CYP19A1 (cytochrome P450 family 19 subfamily A member 1)

2003-02-01  

Identity

HGNC
LOCATION
15q21.2
LOCUSID
ALIAS
ARO,ARO1,CPV1,CYAR,CYP19,CYPXIX,P-450AROM
FUSION GENES

Other Information

Locus ID:

NCBI: 1588
MIM: 107910
HGNC: 2594
Ensembl: ENSG00000137869

Variants:

dbSNP: 1588
ClinVar: 1588
TCGA: ENSG00000137869
COSMIC: CYP19A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137869ENST00000396402P11511
ENSG00000137869ENST00000396402A0A024R5S8
ENSG00000137869ENST00000396404P11511
ENSG00000137869ENST00000396404A0A024R5S8
ENSG00000137869ENST00000405011E9PGZ6
ENSG00000137869ENST00000405913P11511
ENSG00000137869ENST00000439712E7EQ08
ENSG00000137869ENST00000453807E7EPL6
ENSG00000137869ENST00000557858P11511
ENSG00000137869ENST00000557934E7EQ08
ENSG00000137869ENST00000558328H0YLP1
ENSG00000137869ENST00000559646H0YLS2
ENSG00000137869ENST00000559653H0YK57
ENSG00000137869ENST00000559878P11511
ENSG00000137869ENST00000559878A0A024R5S8
ENSG00000137869ENST00000559980H0YKN1
ENSG00000137869ENST00000561075H0YNJ7
ENSG00000137869ENST00000613097A0A087WVQ0

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
Metabolic pathwaysKEGGhsa01100
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estroneKEGGhsa_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estroneKEGGM00110
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Metabolism of steroid hormonesREACTOMER-HSA-196071
Estrogen biosynthesisREACTOMER-HSA-193144
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA133950441hmg coa reductase inhibitorsChemicalClinicalAnnotationassociated26463708
PA164712732Enzyme inhibitorsChemicalPathwayassociated19512956
PA166048848MenopauseDiseaseClinicalAnnotation, VariantAnnotationassociatedPD26463708
PA166122986radiotherapyChemicalClinicalAnnotationassociatedPD
PA166129559hdl cholesterolChemicalClinicalAnnotationassociated26463708
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD20048079, 24590773, 26463708, 26536870
PA445058Neoplasm MetastasisDiseaseClinicalAnnotationassociatedPD
PA448432anastrozoleChemicalClinicalAnnotation, PathwayassociatedPD20048079
PA448771capecitabineChemicalClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449383docetaxelChemicalClinicalAnnotationassociatedPD
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotationassociatedPD
PA449563exemestaneChemicalClinicalAnnotation, PathwayassociatedPD20048079, 24590773, 26536870
PA450196letrozoleChemicalClinicalAnnotation, PathwayassociatedPD20048079, 26463708, 26536870
PA450761paclitaxelChemicalClinicalAnnotationassociatedPD
PA451581tamoxifenChemicalClinicalAnnotationassociatedPD
PA451776triglyceridesChemicalClinicalAnnotation, VariantAnnotationassociated26463708

References

Pubmed IDYearTitleCitations
216227272011Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer.157
191298472009Structural basis for androgen specificity and oestrogen synthesis in human aromatase.108
151991132004Polymorphisms associated with circulating sex hormone levels in postmenopausal women.103
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
225762122012Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women.91
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
127342092003Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line.74
173250272007Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.69
173250272007Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women.69

Citation

Dessen P

CYP19A1 (cytochrome P450 family 19 subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40234/cyp19a1