Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CYP1A1 (cytochrome P450 family 1 subfamily A member 1)

Identity

Alias_namesCYP1
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
cytochrome P450, family 1, subfamily A, polypeptide 1
Alias_symbol (synonym)P450DX
P1-450
P450-C
CP11
Other aliasAHH
AHRR
CYPIA1
HGNC (Hugo) CYP1A1
LocusID (NCBI) 1543
Atlas_Id 40235
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74719542 and ends at 74725610 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CYP1A1 (15q24.1) / CAT (11p13)CYP1A1 (15q24.1) / FTSJ3 (17q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Laryngeal tumors: an overview


External links

Nomenclature
HGNC (Hugo)CYP1A1   2595
Cards
Entrez_Gene (NCBI)CYP1A1  1543  cytochrome P450 family 1 subfamily A member 1
AliasesAHH; AHRR; CP11; CYP1; 
CYPIA1; P1-450; P450-C; P450DX
GeneCards (Weizmann)CYP1A1
Ensembl hg19 (Hinxton)ENSG00000140465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140465 [Gene_View]  chr15:74719542-74725610 [Contig_View]  CYP1A1 [Vega]
ICGC DataPortalENSG00000140465
TCGA cBioPortalCYP1A1
AceView (NCBI)CYP1A1
Genatlas (Paris)CYP1A1
WikiGenes1543
SOURCE (Princeton)CYP1A1
Genetics Home Reference (NIH)CYP1A1
Genomic and cartography
GoldenPath hg38 (UCSC)CYP1A1  -     chr15:74719542-74725610 -  15q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CYP1A1  -     15q24.1   [Description]    (hg19-Feb_2009)
EnsemblCYP1A1 - 15q24.1 [CytoView hg19]  CYP1A1 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBICYP1A1 [Mapview hg19]  CYP1A1 [Mapview hg38]
OMIM108330   
Gene and transcription
Genbank (Entrez)AH007293 AK223108 AK223113 AK310810 AK313880
RefSeq transcript (Entrez)NM_000499 NM_001319216 NM_001319217
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CYP1A1
Cluster EST : UnigeneHs.72912 [ NCBI ]
CGAP (NCI)Hs.72912
Alternative Splicing GalleryENSG00000140465
Gene ExpressionCYP1A1 [ NCBI-GEO ]   CYP1A1 [ EBI - ARRAY_EXPRESS ]   CYP1A1 [ SEEK ]   CYP1A1 [ MEM ]
Gene Expression Viewer (FireBrowse)CYP1A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1543
GTEX Portal (Tissue expression)CYP1A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04798   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04798  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04798
Splice isoforms : SwissVarP04798
Catalytic activity : Enzyme1.14.14.1 [ Enzyme-Expasy ]   1.14.14.11.14.14.1 [ IntEnz-EBI ]   1.14.14.1 [ BRENDA ]   1.14.14.1 [ KEGG ]   
PhosPhoSitePlusP04798
Domaine pattern : Prosite (Expaxy)CYTOCHROME_P450 (PS00086)   
Domains : Interpro (EBI)Cyt_P450    Cyt_P450_CS    Cyt_P450_E_grp-I    Cyt_P450_E_grp-I_CYP1   
Domain families : Pfam (Sanger)p450 (PF00067)   
Domain families : Pfam (NCBI)pfam00067   
Conserved Domain (NCBI)CYP1A1
DMDM Disease mutations1543
Blocks (Seattle)CYP1A1
PDB (SRS)4I8V   
PDB (PDBSum)4I8V   
PDB (IMB)4I8V   
PDB (RSDB)4I8V   
Structural Biology KnowledgeBase4I8V   
SCOP (Structural Classification of Proteins)4I8V   
CATH (Classification of proteins structures)4I8V   
SuperfamilyP04798
Human Protein AtlasENSG00000140465
Peptide AtlasP04798
HPRD00148
IPIIPI00218839   IPI00871435   IPI00552572   
Protein Interaction databases
DIP (DOE-UCLA)P04798
IntAct (EBI)P04798
FunCoupENSG00000140465
BioGRIDCYP1A1
STRING (EMBL)CYP1A1
ZODIACCYP1A1
Ontologies - Pathways
QuickGOP04798
Ontology : AmiGOresponse to hypoxia  lipid hydroxylation  monooxygenase activity  iron ion binding  protein binding  mitochondrion  endoplasmic reticulum membrane  porphyrin-containing compound metabolic process  aging  steroid metabolic process  cell proliferation  response to wounding  response to virus  response to nematode  response to herbicide  ethylene metabolic process  coumarin metabolic process  flavonoid metabolic process  response to iron(III) ion  oxidoreductase activity  oxidoreductase activity, acting on diphenols and related substances as donors  flavonoid 3'-monooxygenase activity  insecticide metabolic process  drug metabolic process  dibenzo-p-dioxin catabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  organelle membrane  response to food  demethylase activity  response to lipopolysaccharide  response to vitamin A  response to immobilization stress  vitamin D metabolic process  response to drug  9-cis-retinoic acid biosynthetic process  camera-type eye development  intracellular membrane-bounded organelle  response to antibiotic  response to arsenic-containing substance  digestive tract development  response to hyperoxia  oxidation-reduction process  maternal process involved in parturition  aromatase activity  hepatocyte differentiation  vitamin D 24-hydroxylase activity  demethylation  cellular response to copper ion  cellular response to organic cyclic compound  omega-hydroxylase P450 pathway  estrogen 16-alpha-hydroxylase activity  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIresponse to hypoxia  lipid hydroxylation  monooxygenase activity  iron ion binding  protein binding  mitochondrion  endoplasmic reticulum membrane  porphyrin-containing compound metabolic process  aging  steroid metabolic process  cell proliferation  response to wounding  response to virus  response to nematode  response to herbicide  ethylene metabolic process  coumarin metabolic process  flavonoid metabolic process  response to iron(III) ion  oxidoreductase activity  oxidoreductase activity, acting on diphenols and related substances as donors  flavonoid 3'-monooxygenase activity  insecticide metabolic process  drug metabolic process  dibenzo-p-dioxin catabolic process  epoxygenase P450 pathway  oxygen binding  enzyme binding  heme binding  organelle membrane  response to food  demethylase activity  response to lipopolysaccharide  response to vitamin A  response to immobilization stress  vitamin D metabolic process  response to drug  9-cis-retinoic acid biosynthetic process  camera-type eye development  intracellular membrane-bounded organelle  response to antibiotic  response to arsenic-containing substance  digestive tract development  response to hyperoxia  oxidation-reduction process  maternal process involved in parturition  aromatase activity  hepatocyte differentiation  vitamin D 24-hydroxylase activity  demethylation  cellular response to copper ion  cellular response to organic cyclic compound  omega-hydroxylase P450 pathway  estrogen 16-alpha-hydroxylase activity  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGSteroid hormone biosynthesis    Tryptophan metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Ovarian steroidogenesis    Chemical carcinogenesis   
NDEx NetworkCYP1A1
Atlas of Cancer Signalling NetworkCYP1A1
Wikipedia pathwaysCYP1A1
Orthology - Evolution
OrthoDB1543
GeneTree (enSembl)ENSG00000140465
Phylogenetic Trees/Animal Genes : TreeFamCYP1A1
HOVERGENP04798
HOGENOMP04798
Homologs : HomoloGeneCYP1A1
Homology/Alignments : Family Browser (UCSC)CYP1A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCYP1A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CYP1A1
dbVarCYP1A1
ClinVarCYP1A1
1000_GenomesCYP1A1 
Exome Variant ServerCYP1A1
ExAC (Exome Aggregation Consortium)CYP1A1 (select the gene name)
Genetic variants : HAPMAP1543
Genomic Variants (DGV)CYP1A1 [DGVbeta]
DECIPHERCYP1A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCYP1A1 
Mutations
ICGC Data PortalCYP1A1 
TCGA Data PortalCYP1A1 
Broad Tumor PortalCYP1A1
OASIS PortalCYP1A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCYP1A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCYP1A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CYP1A1
DgiDB (Drug Gene Interaction Database)CYP1A1
DoCM (Curated mutations)CYP1A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CYP1A1 (select a term)
intoGenCYP1A1
Cancer3DCYP1A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM108330   
Orphanet
MedgenCYP1A1
Genetic Testing Registry CYP1A1
NextProtP04798 [Medical]
TSGene1543
GENETestsCYP1A1
Target ValidationCYP1A1
Huge Navigator CYP1A1 [HugePedia]
snp3D : Map Gene to Disease1543
BioCentury BCIQCYP1A1
ClinGenCYP1A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1543
Chemical/Pharm GKB GenePA27092
Clinical trialCYP1A1
Miscellaneous
canSAR (ICR)CYP1A1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCYP1A1
EVEXCYP1A1
GoPubMedCYP1A1
iHOPCYP1A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:04:31 CEST 2017

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