CYP1A1 (cytochrome P450 family 1 subfamily A member 1)

2003-02-01  

Identity

HGNC
LOCATION
15q24.1
LOCUSID
ALIAS
AHH,AHRR,CP11,CYP1,CYPIA1,P1-450,P450-C,P450DX
FUSION GENES

Other Information

Locus ID:

NCBI: 1543
MIM: 108330
HGNC: 2595
Ensembl: ENSG00000140465

Variants:

dbSNP: 1543
ClinVar: 1543
TCGA: ENSG00000140465
COSMIC: CYP1A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140465ENST00000379727P04798
ENSG00000140465ENST00000379727A0N0X8
ENSG00000140465ENST00000395048P04798
ENSG00000140465ENST00000395048A0N0X8
ENSG00000140465ENST00000395049E7EMT5
ENSG00000140465ENST00000562201P04798
ENSG00000140465ENST00000564596P04798
ENSG00000140465ENST00000566503A4F3V8
ENSG00000140465ENST00000567032P04798
ENSG00000140465ENST00000567032A0N0X8
ENSG00000140465ENST00000569630P04798
ENSG00000140465ENST00000612821Q5J9B1
ENSG00000140465ENST00000617691E7EMT5

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Tryptophan metabolismKEGGko00380
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Steroid hormone biosynthesisKEGGhsa00140
Tryptophan metabolismKEGGhsa00380
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Ovarian steroidogenesisKEGGhsa04913
Ovarian steroidogenesisKEGGko04913
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)REACTOMER-HSA-2142816
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)REACTOMER-HSA-2142670
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164760843deferasiroxChemicalClinicalAnnotationassociatedPK25348619, 27193993
PA166123431heart valve replacementDiseaseClinicalAnnotationassociatedPD27740732
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD22426923
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPKPD21121773, 26951882
PA446432beta-ThalassemiaDiseaseClinicalAnnotationassociatedPK25348619, 27193993
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPK23492908
PA448404amodiaquineChemicalPathwayassociated
PA448771capecitabineChemicalClinicalAnnotationassociatedPD22426923
PA448785carbamazepineChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA449197dacarbazineChemicalVariantAnnotationassociatedPK27428168
PA449383docetaxelChemicalClinicalAnnotationassociatedPD22426923
PA449563exemestaneChemicalVariantAnnotationnot associatedPK
PA449809granisetronChemicalClinicalAnnotation, VariantAnnotationassociatedPK27809336
PA450688olanzapineChemicalClinicalAnnotationassociatedPK23492908
PA450911phenobarbitalChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA450947phenytoinChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA451846valproic acidChemicalClinicalAnnotationassociatedPKPD21121773, 26951882
PA451906warfarinChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD27740732, 8689941

References

Pubmed IDYearTitleCitations
117514402001Metabolic gene polymorphism frequencies in control populations.157
117792612002Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight.157
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
204626152010In utero tobacco exposure epigenetically modifies placental CYP1A1 expression.70
124198322002A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.58
145600342003Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor.54
171608962007Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants.51
223929982012Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor.50
120369132002Effect of germ-line genetic variation on breast cancer survival in a population-based study.49

Citation

Dessen P

CYP1A1 (cytochrome P450 family 1 subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40235/cyp1a1