A1 [ EBI - ARRAY_EXPRESS ]   CYP11A1 [ SEEK ]   CYP11A1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP11A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1583
GTEX Portal (Tissue expression)CYP11A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05108   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05108  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05108
Splice isoforms : SwissVarP05108
Catalytic activity : Enzyme1.14.15.6 [ Enzyme-Expasy ]   1.14.15.61.14.15.6 [ IntEnz-EBI ]   1.14.15.6 [ BRENDA ]   1.14.15.6 [ KEGG ]   
PhosPhoSitePlusP05108
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)CYP11A1    Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP11A1
DMDM Disease mutations1583
Blocks (Seattle)CYP11A1
PDB (SRS)3N9Y    3N9Z    3NA0    3NA1   
PDB (PDBSum)3N9Y    3N9Z    3NA0    3NA1   
PDB (IMB)3N9Y    3N9Z    3NA0    3NA1   
PDB (RSDB)3N9Y    3N9Z    3NA0    3NA1   
Structural Biology KnowledgeBase3N9Y    3N9Z    3NA0    3NA1   
SCOP (Structural Classification of Proteins)3N9Y    3N9Z    3NA0    3NA1   
CATH (Classification of proteins structures)3N9Y    3N9Z    3NA0    3NA1   
SuperfamilyP05108
Human Protein AtlasENSG00000140459
Peptide AtlasP05108
HPRD00326
IPIIPI00295771   IPI00910277   IPI00856028   IPI00878734   IPI00878883   IPI00879050   IPI00879211   
Protein Interaction databases
DIP (DOE-UCLA)P05108
IntAct (EBI)P05108
FunCoupENSG00000140459
BioGRIDCYP11A1
STRING (EMBL)CYP11A1
ZODIACCYP11A1
Ontologies - Pathways
QuickGOP05108
Ontology : AmiGOiron ion binding  mitochondrion  mitochondrial matrix  C21-steroid hormone biosynthetic process  C21-steroid hormone biosynthetic process  cholesterol metabolic process  cholesterol metabolic process  cholesterol metabolic process  cholesterol monooxygenase (side-chain-cleaving) activity  cholesterol monooxygenase (side-chain-cleaving) activity  cholesterol monooxygenase (side-chain-cleaving) activity  sterol metabolic process  heme binding  mitochondrial membrane  vitamin D metabolic process  oxidation-reduction process  
Ontology : EGO-EBIiron ion binding  mitochondrion  mitochondrial matrix  C21-steroid hormone biosynthetic process  C21-steroid hormone biosynthetic process  cholesterol metabolic process  cholesterol metabolic process  cholesterol metabolic process  cholesterol monooxygenase (side-chain-cleaving) activity  cholesterol monooxygenase (side-chain-cleaving) activity  cholesterol monooxygenase (side-chain-cleaving) activity  sterol metabolic process  heme binding  mitochondrial membrane  vitamin D metabolic process  oxidation-reduction process  
Pathways : KEGGSteroid hormone biosynthesis    Ovarian steroidogenesis   
NDEx NetworkCYP11A1
Atlas of Cancer Signalling NetworkCYP11A1
Wikipedia pathwaysCYP11A1
Orthology - Evolution
OrthoDB1583
GeneTree (enSembl)ENSG00000140459
Phylogenetic Trees/Animal Genes : TreeFamCYP11A1
HOVERGENP05108
HOGENOMP05108
Homologs : HomoloGeneCYP11A1
Homology/Alignments : Family Browser (UCSC)CYP11A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP11A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP11A1
dbVarCYP11A1
ClinVarCYP11A1
1000_GenomesCYP11A1 
Exome Variant ServerCYP11A1
ExAC (Exome Aggregation Consortium)CYP11A1 (select the gene name)
Genetic variants : HAPMAP1583
Genomic Variants (DGV)CYP11A1 [DGVbeta]
DECIPHERCYP11A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP11A1 
Mutations
ICGC Data PortalCYP11A1 
TCGA Data PortalCYP11A1 
Broad Tumor PortalCYP11A1
OASIS PortalCYP11A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP11A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP11A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CYP11A1
DgiDB (Drug Gene Interaction Database)CYP11A1
DoCM (Curated mutations)CYP11A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP11A1 (select a term)
intoGenCYP11A1
Cancer3DCYP11A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118485    613743   
Orphanet17771    20739   
MedgenCYP11A1
Genetic Testing Registry CYP11A1
NextProtP05108 [Medical]
TSGene1583
GENETestsCYP11A1
Target ValidationCYP11A1
Huge Navigator CYP11A1 [HugePedia]
snp3D : Map Gene to Disease1583
BioCentury BCIQCYP11A1
ClinGenCYP11A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1583
Chemical/Pharm GKB GenePA27089
Clinical trialCYP11A1
Miscellaneous
canSAR (ICR)CYP11A1 (select the gene name)
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP11A1
EVEXCYP11A1
GoPubMedCYP11A1
iHOPCYP11A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:30:19 CEST 2017

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