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CYP11B1 (cytochrome P450 family 11 subfamily B member 1)

Identity

Alias_namesCYP11B
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
cytochrome P450, family 11, subfamily B, polypeptide 1
Alias_symbol (synonym)P450C11
FHI
CPN1
HGNC (Hugo) CYP11B1
LocusID (NCBI) 1584
Atlas_Id 52986
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143953773 and ends at 143961236 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CYP11B1 (8q24.3) / CYP11B2 (8q24.3)GADD45G (9q22.2) / CYP11B1 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CYP11B1   2591
Cards
Entrez_Gene (NCBI)CYP11B1  1584  cytochrome P450 family 11 subfamily B member 1
AliasesCPN1; CYP11B; FHI; P450C11
GeneCards (Weizmann)CYP11B1
Ensembl hg19 (Hinxton)ENSG00000160882 [Gene_View]  chr8:143953773-143961236 [Contig_View]  CYP11B1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160882 [Gene_View]  chr8:143953773-143961236 [Contig_View]  CYP11B1 [Vega]
ICGC DataPortalENSG00000160882
TCGA cBioPortalCYP11B1
AceView (NCBI)CYP11B1
Genatlas (Paris)CYP11B1
WikiGenes1584
SOURCE (Princeton)CYP11B1
Genetics Home Reference (NIH)CYP11B1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP11B1  -     chr8:143953773-143961236 -  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP11B1  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblCYP11B1 - 8q24.3 [CytoView hg19]  CYP11B1 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBICYP11B1 [Mapview hg19]  CYP11B1 [Mapview hg38]
OMIM103900   202010   610613   
Gene and transcription
Genbank (Entrez)AF478474 AK094090 BC096285 BC096286 BC096287
RefSeq transcript (Entrez)NM_000497 NM_001026213
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_007954 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)CYP11B1
Cluster EST : UnigeneHs.184927 [ NCBI ]
CGAP (NCI)Hs.184927
Alternative Splicing GalleryENSG00000160882
Gene ExpressionCYP11B1 [ NCBI-GEO ]   CYP11B1 [ EBI - ARRAY_EXPRESS ]   CYP11B1 [ SEEK ]   CYP11B1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP11B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1584
GTEX Portal (Tissue expression)CYP11B1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15538   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15538  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15538
Splice isoforms : SwissVarP15538
Catalytic activity : Enzyme1.14.15.4 [ Enzyme-Expasy ]   1.14.15.41.14.15.4 [ IntEnz-EBI ]   1.14.15.4 [ BRENDA ]   1.14.15.4 [ KEGG ]   
PhosPhoSitePlusP15538
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_mitochondrial   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP11B1
DMDM Disease mutations1584
Blocks (Seattle)CYP11B1
SuperfamilyP15538
Human Protein AtlasENSG00000160882
Peptide AtlasP15538
HPRD01943
IPIIPI00291348   IPI00976758   IPI00167781   IPI00607879   
Protein Interaction databases
DIP (DOE-UCLA)P15538
IntAct (EBI)P15538
FunCoupENSG00000160882
BioGRIDCYP11B1
STRING (EMBL)CYP11B1
ZODIACCYP11B1
Ontologies - Pathways
QuickGOP15538
Ontology : AmiGOsteroid 11-beta-monooxygenase activity  steroid 11-beta-monooxygenase activity  steroid 11-beta-monooxygenase activity  iron ion binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  C21-steroid hormone biosynthetic process  glucocorticoid biosynthetic process  immune response  cholesterol metabolic process  regulation of blood pressure  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  heme binding  heme binding  aldosterone biosynthetic process  aldosterone biosynthetic process  cellular response to hormone stimulus  cortisol biosynthetic process  cortisol biosynthetic process  cellular response to potassium ion  glucose homeostasis  secondary metabolite biosynthetic process  corticosterone 18-monooxygenase activity  oxidation-reduction process  cellular response to peptide hormone stimulus  
Ontology : EGO-EBIsteroid 11-beta-monooxygenase activity  steroid 11-beta-monooxygenase activity  steroid 11-beta-monooxygenase activity  iron ion binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  C21-steroid hormone biosynthetic process  glucocorticoid biosynthetic process  immune response  cholesterol metabolic process  regulation of blood pressure  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen  heme binding  heme binding  aldosterone biosynthetic process  aldosterone biosynthetic process  cellular response to hormone stimulus  cortisol biosynthetic process  cortisol biosynthetic process  cellular response to potassium ion  glucose homeostasis  secondary metabolite biosynthetic process  corticosterone 18-monooxygenase activity  oxidation-reduction process  cellular response to peptide hormone stimulus  
Pathways : KEGGSteroid hormone biosynthesis   
NDEx NetworkCYP11B1
Atlas of Cancer Signalling NetworkCYP11B1
Wikipedia pathwaysCYP11B1
Orthology - Evolution
OrthoDB1584
GeneTree (enSembl)ENSG00000160882
Phylogenetic Trees/Animal Genes : TreeFamCYP11B1
HOVERGENP15538
HOGENOMP15538
Homologs : HomoloGeneCYP11B1
Homology/Alignments : Family Browser (UCSC)CYP11B1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP11B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP11B1
dbVarCYP11B1
ClinVarCYP11B1
1000_GenomesCYP11B1 
Exome Variant ServerCYP11B1
ExAC (Exome Aggregation Consortium)CYP11B1 (select the gene name)
Genetic variants : HAPMAP1584
Genomic Variants (DGV)CYP11B1 [DGVbeta]
DECIPHER (Syndromes)8:143953773-143961236  ENSG00000160882
CONAN: Copy Number AnalysisCYP11B1 
Mutations
ICGC Data PortalCYP11B1 
TCGA Data PortalCYP11B1 
Broad Tumor PortalCYP11B1
OASIS PortalCYP11B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP11B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP11B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CYP11B1
DgiDB (Drug Gene Interaction Database)CYP11B1
DoCM (Curated mutations)CYP11B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP11B1 (select a term)
intoGenCYP11B1
Cancer3DCYP11B1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103900    202010    610613   
Orphanet913    12098   
MedgenCYP11B1
Genetic Testing Registry CYP11B1
NextProtP15538 [Medical]
TSGene1584
GENETestsCYP11B1
Huge Navigator CYP11B1 [HugePedia]
snp3D : Map Gene to Disease1584
BioCentury BCIQCYP11B1
ClinGenCYP11B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1584
Chemical/Pharm GKB GenePA133
Clinical trialCYP11B1
Miscellaneous
canSAR (ICR)CYP11B1 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP11B1
EVEXCYP11B1
GoPubMedCYP11B1
iHOPCYP11B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:35:11 CET 2016

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