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CYP19A1 (cytochrome P450, family 19, subfamily A, polypeptide 1)

Identity

Other namesARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
HGNC (Hugo) CYP19A1
LocusID (NCBI) 1588
Location 15q21.2
Location_base_pair Starts at 51500254 and ends at 51630795 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP19A1   2594
Cards
Entrez_Gene (NCBI)CYP19A1  1588  cytochrome P450, family 19, subfamily A, polypeptide 1
GeneCards (Weizmann)CYP19A1
Ensembl (Hinxton)ENSG00000137869 [Gene_View]  chr15:51500254-51630795 [Contig_View]  CYP19A1 [Vega]
ICGC DataPortalENSG00000137869
cBioPortalCYP19A1
AceView (NCBI)CYP19A1
Genatlas (Paris)CYP19A1
WikiGenes1588
SOURCE (Princeton)NM_000103 NM_031226
Genomic and cartography
GoldenPath (UCSC)CYP19A1  -  15q21.2   chr15:51500254-51630795 -  15q21.2   [Description]    (hg19-Feb_2009)
EnsemblCYP19A1 - 15q21.2 [CytoView]
Mapping of homologs : NCBICYP19A1 [Mapview]
OMIM107910   139300   613546   
Gene and transcription
Genbank (Entrez)AK291778 AM392533 AM393184 BC020767 BC022896
RefSeq transcript (Entrez)NM_000103 NM_031226
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_007982 NT_010194 NW_001838218 NW_004929398
Consensus coding sequences : CCDS (NCBI)CYP19A1
Cluster EST : UnigeneHs.260074 [ NCBI ]
CGAP (NCI)Hs.260074
Alternative Splicing : Fast-db (Paris)GSHG0010414
Alternative Splicing GalleryENSG00000137869
Gene ExpressionCYP19A1 [ NCBI-GEO ]     CYP19A1 [ SEEK ]   CYP19A1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11511 (Uniprot)
NextProtP11511  [Medical]
With graphics : InterProP11511
Splice isoforms : SwissVarP11511 (Swissvar)
Catalytic activity : Enzyme1.14.14.14 [ Enzyme-Expasy ]   1.14.14.141.14.14.14 [ IntEnz-EBI ]   1.14.14.14 [ BRENDA ]   1.14.14.14 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450 [organisation]   Cyt_P450_CS [organisation]   Cyt_P450_E_grp-I [organisation]  
Related proteins : CluSTrP11511
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1588
Blocks (Seattle)P11511
PDB (SRS)1TQA    3EQM    3S79    3S7S    4GL5    4GL7    4KQ8   
PDB (PDBSum)1TQA    3EQM    3S79    3S7S    4GL5    4GL7    4KQ8   
PDB (IMB)1TQA    3EQM    3S79    3S7S    4GL5    4GL7    4KQ8   
PDB (RSDB)1TQA    3EQM    3S79    3S7S    4GL5    4GL7    4KQ8   
Human Protein AtlasENSG00000137869 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP11511
HPRD00488
IPIIPI00465065   IPI00879236   IPI00792386   IPI00878829   IPI00878332   
Protein Interaction databases
DIP (DOE-UCLA)P11511
IntAct (EBI)P11511
FunCoupENSG00000137869
BioGRIDCYP19A1
InParanoidP11511
Interologous Interaction database P11511
IntegromeDBCYP19A1
STRING (EMBL)CYP19A1
Ontologies - Pathways
Ontology : AmiGOiron ion binding  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  estrogen biosynthetic process  xenobiotic metabolic process  steroid metabolic process  androgen metabolic process  electron carrier activity  membrane  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  oxygen binding  heme binding  small molecule metabolic process  oxidation-reduction process  prostate gland growth  aromatase activity  
Ontology : EGO-EBIiron ion binding  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  estrogen biosynthetic process  xenobiotic metabolic process  steroid metabolic process  androgen metabolic process  electron carrier activity  membrane  sterol metabolic process  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  oxygen binding  heme binding  small molecule metabolic process  oxidation-reduction process  prostate gland growth  aromatase activity  
Pathways : KEGGSteroid hormone biosynthesis    Ovarian steroidogenesis   
Protein Interaction DatabaseCYP19A1
Wikipedia pathwaysCYP19A1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP19A1
snp3D : Map Gene to Disease1588
SNP (GeneSNP Utah)CYP19A1
SNP : HGBaseCYP19A1
Genetic variants : HAPMAPCYP19A1
Exome VariantCYP19A1
1000_GenomesCYP19A1 
ICGC programENSG00000137869 
Somatic Mutations in Cancer : COSMICCYP19A1 
CONAN: Copy Number AnalysisCYP19A1 
Mutations and Diseases : HGMDCYP19A1
Mutations and Diseases : intOGenCYP19A1
Genomic VariantsCYP19A1  CYP19A1 [DGVbeta]
dbVarCYP19A1
ClinVarCYP19A1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM107910    139300    613546   
MedgenCYP19A1
GENETestsCYP19A1
Disease Genetic AssociationCYP19A1
Huge Navigator CYP19A1 [HugePedia]  CYP19A1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCYP19A1
Homology/Alignments : Family Browser (UCSC)CYP19A1
Phylogenetic Trees/Animal Genes : TreeFamCYP19A1
Chemical/Protein Interactions : CTD1588
Chemical/Pharm GKB GenePA27091
Clinical trialCYP19A1
Cancer Resource (Charite)ENSG00000137869
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCYP19A1
iHOPCYP19A1
OncoSearchCYP19A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:43:50 CEST 2014

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