Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYP17A1 (cytochrome P450 family 17 subfamily A member 1)

Identity

Alias_namesCYP17
cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
cytochrome P450, family 17, subfamily A, polypeptide 1
Alias_symbol (synonym)P450C17
CPT7
S17AH
Other alias
HGNC (Hugo) CYP17A1
LocusID (NCBI) 1586
Atlas_Id 40233
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102830531 and ends at 102837533 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHGB (20p12.3) / CYP17A1 (10q24.32)CYP17A1 (10q24.32) / LHFP (13q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Male breast cancer
del(10)(q24q24) SUFU/CYP17A1

External links

Nomenclature
HGNC (Hugo)CYP17A1   2593
Cards
Entrez_Gene (NCBI)CYP17A1  1586  cytochrome P450 family 17 subfamily A member 1
AliasesCPT7; CYP17; P450C17; S17AH
GeneCards (Weizmann)CYP17A1
Ensembl hg19 (Hinxton)ENSG00000148795 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148795 [Gene_View]  chr10:102830531-102837533 [Contig_View]  CYP17A1 [Vega]
ICGC DataPortalENSG00000148795
TCGA cBioPortalCYP17A1
AceView (NCBI)CYP17A1
Genatlas (Paris)CYP17A1
WikiGenes1586
SOURCE (Princeton)CYP17A1
Genetics Home Reference (NIH)CYP17A1
Genomic and cartography
GoldenPath hg38 (UCSC)CYP17A1  -     chr10:102830531-102837533 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP17A1  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblCYP17A1 - 10q24.32 [CytoView hg19]  CYP17A1 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBICYP17A1 [Mapview hg19]  CYP17A1 [Mapview hg38]
OMIM202110   609300   
Gene and transcription
Genbank (Entrez)AI492406 AK094106 AK289898 AK308466 AK312235
RefSeq transcript (Entrez)NM_000102
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP17A1
Cluster EST : UnigeneHs.438016 [ NCBI ]
CGAP (NCI)Hs.438016
Alternative Splicing GalleryENSG00000148795
Gene ExpressionCYP17A1 [ NCBI-GEO ]   CYP17A1 [ EBI - ARRAY_EXPRESS ]   CYP17A1 [ SEEK ]   CYP17A1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP17A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1586
GTEX Portal (Tissue expression)CYP17A1
Human Protein AtlasENSG00000148795-CYP17A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05093   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05093  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05093
Splice isoforms : SwissVarP05093
PhosPhoSitePlusP05093
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP17A1
DMDM Disease mutations1586
Blocks (Seattle)CYP17A1
PDB (SRS)2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
PDB (PDBSum)2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
PDB (IMB)2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
PDB (RSDB)2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
Structural Biology KnowledgeBase2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
SCOP (Structural Classification of Proteins)2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
CATH (Classification of proteins structures)2C17    3RUK    3SWZ    4NKV    4NKW    4NKX    4NKY    4NKZ   
SuperfamilyP05093
Human Protein Atlas [tissue]ENSG00000148795-CYP17A1 [tissue]
Peptide AtlasP05093
HPRD01944
IPIIPI00006665   
Protein Interaction databases
DIP (DOE-UCLA)P05093
IntAct (EBI)P05093
FunCoupENSG00000148795
BioGRIDCYP17A1
STRING (EMBL)CYP17A1
ZODIACCYP17A1
Ontologies - Pathways
QuickGOP05093
Ontology : AmiGOsteroid 17-alpha-monooxygenase activity  steroid 17-alpha-monooxygenase activity  steroid 17-alpha-monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  androgen biosynthetic process  glucocorticoid biosynthetic process  sex differentiation  steroid metabolic process  sterol metabolic process  oxygen binding  heme binding  axon  hormone biosynthetic process  progesterone metabolic process  neuronal cell body  17-alpha-hydroxyprogesterone aldolase activity  oxidation-reduction process  
Ontology : EGO-EBIsteroid 17-alpha-monooxygenase activity  steroid 17-alpha-monooxygenase activity  steroid 17-alpha-monooxygenase activity  iron ion binding  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  androgen biosynthetic process  glucocorticoid biosynthetic process  sex differentiation  steroid metabolic process  sterol metabolic process  oxygen binding  heme binding  axon  hormone biosynthetic process  progesterone metabolic process  neuronal cell body  17-alpha-hydroxyprogesterone aldolase activity  oxidation-reduction process  
Pathways : KEGGC21-Steroid hormone metabolism   
NDEx NetworkCYP17A1
Atlas of Cancer Signalling NetworkCYP17A1
Wikipedia pathwaysCYP17A1
Orthology - Evolution
OrthoDB1586
GeneTree (enSembl)ENSG00000148795
Phylogenetic Trees/Animal Genes : TreeFamCYP17A1
HOVERGENP05093
HOGENOMP05093
Homologs : HomoloGeneCYP17A1
Homology/Alignments : Family Browser (UCSC)CYP17A1
Gene fusions - Rearrangements
Fusion : QuiverCYP17A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP17A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP17A1
dbVarCYP17A1
ClinVarCYP17A1
1000_GenomesCYP17A1 
Exome Variant ServerCYP17A1
ExAC (Exome Aggregation Consortium)ENSG00000148795
GNOMAD BrowserENSG00000148795
Genetic variants : HAPMAP1586
Genomic Variants (DGV)CYP17A1 [DGVbeta]
DECIPHERCYP17A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP17A1 
Mutations
ICGC Data PortalCYP17A1 
TCGA Data PortalCYP17A1 
Broad Tumor PortalCYP17A1
OASIS PortalCYP17A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP17A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP17A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP17A1
DgiDB (Drug Gene Interaction Database)CYP17A1
DoCM (Curated mutations)CYP17A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP17A1 (select a term)
intoGenCYP17A1
Cancer3DCYP17A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM202110    609300   
Orphanet12096    12099   
DisGeNETCYP17A1
MedgenCYP17A1
Genetic Testing Registry CYP17A1
NextProtP05093 [Medical]
TSGene1586
GENETestsCYP17A1
Target ValidationCYP17A1
Huge Navigator CYP17A1 [HugePedia]
snp3D : Map Gene to Disease1586
BioCentury BCIQCYP17A1
ClinGenCYP17A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1586
Chemical/Pharm GKB GenePA27090
Clinical trialCYP17A1
Miscellaneous
canSAR (ICR)CYP17A1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP17A1
EVEXCYP17A1
GoPubMedCYP17A1
iHOPCYP17A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:16:48 CEST 2018
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