Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYP11B2 (cytochrome P450 family 11 subfamily B member 2)

Identity

Alias_namesCYP11B
cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
cytochrome P450, family 11, subfamily B, polypeptide 2
Alias_symbol (synonym)CYP11BL
CPN2
P-450C18
P450aldo
ALDOS
Other aliasCYPXIB2
P450C18
HGNC (Hugo) CYP11B2
LocusID (NCBI) 1585
Atlas_Id 52987
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 142910559 and ends at 142917843 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CYP11B1 (8q24.3) / CYP11B2 (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP11B2   2592
Cards
Entrez_Gene (NCBI)CYP11B2  1585  cytochrome P450 family 11 subfamily B member 2
AliasesALDOS; CPN2; CYP11B; CYP11BL; 
CYPXIB2; P-450C18; P450C18; P450aldo
GeneCards (Weizmann)CYP11B2
Ensembl hg19 (Hinxton)ENSG00000179142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179142 [Gene_View]  chr8:142910559-142917843 [Contig_View]  CYP11B2 [Vega]
ICGC DataPortalENSG00000179142
TCGA cBioPortalCYP11B2
AceView (NCBI)CYP11B2
Genatlas (Paris)CYP11B2
WikiGenes1585
SOURCE (Princeton)CYP11B2
Genetics Home Reference (NIH)CYP11B2
Genomic and cartography
GoldenPath hg38 (UCSC)CYP11B2  -     chr8:142910559-142917843 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP11B2  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblCYP11B2 - 8q24.3 [CytoView hg19]  CYP11B2 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBICYP11B2 [Mapview hg19]  CYP11B2 [Mapview hg38]
OMIM124080   203400   610600   
Gene and transcription
Genbank (Entrez)X54741
RefSeq transcript (Entrez)NM_000498
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP11B2
Cluster EST : UnigeneHs.632054 [ NCBI ]
CGAP (NCI)Hs.632054
Alternative Splicing GalleryENSG00000179142
Gene ExpressionCYP11B2 [ NCBI-GEO ]   CYP11B2 [ EBI - ARRAY_EXPRESS ]   CYP11B2 [ SEEK ]   CYP11B2 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP11B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1585
GTEX Portal (Tissue expression)CYP11B2
Human Protein AtlasENSG00000179142-CYP11B2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19099   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19099  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19099
Splice isoforms : SwissVarP19099
Catalytic activity : Enzyme1.14.15.4 [ Enzyme-Expasy ]   1.14.15.41.14.15.4 [ IntEnz-EBI ]   1.14.15.4 [ BRENDA ]   1.14.15.4 [ KEGG ]   
PhosPhoSitePlusP19099
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_mitochondrial   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP11B2
DMDM Disease mutations1585
Blocks (Seattle)CYP11B2
PDB (SRS)4DVQ    4FDH    4ZGX   
PDB (PDBSum)4DVQ    4FDH    4ZGX   
PDB (IMB)4DVQ    4FDH    4ZGX   
PDB (RSDB)4DVQ    4FDH    4ZGX   
Structural Biology KnowledgeBase4DVQ    4FDH    4ZGX   
SCOP (Structural Classification of Proteins)4DVQ    4FDH    4ZGX   
CATH (Classification of proteins structures)4DVQ    4FDH    4ZGX   
SuperfamilyP19099
Human Protein Atlas [tissue]ENSG00000179142-CYP11B2 [tissue]
Peptide AtlasP19099
HPRD00492
IPIIPI00290116   IPI01024713   
Protein Interaction databases
DIP (DOE-UCLA)P19099
IntAct (EBI)P19099
FunCoupENSG00000179142
BioGRIDCYP11B2
STRING (EMBL)CYP11B2
ZODIACCYP11B2
Ontologies - Pathways
QuickGOP19099
Ontology : AmiGOregulation of blood volume by renal aldosterone  renal water homeostasis  steroid 11-beta-monooxygenase activity  steroid 11-beta-monooxygenase activity  iron ion binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  C21-steroid hormone biosynthetic process  mineralocorticoid biosynthetic process  steroid hydroxylase activity  sterol metabolic process  heme binding  heme binding  aldosterone biosynthetic process  aldosterone biosynthetic process  cellular response to hormone stimulus  cortisol biosynthetic process  cortisol biosynthetic process  cellular response to potassium ion  corticosterone 18-monooxygenase activity  potassium ion homeostasis  sodium ion homeostasis  oxidation-reduction process  
Ontology : EGO-EBIregulation of blood volume by renal aldosterone  renal water homeostasis  steroid 11-beta-monooxygenase activity  steroid 11-beta-monooxygenase activity  iron ion binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  C21-steroid hormone biosynthetic process  mineralocorticoid biosynthetic process  steroid hydroxylase activity  sterol metabolic process  heme binding  heme binding  aldosterone biosynthetic process  aldosterone biosynthetic process  cellular response to hormone stimulus  cortisol biosynthetic process  cortisol biosynthetic process  cellular response to potassium ion  corticosterone 18-monooxygenase activity  potassium ion homeostasis  sodium ion homeostasis  oxidation-reduction process  
Pathways : KEGGAndrogen and estrogen metabolism    C21-Steroid hormone metabolism   
NDEx NetworkCYP11B2
Atlas of Cancer Signalling NetworkCYP11B2
Wikipedia pathwaysCYP11B2
Orthology - Evolution
OrthoDB1585
GeneTree (enSembl)ENSG00000179142
Phylogenetic Trees/Animal Genes : TreeFamCYP11B2
HOVERGENP19099
HOGENOMP19099
Homologs : HomoloGeneCYP11B2
Homology/Alignments : Family Browser (UCSC)CYP11B2
Gene fusions - Rearrangements
Fusion : QuiverCYP11B2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP11B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP11B2
dbVarCYP11B2
ClinVarCYP11B2
1000_GenomesCYP11B2 
Exome Variant ServerCYP11B2
ExAC (Exome Aggregation Consortium)ENSG00000179142
GNOMAD BrowserENSG00000179142
Genetic variants : HAPMAP1585
Genomic Variants (DGV)CYP11B2 [DGVbeta]
DECIPHERCYP11B2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP11B2 
Mutations
ICGC Data PortalCYP11B2 
TCGA Data PortalCYP11B2 
Broad Tumor PortalCYP11B2
OASIS PortalCYP11B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP11B2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP11B2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CYP11B2
DgiDB (Drug Gene Interaction Database)CYP11B2
DoCM (Curated mutations)CYP11B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP11B2 (select a term)
intoGenCYP11B2
Cancer3DCYP11B2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM124080    203400    610600   
Orphanet913    14336   
DisGeNETCYP11B2
MedgenCYP11B2
Genetic Testing Registry CYP11B2
NextProtP19099 [Medical]
TSGene1585
GENETestsCYP11B2
Target ValidationCYP11B2
Huge Navigator CYP11B2 [HugePedia]
snp3D : Map Gene to Disease1585
BioCentury BCIQCYP11B2
ClinGenCYP11B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1585
Chemical/Pharm GKB GenePA134
Clinical trialCYP11B2
Miscellaneous
canSAR (ICR)CYP11B2 (select the gene name)
Probes
Litterature
PubMed326 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP11B2
EVEXCYP11B2
GoPubMedCYP11B2
iHOPCYP11B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:08:38 CET 2018
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