Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1)

Identity

Other namesAHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
HGNC (Hugo) CYP1A1
LocusID (NCBI) 1543
Location 15q24.1
Location_base_pair Starts at 75011883 and ends at 75017877 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP1A1   2595
Cards
Entrez_Gene (NCBI)CYP1A1  1543  cytochrome P450, family 1, subfamily A, polypeptide 1
GeneCards (Weizmann)CYP1A1
Ensembl hg19 (Hinxton)ENSG00000140465 [Gene_View]  chr15:75011883-75017877 [Contig_View]  CYP1A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140465 [Gene_View]  chr15:75011883-75017877 [Contig_View]  CYP1A1 [Vega]
ICGC DataPortalENSG00000140465
cBioPortalCYP1A1
AceView (NCBI)CYP1A1
Genatlas (Paris)CYP1A1
WikiGenes1543
SOURCE (Princeton)CYP1A1
Genomic and cartography
GoldenPath hg19 (UCSC)CYP1A1  -     chr15:75011883-75017877 -  15q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CYP1A1  -     15q24.1   [Description]    (hg38-Dec_2013)
EnsemblCYP1A1 - 15q24.1 [CytoView hg19]  CYP1A1 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBICYP1A1 [Mapview hg19]  CYP1A1 [Mapview hg38]
OMIM108330   
Gene and transcription
Genbank (Entrez)AF040259 AK223108 AK223113 AK310810 AK313880
RefSeq transcript (Entrez)NM_000499
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_008431 NT_010194 NW_001838219 NW_004929398
Consensus coding sequences : CCDS (NCBI)CYP1A1
Cluster EST : UnigeneHs.72912 [ NCBI ]
CGAP (NCI)Hs.72912
Alternative Splicing : Fast-db (Paris)GSHG0010588
Alternative Splicing GalleryENSG00000140465
Gene ExpressionCYP1A1 [ NCBI-GEO ]     CYP1A1 [ SEEK ]   CYP1A1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04798 (Uniprot)
NextProtP04798  [Medical]
With graphics : InterProP04798
Splice isoforms : SwissVarP04798 (Swissvar)
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP1   
Related proteins : CluSTrP04798
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM Disease mutations1543
Blocks (Seattle)P04798
PDB (SRS)4I8V   
PDB (PDBSum)4I8V   
PDB (IMB)4I8V   
PDB (RSDB)4I8V   
Human Protein AtlasENSG00000140465
Peptide AtlasP04798
HPRD00148
IPIIPI00218839   IPI00871435   IPI00552572   
Protein Interaction databases
DIP (DOE-UCLA)P04798
IntAct (EBI)P04798
FunCoupENSG00000140465
BioGRIDCYP1A1
IntegromeDBCYP1A1
STRING (EMBL)CYP1A1
Ontologies - Pathways
QuickGOP04798
Ontology : AmiGOresponse to hypoxia  iron ion binding  mitochondrion  endoplasmic reticulum membrane  porphyrin-containing compound metabolic process  xenobiotic metabolic process  aging  cell proliferation  steroid hydroxylase activity  amine metabolic process  response to wounding  response to virus  response to nematode  response to herbicide  embryo development ending in birth or egg hatching  coumarin metabolic process  flavonoid metabolic process  response to iron(III) ion  oxidoreductase activity  oxidoreductase activity, acting on diphenols and related substances as donors  flavonoid 3'-monooxygenase activity  insecticide metabolic process  drug metabolic process  dibenzo-p-dioxin catabolic process  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  response to food  demethylase activity  response to lipopolysaccharide  response to vitamin A  vitamin D metabolic process  response to drug  9-cis-retinoic acid biosynthetic process  camera-type eye development  cellular lipid metabolic process  small molecule metabolic process  response to antibiotic  response to arsenic-containing substance  digestive tract development  hydrogen peroxide biosynthetic process  response to hyperoxia  oxidation-reduction process  maternal process involved in parturition  aromatase activity  hepatocyte differentiation  vitamin D 24-hydroxylase activity  demethylation  cellular response to organic cyclic compound  omega-hydroxylase P450 pathway  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIresponse to hypoxia  iron ion binding  mitochondrion  endoplasmic reticulum membrane  porphyrin-containing compound metabolic process  xenobiotic metabolic process  aging  cell proliferation  steroid hydroxylase activity  amine metabolic process  response to wounding  response to virus  response to nematode  response to herbicide  embryo development ending in birth or egg hatching  coumarin metabolic process  flavonoid metabolic process  response to iron(III) ion  oxidoreductase activity  oxidoreductase activity, acting on diphenols and related substances as donors  flavonoid 3'-monooxygenase activity  insecticide metabolic process  drug metabolic process  dibenzo-p-dioxin catabolic process  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  response to food  demethylase activity  response to lipopolysaccharide  response to vitamin A  vitamin D metabolic process  response to drug  9-cis-retinoic acid biosynthetic process  camera-type eye development  cellular lipid metabolic process  small molecule metabolic process  response to antibiotic  response to arsenic-containing substance  digestive tract development  hydrogen peroxide biosynthetic process  response to hyperoxia  oxidation-reduction process  maternal process involved in parturition  aromatase activity  hepatocyte differentiation  vitamin D 24-hydroxylase activity  demethylation  cellular response to organic cyclic compound  omega-hydroxylase P450 pathway  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGSteroid hormone biosynthesis    Tryptophan metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Ovarian steroidogenesis    Chemical carcinogenesis   
Protein Interaction DatabaseCYP1A1
DoCM (Curated mutations)CYP1A1
Wikipedia pathwaysCYP1A1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCYP1A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP1A1
dbVarCYP1A1
ClinVarCYP1A1
1000_GenomesCYP1A1 
Exome Variant ServerCYP1A1
SNP (GeneSNP Utah)CYP1A1
SNP : HGBaseCYP1A1
Genetic variants : HAPMAPCYP1A1
Genomic VariantsCYP1A1  CYP1A1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000140465 
Somatic Mutations in Cancer : COSMICCYP1A1 
CONAN: Copy Number AnalysisCYP1A1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:75011883-75017877
Mutations and Diseases : HGMDCYP1A1
OMIM108330   
MedgenCYP1A1
NextProtP04798 [Medical]
GENETestsCYP1A1
Disease Genetic AssociationCYP1A1
Huge Navigator CYP1A1 [HugePedia]  CYP1A1 [HugeCancerGEM]
snp3D : Map Gene to Disease1543
DGIdb (Drug Gene Interaction db)CYP1A1
General knowledge
Homologs : HomoloGeneCYP1A1
Homology/Alignments : Family Browser (UCSC)CYP1A1
Phylogenetic Trees/Animal Genes : TreeFamCYP1A1
Chemical/Protein Interactions : CTD1543
Chemical/Pharm GKB GenePA27092
Clinical trialCYP1A1
Cancer Resource (Charite)ENSG00000140465
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCYP1A1
GoPubMedCYP1A1
iHOPCYP1A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:05:48 CET 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.