Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1)

Identity

Other namesAHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
HGNC (Hugo) CYP1A1
LocusID (NCBI) 1543
Location 15q24.1
Location_base_pair Starts at 75011883 and ends at 75017877 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CYP1A1   2595
Entrez_Gene (NCBI)CYP1A1  1543  cytochrome P450, family 1, subfamily A, polypeptide 1
Cards
GeneCards (Weizmann)CYP1A1
Ensembl (Hinxton)ENSG00000140465 [Gene_View]  chr15:75011883-75017877 [Contig_View]  CYP1A1 [Vega]
AceView (NCBI)CYP1A1
Genatlas (Paris)CYP1A1
SOURCE (Stanford)NM_000499
Genomic and cartography
GoldenPath (UCSC)CYP1A1  -  15q24.1   chr15:75011883-75017877 -  15q24.1   [Description]    (hg19-Feb_2009)
EnsemblCYP1A1 - 15q24.1 [CytoView]
Mapping of homologs : NCBICYP1A1 [Mapview]
OMIM108330   
Gene and transcription
Genbank (Entrez)AF040259 AK223108 AK223113 AK310810 AK313880
RefSeq transcript (SRS)NM_000499
RefSeq transcript (Entrez)NM_000499
RefSeq genomic (SRS)AC_000147 NC_000015 NC_018926 NG_008431 NT_010194 NW_001838219 NW_004078084
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_008431 NT_010194 NW_001838219 NW_004078084
Consensus coding sequences : CCDS (NCBI)CYP1A1
Cluster EST : UnigeneHs.72912 [ SRS ] Hs.72912 [ NCBI ]
CGAP (NCI)Hs.72912
Alternative Splicing : Fast-db (Paris)GSHG0010588
Alternative Splicing GalleryENSG00000140465
Gene ExpressionCYP1A1 [ NCBI-GEO ]   CYP1A1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04798 (SRS) P04798 (Uniprot)
NextProtP04798
With graphics : InterProP04798
Splice isoforms : SwissVarP04798(Swissvar)
Domaine pattern : Prosite (SRS)CYTOCHROME_P450 (PS00086)   
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (SRS)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP1   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP1   
Related proteins : CluSTrP04798
Domain families : Pfam (SRS)p450 (PF00067)   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
DMDM1543
Blocks (Seattle)P04798
PDB (SRS)4I8V   
PDB (PDBSum)4I8V   
PDB (IMB)4I8V   
PDB (RSDB)4I8V   
Human Protein AtlasENSG00000140465
HPRD00148
IPIIPI00218839   IPI00871435   IPI00552572   
Protein Interaction databases
DIP (DOE-UCLA)P04798
IntAct (EBI)P04798
FunCoupENSG00000140465
REACTOMECYP1A1
Protein Interaction Database1543
BioGRIDCYP1A1
InParanoidP04798
Interologous Interaction database P04798
IntegromeDBCYP1A1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CYP1A1
SNP (GeneSNP Utah)CYP1A1
SNP : HGBaseCYP1A1
Genetic variants : HAPMAPCYP1A1
Somatic Mutations in Cancer : COSMICCYP1A1 
CONAN: Copy Number AnalysisCYP1A1 
Mutations and Diseases : HGMDCYP1A1
OMIM108330   
GENETests108330   
Disease Genetic AssociationCYP1A1
Huge Navigator CYP1A1 [HugePedia]  CYP1A1 [HugeCancerGEM]
Genomic VariantsCYP1A1  CYP1A1 [DGVbeta]
ClinVarCYP1A1
snp3D : Map Gene to Disease1543
General knowledge
Homologs : HomoloGeneCYP1A1
Homology/Alignments : Family Browser (UCSC)CYP1A1
Phylogenetic Trees/Animal Genes : TreeFamCYP1A1
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.1 [ Enzyme-SRS ]   1.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
Chemical/Protein Interactions : CTD1543
Chemical/Pharm GKB GenePA27092
Clinical trialCYP1A1
Cancer Resource (Charite)ENSG00000140465
Ontology : AmiGOresponse to hypoxia  iron ion binding  mitochondrion  endoplasmic reticulum membrane  porphyrin-containing compound metabolic process  xenobiotic metabolic process  aging  cell proliferation  steroid hydroxylase activity  electron carrier activity  amine metabolic process  response to wounding  response to virus  response to nematode  response to herbicide  embryo development ending in birth or egg hatching  coumarin metabolic process  flavonoid metabolic process  response to iron(III) ion  response to organic cyclic compound  oxidoreductase activity  oxidoreductase activity, acting on diphenols and related substances as donors  flavonoid 3'-monooxygenase activity  insecticide metabolic process  drug metabolic process  dibenzo-p-dioxin catabolic process  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  response to food  demethylase activity  response to lipopolysaccharide  response to vitamin A  vitamin D metabolic process  response to drug  9-cis-retinoic acid biosynthetic process  camera-type eye development  cellular lipid metabolic process  small molecule metabolic process  positive regulation of S phase of mitotic cell cycle  response to antibiotic  response to arsenic-containing substance  digestive tract development  hydrogen peroxide biosynthetic process  response to hyperoxia  oxidation-reduction process  maternal process involved in parturition  aromatase activity  hepatocyte differentiation  vitamin D 24-hydroxylase activity  omega-hydroxylase P450 pathway  
Ontology : EGO-EBIresponse to hypoxia  iron ion binding  mitochondrion  endoplasmic reticulum membrane  porphyrin-containing compound metabolic process  xenobiotic metabolic process  aging  cell proliferation  steroid hydroxylase activity  electron carrier activity  amine metabolic process  response to wounding  response to virus  response to nematode  response to herbicide  embryo development ending in birth or egg hatching  coumarin metabolic process  flavonoid metabolic process  response to iron(III) ion  response to organic cyclic compound  oxidoreductase activity  oxidoreductase activity, acting on diphenols and related substances as donors  flavonoid 3'-monooxygenase activity  insecticide metabolic process  drug metabolic process  dibenzo-p-dioxin catabolic process  arachidonic acid metabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  response to food  demethylase activity  response to lipopolysaccharide  response to vitamin A  vitamin D metabolic process  response to drug  9-cis-retinoic acid biosynthetic process  camera-type eye development  cellular lipid metabolic process  small molecule metabolic process  positive regulation of S phase of mitotic cell cycle  response to antibiotic  response to arsenic-containing substance  digestive tract development  hydrogen peroxide biosynthetic process  response to hyperoxia  oxidation-reduction process  maternal process involved in parturition  aromatase activity  hepatocyte differentiation  vitamin D 24-hydroxylase activity  omega-hydroxylase P450 pathway  
Pathways : KEGGTryptophan metabolismMetabolism of xenobiotics by cytochrome P450
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneCYP1A1
iHOPCYP1A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:39:18 CEST 2013
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